Michael Narkewicz, MD

Professional Titles

• Professor of Pediatrics
• Associate Dean for Health Affairs, Children's Hospital
• Executive, Provider Strategic Partnerships

Recognitions

• Top Doctor in Denver, Pediatric Transplant Hepatology, 5280 Magazine (2019)
• Distinguished Service Award, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2018)
• Top Doctor in Denver, Pediatric Transplant Hepatology, 5280 Magazine (2018)
• Top Doctor in Denver, Pediatric Transplant Hepatology, 5280 Magazine (2017)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver: Pediatric Transplant Hepatology, 5280 Magazine (2016)
• Top Doctor in Denver: Pediatric Transplant Hepatology, 5280 Magazine (2015)
• 5280 Top Doctors of Denver: Pediatric Gastroenterology and Pediatric Transplant Hepatology, 5280 Magazine (2014)

Research Interests

Publications

• Chan CL, Shirley Bezerra M, Stefanovski D, Gallop RJ, Walega R, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Narkewicz MR, Rowe SM, Sagel SD, Schwarzenberg SJ, Solomon GM, Stalvey MS, Kelly A. Glycemia and Insulin Secretion in Cystic Fibrosis Two Years After Elexacaftor/Tezacaftor/Ivacaftor: PROMISE-ENDO. J Clin Endocrinol Metab. 2024 Dec 9. [Epub ahead of print] PubMed PMID: 39657947
• Freeman AJ, Narkewicz MR. Understanding advanced cystic fibrosis liver disease through genetic variation: Where do the pathways lead and how much further must we go?. Hepatology. 2024 Nov 1;80(5):997-999. PubMed PMID: 38652596
• Jonas MM, Romero R, Rosenthal P, Lin CH, Verucchi G, Wen J, Balistreri WF, Whitworth S, Bansal S, Leung DH, Narkewicz MR, Gonzalez-Peralta RP, Mangia A, Karnsakul W, Rao GS, Shao J, de Jong J, Parhy B, Osinusi A, Kersey K, Murray KF, Sokal EM, Schwarz KB. Sofosbuvir-velpatasvir in children 3-17 years old with hepatitis C virus infection. J Pediatr Gastroenterol Nutr. 2024 Jun;78(6):1342-1354. PubMed PMID: 38644678
• Duong JT, Pope CE, Hayden HS, Miller C, Salipante SJ, Rowe SM, Solomon GM, Nichols D, Hoffman LR, Narkewicz MR, Green N. Alterations in the fecal microbiota in patients with advanced cystic fibrosis liver disease after 6 months of elexacaftor/tezacaftor/ivacaftor. J Cyst Fibros. 2024 May;23(3):490-498. PubMed PMID: 38448281
• Bodewes FAJA, Freeman AJ, Weymann A, Debray D, Scheers I, Verkade HJ, Narkewicz MR. Towards a Standardized Classification of the Hepatobiliary Manifestations in Cystic Fibrosis (CFHBI): A Joint ESPGHAN/NASPGHAN Position Paper. J Pediatr Gastroenterol Nutr. 2024 Jan;78(1):153-165. PubMed PMID: 38291686
• Brigham D, Narkewicz MR. Profile of Sofosbuvir and Velpatasvir Combination in the Treatment of Chronic Hepatitis C in Children and Adolescents: Current Evidence. Ther Clin Risk Manag. 2024;20:1-7. PubMed PMID: 38230373
• Sellers ZM, Assis DN, Paranjape SM, Sathe M, Bodewes F, Bowen M, Cipolli M, Debray D, Green N, Hughan KS, Hunt WR, Leey J, Ling SC, Morelli G, Peckham D, Pettit RS, Philbrick A, Stoll J, Vavrina K, Allen S, Goodwin T, Hempstead SE, Narkewicz MR. Cystic fibrosis screening, evaluation, and management of hepatobiliary disease consensus recommendations. Hepatology. 2024 May 1;79(5):1220-1238. PubMed PMID: 37934656
• Narkewicz MR. Cystic fibrosis liver disease in the post-modulator era. Curr Opin Pulm Med. 2023 Sep 6. [Epub ahead of print] PubMed PMID: 37678151
