Sean Colgan, PhD

94. Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, and Colgan SP: Endothelial catabolism of extracellular adenosine during hypoxia: role of surface adenosine deaminase and CD26. Blood 2006: 108: 1602-1610.

95. Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP: HIF-dependent induction of adenosine A2B receptors in hypoxia. FASEB J 2006: 20: 2242-2250.

96. Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y. Role of complement component C5 in cerebral ischemia/reperfusion injury. Brain Res 2006: 1100: 142-151.

Ehrentraut SF, Kominsky DJ, Glover LE, Campbell EL, Kelly CJ, Bowers BE, Bayless AJ, Colgan SP. Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. J Immunol. 2013 Jan 1;190(1):392-400. PubMed PMID: 23209320

Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension. Circ Res. 2013 May 24;112(11):1466-78. PubMed PMID: 23584256

Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul;6(4):762-75. PubMed PMID: 23187315

Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. Fundamental role for HIF-1a in constitutive expression of human ß defensin-1. Mucosal Immunol. 2013 Nov;6(6):1110-8. PubMed PMID: 23462909

Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73 regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun;27(6):2207-19. PubMed PMID: 23413361

Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19820-5. PubMed PMID: 24248342

97. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1a activation by Pseudomonas aeruginosa. Am. J. Physiol. In press.

Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16;40(1):66-77. PubMed PMID: 24412613

Weissmüller T, Glover LE, Fennimore B, Curtis VF, MacManus CF, Ehrentraut SF, Campbell EL, Scully M, Grove BD, Colgan SP. HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function. FASEB J. 2014 Jan;28(1):256-64. PubMed PMID: 24029533

98. Eltzschig HK, Eckle T, Mager A, Küper N, Karcher C, Weissmuller T, Boengler K, Schulz R, Robson SC, and Sean P. Colgan. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ. Res 2006: 99: 1100-1108.

99. Khoury J, Ibla JC, Neish AS, and Colgan SP. Anti-inflammatory adaptation to hypoxia through adenosine-mediated Cullin-1 deneddylation. J Clin Invest. 2007: 117: 703–711.

100. Sun Y-P, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN: Resolvin D1 and its aspirin-triggered 17R epimer: Sterochemical assignments, anti-inflammatory properties and enzymatic inactivation. J. Biol. Chem., 2007, In press.

Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014 Jan;7(1):114-23. PubMed PMID: 23695513

Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, Macmanus CF, Müller W, Colgan SP, Bruder D. IFN-?-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia. J Immunol. 2014 Feb 1;192(3):1267-76. PubMed PMID: 24367025

Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury. J Immunol. 2014 Feb 1;192(3):1249-56. PubMed PMID: 24391213

101. Rosenberger P, Khoury J, Kong T, Weissmüeller T, Robinson A, and Colgan SP: Identification of vasodilator-stimulated phosphoprotein (VASP) as a HIF-regulated tissue permeability factor during hypoxia, FASEB J 2007, In press.

Colgan SP, Curtis VF, Campbell EL. The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis. 2013 Sep;19(10):2238-44. PubMed PMID: 23702808

Colgan SP, editor. Cell-Cell Interactions. Methods in Molecular Biology. Humana Press. Totowa, NJ. 2006.

Colgan SP. Swimming through the gut: implications of fluid transport on the microbiome. Dig Dis Sci. 2013 Mar;58(3):602-3. PubMed PMID: 23361577

26. Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiologic roles of ecto-5’-nucleotidase (CD73). Purinergic Signalling 2006; 2: 351-360.

Colgan SP, Fennimore B, Ehrentraut SF. Adenosine and gastrointestinal inflammation. J Mol Med (Berl). 2013 Feb;91(2):157-64. PubMed PMID: 23296303

25. Takedachi M, Colgan SP, Thompson LF. The role of CD73 in the generation of extracellular adenosine for adenosine receptor signaling. In Hasko G, Cronstein BN, Szabo C, editors. Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. Critical Reviews in Biochemistry, Taylor and Francis Press, New York. 2006. p. 39-48

Colgan SP, Ehrentraut SF, Glover LE, Kominsky DJ, Campbell EL. Contributions of neutrophils to resolution of mucosal inflammation. Immunol Res. 2013 Mar;55(1-3):75-82. PubMed PMID: 22968707

24. Louis NA, Daniels D, Colgan SP. Cell- cell interactions on solid matrices. In: Colgan SP, editor. Cell-Cell Interactions: Methods and Protocols. Methods in Molecular Biology. Humana Press, Totowa, NJ. 2006. p. 51-59.

27. Louis NA, Campbell E, Colgan SP. Methods and protocols to study neutrophil adhesion and chemotaxis. In: Quinn M, DeLeo F and Bokoch G, editors. Neutrophil Methods and Protocols. Methods in Molecular Biology. Humana Press, Totowa, NJ. 2006. In press.

Khoury J, Ibla JC, Neish AS, and Colgan SP. Anti-inflammatory adaptation to hypoxia through adenosine-mediated Cullin-1 deneddylation. J Clin Invest. 2007: 117: 703–711.

Kong T, Scully M, CS Shelley, Colgan SP. Identificaton of Pura as a new hypoxia response factor responsible for coordinated induction of the ß2 integrin family. J Immunol 2007: 179: 1934-1941.

Rosenberger P, Khoury J, Kong T, Weissmüeller T, Robinson A, and Colgan SP: Identification of vasodilator-stimulated phosphoprotein (VASP) as a HIF-regulated tissue permeability factor during hypoxia, FASEB J 2007: 21: 2613-2621.

