Charles Edelstein, MD, PhD

Research Interests

Polycystic kidney disease

Publications

• Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. (in press).
• Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Ischemic acute renal failure (ARF) following nephrectomy impairs long-term renal function. Transplantation (in press)
• Faubel S, Ljubanovic D, Poole B, Dursun B, He Z, Cushing S, Somerset H, Gill RG, Edelstein CL. Ischemic acute renal failure is a CD4+ T cell independent process. Transplantation 80, 643-649, 2005
• Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL. Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit. J. Am. Soc. Nephrol 16, 3046-3052, 2005
• Tao Y, Kim J, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci USA102, 6954-6959, 2005
• Wang W, Faubel S, Ljubanovic D, Tao Y, Soloviev A, Reznikov LL, Mitra A, Kim J, Dinarello CA, Schrier RW, Edelstein CL. Endotoxemic acute renal failure (ARF) is attenuated in caspase-1 deficient mice. Am. J. Physiol-Renal Physiology 288, F997-1004, 2005
• Dursun B and Edelstein CL. Acute renal failure-core curriculum. Am. J. Kid. Dis. 45, 614-618, 2005
• Tao Y, Kim J, Faubel S, Stanley M, He Z, Faubel S, Schrier RW, Edelstein CL. Pathways of caspase--mediated apoptosis in autosomal dominant polycystic kidney disease (ADPKD). Kidney Int. 67, 909-919, 2005.
• Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J. Transplant (in press)
• Parikh CR,Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly K, Dent C, Devarajan P, Edelstein CL. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int (in press)
• Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine mediated pulmonary injury J. Am. Soc. Nephrol 18, 155-164, 2007
• Parikh CR,Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly K, Dent C, Devarajan P, Edelstein CL. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int 70, 199-203, 2006
• Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant 6, 1639-45, 2006
• Dursun B, He Z, Somerset H Oh DJ, Faubel S, Edelstein CL. Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. Am J Physiol Renal Physiol. 291, F578-87, 2006
• Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Ischemic acute renal failure (ARF) following nephrectomy impairs long-term renal function. Transplantation 81 (5), 800-803, 2006
• Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. J. Am. Soc. Nephrol 17 (3), 707-715, 2006
• Edelstein CL, Schrier RW. Acute renal failure: pathogenesis, diagnosis and management. In Schrier RW (ed), Renal and Electrolyte disorders, 7th Edition, Lippincott Williams and Wilkins, Philadelphia, 2007.
• Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello C, Faubel S. Proximal tubules from caspase-1 deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant (in press)
• 10 published abstracts not listed
• Tao Y, Zafar I, Kim J,. Schrier RW and Edelstein CL. Deletion of the caspase-3 gene markedly prolongs survival in the cpk mouse model of polycystic kidney disease (PKD). J. Am. Soc. Nephrol (in press)
• Washburn KK, Zappitelli M, Arikan AA, Loftis L, Yalavarthy R, Parikh CR, Edelstein CL, Goldstein SL. Urinary Interleukin-18 as an Acute Kidney Injury Biomarker in Critically Ill Children. Nephrol. Dial. Transpl (in press)
• Oh DJ , Dursun B, He Z, Lu L , Hoke TS , Ljubanovic D , Faubel S and Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am. J. Physiol. Renal Physiol 294(1):F264-71, 2008
• Lu L, Oh DJ, Dursun B, He Zhibin, Hoke T, Faubel S, Edelstein CL. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J. Pharmacol. Exp.Therap. 324(1):111-7, 2008.
• Parikh C, Cantley L, Devarajan P, Edelstein CL. Biomarkers of Acute Kidney Injury- Early Diagnosis, Pathogenesis and Recovery. J. Investigative Med 55,7,333-340, 2007
• Tao Y, Zafar I, Falk S, Faubel S, He Z, Schrier RW, Edelstein CL. VEGF Receptor (VEGFR) Inhibition Slows the Progression of Polycystic Kidney Disease (PKD). Kidney Int 72(11):1358-66, 2007.