• Towbin AJ, Ye W, Huang S, Karmazyn BW, Molleston JP, Masand P, Leung DH, Chang S, Narkewicz MR, Alazraki AL, Freeman AJ, Otto RK, Green N, Kamel IR, Karnsakul WW, Magee JC, Tkach J, Palermo JJ. Prospective study of quantitative liver MRI in cystic fibrosis: feasibility and comparison to PUSH cohort ultrasound. Pediatr Radiol. 2023 Jul 28. [Epub ahead of print] PubMed PMID: 37500799
• Siegel MJ, Leung DH, Molleston JP, Ye W, Paranjape SM, Freeman AJ, Palermo JJ, Stoll J, Masand P, Karmazyn B, Harned R, Ling SC, Navarro OM, Karnsakul W, Alazraki A, Schwarzenberg SJ, Towbin AJ, Alonso EM, Nicholas JL, Green N, Otto RK, Magee JC, Narkewicz MR. Heterogeneous liver on research ultrasound identifies children with cystic fibrosis at high risk of advanced liver disease. J Cyst Fibros. 2023 Jul;22(4):745-755. PubMed PMID: 37032248
• Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD. Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI. J Cyst Fibros. 2023 Mar;22(2):282-289. PubMed PMID: 36280527
• Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Hepatology. 2023 Feb 1;77(2):530-545. PubMed PMID: 36069569
• Leung DH, Ye W, Schwarzenberg SJ, Freeman AJ, Palermo JJ, Weymann A, Alonso EM, Karnsakul WW, Murray KF, Stoll JM, Huang S, Karmazyn B, Masand P, Magee JC, Alazraki AL, Towbin AJ, Nicholas JL, Green N, Otto RK, Siegel MJ, Ling SC, Navarro OM, Harned RK, Narkewicz MR, Molleston JP. Long-term follow-up and liver outcomes in children with cystic fibrosis and nodular liver on ultrasound in a multi-center study. J Cyst Fibros. 2023 Mar;22(2):248-255. PubMed PMID: 35985930
• Schwarzenberg SJ, Palermo JJ, Ye W, Huang S, Magee JC, Alazraki A, Freeman AJ, Harned R, Karmazyn B, Karnsakul W, Leung DH, Ling SC, Masand P, Molleston JP, Murray KF, Navarro OM, Nicholas JL, Otto RK, Paranjape SM, Siegel MJ, Stoll J, Towbin AJ, Narkewicz MR, Alonso EM. Health-related Quality of Life in a Prospective Study of Ultrasound to Detect Cystic Fibrosis-related Liver Disease in Children. J Pediatr Gastroenterol Nutr. 2022 Nov 1;75(5):635-642. PubMed PMID: 36070552
• Schwarzenberg SJ, Palermo JJ, Ye W, Huang S, Magee JC, Alazraki A, Freeman AJ, Harned R, Karmazyn B, Karnsakul W, Leung DH, Ling SC, Masand P, Molleston JP, Murray KF, Navarro OM, Nicholas JL, Otto RK, Paranjape SM, Siegel MJ, Stoll J, Towbin AJ, Narkewicz MR, Alonso EM. Health-related quality of life in a prospective study of ultrasound to detect cystic fibrosis-related liver disease in children. J Pediatr Gastroenterol Nutr. 2022 Sep 6. [Epub ahead of print] PubMed PMID: 36070552
• Leung DH, Ye W, Schwarzenberg SJ, Freeman AJ, Palermo JJ, Weymann A, Alonso EM, Karnsakul WW, Murray KF, Stoll JM, Huang S, Karmazyn B, Masand P, Magee JC, Alazraki AL, Towbin AJ, Nicholas JL, Green N, Otto RK, Siegel MJ, Ling SC, Navarro OM, Harned RK, Narkewicz MR, Molleston JP. Long-term follow-up and liver outcomes in children with cystic fibrosis and nodular liver on ultrasound in a multi-center study. J Cyst Fibros. 2022 Aug 16. [Epub ahead of print] PubMed PMID: 35985930
• Nichols DP, Paynter AC, Heltshe SL, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Clancy JP, Kirby S, Van Dalfsen JM, Kloster MH, Rowe SM. Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial. Am J Respir Crit Care Med. 2022 Mar 1;205(5):529-539. PubMed PMID: 34784492
• Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: report of PROMISE-GI. J Cyst Fibrosis online ahead of print PMID 36280527
• Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD. Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI. J Cyst Fibros. 2022 Oct 21. [Epub ahead of print] PubMed PMID: 36280527
• Ye W, Leung DH, Molleston JP, Ling SC, Murray KF, Nicholas JL, Huang S, Karmazyn BW, Harned RK, Masand P, Alazraki AL, Navarro OM, Otto RK, Palermo JJ, Towbin AJ, Alonso EM, Karnsakul WW, Jane Schwarzenberg S, Seidel GF, Siegel M, Magee JC, Narkewicz MR, Jay Freeman A. Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis. Hepatol Commun. 2021 Aug;5(8):1362-1372. PubMed PMID: 34430781
• Jonas MM, Rhee S, Kelly DA, Del Valle-Segarra A, Feiterna-Sperling C, Gilmour S, Gonzalez-Peralta RP, Hierro L, Leung DH, Ling SC, Lobzin Y, Lobritto S, Mizuochi T, Narkewicz MR, Sabharwal V, Wen J, Kei Lon H, Marcinak J, Topp A, Tripathi R, Sokal E. Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Children With Chronic HCV: Part 2 of the DORA Study. Hepatology. 2021 Jul;74(1):19-27. PubMed PMID: 33811356
• Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM. PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy. J Cyst Fibros. 2021 Mar;20(2):205-212. PubMed PMID: 33619012
• Khalaf R, Narkewicz M, El-Haija MA. Menstruation-Associated Acute Pancreatitis in Patients with Hereditary Pancreatitis. J Pediatr. 2021 Mar;230:248-250. PubMed PMID: 33238169
• Lusman SS, Borowitz D, Marshall BC, Narkewicz MR, Gonska T, Grand RJ, Simon RH, Mascarenhas MR, Schwarzenberg SJ, Freedman SD. DIGEST: Developing innovative gastroenterology specialty training. J Cyst Fibros. 2021 Jul;20(4):586-590. PubMed PMID: 32736950
• Lusman SS, Borowitz D, Marshall BC, Narkewicz MR, Gonska T, Grand RJ, Simon RH, Mascarenhas MR, Schwarzenberg SJ, Freedman SD. DIGEST: Developing innovative gastroenterology specialty training. J Cyst Fibros. 2020 Jul 28. [Epub ahead of print] PubMed PMID: 32736950
• Masand PM, Narkewicz MR, Leung DH. The Emergence of Elastography for Cystic Fibrosis Liver Disease. J Cyst Fibros. 2020 May;19(3):339-341. PubMed PMID: 32600654
• Rosenthal P, Narkewicz MR, Yao BB, Jolley CD, Lobritto SJ, Wen J, Molleston JP, Hsu EK, Jonas MM, Zha J, Liu L, Leung DH. Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3-11 Years with Hepatitis C Genotype 1a. Adv Ther. 2020 Jul;37(7):3299-3310. PubMed PMID: 32451952
• Robson J, Lusman SS, Lee CK, Merves J, Middleton J, Perez ME, Desai NK, Sayej W, Sivagnanam M, Solomon AB, Colombo JM, Rosen JM, Van Buren KW, Brown JB, Turmelle YP, Cerezo CS, Loomes KM, Huang JS, Quiros-Tejeira RE, Benkov K, Leichtner A, Narkewicz MR, Weinstein T, Sauer CG. Pediatric Gastroenterology, Hepatology, and Nutrition Entrustable Professional Activities: Development of an Assessment Tool and Curricular Resources. J Pediatr Gastroenterol Nutr. 2020 Jul;71(1):e40-e45. PubMed PMID: 32265411
• Sauer CG, Robson J, Turmelle YP, Cerezo CS, Loomes KM, Huang JS, Quiros-Tejeira RE, Benkov KJ, Narkewicz MR, Leichtner A, Weinstein T. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on Entrustable Professional Activities: Development of Pediatric Gastroenterology, Hepatology, and Nutrition Entrustable Professional Activities. J Pediatr Gastroenterol Nutr. 2020 Jul;71(1):136-143. PubMed PMID: 32187140
