Leigh Perreault, MD

Professional Titles

• Associate Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes
• Associate Professor of Epidemiology and Biostatistics
• Affiliate, Center for Global Health

Recognitions

• Fellow, American College of Physicians (2019)
  Elected as a fellow to the American College of Physicians (FACP)
• Ruth Gray Memorial Lectureship, Northshore University Health System (2016)
  Awarded to a clinic-scientist for excellence in metabolic and/or cardiovascular disease research
• Lancet symposium lecture, American Diabetes Association (2012)
  As the lead author of a paper published in the Lancet, our work was selected for an award lecture as one of the most important papers the journal published on diabetes in 2012

Research Interests

I feel incredibly privileged to do what I do and I love it: patient care, research and education. Believe it or not, these three pillars exist more together than they do apart. My research interests are in obesity, pre diabetes and type 2 diabetes. My projects range from identifying communicable/infectious diseases as complications of diabetes to building a workflow and disease state optimization tool for chronic weight management into EPIC (our electronic health record). Everything I do comes back to patient care, so I take the time to educate my patients the same way I do other doctors. I think everyone really likes that!

Publications

• Broussard JL, Garfield A, Zarini S, Brozinick JT, Perreault L, Newsom SA, Kahn D, Kerege A, Berry KZ, Bui HH, Bergman BC. Combined diet and exercise training decreases serum lipids associated with insulin resistance. Obesity (Silver Spring). 2024 Dec;32(12):2334-2344. PubMed PMID: 39587896
• Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, Wharton S, Wilding JPH, Perreault L, Zhang S, Battula R, Bunck MC, Ahmad NN, Jouravskaya I. Tirzepatide for Obesity Treatment and Diabetes Prevention. N Engl J Med. 2024 Nov 13. [Epub ahead of print] PubMed PMID: 39536238
• Zemski Berry KA, Garfield A, Jambal P, Zarini S, Perreault L, Bergman BC. Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle. Diabetologia. 2024 Dec;67(12):2819-2832. PubMed PMID: 39347985
• McKenna CF, Stierwalt HD, Zemski Berry KA, Ehrlicher SE, Robinson MM, Zarini S, Kahn DE, Snell-Bergeon JK, Perreault L, Bergman BC, Newsom SA. Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E183-E193. PubMed PMID: 38895980
• Perreault L, Bergman BC. Out of stock: A brief clinical reference for rough equivalency of glucagon-like peptide-1 (GLP-1) ± glucose-dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes. J Diabetes. 2024 Jun;16(6):e13505. PubMed PMID: 37986549
• Wild J, Kaizer A, Willems E, Kramer ES, Perreault L. Prelude to PATHWEIGH: pragmatic weight management in primary care. Fam Pract. 2023 Mar 28;40(2):322-329. PubMed PMID: 35997768
• Kalyani RR, Everett BM, Perreault L, Michos ED. Heart Disease and Diabetes. . 2023. PubMed PMID: 38117924
• Perreault L, Kramer ES, Smith PC, Schmidt D, Argyropoulos C. A closer look at weight loss interventions in primary care: a systematic review and meta-analysis. Front Med (Lausanne). 2023;10:1204849. PubMed PMID: 38076252
• Perreault L, Bergman BC. Out of stock: A brief clinical reference for rough equivalency of glucagon-like peptide-1 (GLP-1) ± glucose-dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes. J Diabetes. 2023 Nov 20. [Epub ahead of print] PubMed PMID: 37986549
• Perreault L, Suresh K, Rodriguez C, Dickinson LM, Willems E, Smith PC, Williams J Jr, Gritz RM, Holtrop JS. Baseline Characteristics of PATHWEIGH: A Stepped-Wedge Cluster Randomized Study for Weight Management in Primary Care. Ann Fam Med. 2023 May-Jun;21(3):249-255. PubMed PMID: 37217322
