Robert Allen, MD

Publications

• Metabolism 54:351-60
• Stroke 36:1207-11
• J Nutr Elder 24:47-65
• CMAJ 172:1569-73
• J Inherit Metab Dis 28:885-902
• Free Radic Biol Med 40:348-58
• J Inherit Metab dis
• AJCN
• J Clin Oncol
• 150. Panayiotidias, Mihalis I, Stabler, Sally P., Ahmad, Aftab, Pappa, Aglaia, Legros Jr, Leighton H, Hernandez, Daniel, Schneider, B. Kelly, Allen, Robert H., Vasilou, Vasiliou, McCord, Joe M., Kotb, Malak, White, Carl W. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Radic Biol Med 40:348-58, 2006
• 151. Buist NRM, Glenn B, Vugrek O, Wagner C, Stabler S, Allen RH, Pogribny I, Schulze A, Zeisel SH, Baric I, Mudd SH. S-adenosylhomocysteine hydrolase deficiency in a 26 year old man. J Inherit Metab Dis, 29:538-545, 2006.
• 152. Chandler RJ, Aswani V, Tsai MS, Falk M, Wehrli N, Stabler S, Allen R, Sedensky M, Kazazian HH, Vendetti CP. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Mol Genet Metab 89:64-73, 2006.
• 153. Moat SJ, Madhavan A, Taylor SY, Payne N, Allen RH, Stabler SP, Goodfellow J, McDowell IFW, Lewis MJ, Lang D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 36:850–859, 2006.
• 154. Stabler SP, Allen RH, Dolce ET, Johnson MA. Elevated serum S-adenosylhomocysteine in cobalamin deficient elderly and response to treatment. AJCN 84:1422-1429, 2006.
• 155. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. AJCN 85:19-25, 2007
• 157. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. AJCN 85:19-25, 2007.
• 158. Guerra-Shinohara EM, Morita OE, Pagliusi RA, Blaia-d’Avila VL, Allen RH, Stabler SP. Elevated serum S-adenosylhomocysteine in cobalamin deficient megaloblastic anemia. Metabolism 56:339-347, 2007.
• 159. Strauss KA, Holmes Morton D, Puffenberger EG, Hendrickson C, Robinson DL, Wagner C, Stabler SP, Allen RH, Chwatko G, Jakubowski H, Niculescu MD, Mudd SH. Prevention of brain disease from severe 5, 10-methylenetetrahydrofolate reductase deficiency. Mol Genet Metab 91:165-175, 2007.
• 160. Fischer LM, daCosta KA, Kwock L, Stewart PW, Lu TS, Stabler SP, Allen RH, Zeisel SH. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr 85:1275-1285, 2007.
• 161. Chandler RJ, Sloan J, Fu H, Tsai M, Stabler S, Allen R, Kaestner KH, Kazazian HH, Venditti CP. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. BMC Med Genet 8:64, 2007.
• 162. Barbosa PR, Stabler SP, Trentin R, Carvalho FR, Luchessi AD, Hirata MH, Allen RH, Guerra-Shinohara EM. Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine and S-adenosylhomocysteine values in Brazilian childbearing age women. Clin Chim Acta 388:139-47, 2008.
• 163. Gibson RS, Abebe Y, Stabler S, Allen RH, Westcott JE, Stoecker BJ, Krebs NF, Hambidge KM. Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr 138:581-586, 2008.
• 172. Barbosa PR, Stabler SP, Trentin R, Carvalho FR, Luchessi AD, Hirata MH, Allen RH, Guerra-Shinohara EM. Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine and S-adenosylhomocysteine values in Brazilian childbearing age women. Clin Chim Acta 388:139-47, 2008.
• 173. Gibson RS, Abebe Y, Stabler S, Allen RH, Westcott JE, Stoecker BJ, Krebs NF, Hambidge KM. Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr 138:581-586, 2008.
• 174. Matteini AM, Walston JD, Fallin MD, Bandeen-Roche K, Kao WHL, Semba RD, Allen RH, Guralnik J, Fried LP, Stabler SP. Markers of B-vitamin deficiency and frailty in older women. JNHA 12:303-308, 2008.
• 175. Allen RH and Stabler SP. Identification and quantitation of cobalamin and cobalamin analogues in human feces. Am J Clin Nutr 87:1324-1335, 2008.
• 176. Lopreato FR, Stabler SP, Carvalho FR, Hirata RDC, Hirata MH, Robi DL, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM. Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates. Clin Chim Acta 398:134-139, 2008
• 177. Barbosa PR, Stabler SP, Machado AL, Braga RC, Hirata RD, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur J Clin Nutr 62:1010-1021, 2008.