• Siegel MJ, Freeman AJ, Ye W, Palermo JJ, Molleston JP, Paranjape SM, Stoll J, Leung DH, Masand P, Karmazyn B, Harned R, Ling SC, Navarro OM, Karnsakul W, Alazraki A, Schwarzenberg SJ, Seidel FG, Towbin A, Alonso EM, Nicholas JL, Murray KF, Otto RK, Sherker AH, Magee JC, Narkewicz MR. Heterogeneous Liver on Research Ultrasound Identifies Children with Cystic Fibrosis at High Risk of Advanced Liver Disease: Interim Results of a Prospective Observational Case-Controlled Study. J Pediatr. 2020 Apr;219:62-69.e4. PubMed PMID: 32061406
• Schwarz KB, Rosenthal P, Murray KF, Honegger JR, Hardikar W, Hague R, Mittal N, Massetto B, Brainard DM, Hsueh CH, Shao J, Parhy B, Narkewicz MR, Rao GS, Whitworth S, Bansal S, Balistreri WF. Ledipasvir-Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C. Hepatology. 2020 Feb;71(2):422-430. PubMed PMID: 31220349
• Siegel MJ, Freeman AJ, Ye W, Palermo JJ, Molleston JP, Paranjape SM, Stoll J, Leung DH, Masand P, Karmazyn B, Harned R, Ling SC, Navarro OM, Karnsakul W, Alazraki A, Schwarzenberg SJ, Seidel FG, Towbin A, Alonso EM, Nicholas JL, Murray KF, Otto RK, Sherker AH, Magee JC, Narkewicz MR. Heterogeneous Liver on Research Ultrasound Identifies Children with Cystic Fibrosis at High Risk of Advanced Liver Disease: Interim Results of a Prospective Observational Case-Controlled Study. J Pediatr. 2020 Apr;219:62-69.e4. PubMed PMID: 32061406
• Narkewicz MR. Integrating Clinical Ultrasound Into Screening for Cystic Fibrosis Liver Disease: Approach With Caution and Optimism. J Pediatr Gastroenterol Nutr. 2019 Oct;69(4):394-395. PubMed PMID: 31436709
• Ling SC, Ye W, Leung DH, Navarro OM, Weymann A, Karnsakul W, Freeman AJ, Magee JC, Narkewicz MR. Liver Ultrasound Patterns in Children With Cystic Fibrosis Correlate With Noninvasive Tests of Liver Disease. J Pediatr Gastroenterol Nutr. 2019 Sep;69(3):351-357. PubMed PMID: 31436672
• Schwarz KB, Rosenthal P, Murray KF, Honegger JR, Hardikar W, Hague R, Mittal N, Massetto B, Brainard DM, Hsueh CH, Shao J, Parhy B, Narkewicz MR, Rao GS, Whitworth S, Bansal S, Balistreri WF. Ledipasvir-Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C. Hepatology. 2019 Jun 20. [Epub ahead of print] PubMed PMID: 31220349
• Freeman AJ, Sellers ZM, Mazariegos G, Kelly A, Saiman L, Mallory G, Ling SC, Narkewicz MR, Leung DH. A Multidisciplinary Approach to Pretransplant and Posttransplant Management of Cystic Fibrosis-Associated Liver Disease. Liver Transpl. 2019 Apr;25(4):640-657. PubMed PMID: 30697907
• Toney NA, Bell MJ, Belle SH, Hardison RM, Rodriguez-Baez N, Loomes KM, Vodovotz Y, Zamora R, Squires RH. Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers. J Pediatr Gastroenterol Nutr. 2019 Jul;69(1):108-115. PubMed PMID: 31058776
• Leung DH, Wirth S, Yao BB, Viani RM, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Narkewicz MR, Sokal E, Fortuny C, Hsu EK, Del Valle-Segarra A, Zha J, Larsen L, Liu L, Shuster DL, Cohen DE, Rosenthal P. Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4. Hepatol Commun. 2018 Nov;2(11):1311-1319. PubMed PMID: 30411078
• Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH. A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1801-1810.e3. PubMed PMID: 29723692