• Zafar I, Tao Y, Falk S, McFann K, Schrier RW, Edelstein CL. Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model. Am. J. Physiol-Renal 293(3):F854-9, 2007.
• Yalavarthy R, Smith M, Edelstein CL. Acute Kidney Injury Complicating Minimal Change Disease: The Case for Careful Use of Diuretics and ACE Inhibitors. Nephrology 12(5):529-31, 2007
• Yalavarthy R, Edelstein CL, Teitelbaum I. Acute renal failure and chronic kidney disease following liver transplantation. Hemodialysis Int 11 Suppl 3:S7-12, 2007.
• Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced ARF is associated with an increase in the cytokines IL-1ß, IL-18, IL-6 and neutrophil infiltration in the kidney. J. Pharmacol. Exp.Therap. 322(1):8-15, 2007.
• Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello C, Faubel S. Proximal tubules from caspase-1 deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant 2007, 22, 1052-1061
• Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine mediated pulmonary injury. J. Am. Soc. Nephrol 2007, 18, 155-164
• Edelstein CL.Therapeutic interventions for ADPKD.Nephrology News.
• 8 published abstracts-not listed
• He Z, Dursun B, Oh DJ, Lu L, FaubelS, Edelstein CL. Macrophages are not the source of injurious IL-18 in ischemic AKI. Am J. Physiol Renal Physiol (in press)
• 86. Yalavarthy R, Edelstein CL. Therapeutic and predictive targets of AKI. Clin Nephrol 70 (6), 453-463, 2008
• 85. Belibi FA, Edelstein CL. Unified ultrasonographic criteria for the diagnosis of ADPKD - Editorial. J. Am. Soc. Nephrol 20(1):6-8, 2009
• 84. Yalavarthy R, Smith ML, Edelstein CL. HIV-associated nephropathy in Caucasians: case report and review of literature. Int J STD AIDS. 2008 Nov;19(11):789-90.
• 83. He Z, Lu L, Hoke T, Altmann C, Ljubanovic D, Dinarello C, FaubelS, Edelstein CL. IL-18 binding protein transgenic mice are protected against ischemic acute kidney injury, Am J. Physiol Renal Physiol 295 (5), F414-421, 2008
• 82. Edelstein CL. Mammalian target of rapamycin (mTOR) and caspase inhibition in polycystic kidney disease (PKD). Clin. J. Am. Soc. Nephrol 3 (4), 1219-1226, 2008
• 81. Edelstein CL. Biomarkers of acute kidney injury (AKI) Adv. Chronic Kid. Dis. 15 (3), 222-234, 2008
• 80 Faubel S and Edelstein CL. Exciting times in research on the definition, diagnosis, complications and outcomes of AKI. Adv. Chronic Kid. Dis. 15 930, 211-2, 2008
• 78. Tao Y, Zafar I, Kim J,. Schrier RW and Edelstein CL. Deletion of the caspase-3 gene markedly prolongs survival in the cpk mouse model of polycystic kidney disease (PKD). J. Am. Soc. Nephrol 19, 749-755, 2008.
• 77. Washburn KK, Zappitelli M, Arikan AA, Loftis L, Yalavarthy R, Parikh CR, Edelstein CL, Goldstein SL. Urinary Interleukin-18 as an Acute Kidney Injury Biomarker in Critically Ill Children. Nephrol. Dial. Transpl 23(2):566-72, 2008
• 76. Oh DJ , Dursun B, He Z, Lu L , Hoke TS , Ljubanovic D , Faubel S and Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am. J. Physiol. Renal Physiol 294(1):F264-71, 2008
• 75. Lu L, Oh DJ, Dursun B, He Zhibin, Hoke T, Faubel S, Edelstein CL. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J. Pharmacol. Exp.Therap. 324(1):111-7, 2008.
• 5. Faubel S, Cronin RE and Edelstein CL. The patient with acute renal failure. In Schrier RW (ed), Manual of Nephrology, Lippincott, Williams and Wilkins, 2008
• 9. West S, Agenbach G, Edelstein CL .Lupus Nephritis. In Schrier RW (ed), Diseases of the kidney, 8th edition, Lippincott, Williams and Wilkins, Philadelphia, 2007
• 6. Edelstein CL and Schrier RW. Pathophysiology of ischemic acute renal failure. In Schrier RW (ed), Diseases of the kidney, 8th edition, Lippincott, Williams and Wilkins, Philadelphia, 2007
• American Society of Nephrology 4 published abstracts
• Belibi F, Edelstein CL. Metastatic renal cancer: What role for Everolimus ?. Clinical Medicine Reviews in Oncology (in press)