• Zarini S, Zemski Berry KA, Kahn DE, Garfield A, Perreault L, Kerege A, Bergman BC. Deoxysphingolipids: Atypical Skeletal Muscle Lipids Related to Insulin Resistance in Humans That Decrease Insulin Sensitivity In Vitro. Diabetes. 2023 Jul 1;72(7):884-897. PubMed PMID: 37186949
• Zarini S, Zemski Berry KA, Kahn DE, Garfield A, Perreault L, Kerege A, Bergman BC. Deoxysphingolipids - atypical skeletal muscle lipids related to insulin resistance in humans that decrease insulin sensitivity in vitro. Diabetes. 2023 Apr 24. [Epub ahead of print] PubMed PMID: 37094369
• Ritchie ND, Sauder KA, Perreault L. Glycemic Improvement and Health Equity in the National Diabetes Prevention Program. Diabetes Care. 2023 Jun 1;46(6):e128-e129. PubMed PMID: 37083982
• Echouffo-Tcheugui JB, Perreault L, Ji L, Dagogo-Jack S. Diagnosis and Management of Prediabetes: A Review. JAMA. 2023 Apr 11;329(14):1206-1216. PubMed PMID: 37039787
• Lutter D, Sachs S, Walter M, Kerege A, Perreault L, Kahn DE, Wolide AD, Kleinert M, Bergman BC, Hofmann SM. Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response. Diabetologia. 2023 May;66(5):873-883. PubMed PMID: 36790478
• Suresh K, Willems E, Williams J, Gritz RM, Dickinson LM, Perreault L, Holtrop JS. An Assessment of Weight Loss Management in Health System Primary Care Practices. J Am Board Fam Med. 2023 Feb 8;36(1):51-65. PubMed PMID: 36460354
• Zarini S, Brozinick JT, Zemski Berry KA, Garfield A, Perreault L, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Bergman BC. Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro. J Lipid Res. 2022 Oct;63(10):100270. PubMed PMID: 36030929
• Perreault L, Davies M, Frias JP, Laursen PN, Lingvay I, Machineni S, Varbo A, Wilding JPH, Wallenstein SOR, le Roux CW. Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program. Diabetes Care. 2022 Oct 1;45(10):2396-2405. PubMed PMID: 35724304
• Mottl AK, Alicic R, Argyropoulos C, Brosius FC, Mauer M, Molitch M, Nelson RG, Perreault L, Nicholas SB. KDOQI US Commentary on the KDIGO 2020 Clinical Practice Guideline for Diabetes Management in CKD. Am J Kidney Dis. 2022 Apr;79(4):457-479. PubMed PMID: 35144840
• Suresh K, Holtrop JS, Dickinson LM, Willems E, Smith PC, Gritz RM, Perreault L. PATHWEIGH, pragmatic weight management in adult patients in primary care in Colorado, USA: study protocol for a stepped wedge cluster randomized trial. Trials. 2022 Jan 10;23(1):26. PubMed PMID: 35012628
• Suresh K, Holtrop JS, Dickinson LM, Willems E, Smith PC, Gritz RM, Perreault L. PATHWEIGH, pragmatic weight management in adult patients in primary care in Colorado, USA: study protocol for a stepped wedge cluster randomized trial. Trials. 2022 Jan 10;23(1):26. PubMed PMID: 35012628
• Suresh K, Willems E, Williams J, Gritz RM, Dickinson LM, Perreault L, Holtrop JS. An Assessment of Weight Loss Management in Health System Primary Care Practices. J Am Board Fam Med. 2022 Dec 2. [Epub ahead of print] PubMed PMID: 36460354
• Zarini S, Brozinick JT, Zemski Berry KA, Garfield A, Perreault L, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Bergman BC. Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro. J Lipid Res. 2022 Oct;63(10):100270. PubMed PMID: 36030929
• Wild J, Kaizer A, Willems E, Kramer ES, Perreault L. Prelude to PATHWEIGH: pragmatic weight management in primary care. Fam Pract. 2022 Aug 23. [Epub ahead of print] PubMed PMID: 35997768
• Perreault L, Davies M, Frias JP, Laursen PN, Lingvay I, Machineni S, Varbo A, Wilding JPH, Wallenstein SOR, le Roux CW. Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program. Diabetes Care. 2022 Oct 1;45(10):2396-2405. PubMed PMID: 35724304
• Mottl AK, Alicic R, Argyropoulos C, Brosius FC, Mauer M, Molitch M, Nelson RG, Perreault L, Nicholas SB. KDOQI US Commentary on the KDIGO 2020 Clinical Practice Guideline for Diabetes Management in CKD. Am J Kidney Dis. 2022 Apr;79(4):457-479. PubMed PMID: 35144840