• Di Maria MV, Silverman L, Younoszai AK, Meyers ML, Capocelli KE, Narkewicz MR. Acoustic radiation force impulse of the liver after Fontan operation: Correlation with cardiopulmonary exercise test. Congenit Heart Dis. 2018 May;13(3):444-449. PubMed PMID: 29473337
• Murray KF, Balistreri WF, Bansal S, Whitworth S, Evans HM, Gonzalez-Peralta RP, Wen J, Massetto B, Kersey K, Shao J, Garrison KL, Parhy B, Brainard DM, Arnon R, Gillis LA, Jonas MM, Chuan-Hao L, Narkewicz MR, Schwarz K, Rosenthal P. Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11. Hepatology. 2018 Aug 2. [Epub ahead of print] PubMed PMID: 30070726
• Anderson BT, Feinstein JA, Kramer RE, Narkewicz MR, Bruckner AL, Brumbaugh DE. The approach and safety of esophageal dilation for treatment of strictures in children with epidermolysis bullosa. J Pediatr Gastroenterol Nutr. 2018 Jul 26. [Epub ahead of print] PubMed PMID: 30052567
• Liptzin DR, Di Maria MV, Younoszai A, Narkewicz MR, Kelly SL, Wolfe KR, Veress LA. Pulmonary Screening in Subjects after the Fontan Procedure. J Pediatr. 2018 Aug;199:140-143. PubMed PMID: 29747936
• Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH. A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1801-1810.e3. PubMed PMID: 29723692
• Mark J, Narkewicz MR. Cutting-edge Treatment for Benign Pediatric Esophageal Strictures, a Step Forward, More to Go. J Pediatr Gastroenterol Nutr. 2018 Oct;67(4):433-434. PubMed PMID: 29697551
• Di Maria MV, Silverman L, Younoszai AK, Meyers ML, Capocelli KE, Narkewicz MR. Acoustic radiation force impulse of the liver after Fontan operation: Correlation with cardiopulmonary exercise test. Congenit Heart Dis. 2018 May;13(3):444-449. PubMed PMID: 29473337
• Leung DH, Yao BB, Viani RM, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Narkewicz MR, Sokal E, Fortuny C, Hsu EK, Wirth S, Del Valle-Segarra A, Zha J, Larsen L, Liu L, Shuster DL, Cohen DE, Rosenthal P. Ombitasvir/Paritaprevir/Ritonavir with or without Dasabuvir and with or without Ribavirin for adolescents with HCV genotype 1 or 4. Hepatology Communications 2:1311-1319, 2018
• Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ. Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr. 2018 May;196:139-147.e3. PubMed PMID: 29519540
• Bozic, M and Narkewicz MR. Executive Summary of Cystic Fibrosis Liver Disease Clinical Care Guidelines August 2018 https://www.cff.org/Care/Clinical-Care-Guidelines/Other-CF-Related-Conditions-Clinical-Care-Guidelines/Liver-Disease-Clinical-Care-Guidelines/
• Leung DH, Narkewicz MR. Cystic Fibrosis-related cirrhosis. J Cyst Fibros. 2017 Sep 16. [Epub ahead of print] PubMed PMID: 28986027
• Ye W, Narkewicz MR, Leung DH, Karnsakul W, Murray KF, Alonso EM, Magee JC, Schwarzenberg SJ, Weymann A, Molleston JP. Variceal Hemorrhage and Adverse Liver Outcomes in Patients With Cystic Fibrosis Cirrhosis. J Pediatr Gastroenterol Nutr. 2017 Sep 12. [Epub ahead of print] PubMed PMID: 28906321
• Debray D, Narkewicz MR, Bodewes FAJA, Colombo C, Housset C, de Jonge HR, Jonker JW, Kelly DA, Ling SC, Poynard T, Sogni P, Trauner M, Witters P, Baumann U, Wilschanski M, Verkade HJ. Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives. J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):443-448. PubMed PMID: 28753176
• Feldman AG, Sokol RJ, Hardison RM, Alonso EM, Squires RH, Narkewicz MR. Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure. J Pediatr. 2017 Mar;182:217-222.e3. PubMed PMID: 28088395