• Akcay a, Nguyen Q, Edelstein CL. Mediators of inflammation in AKI. Mediators of Inflammation (in press).
• Belibi F, Edelstein CL. Novel therapeutic targets for the treatment of autosomal dominant polycystic kidney disease. Expert Opinion in Investigational Drugs (in press)
• Liu C, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum IL-6 and IL-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit. Care 13, R104, 2009
• Jimenez C, capasso JM, Edelstein CL, Rivard CJ, Lucia S, Breusegem S, Berl T, Segovia M. Different ways to die: cell death modes of the unicellular chlorophyte Dunaliella viridis exposed to various environmental stresses are mediated by the caspase-like activity DEVDase. J. Exp. Botany 60, 815-28, 2009
• Zafar I, Belibi F, Edelstein CL. Long term rapamycin therapy in a rat model of PKD. Nephrol. Dial. Transpl. 24(8):2349-53
• He Z, Dursun B, Oh DJ, Lu L, FaubelS, Edelstein CL. Macrophages are not the source of injurious IL-18 in ischemic AKI. Am J. Physiol Renal Physiol 296, F535-42, 2009
• Belibi FA, Edelstein CL. Unified ultrasonographic criteria for the diagnosis of ADPKD - Editorial. J. Am. Soc. Nephrol 20(1):6-8, 2009
• Edelstein CL, Schrier RW. Acute renal failure: pathogenesis, diagnosis and management. In Schrier RW (ed), Renal and Electrolyte disorders, 7th Edition, Lippincott Williams and Wilkins, Philadelphia, 2010.
• Biomarkers of Kidney Disease
• Belibi F, Edelstein CL. Novel therapeutic targets for the treatment of autosomal dominant polycystic kidney disease. Expert Opinion in Investigational Drugs 2010 Mar;19(3):315-28. PMC2861144
• Akcay a, Nguyen Q, Edelstein CL. Mediators of inflammation in AKI. Mediators of Inflammation (in press). PMC2825552
• Belibi F, Edelstein CL. Metastatic renal cancer: What role for Everolimus ?. Clinical Medicine Reviews in Oncology (in press)
• Doctor RB, Serkova NJ, Hasebroock KM, Zafar I, Edelstein CL. Distinct patterns of kidney and liver cyst growth in pkdWS25/- mice. Nephrol Dial Transplant 2010 Nov;25(11):3496-504
• Zafar I, Ravichandran K, Belibi F, Doctor B, Edelstein CL, mTORC1/2 and rapamycin in PKD2(WS25/-) mice with polycystic kidney disease. Kidney International 2010 Oct;78(8):754-61
• Enomoto L, Anderson P, Li S, Edelstein CL, Weinberg A. Effect of nucleoside and nucleotide analogue reverse transcriptase inhibitors on cell-mediated immune functions. AIDS Research and Human Retroviruses 2010 E pub
• Dennen P, Altmann C, Kaufman J, Klein C, Andres-Hernando A, Ahuja N, Edelstein CL, Cadnapaphornchai M, Keniston A and Faubel S. Urine IL-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Critical Care 2010; 14; R181.
• Alkesh Jani , Michael Zimmerman, Jessica Martin , Li Lu, Kultigin Turkmen, K Ravichandran, Arijana Pacic, Danica Ljubanovic and Charles L. Edelstein. Pulsatile perfusion reduces apoptosis in a porcine kidney model of donation after cardiac death (DCD). Transplantation 2011 E pub
• Belibi F, Ravichandran K, Zafar I, He Z, Edelstein CL, mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease (PKD). Am. J. Physiol. Renal Physiol 2011 Jan;300(1):F236-44.
• Justin M. Belcher, Charles L. Edelstein, Chirag R. Parikh. Clinical Applications of Biomarkers for Acute Kidney Injury. Am. J. Kid. Dis. (in press)
• Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV et al. Comparative performance of AKI biomarkers in the critically ill: poor performance improves with stratification for duration of injury and baseline renal function. Kidney Int (in press)
• Lee DW, Faubel S, Edelstein. Cytokines in acute kidney injury. Clin. Nephrol (in press)
• Belibi F, Zafar I, Ravichandran K, Bauer Segvic A, Jani A, Galesic Ljubanovic D, Edelstein CL. Hypoxia-inducible factor-1a and autophagy in polycytic kidney disease. Am. J. Physiol Renal Physiol (in press)
• Biomarkers of Kidney Disease
