Ann-Charlotte Granholm-Bentley, DDS, PhD
Professor, Neurosurgery

Department: Neurosurgery


  • Granholm AC. Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms. J Clin Med. 2023 Apr 28;12(9). PubMed PMID: 37176630
  • Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Mol Syndromol. 2023 Apr;14(2):89-100. PubMed PMID: 37064334
  • Colvett I, Gilmore A, Guzman S, Ledreux A, Quintero JE, Ginjupally DR, Gurwell JA, Slevin JT, Guduru Z, Gerhardt GA, van Horne CG, Granholm AC. Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. J Clin Med. 2023 Sep 22;12(19). PubMed PMID: 37834764
  • BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults Casey M. Nicastri, Brittany M. McFeeley, Sharon S. Simon, Aurélie Ledreux, Krister Håkansson, Ann-Charlotte Granholm, Abdul H. Mohammed, Kirk R. Daffner Alzheimers Dement (N Y) 2022; 8(1): e12337. Published online 2022 Aug 30. doi: 10.1002/trc2.12337 PMCID: PMC9428279
  • Nicastri CM, McFeeley BM, Simon SS, Ledreux A, Håkansson K, Granholm AC, Mohammed AH, Daffner KR. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Alzheimers Dement (N Y). 2022;8(1):e12337. PubMed PMID: 36089933
  • Hendrix JA, Angelika Amon, Leonard Abbeduto, Stamatis Agiovlasitis, Tarek Alsaied, Heather A. Anderson, Lisa J. Bain, Nicole Baumer, Anita Bhattacharyya, Dusan Bogunovic, Kelly N. Botteron, George Capone, Priya Chandan, Isabelle Chase, Brian Chicoine, Cécile Cieuta-Walti, Lara R. DeRuisseau, Sophie Durand, Anna Esbensen, Juan Fortea, Sandra Giménez, Ann-Charlotte Granholm, Laura J. Hahn, Elizabeth Head, Hampus Hillerstrom, Lisa M. Jacola, Matthew P. Janicki, Joan M. Jasien, Angela R. Kamer, Raymond D. Kent, Bernard Khor, Jeanne B. Lawrence, Catherine Lemonnier, Amy Feldman Lewanda, William Mobley, Paul E. Moore, Linda Pollak Nelson, Nicolas M. Oreskovic, Ricardo S. Osorio, David Patterson, Sonja A. Rasmussen, Roger H. Reeves, Nancy Roizen, Stephanie Santoro, Stephanie L. Sherman, Nasreen Talib, Ignacio E. Tapia, Kyle M. Walsh, Steven F. Warren, A. Nicole White, Guang William Wong, John S. Yi. Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. Author manuscript; available in PMC 2021 Jul 14. Published in final edited form as: Transl Sci Rare Dis. 2021; 5(3-4): 99–129. Published online 2021 Apr 15. doi: 10.3233/trd-200090. PMCID: PMC8279178. PMID: 34268067.
  • Granholm, AC., Ledreux, A. Biomarkers show value of studying dementia in Down syndrome. Nat Rev Neurol 17, 599–600 (2021).
  • Grossberg AN, Koza LA, Ledreux A, Prusmack C, Krishnamurthy HK, Jayaraman V, Granholm A-C*, Linseman DA*. A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients. Nat Commun. 2021; 12: 740. Published online 2021 Feb 2. doi: 10.1038/s41467-021-21040-7 PMCID: PMC7854643. *Linseman and Granholm co-senior authors.
  • Lemoine L., Ledreux A., Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm A-C. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Mol Neurodegener. 2020; 15: 68. Published online 2020 Nov 23. doi: 10.1186/s13024-020-00414-3 PMCID: PMC7682014.
  • Alldred MJ, Martini AC, Patterson D, Hendrix J, Granholm AC. Aging with Down Syndrome—Where Are We Now and Where Are We Going? J Clin Med. 2021 Oct; 10(20): 4687. Published online 2021 Oct 13. doi: 10.3390/jcm10204687 PMCID: PMC8539670. PMID: 34682809.
  • Aging in Down Syndrome: Latest Clinical Advances and Prospects Alessandra C. Martini, Melissa J. Alldred, Ann-Charlotte Granholm J Clin Med. 2021 Nov; 10(21): 5037. Published online 2021 Oct 28. doi: 10.3390/jcm10215037 PMCID: PMC8584622
  • Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. J Clin Med. 2021 Sep; 10(17): 3931. Published online 2021 Aug 31. doi: 10.3390/jcm10173931. PMCID: PMC8432237. PMID: 34501378.
  • Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer’s disease. Brain Commun. 2021; 3(2): fcab079. Published online 2021 May 13. doi: 10.1093/braincomms/fcab079. PMCID: PMC8117432. PMID: 34013204.
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UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

General Information

Department: Neurosurgery
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CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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