• Woodruff SA, Sontag MK, Accurso FJ, Sokol RJ, Narkewicz MR. Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen. J Cyst Fibros. 2017 Jan;16(1):139-145. PubMed PMID: 27555301
• Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH. Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):210-217. PubMed PMID: 27496798
• Bozic, M and Narkewicz MR. Executive Summary of Cystic Fibrosis Liver Disease Clinical Care Guidelines August 2017 https://www.cff.org/Care/Clinical-Care-Guidelines/
• Pediatric Update: Hepatitis C: Chronic or Curable: audio recording 2017. http://www.pedupdate.com/?gp_page=p_onecourse&gp_skey=460
• Rogers GB, Narkewicz MR, Hoffman LR. The CF gastrointestinal microbiome: Structure and clinical impact. Pediatr Pulmonol. 2016 Oct;51(S44):S35-S44. PubMed PMID: 27662102
• Li R, Belle SH, Horslen S, Chen LW, Zhang S, Squires RH. Clinical Course among Cases of Acute Liver Failure of Indeterminate Diagnosis. J Pediatr. 2016 Apr;171:163-70.e1-3. PubMed PMID: 26831743
• Woodruff SA, Sontag MK, Accurso FJ, Sokol RJ, Narkewicz MR. Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen. J Cyst Fibros. 2016 Aug 20. [Epub ahead of print] PubMed PMID: 27555301
• Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH. Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2016 Aug 4. [Epub ahead of print] PubMed PMID: 27496798
• Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. CD4 and CD8 T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar;170:142-8.e1. PubMed PMID: 26743497
• Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016 Mar;170:211-7.e1-2. PubMed PMID: 26725209
• Vue PM, McFann K, Narkewicz MR. Genetic Mutations in Pediatric Pancreatitis. Pancreas. 2016 Aug;45(7):992-6. PubMed PMID: 26692446
• Narkewicz MR. Cystic Fibrosis Liver Disease and Ursodeoxycholic Acid: One Small Step Forward, Miles to Go. J Pediatr. 2016 Oct;177:17-8. PubMed PMID: 27423176
• Kramer RE, Narkewicz MR. Adverse Events Following Gastrointestinal Endoscopy in Children: Classifications, Characterizations, and Implications. J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):828-33. PubMed PMID: 26594830
• Brown K, Lingard C, Narkewicz MR.Nutrition and Cystic Fibrosis Related Liver Disease. IN: Yen EH and Leonard A (eds), Nutrition in Cystic Fibrosis: A Guide for Clinicians. Springer International Publishing, New York, NY pp 165-78, 2016
• Sokol RJ, Narkewicz MR, Sundaram SS, Mack CL: Liver & Pancreas. IN: Hay WW, Levin MJ, Deterding RR, Abzug MJ, (eds), Current Pediatric Diagnosis ? Treatment, 23rd edition McGraw-Hill Medical, NY NY, pp 653-698, 2016
• Leung DH, Ye W, Molleston JP, Weymann A, Ling S, Paranjape SM, Romero R, Schwarzenberg SJ, Palermo J, Alonso EM, Murray KF, Marshall BC, Sherker AH, Siegel MJ, Krishnamurthy R, Harned R, Karmazyn B, Magee JC, Narkewicz MR. Baseline Ultrasound and Clinical Correlates in Children with Cystic Fibrosis. J Pediatr. 2015 Oct;167(4):862-868.e2. PubMed PMID: 26254836
• Flass T, Tong S, Frank DN, Wagner BD, Robertson CE, Kotter CV, Sokol RJ, Zemanick E, Accurso F, Hoffenberg EJ, Narkewicz MR. Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis. PLoS One. 2015;10(2):e0116967. PubMed PMID: 25658710
• Sauer CG, Narkewicz MR. GiECAT(KIDS) validated pediatric colonoscopy assessment tool: a call to action. J Pediatr Gastroenterol Nutr. 2015 Apr;60(4):425-7. PubMed PMID: 25611036