• Alkesh Jani , Michael Zimmerman, Jessica Martin , Li Lu, Kultigin Turkmen, K Ravichandran, Arijana Pacic, Danica Ljubanovic and Charles L. Edelstein. Pulsatile perfusion reduces apoptosis in a porcine kidney model of donation after cardiac death (DCD). Transplantation 2011 Jan 27;91(2):169-75
• Belibi F, Ravichandran K, Zafar I, He Z, Edelstein CL, mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease (PKD). Am. J. Physiol. Renal Physiol 2011 Jan;300(1):F236-44. PMC Journal – in process.
• Justin M. Belcher, Charles L. Edelstein, Chirag R. Parikh. Clinical Applications of Biomarkers for Acute Kidney Injury. Am. J. Kid. Dis. 2011 Jun;57(6):930-40. PMC Journal – in process.
• Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV et al. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int 2011; 79(10):1119-30
• Lee DW, Faubel S, Edelstein. Cytokines in acute kidney injury. Clin. Nephrol 2011 Sep;76(3):165-73. PMC Journal – in process.
• Belibi F, Zafar I, Ravichandran K, Bauer Segvic A, Jani A, Galesic Ljubanovic D, Edelstein CL. Hypoxia-inducible factor-1a and autophagy in polycytic kidney disease. Am. J. Physiol Renal Physiol 2011; 300(5):F1235-43. PMC Journal – in process.
• Kultigin Turkmen, Jessica Martin, Ali Akcay, Quocan Nguyen, K Ravichandran, Sarah Faubel, Arijana Pacic, Danica Ljubanovic, Charles L. Edelstein, and Alkesh Jani. Apoptosis and autophagy in cold preservation ischemia. Transplantation 2011 Jun 15;91(11):1192-7.
• Parikh CR, Devarajan P, Zapitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner J, Coca S, Edelstein CL, Schlipak MG, Garg AX and Krawczeski CD for the TRIBE-AKI consortium. Early post-operative urine and serum biomarkers predict AKI and poor outcomes after pediatric cardiac surgery. J. Am. Soc. Nephrol 2011 2011 Sep;22(9):1737-47. PMC Journal – in process.
• Parikh CR, Coca S, Thiessen-Philbrook H, Schlipak MG, Koyner J, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zapitelli M, Krawczeski CD Passik CS, Swaminathan M, Garg for the TRIBE-AKI consortium. Post-operative biomarkers predict AKI and poor outcomes after cardiac surgery in adults. J. Am. Soc. Nephrol 2011 2011 Sep;22(9):1748-57. PMC Journal – in process.
• Nejat M, Hill JV, Pickering JW, Edelstein CL, Devarajan P, Endre ZH. Albuminuria increases cystatin C excetion: implications for urinary biomarkers. Nephrol Dialysis Transpl (in press). PMC Journal – in process.
• Ali Akcay, Quocan Nguyen, Zhibin He, Kultigin Turkmen, Dong Won Lee, Ana Andres Hernando, Christopher Altmann, Aysun Toker, Arijana Pacic, Danica Galesic Ljubanovic, Alkesh Jani Sarah Faubel and Charles L. Edelstein. Il-33 exacerbates acute kidney injury in mice. J. Am. Soc. Nephrol 2011 Nov;22(11):2057-67.. PMC Journal – in process.
• Jani A, Epperson E, Martin J, Pacic A, Ljubanovic D, Martin SL and Edelstein CL. Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels. Transplantation 2011, 92(11):1215-21.
• Sirota JC, Klawitter J, Edelstein CL. Biomarkers of acute kidney injury. J. Toxiciol (in press)
• Azrina Md Ralib, John W Pickering, Geoffrey M Shaw, Prasad Devarajan, Charles L Edelstein, Joseph V Bonventre, Zoltan H Endre. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J. Am. Soc. Nephrol 2012 Feb;23(2):322-33.
• Faubel S, Edelstein CL. Severity of illness scoring systems in acute kidney injury. Nature Reviews Nephrol 2011 Nov 1;8(1):8-10.
• Parikh CR, Dahl NK, Chapman A, Bost JE, Edelstein CL, Comer DM, Zeltner R, Tian X, Grantham JJ, Somlo S. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Kidney Int (in press).
• Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, Zhibin He, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am. J. Physiol Renal Physiol 2012 Feb;302(4):F421-32..
• Lu L, Faubel S, He Z, Andres-Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am. J. Nephrol 2012 Jan 25;35(2):181-190.