• Suresh K, Holtrop JS, Dickinson LM, Willems E, Smith PC, Gritz RM, Perreault L. PATHWEIGH, pragmatic weight management in adult patients in primary care in Colorado, USA: study protocol for a stepped wedge cluster randomized trial. Trials. 2022 Jan 10;23(1):26. PubMed PMID: 35012628
• Ritchie ND, Sauder KA, Kaufmann PG, Perreault L. Patient-Centered Goal-Setting in the National Diabetes Prevention Program: A Pilot Study. Diabetes Care. 2021 Nov;44(11):2464-2469. PubMed PMID: 34404739
• Depner CM, Melanson EL, Eckel RH, Higgins JA, Bergman BC, Perreault L, Knauer OA, Birks BR, Wright KP. Effects of ad libitum food intake, insufficient sleep and weekend recovery sleep on energy balance. Sleep. 2021 Nov 12;44(11). PubMed PMID: 34059916
• Goldberg RB, Tripputi MT, Boyko EJ, Budoff M, Chen ZZ, Clark JM, Dabelea DM, Edelstein SL, Gerszten RE, Horton E, Mather KJ, Perreault L, Temprosa M, Wallia A, Watson K, Irfan Z. Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4746-e4765. PubMed PMID: 33705543
• Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. PubMed PMID: 33667417
• Broussard JL, Perreault L, Macias E, Newsom SA, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D'Alessandro A, Brozinick JT, Bergman BC. Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution. Obesity (Silver Spring). 2021 Mar;29(3):550-561. PubMed PMID: 33624435
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Tuttle KR, Brosius FC 3rd, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2021 Jan;77(1):94-109. PubMed PMID: 33121838
• Tuttle KR, Brosius FC 3rd, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Diabetes. 2021 Jan;70(1):1-16. PubMed PMID: 33106255
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Tuttle KR, Brosius FC 3rd, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2020 Oct 22. [Epub ahead of print] PubMed PMID: 33121838
• Tuttle KR, Brosius FC 3rd, Cavender MA, Fioretto P, Fowler KJ, Heerspink HJL, Manley T, McGuire DK, Molitch ME, Mottl AK, Perreault L, Rosas SE, Rossing P, Sola L, Vallon V, Wanner C, Perkovic V. SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Diabetes. 2020 Oct 26. [Epub ahead of print] PubMed PMID: 33106255
• Bruhn L, Vistisen D, Vainø CTR, Perreault L, Færch K. Physiological factors contributing to HbA(1c) in the normal and pre-diabetic range: a cross-sectional analysis. Endocrine. 2020 May;68(2):306-311. PubMed PMID: 32112239
• Garber AJ, Handelsman Y, Grunberger G, Einhorn D, Abrahamson MJ, Barzilay JI, Blonde L, Bush MA, DeFronzo RA, Garber JR, Garvey WT, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Perreault L, Rosenblit PD, Samson S, Umpierrez GE. CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2020 EXECUTIVE SUMMARY . Endocr Pract. 2020 Jan;26(1):107-139. PubMed PMID: 32022600
• Harding JL, Benoit SR, Gregg EW, Pavkov ME, Perreault L. Trends in Rates of Infections Requiring Hospitalization Among Adults With Versus Without Diabetes in the U.S., 2000-2015. Diabetes Care. 2020 Jan;43(1):106-116. PubMed PMID: 31615853
• Aroda VR, Christophi CA, Edelstein SL, Perreault L, Kim C, Golden SH, Horton E, Mather KJ. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program. BMJ Open Diabetes Res Care. 2020 Dec;8(2). PubMed PMID: 33328161
• Harman NL, Wilding JPH, Curry D, Harris J, Logue J, Pemberton RJ, Perreault L, Thompson G, Tunis S, Williamson PR. Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 diabetes (SCORE-IT): a patient and healthcare professional consensus on a core outcome set for type 2 diabetes. BMJ Open Diabetes Res Care. 2019;7(1):e000700. PubMed PMID: 31908789