• 178. Macfarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem 283:25846-25853, 2008.
• 179. Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. To be published in Mutat Res Oct 25, 2008
• 180. Macfarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. To be published in J Biol Chem, Nov 25, 2008.
• 1. Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res 674: 23-30, 2009. 2. MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem 284: 1533-1539, 2009. 3. Kraus JP, Hasek J, Kozich V, Collard R, Venezia S, Janosikova B, Wang J, Stabler SP, Allen RH, Jakobs C, Finn CT, Chien YH, Hwu WL, Hegele RA, Mudd SH. Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. Mol Genet Metab 97: 250-259, 2009. 4. Girard CL, Santschi DE, Stabler SP, Allen RH. Apparent ruminal synthesis and intestinal disappearance of vitamin B12 and its analogs in dairy cows. J Dairy Sci 92: 4524-4529, 2009. 5. Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. alpha-Lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. Free Radic Biol Med 47: 1147-1153, 2009. 6. Vanderjagt DJ, Ujah IA, Patel A, Kellywood J, Crossey MJ, Allen RH, Stabler SP, Obande OS, Glew RH. Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria. J Obstet Gynaecol 29: 288-295, 2009. 7. Girard CL, Berthiaume R, Stabler SP, Allen RH. Identification of cobalamin and cobalamin analogues along the gastrointestinal tract of dairy cow. Arch Anim Nutr 63: 379-388, 2009. 8. Matteini AM, Walston JD, Bandeen-Roche K, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD. Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty. J Nutr Health Aging 14: 73-77, 2010. 9. Guerra-Shinohara EM, Pereira PM, Kubota AM, Silva TA, Reis JL, Miyashita GS, D'Almeida V, Allen RH, Stabler SP. Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study. Clin Chim Acta 411: 423-427, 2010. 10. Bor MV, von Castel-Roberts KM, Kauwell GP, Stabler SP, Allen RH, Maneval DR, Bailey LB, Nexo E. Daily intake of 4 to 7 ug dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr 91: 571-577, 2010. 11. Johnson, MA, Hausman DB, Davey A, Poon LW, Allen RH, Stabler SP for the Georgia Centenarian Study. Vitamin B12 deficiency in African-American and white octogenarians and centenarians in Georgia. J Nutr Health Aging 14: 339-345, 2010. 12. Fernández-Irigoyen J, Santamaría E, Chien YH, Hwu WL, Korman SH, Faghfoury H, Schulze A, Hoganson GE, Stabler SP, Allen RH, Wagner C, Mudd SH, Corrales FJ. Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia. Mol Genet Metab 101: 172-177, 2010. 13. Maclean K, Sikora J, Kozich V, Jiang H, Greiner L, Kraus E, Krijt J, Crnic L, Allen RH, Stabler S, Elleder M, Kraus J. Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment. Mol Genet Metab 101: 163-171, 2010. 14. Maclean K, Sikora J, Kozich V, Jiang H, Greiner L, Kraus E, Krijt J, Overdier K, Collard R, Brodsky G, Meltesen L, Crnic L, Allen R, Stabler S, Elleder M, Rozen R, Patterson D, Kraus J. A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Mol Genet Metab 101:153-162, 2010. 15. Grubbs R, Vugrek O, Deisch J, Wagner C, Stabler S, Allen R, Baric I, Rados M, Mudd SH. S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes. J Inherit Metab Dis 33: 705-713. 2010. 16. Yan J, Wang W, Gregory III JF, Malysheva O, Brenna JT, Stabler SP, Allen RH, Caudill MA. MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr 93: 348-355, 2011. 17. Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr 93: 789-798, 2011. 18. Keating AK, Freehauf C, Jiang H, Brodsky GL, Stabler SP, Allen RH, Graham DK, Thomas JA, Van Hove JL, Maclean KN. Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria. Mol Genet Metab 103: 330-337, 2011. 19. Stabler S, Koyama T, Zhao Z, Martinez-Ferrer M, Allen RH, Luka Z, Loukachevitch LV, Clark PE, Wagner C, Bhowmick NA. Serum methionine metabolites are risk factors for metastatic prostate cancer progression. PLoS ONE 6: e22486, 2011. 20. Hausman DB, Johnson MA, Davey A, Woodard JL, Poon LW, Allen RH, Stabler SP. The oldest old: red blood cell and plasma folate in african american and white octogenarians and centenarians in Georgia. J Nutr Health Aging 15:744-750, 2011. 21. Macfarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ. Nuclear localization of the de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. J Biol Chem 286: 44015-44022, 2011. 