• Nejat M, Pickering JW, Geoffrey Devarajan P, Joseph V Bonventre, Edelstein CL, Walker RJ, Endre ZH. Acute kidney injury biomarkers increased in pre-renal AKI. Kidney Int (in press)
• Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery. Shlipak MG, Coca SG, Wang Z, Devarajan P, Koyner JL, Patel UD, Thiessen-Philbrook H, Garg AX, Parikh CR; TRIBE-AKI Consortium. Am J Kidney Dis. 2011 Sep;58(3):366-73. Epub 2011 May 20.
• Sirota JC, Klawitter J, Edelstein CL. Biomarkers of acute kidney injury. J. Toxiciol (in press)
• Ralib A, Pickering JW, Shaw GM, Devarajan P, Edelstein CL, Bonventre JV, Endre ZH. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J. Am. Soc. Nephrol 2012 Feb;23(2):322-33.
• Parikh CR, Dahl NK, Chapman A, Bost JE, Edelstein CL, Comer DM, Zeltner R, Tian X, Grantham JJ, Somlo S. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Kidney Int 2012 Apr;81(8):784-90.
• Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, Zhibin He, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am. J. Physiol Renal Physiol 2012 Feb;302(4):F421-32..
• Lu L, Faubel S, He Z, Andres-Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am. J. Nephrol 2012 Jan 25;35(2):181-190.
• Nejat M, Pickering JW, Geoffrey Devarajan P, Joseph V Bonventre, Edelstein CL, Walker RJ, Endre ZH. Acute kidney injury biomarkers increased in pre-renal AKI. Kidney Int (in press)
• Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Yoshida S, Quiroga A, Ravichandran K, Susztak K, Dong Z Emerging role of autophagy in kidney function, diseases and aging. Autophagy (in press)
• Ahuja N, Andres-Hernando A, Altmann C, Bhargava R, Bacalja J, Webb RG, He Z, Edelstein CL, Faubel S. Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am. J. Physiol Renal Physiol (in press)
• Spahillari A, Parikh CR, Sint K, Koyner JL, Patel UD, Edelstein CL, Passik CS, Thiessen-Philbrook H, Swaminathan M, Shlipak MG; TRIBE-AKI Consortium Serum Cystatin C- Versus Creatinine-Based Definitions of Acute Kidney Injury Following Cardiac Surgery: A Prospective Cohort Study. Am J Kidney Dis. 60, 922-929, 2012
• Koyner JL, Garg AX, Coca SG, Sint K, Thiessen-Philbrook H, Patel UD, Shlipak MG, Parikh CR; TRIBE-AKI Consortium. Biomarkers predict progression of acute kidney injury after cardiac surgery. J Am Soc Nephrol. 2012 May;23(5):905-14
• Patel UD, Garg AX, Krumholz HM, Shlipak MG, Coca SG, Sint K, Thiessen-Philbrook H, Koyner JL, Swaminathan M, Passik CS, Parikh CR; Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium. Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery. Circulation. 2012 Mar 20;125(11):1347-55.
• Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17;14(1):17.
• Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 2;11(11):5135-44
• Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2015 Dec 1. [Epub ahead of print] PubMed PMID: 26620676
• Ozkok A, Ravichandran K, Wang Q, Ljubanovic D, Edelstein CL. NF-?B transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI). Toxicol Lett. 2016 Jan 5;240(1):105-13. PubMed PMID: 26546572
• Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2015 Oct 9. [Epub ahead of print] PubMed PMID: 26457601
• Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
• Jain S, Keys D, Ljubanovic D, Edelstein CL, Jani A. Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. Transplantation. 2015 Nov;99(11):2311-6. PubMed PMID: 26177086
• Hladinova Z, Hruskova Z, Svobodova B, Malickova K, Lanska V, Konopásek P, Jancova E, Rysava R, Edelstein CL, Tesar V. Increased levels of soluble ST2 in patients with active newly diagnosed ANCA-associated vasculitis. Mediators Inflamm. 2015;2015:603750. PubMed PMID: 25802482
• Ravichandran K, Ozkok A, Wang Q, Mullick AE, Edelstein CL. Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F349-57. PubMed PMID: 25537744
• Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb;37(1):144-50. PubMed PMID: 25310769