• Coppell K, Freer T, Abel S, Whitehead L, Tipene-Leach D, Gray AR, Merriman T, Sullivan T, Krebs J, Perreault L. What predicts regression from pre-diabetes to normal glucose regulation following a primary care nurse-delivered dietary intervention? A study protocol for a prospective cohort study. BMJ Open. 2019 Dec 9;9(12):e033358. PubMed PMID: 31822546
• Chen ZZ, Liu J, Morningstar J, Heckman-Stoddard BM, Lee CG, Dagogo-Jack S, Ferguson JF, Hamman RF, Knowler WC, Mather KJ, Perreault L, Florez JC, Wang TJ, Clish C, Temprosa M, Gerszten RE. Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program. Diabetes. 2019 Dec;68(12):2337-2349. PubMed PMID: 31582408
• Perreault L, Pan Q, Schroeder EB, Kalyani RR, Bray GA, Dagogo-Jack S, White NH, Goldberg RB, Kahn SE, Knowler WC, Mathioudakis N, Dabelea D. Regression From Prediabetes to Normal Glucose Regulation and Prevalence of Microvascular Disease in the Diabetes Prevention Program Outcomes Study (DPPOS). Diabetes Care. 2019 Sep;42(9):1809-1815. PubMed PMID: 31320445
• Vistisen D, Kivimäki M, Perreault L, Hulman A, Witte DR, Brunner EJ, Tabák A, Jørgensen ME, Færch K. Reversion from prediabetes to normoglycaemia and risk of cardiovascular disease and mortality: the Whitehall II cohort study. Diabetologia. 2019 Aug;62(8):1385-1390. PubMed PMID: 31123789
• Perreault L, Vincent L, Neumiller JJ, Santos-Cavaiola T. Initiation and Titration of Basal Insulin in Primary Care: Barriers and Practical Solutions. J Am Board Fam Med. 2019 May-Jun;32(3):431-447. PubMed PMID: 31068410
• Herman WH, Pan Q, Edelstein SL, Mather KJ, Perreault L, Barrett-Connor E, Dabelea DM, Horton E, Kahn SE, Knowler WC, Lorenzo C, Pi-Sunyer X, Venditti E, Ye W. Erratum. Impact of lifestyle and metformin interventions on the risk of progression to diabetes and regression to normal glucose regulation in overweight or obese people with impaired glucose regulation. Diabetes Care 2017;40:1668-1677. Diabetes Care. 2019 Apr;42(4):701. PubMed PMID: 30894384
• Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP Jr. Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Curr Biol. 2019 Mar 18;29(6):957-967.e4. PubMed PMID: 30827911
• Perreault L, Boardman MK, Pak J. The Association Between Type 2 Diabetes and Cardiovascular Disease: The "For Your SweetHeart™" Survey. Adv Ther. 2019 Mar;36(3):746-755. PubMed PMID: 30758740
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann SM, Bergman BC. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E866-E879. PubMed PMID: 30620635
• Perreault L, Rodbard H, Valentine V, Johnson E. Optimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes. Adv Ther. 2019 Feb;36(2):265-277. PubMed PMID: 30610613
• Goldberg RB, Bray GA, Marcovina SM, Mather KJ, Orchard TJ, Perreault L, Temprosa M. Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions. Diabetologia. 2019 Jan;62(1):58-69. PubMed PMID: 30334082
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann S, Bergman BC. Intermuscular adipose tissue (IMAT) directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 Jan 8. [Epub ahead of print] PubMed PMID: 30620635
• Perreault L, Rodbard H, Valentine V, Johnson E. Optimizing Fixed-Ratio Combination Therapy in Type 2 Diabetes. Adv Ther. 2019 Feb;36(2):265-277. PubMed PMID: 30610613
• Goldberg RB, Bray GA, Marcovina SM, Mather KJ, Orchard TJ, Perreault L, Temprosa M. Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions. Diabetologia. 2019 Jan;62(1):58-69. PubMed PMID: 30334082
• Perreault L. GOALS FOR MEDICAL TREATMENT IN OBESITY AND PREDIABETES: IMPROVING OUTCOMES FOR BOTH. Endocr Pract. 2018 Oct 5. [Epub ahead of print] PubMed PMID: 30289308
• Harman NL, Wilding J, Curry D, Harris J, Logue J, Pemberton RJ, Perreault L, Thompson G, Tunis S, Williamson PR. Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 Diabetes (SCORE-IT): study protocol for the development of a core outcome set. Trials. 2018 Aug 7;19(1):427. PubMed PMID: 30086771