22. Haslam A, Hausman DB, Johnson MA, Davey A, Poon LW, Allen RH, Stabler SP; for the Georgia Centenarian Study. Prevalence and Predictors of Anemia in a Population-Based Study of Octogenarians and Centenarians in Georgia. J Gerontol A Biol Sci Med Sci 67A: 100-106, 2012. 23. Mudd SH, Wagner C, Luka Z, Stabler SP, Allen RH, Schroer R, Wood T, Wang J, Wong LJ. Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine. Mol Genet Metab 105: 228-236, 2012. 24. Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: Decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. Mol Genet Metab, December 2, 2011. 25. Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RH, Caudill MA. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. In Press, AJCN, 2012. 26. Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ. Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. Submitted to AJCN, 2011. 27. Stabler S, Korson M, Jethva R, Allen RH, Kraus JP, Spector EB, Wagner C, Mudd SH. Marked pyridoxine responsiveness in cystathionine beta-synthase due to compound heterozygous p.G307S and p.P49L mutations in two generations of a family with thrombophilia. Submitted to J Inherit Metab Dis, 2011. 28. Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Allen RH, Stabler SP, Green RC, Poon LW for the Georgia Centenarian Study. Profiles of Cognitive Functioning in a Population-Based Sample of Centenarians Using Factor Mixture Analysis. Submitted to Am J Geriatr Psychiatry, 2012.
• Haslam A, Hausman DB, Johnson MA, Davey A, Poon LW, Allen RH, Stabler SP; for the Georgia Centenarian Study. Prevalence and Predictors of Anemia in a Population-Based Study of Octogenarians and Centenarians in Georgia. J Gerontol A Biol Sci Med Sci 67A: 100-106, 2012.
• Mudd SH, Wagner C, Luka Z, Stabler SP, Allen RH, Schroer R, Wood T, Wang J, Wong LJ. Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine. Mol Genet Metab 105: 228-236, 2012.
• Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: Decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. Mol Genet Metab 105: 395-403, 2012.
• Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ. Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. Am J Clin Nutr 95: 882-891, 2012.
• Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RH, Caudill MA. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr 95: 1060-1071, 2012.
• Maclean KN, Greiner LS, Evans JR, Sood SK, Lhotak S, Markham NE, Stabler SP, Allen RH, Austin RC, Balasubramaniam V, Jiang H. Cystathionine protects against endoplasmic reticulum stress induced lipid accumulation, tissue injury and apoptotic cell death. J Biol Chem 287: 31994-32005, 2012.
• Jiang H, Stabler SP, Allen RH, Maclean KN. Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: Possible implications for cardiovascular outcomes. Mol Genet Metab 107: 55-65, 2012.
• Yi S, Seth EC, Men YJ, Stabler SP, Allen RH, Alvarez-Cohen L, Taga ME. Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in dehalococcoides mccartyi. Appl Environ Microbiol 78: 7745-7752, 2012.
• Field MS, Shields KS, Abarinov EV, Malysheva OV, Allen RH, Stabler SP, Ash JA, Strupp BJ, Stover PJ, Caudill MA. Reduced MTHFD1 activity in male mice perturbs folate and choline dependent one-carbon metabolism as well as transsulfuration. J Nutr 143: 41-5, 2013.
• Delaney C, Garg SK, Fernandes C, Hoeltzel M, Allen RH, Stabler S, Yung R. Maternal diet supplemented with Methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice. PLoS One 8: e56253, 2013.
• Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Green RC, Allen RH, Stabler SP, Poon LW For The Georgia Centenarian Study. Profiles of cognitive functioning in a population based sample of Centenarians using factor mixture analysis. Exp Aging Res 39:125-144, 2013.
• Infante JR, Novello S, Ma WW, Dy GK, Bendell JC, Huff A, Wang Q, Suttle AB, Allen R, Xu CF, Ottesen LH, Burris HA 3rd, Adjei AA. Phase Ib trial of the oral angiogenesis inhibitor pazopanib administered concurrently with pemetrexed in patients with advanced solid tumors. In Press, Invest New Drugs, 2012.
• Stabler S, Korson M, Jethva R, Allen RH, Kraus JP, Spector EB, Wagner C, Mudd SH. Metabolic Profiling of Total Homocysteine and Related Compounds in Hyperhomocysteinemia: Utility and limitations in diagnosing the cause of puzzling thrombophilia in a family. In Press, J Inherit Metab Dis, 2012.