• Jain S, Keys D, Nydam T, Plenter RJ, Edelstein CL, Jani A. Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Transpl Int. 2015 Feb;28(2):214-23. PubMed PMID: 25270002
• Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med. 2016 Aug 30. [Epub ahead of print] PubMed PMID: 27576016
• Ravichandran K, Zafar I, Ozkok A, Edelstein CL. An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease. Nephrol Dial Transplant. 2015 Jan;30(1):45-53. PubMed PMID: 25239638
• Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. PubMed PMID: 26926297
• Klionsky D, Edelstein CL et al. Gudelines for the use and monitoring of assays for measuring autophagy. Autophagy 2016 Jan 2;12(1):1-222.
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PubMed PMID: 26799652
• Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2016 Apr;94(4):443-55. PubMed PMID: 26620676
• Ozkok A, Ravichandran K, Wang Q, Ljubanovic D, Edelstein CL. NF-?B transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI). Toxicol Lett. 2016 Jan 5;240(1):105-13. PubMed PMID: 26546572
• Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2016 Mar;100(3):538-45. PubMed PMID: 26457601
• Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
• 150. Gist KM, Kaufman J, da Cruz EM, Friesen RH, Crumback SL, Linders M, Edelstein C, Altmann C, Palmer C, Jalal D, Faubel S.A Decline in Intraoperative Renal Near-Infrared Spectroscopy Is Associated With Adverse Outcomes in Children Following Cardiac Surgery. Pediatr Crit Care Med. 2016 Feb 24. [Epub ahead of print]
• Biomarkers of Kidney Disease CL Edelstein Editor
• Biomarkers of AKI in the ICU. In Vincent/Fink. Textbook of Critical care
• Pathophysiology of AKI. In Renal and Electrolyte Disorders RW Schrier Ed
• Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med. 2017 Feb 15;195(4):482-490. PubMed PMID: 27576016
• Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrol. 2017 Jul 6;18(1):218. PubMed PMID: 28683730
• Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff RA, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2017 Oct 25;:ajprenal000402017. [Epub ahead of print] PubMed PMID: 29070568
• Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O. Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease. N Engl J Med. 2017 Nov 16;377(20):1930-1942. PubMed PMID: 29105594
• de Fontnouvelle CA, Greenberg JH, Thiessen-Philbrook HR, Zappitelli M, Roth J, Kerr KF, Devarajan P, Shlipak M, Coca S, Parikh CR. Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery. Ann Thorac Surg. 2017 Dec;104(6):2072-2079. PubMed PMID: 28821332
• Edelstein CL. Biomarkers of Kidney Disease: Second Edition Elsevier 2017
• Griffin BR, Faubel S, Edelstein CL. Biomarkers of drug-induced kidney toxicity. Ther Drug Monit. 2018 Dec 10. [Epub ahead of print] PubMed PMID: 30531196
• Davis S, Gralla J, Chan L, Wiseman A, Edelstein CL. Effect of Sirolimus on Native Total Kidney Volume After Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Pilot Study. Transplant Proc. 2018 Jun;50(5):1243-1248. PubMed PMID: 29880342
• Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff R, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F356-F366. PubMed PMID: 29070568
• Benjamin M Fox, Hyo-Wook Gil, Benjamin Griffin, Anna Jovanovich, Lara Kirkbride-Romeo, Danielle E. Soranno, Katja Gist Julie R Haines, Matthew Wither Angelo D'Alessandro, Timothy McKinsey, Charles L Edelstein, Sara Wennersten, Nathan Clendenen, Rushita A. Bagchi, Christopher Altmann, Sarah Faubel. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney International (in press) 2018
• Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2019 Dec 24;:109518. [Epub ahead of print] PubMed PMID: 31881325
• Holditch SJ, Brown CN, Atwood DJ, Pokhrel D, Brown SE, Lombardi AM, Nguyen KN, Hill RC, Lanaspa M, Hopp K, Weiser-Evans MCM, Edelstein CL. The consequences of increased 4E-BP1 in polycystic kidney disease. Hum Mol Genet. 2019 Oct 19. [Epub ahead of print] PubMed PMID: 31646342