• Su W, Chen F, Dall TM, Zvenyach T, Kyle TK, Perreault L. Where can obesity management policy make the largest impact? Evaluating sub-populations through a microsimulation approach. J Med Econ. 2018 Sep;21(9):936-943. PubMed PMID: 29973101
• Herman WH, Pan Q, Edelstein SL, Mather KJ, Perreault L, Barrett-Connor E, Dabelea DM, Horton E, Kahn SE, Knowler WC, Lorenzo C, Pi-Sunyer X, Venditti E, Ye W. Erratum. Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care 2017;40:1668-1677. Diabetes Care. 2018 Apr;41(4):913. PubMed PMID: 29475844
• Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 8;3(3). [Epub ahead of print] PubMed PMID: 29415895
• Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E152-E164. PubMed PMID: 28978544
• Herman WH, Pan Q, Edelstein SL, Mather KJ, Perreault L, Barrett-Connor E, Dabelea DM, Horton E, Kahn SE, Knowler WC, Lorenzo C, Pi-Sunyer X, Venditti E, Ye W. Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care. 2017 Dec;40(12):1668-1677. PubMed PMID: 29021207
• Bergman BC, Perreault L, Strauss A, Bacon SD, Kerege AA, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis - importance in partitioning muscle lipids in humans. Am J Physiol Endocrinol Metab. 2017 Oct 3;:ajpendo.00142.2017. [Epub ahead of print] PubMed PMID: 28978544
• Perreault L, Pan Q, Aroda VR, Barrett-Connor E, Dabelea D, Dagogo-Jack S, Hamman RF, Kahn SE, Mather KJ, Knowler WC. Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS). Diabet Med. 2017 Dec;34(12):1747-1755. PubMed PMID: 28833481
• Aroda VR, Knowler WC, Crandall JP, Perreault L, Edelstein SL, Jeffries SL, Molitch ME, Pi-Sunyer X, Darwin C, Heckman-Stoddard BM, Temprosa M, Kahn SE, Nathan DM. Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetologia. 2017 Sep;60(9):1601-1611. PubMed PMID: 28770322
• Perreault L, Færch K, Gregg EW. Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?. Curr Diab Rep. 2017 Sep;17(9):77. PubMed PMID: 28766246
• Perreault L. EMPA-REG OUTCOME: The Endocrinologist's Point of View. Am J Cardiol. 2017 Jul 1;120(1S):S48-S52. PubMed PMID: 28606344
• Perreault L. EMPA-REG OUTCOME: The Endocrinologist's Point of View. Am J Med. 2017 Jun;130(6S):S51-S56. PubMed PMID: 28526185
• Goldberg RB, Temprosa M, Mele L, Orchard T, Mather K, Bray G, Horton E, Kitabchi A, Krakoff J, Marcovina S, Perreault L, White N. Erratum to: "Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the diabetes prevention program" [Metabolism (2016) 65; 764-775]. Metabolism. 2017 Mar;68:184-186. PubMed PMID: 28065437
• Kim C, Christophi CA, Goldberg RB, Perreault L, Dabelea D, Marcovina SM, Pi-Sunyer FX, Barrett-Connor E. Adiponectin, C-reactive protein, fibrinogen, and tissue plasminogen activator antigen among glucose-intolerant women with and without histories of gestational diabetes. Diabet Med 2016 Jan 33(1): 32-8.
• Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC. Biomarkers of ectopic fat deposition: The next frontier in plasma lipidomics. J Clin Endocrinol Metab 101: 176-182, 2016.
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Kuo MS, Perreault L. Muscle sphingolipids during rest and exercise – a C18:0 signature for insulin resistance in humans. Diabetologia 2016 Jan 6 [ePub ahead of print].
• Su W, Chen F, Dall TM, Iacobucci W, Perreault L. Return on Investment for Digital Behavioral Counseling in Patients with Prediabetes and Cardiovascular Disease. Prev Chronic Dis 2016 Jan 28, 13: 150357.
• Hivert MF, Christophi CA, Franks PW, Jablonski KA, Ehrmann D, Kahn SE, Horton ES, Pollin T, Mather K, Perreault L, Barrett-Connor E, Knowler WC, Florez JC. Lifestyle and metformin ameliorate insulin sensitivity independently of the genetic burden of insulin resistance risk variants in Diabetes Prevention Program participants. Diabetes 2016 Feb; 65(2): 520-6.