• Narkewicz MR: CF Liver Disease: Clinical Presentations and Definitions. Pediatric Pulmonology S38:133-4, 2014
• Sokol RJ, Narkewicz MR, Sundaram SS, Mack CL: Liver & Pancreas. IN: Hay WW, Levin MJ, Deterding RR, Abzug MJ, (eds), Current Pediatric Diagnosis ? Treatment, 22nd edition In Press McGraw-Hill Medical, NY NY, 2014, 22nd edition
• Narkewicz MR and Waasdorp-Hurtado C Metabolic liver Disease: Part 2 IN: Murray KF and Horslen S (eds), Diseases of the Liver in Children 185-214. Springer Science & Business Media, NYC, NY; 2014.
• Mayer-Hamblett N, Kloster M, Ramsey BW, Narkewicz MR, Saiman L, Goss CH. Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials. Contemp Clin Trials. 2012 Nov 29;34(2):232-238. [Epub ahead of print] PubMed PMID: 23200843
• Acker SN, Bruny JL, Narkewicz MR, Roach JP, Rogers A, Karrer FM. Preoperative imaging does not predict intrahepatic involvement in choledochal cysts. J Pediatr Surg. 2013 Dec;48(12):2378-82. PubMed PMID: 24314174
• Mohan P, Barton BA, Narkewicz MR, Molleston JP, Gonzalez-Peralta RP, Rosenthal P, Murray KF, Haber B, Schwarz KB, Goodman ZD. Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: A retrospective study. Hepatology. 2013 May 23. [Epub ahead of print] PubMed PMID: 23703847
• Narkewicz MR, Green M, Dunn S, Millis M, McDiarmid S, Mazariegos G, Anand R, Yin W, Studies of Pediatric Liver Transplantation Research Group. Decreasing incidence of symptomatic Epstein-Barr virus disease and posttransplant lymphoproliferative disorder in pediatric liver transplant recipients: report of the studies of pediatric liver transplantation experience. Liver Transpl. 2013 Jul;19(7):730-40. PubMed PMID: 23696264
• Molleston JP, Mellman W, Narkewicz MR, Balistreri WF, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Mohan P, Murray KF, Njoku D, Rosenthal P, Barton BA, Talor MV, Cheng I, Schwarz KB, Haber BA, PEDS-C Clinical Research Network. Autoantibodies and autoimmune disease during treatment of children with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):304-10. PubMed PMID: 23439301
• Leichtner AM, Gillis LA, Gupta S, Heubi J, Kay M, Narkewicz MR, Rider EA, Rufo PA, Sferra TJ, Teitelbaum J, NASPGHAN Training Committee, North American Society for Pediatric Gastroenterology. NASPGHAN guidelines for training in pediatric gastroenterology. J Pediatr Gastroenterol Nutr. 2013 Jan;56 Suppl 1:S1-8. PubMed PMID: 23263531
• Lu BR, Zhang S, Narkewicz MR, Belle SH, Squires RH, Sokol RJ, Pediatric Acute Liver Failure Study Group. Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure. J Pediatr. 2013 May;162(5):1010-6.e1-4. PubMed PMID: 23260095
• Mayer-Hamblett N, Kloster M, Ramsey BW, Narkewicz MR, Saiman L, Goss CH. Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials. Contemp Clin Trials. 2013 Mar;34(2):232-8. PubMed PMID: 23200843
• Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype predicts outcome in pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):311-5. PubMed PMID: 23111765
• Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology. 2013 Apr;57(4):1542-9. PubMed PMID: 22886633
• Narkewicz MR. Heavy breathing: a step to noninvasive assessment of hepatic fibrosis and function in infants and children. J Pediatr Gastroenterol Nutr. 2013 Jan;56(1):2. PubMed PMID: 22847465
• Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2012 Oct 29. [Epub ahead of print] PubMed PMID: 23111765
• Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, James Lopez M, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial. Hepatology. 2012 Aug 10. [Epub ahead of print] PubMed PMID: 22886633
• Narkewicz MR. Heavy Breathing: A Step to Non-Invasive Assessment of Hepatic Fibrosis and Function in Infants and Children. J Pediatr Gastroenterol Nutr. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22847465
• Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. PubMed PMID: 22487950
• Kelly DA, Haber B, González-Peralta RP, Murray KF, Jonas MM, Molleston JP, Narkewicz MR, Sinatra FR, Lang T, Lachaux A, Wirth S, Shelton M, Te HS, Pollack H, Deng W, Noviello S, Albrecht JK. Durability of sustained response shown in paediatric patients with chronic hepatitis C who were treated with interferon alfa-2b plus ribavirin. J Viral Hepat. 2012 Apr;19(4):263-70. PubMed PMID: 22404724
• Jonas MM, Balistreri W, Gonzalez-Peralta RP, Haber B, Lobritto S, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Schwarz KB, Barton BA, Shepherd JA, Mitchell PD, Duggan C. Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial. Hepatology. 2012 Aug;56(2):523-31. PubMed PMID: 22383118
• Miller MR, Sokol RJ, Narkewicz MR, Sontag MK. Pulmonary function in individuals who underwent liver transplantation: from the US cystic fibrosis foundation registry. Liver Transpl. 2012 May;18(5):585-93. PubMed PMID: 22271602
• Flass T, Narkewicz MR. Cirrhosis and other liver disease in cystic fibrosis. J Cyst Fibros. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23266093
• Lu BR, Zhang S, Narkewicz MR, Belle SH, Squires RH, Sokol RJ, Pediatric Acute Liver Failure (PALF) Study Group. Evaluation of the Liver Injury Unit Scoring System to Predict Survival in a Multinational Study of Pediatric Acute Liver Failure. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260095
• Sokol RJ, Narkewicz MR: Liver & Pancreas. IN: Hay WW, Hayward AR, Levin MJ, Deterding RR, Abzug MJ, Sondheimer JM (eds), Current Pediatric Diagnosis & Treatment, 21st edition pp 663-706 McGraw-Hill Medical, NY NY, 2012, 21st edition.
• Brown K, Lingard C, Narkewicz MR: Nutrition and Cystic Fibrosis Related Liver Disease. IN: Yen EH and Leonard A (eds), Nutrition in Cystic Fibrosis: A Guide for Clinicians. Springer in Press 2015
• Narkewicz MR: What routine health maintenance should I assure for my pediatric patient who has undergone liver transplantation? IN: Bousvaros A and Rosh J (eds), Curbside Consultations in Pediatric Gastroenterology

Professional Memberships

• North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), Member
• American Association for the Study of Liver Disease (AASLD), Fellow Member
• American Academy of Pediatrics (AAP), Fellow AAP
• American Pediatric Society, Member

Practice Locations

• Children's Hospital Colorado
• Saint Joseph Hospital

Specialty Information

• Pediatric Transplant Hepatology, Board Certification (2007, 2017)
• Pediatric Gastroenterology, Board Certification (1990, 2016)
• Pediatrics, Board Certification (1988)

• Digestive System - Hepatology (Liver Disorders)
• Surgery - Liver Transplant Surgery
• Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
• Digestive System
• Surgery