• Holditch SJ, Brown CN, Lombardi AM, Nguyen KN, Edelstein CL. Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2019 Jun 20;20(12). PubMed PMID: 31226747
• Holditch SJ, Brown CN, Atwood DJ, Lombardi AM, Nguyen KN, Toll HW, Hopp K, Edelstein CL. A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F187-F196. PubMed PMID: 31042058
• Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 Apr;41(2):213-226. PubMed PMID: 30883514
• Lee DW, Kim JS, Kim IY, Kim HS, Kim JY, Rhee H, Seong EY, Song SH, Lee SB, Edelstein CL, Kwak IS. Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome. Anatol J Cardiol. 2019 Mar;21(3):134-141. PubMed PMID: 30821713
• Atwood DJ, Brown CN, Holditch SJ, Pokhrel D, Thorburn A, Hopp K, Edelstein CL. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 Nov;75:109760. PubMed PMID: 32866627
• Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
• Atwood DJ, Pokhrel D, Brown CN, Holditch SJ, Bachu DM, Thorburn A, Hopp K, Edelstein CL. Increased mTOR and suppressed autophagic flux in the heart of a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 Oct;74:109730. PubMed PMID: 32730856
• Edelstein CL, Venkatachalam MA, Dong Z. Autophagy inhibition by chloroquine and hydroxychloroquine could adversely affect acute kidney injury and other organ injury in critically ill patients with COVID-19. Kidney Int. 2020 Jul;98(1):234-235. PubMed PMID: 32437765
• Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cell Signal. 2020 Jul;71:109605. PubMed PMID: 32194168
• Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
• Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2020 Apr;68:109518. PubMed PMID: 31881325
• Surgical procedures suppress autophagic flux in the kidney. Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Cell Death Dis. 2021 Mar 5;12(3):248. doi: 10.1038/s41419-021-03518-w. PMID: 33674554
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Klionsky DJ, Edelstein CL Multiple Authors Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751
• Campbell RE, Chen CH, Edelstein CL. Overview of Antibiotic-Induced Nephrotoxicity. Kidney Int Rep. 2023 Nov;8(11):2211-2225. PubMed PMID: 38025228
• Oto OA, Atwood DJ, Chaudhary A, He Z, Li AS, Wempe MF, Edelstein CL. Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease. Physiol Rep. 2023 Sep;11(17):e15776. PubMed PMID: 37653564
• Stenson EK, Edelstein CL, You Z, Miyazaki-Anzai S, Thurman JM, Dixon BP, Zappitelli M, Goldstein SL, Akcan Arikan A, Kendrick J. Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children. Kidney360. 2023 Mar 1;4(3):326-332. PubMed PMID: 36758197

Professional Memberships

• American Society of Nephrology, Member
• International Society of Nephrology, Member
• Western Society for Clinical Investigation, Member
• American Heart Association (AHA), Fellow
• American Society of Transplantation, Member
• American Physiological Society, Member
• Western Association of Physicians, Member

Practice Locations

UCHealth Kidney Disease and Hypertension Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 7th floor
Aurora, CO 80045
720-848-0749

UCHealth Polycystic Kidney Disease Clinic - Anschutz Medical Campus
1635 Aurora Court
Anschutz Outpatient Pavilion, 7th floor
Aurora, CO 80045
720-848-0749

UCHealth Glomerular Diseases Clinic - Anschutz Medical Campus
1635 Aurora Court
Anschutz Outpatient Pavilion, 7th floor
Aurora, CO 80045
720-848-0749

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital
• Veterans Affairs Medical Center

Specialty Information

Specialties

• Nephrology, Board Certification
• Internal Medicine, Board Certification

Conditions & Treatments

• Kidneys and Urinary System - Kidney Failure
• Kidneys and Urinary System - Polycystic Kidney Disease
• Kidneys and Urinary System - Nephropathy (Nephrosis)
• Kidneys and Urinary System