• Guess ND, Perreault L, Kerege A, Strauss, A, Bergman BC. The Impact of Dietary Fatty Acids on Fasting versus Postprandial Glucose Homeostasis. Plos One, in press 2016.
• Perreault L. Diabetes Prevention. Diabetes and Exercise: From Pathophysiology to Clinical Implementation, Second Edition. Springer. Powell, WY 2016.
• Goldberg RB, Temprosa M, Mele L, Orchard T, Mather K, Bray G, Horton E, Kitabchi A, Krakoff J, Marcovina S, Perreault L, White N. Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program. Metabolism. 2016 May;65(5):764-75. PubMed PMID: 27085783
• Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016 Jun 1;120(11):1355-63. PubMed PMID: 27032901
• Guess N, Perreault L, Kerege A, Strauss A, Bergman BC. Dietary Fatty Acids Differentially Associate with Fasting Versus 2-Hour Glucose Homeostasis: Implications for The Management of Subtypes of Prediabetes. PLoS One. 2016 Mar 21;11(3):e0150148. PubMed PMID: 26999667
• Su W, Chen F, Dall TM, Iacobucci W, Perreault L. Return on Investment for Digital Behavioral Counseling in Patients With Prediabetes and Cardiovascular Disease. Prev Chronic Dis. 2016 Jan 28;13:E13. PubMed PMID: 26820045
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Perreault L. Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia. 2016 Apr;59(4):785-98. PubMed PMID: 26739815
• Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC. Biomarkers of Ectopic Fat Deposition: The Next Frontier in Serum Lipidomics. J Clin Endocrinol Metab. 2016 Jan;101(1):176-82. PubMed PMID: 26574956
• Hivert MF, Christophi CA, Franks PW, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI, Mather KJ, Perreault L, Barrett-Connor E, Knowler WC, Florez JC. Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes. 2016 Feb;65(2):520-6. PubMed PMID: 26525880
• Kim C, Christophi CA, Goldberg RB, Perreault L, Dabelea D, Marcovina SM, Pi-Sunyer X, Barrett-Connor E. Adiponectin, C-reactive protein, fibrinogen and tissue plasminogen activator antigen levels among glucose-intolerant women with and without histories of gestational diabetes. Diabet Med. 2016 Jan;33(1):32-8. PubMed PMID: 25970741
• Su W, Huang J, Chen F, Iacobucci W, Mocarski M, Dall TM, Perreault L. Development and validation of a microsimulation model of the clinical and economic implications of obesity. J Med Econ 2015 Aug 13:1-12.
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Kuo MS, Perreault L. Serum sphingolipids – relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol 2015 Aug 15; 309(4):E398-408.
• Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, Higgins J, Melanson EL, Wright KP. Morning circadian misalignment during short sleep duration impacts insulin sensitivity. Curr Biol 2015 Nov 16; 25(22): 3004-3010.
• Goldberg R, Temprosa M, Marcovina S, Orchard T, White N, Kitabchi A, Krakoff J, Mele L, Mather K, Horton E, Perreault L, Bray G. Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program. Metabolism 2015 Dec 2 [ePub ahead of print].
• Delahanty LM, Pan Q, Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L, Franks PW, Diabetes Prevention Program Research Group. Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program. Diabetes Care. 2014 Oct;37(10):2738-45. PubMed PMID: 25024396
• Perreault L, Temprosa M, Mather KJ, Horton E, Kitabchi A, Larkin M, Montez MG, Thayer D, Orchard TJ, Hamman RF, Goldberg RB, Diabetes Prevention Program Research Group. Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study. Diabetes Care. 2014 Sep;37(9):2622-31. PubMed PMID: 24969574
• Perreault L, McCurdy C, Kerege AA, Houck J, Færch K, Bergman BC. Bisphenol A Impairs Hepatic Glucose Sensing in C57BL/6 Male Mice. PLoS One 2013 Jul 29;8(7): e69991.
• Perreault L, Færch K. Approaching Pre-diabetes. Journal of Diabetes and Its Complications 2013 Oct 28: S1056-8727(13)00274-2.
• Perreault L, Færch K, Kerege AA, Bacon SD, Bergman BC. Hepatic Glucose Sensing is Impaired, but can be Normalized, in People with Impaired Fasting Glucose. J Clin Endocrinol Metab in press 2013.
• Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP. Impact of insufficient sleep on total daily energy expenditure and food intake: Implications for risk of weight gain. Proc Nat Acad Sci, in press 2013.
• Faerch K, Wiite DR, Tabak AG, Perreault L, Brunner EJ, Kivimaki M, Vistisen D. Evidence for different subtypes of type 2 diabetes in the prospective Whitehall II study. Lancet Diabetes & Endocrinology, in press 2013.
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Eckel RH, Perreault L, Rewers M. Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes in humans. J Clin Endocrinol Metab, in press 2012.
• Perreault L, Pan Q, Mather KJ, Watson KE, Hamman RF, Kahn SE. Regression from pre-diabetes to normal glucose regulation is associated with long-term reduction in diabetes risk: Results from the Diabetes Prevention Program Outcomes Study. Lancet 2012 Jun 16;379(9833):2243-51.
• Faerch, K, Bergman BC, Perreault, L. Insulin resistance, not plasma glucose, drives cardiovascular disease risk in humans. PLoS One 2012 June 7(6): e39260.
• Bergman BC, Perreault L, Hunerdosse, Kerege A, Playdon M, Samek AM, Eckel RH. Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Diabetes 2012; 61(12):3156-66.
• Price D, Ma Y, Rubin RR, Perreault L, Bray G, Marrero D, Knowler WC, Barrett- Connor E, LaCoursiere’ Y. Depression as a predictor of weight regain among successful weight losers in the Diabetes Prevention Program. Diabetes Care [ePub ahead of print September 21, 2012].
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Eckel RH, Perreault L, Rewers M. The importance of palmitoleic acid to adipocyte insulin resistance and whole body insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab, [ePub ahead of print November 12, 2012].
• Perreault L, Bergman BC, Hunerdosse DM, Howard DJ, Eckel RH. Fenofibrate adminstration does not affect intramuscular triglyceride concentration or insulin sensitivity in humans. Metabolism, 2011 Feb 7 [Epub ahead of print].
• Hivert MF, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE, Haffner S, Meigs JB, Altshuler D, Knowler WC, Florez JC. An updated genetic score based on 34 confirmed type 2 diabetes loci predicts diabetes incidence and regression to normoglycemia in the Diabetes Prevention Program. Diabetes, 2011 March 4 [Epub ahead of print].
• Florez H, Ma Y, Crandall J, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC. Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol, in press 2011.
• Florez H, Ma Y, Crandall J, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC. Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol, in press 2011.
• Florez H, Ma Y, Crandall J, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC. Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol, in press 2011.
• Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Inflexibility in intramuscular triglyceride fractional synthesis distinguishes pre-diabetes from obesity in humans. Obesity, in press 2010.
• Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Alterations in intramuscular lipid metabolism relate to diminished insulin action in men, but not women, in the progression to diabetes. Obesity, in press 2010.
• Bergman BC, Perreault L, Koehler MC, Samek AM, Eckel RH, The athlete’s paradox: alterations in intramuscular lipid turnover and diacylglycerol saturation influence insulin action. J Appl Physiol in press 2010.
• SEX DIFFERENCES IN INSULIN ACTION RELATE TO DIFFERENCES IN INTRAMUSCULAR TRIGLYCERIDE SATURATION AND ARE UNAFFECTED BY FENOFIBRATE L Perreault, BC Bergman, DM Hunerdosse, D Howard, RH Eckel to ADA
• INCRETIN ACTION MAINTAINS INSULIN SECRETION, BUT NOT HEPATIC INSULIN ACTION, IN PEOPLE WITH IMPAIRED FASTING GLUCOSE L Perreault, C Dalla Man, DM Hunerdosse, C Cobelli, BC Bergman to ADA
• Genetic risk score is associated with insulin secretion but not with diabetes incidence in the Diabetes Prevention Program (DPP). Marie-France Hivert, Kathleen A. Jablonski, Leigh Perreault, Dick Hamman, Richa Saxena, Jarred B. McAteer, Paul W. Franks, James B. Meigs, David Altshuler, Steven Haffner, Steven E. Kahn, William C. Knowler, and Jose C. Florez for the Diabetes Prevention Program Research Group to ADA
• Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Inflexibility in intramuscular triglyceride fractional synthesis distinguishes pre-diabetes from obesity in humans. Obesity (Silver Spring). 2010 Aug; 18(8):1524-31.
• Bergman BC, Perreault L, Koehler MC, Samek AM, Eckel RH, The athlete’s paradox: alterations in intramuscular lipid turnover and diacylglycerol saturation influence insulin action. J Appl Physiol 2010 May;108(5):1134-41.
• Perreault L, Bergman BC, Hunerdosse DM, Eckel RH. Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in the progression to diabetes. Obesity (Silver Spring) 2010 Oct; 18(11): 2093-2100.
• Perreault L, Dalla Man C, Hunerdosse DM, Cobelli C, Bergman BC. Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose. Diab Res Clin Pract. 2010 Oct; 90(1); 87-94.
• Jung, JM, Melanson, LE, Perreault, L, Eckel, RH, Wright KP, The metabolic cost of sleep deprivation, J Physiol, 2011 Jan 1;589(Pt 1):235-44.
• Kim C, Edelstein SL, Crandal JP, Dabelea D, Kitabchi AE, Hamman RF, Montez MG, Perreault L, Foulkes MA, Barrett-Connor E. Menopause and risk of diabetes in the Diabetes Prevention Program. Menopause, in press 2011.
• Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Inflexibility in intramuscular triglyceride fractional synthesis distinguishes pre-diabetes from obesity in humans. Diabetes 2009
• Polsky S, Howard AA, Crandall J, Bray GA, Brown-Friday J, Perreault L, Whittington T, Barrett-Connor E, Foor S, Ma Y, Edelstein S. Moderate alcohol consumption is associated with lower diabetes risk in the Diabetes Prevention Program. Am J Clin Nut 2009.
• Jung, JM, Melanson, LE, Perreault, L, Eckel, RH, Wright, KP, The metabolic cost of sleep deprivation. The Journal of Sleep, 2008.
• Polsky, S, Howard, AA, Crandall, J, Bray, GA, Brown-Friday, J, Perreault, L, Whittington, T, Barrett-Connor, E, Foo, S, Ma, Y, Edelstein, S. Moderate alcohol consumption is associated with lower diabetes risk in the Diabetes Prevention Program. Diabetes, 2008.
• Bergman, B, Perreault, L, Koehler, M, Samek, A, Eckel, RH. Does intramuscular triglyceride concentration, saturation or turnover explain insulin resistance in smokers? Diabetes SUPPL, 2008.
• Perreault L, Bergman BC,Playdon MC, Dalla Man C, Eobelli C, ckel RH. Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of pre-diabetes? Am J Physiol Metab 295: E428-435, 2008.
• Perreault L, Dagogo-Jack S, Horton E, Marrero D, Crandall J, Barrett-Connor E. Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program. Diab Care, 31:1-6, 2008.
• Perreault L, Lavely J, Horton TJ. Gender differences in lipoprotein lipase activity following acute exercise. FASEB J 16(5): A1144 Part 2, 2002 (abstract), Obes Res, 12:241-249, March 2004 (full text).
• Dean T, Perreault L, Mazzeo RS, Horton TJ. No effect of menstrual cycle phase on lactate threshold. J Appl Physiol, 95: 2537-2543, 2003.
• Perreault L. European Association for the Study of Diabetes Meeting (Glasgow, Scotland 2001): Correspondence on three symposia, Resident & Staff Physician, 3-8, March 2002.
• Perreault L. Cushing's disease from thymic neuroendocrine carcinoma: Case report and literature review. The Endocrinologist, 12: 285-288, 2002.
• Perreault L. Prediabetes. . 2000. PubMed PMID: 30860692
• Perreault L. Prediabetes. . 2000. PubMed PMID: 30860692
• Odenweller (Perreault) L. The effect of altitude on neonatal hematocrit and respiratory effort. USC Journal of Medicine, 7(1):5-6, 1995
• Bergman BC, Hunerdosse DM, Kerege A, Playdon MC, Perreault L. Membrane localization of unique diacylglycerol species predicts insulin resistance in humans. Diabetologia, Jan 15, 2012 [Epub ahead of print].

Practice Locations

UCHealth Family Medicine - Westminster
7403 Church Ranch Blvd
Suite 107
Westminster, CO 80021
720-848-9400

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Endocrinology, Diabetes and Metabolism, Board Certification (2001, 2011)

Conditions & Treatments

• Endocrine System (Hormones)