Campbell EL, Bruyninckx WJ, Kelly C, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Ehrentraut SF, Burgess A, Golden-Mason L, Garvey JF, Sorenson A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, and Colgan SP: Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence inflammatory resolution. Immunity 2014: 40: 66-77. PMID 24412613.

Weissmuller T, Glover LE, Fennimore B, Curtis VF, MacManus CF, Ehrentraut SF, Campbell EL, Scully M, Grove BD, Colgan SP: HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function. FASEB J 2014: 28: 256-264. PMID 24029533

Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by proly hydroxylase inhibition in murine colits. Mucosal Immunol, 2014: 7: 114-123. PMID 23695513.

Campbell E, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, and Colgan SP: Resolvin E1 promotes mucosal surface clearance of neutrophils: A new paradigm for inflammatory resolution. FASEB J 2007: 21: 3162-3170.

Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Reigel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor (HIF)-1 as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 2014: 192-1249-1256. PMID 24367025.

Kominsky D, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, Muller W, Colgan SP, Bruder D. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia, J Immunol 2014: 192-1267-1276. PMID 24391213.

Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless AJ, Kelly CJ, Kominsky DJ, Colgan SP. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J 2014, In press. PMID 25326537.

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-derived protectin D attenuates inflammatory responses in experimental colitis, Gut 2014, In press. PMID 25209655.

Kelly CJ, Zheng L, Campbell EL, Saeedi BJ, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Host-microbe crosstalk between short-chain fatty acids and intestinal epithelial HIF provides a new mechanism to augment tissue barrier function. Cell Host Microbe, In press.

Xiong W, Knox AJ, Mei Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian sterile 20-like kinase 4 (MST4) promotes gonadotrope pituitary tumorigenesis in a hypoxic microenvironment. Mol Endocrinology In press.

Eltzschig HK, Bratton DL, Colgan SP: Targeting hypoxia signaling for the treatment of ischemic or inflammatory diseases. Nat Rev Drug Discovery, 2014: 13: 852-869. PMID: 25359381

Colgan SP, Curtis VK, Lanis JM, Glover LE: Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers, 2014, In press.

Curtis VF, Ehrentraut SF, Colgan SP: Actions of adenosine on cullin neddylation: implications for inflammatory responses. Comp Struct Biotech J, 2014, In press.

Robinson AM, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor (HIF) prolyl hydroxylation inhibition. Gastroenterol, 2008; 134: 145-155.

Xiong W, Knox AJ, Mei Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian sterile 20-like kinase 4 (MST4) promotes gonadotrope pituitary tumorigenesis in a hypoxic microenvironment. Mol Endocrinology 2015: 29: 460-472. PMID: 25650755.

Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless AJ, Kelly CJ, Kominsky DJ, Colgan SP. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J 2015: 29: 208-215. PMID 25326537. PMCID: PMC4285538

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-derived protectin D attenuates inflammatory responses in experimental colitis, Gut 2014: 64: 1236-1247. PMID 25209655. PMCID: PMC4515997

Kelly CJ, Zheng L, Campbell EL, Saeedi BJ, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Host-microbe crosstalk between short-chain fatty acids and intestinal epithelial HIF provides a new mechanism to augment tissue barrier function. Cell Host Microbe, 2015: 17: 662-671. PMID 25865369. PMCID: PMC4433427

Saeedi BJ, Kao DJ, Kitzenberg D, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell 2015: 26: 2252-2262. PMID 25904334.

Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp C, Curtis V, Bayless A, Fletcher A, Glover LE, Evans C, Jedlicka P, Furuta GT, deZoeten EF, Colgan SP, Eltzschig HK. Epithelial specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol 2015: 8: 1324-1331. PMID 25943416. PMCID: PMC4598274

Colgan SP, Curtis VK, Lanis JM, Glover LE: Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers, 2015: 3: e970936. PMID: 25838978.

Colgan SP: Neutrophils and inflammatory resolution in the mucosa. Semin Immunol, 2015: 27: 177-183. PMID: 25818531.

Campbell EL, Colgan SP: Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa. J Leuko Biol, 2016, In press. PMID: 25714801

Fu Q, Colgan SP, Shelley CS: Hypoxia and development of end stage renal disease. Clin Med Res, 2016, In press.

Colgan SP: Targeting hypoxia in inflammatory disease. J Invest Med, 2015, In press. PMID: 26098381.

Zheng L, Kelly CJ, Colgan SP: Physiologic hypoxia and oxygen homeostasis in the intestine. Am J Physiol (Cell), 2015: 309: 350-360. PMID: 26179603.

Colgan SP, Campbell EL, Kominsky DJ: Hypoxia and mucosal inflammation. Ann Rev Pathol, 2016, In press.

Campbell EL, Colgan SP: Immune functions of epithelial cells in inflammatory bowel disease. Baumgart D, editor, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition. Springer Publishers, New York, NY, 2015, In press.

Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Tazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VAJ. Hypoxia-independent activation of HIF-1 by Enterbacteriaceae and their siderophores. Gastroenterol, 2008, In press.

Wang RX, Colgan SP. Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Med. 2017 Feb 21. [Epub ahead of print] PubMed PMID: 28232096

Sun Y-P, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN: Resolvin D1 and its aspirin-triggered 17R epimer: Sterochemical assignments, anti-inflammatory properties and enzymatic inactivation. J. Biol. Chem., 2007: 282: 9323-9334.

Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 2017 Jan 18. [Epub ahead of print] PubMed PMID: 28098246

Chun C, Zheng L, Colgan SP. Tissue metabolism and host-microbial interactions in the intestinal mucosa. Free Radic Biol Med. 2016 Sep 28. [Epub ahead of print] PubMed PMID: 27687211

Ehrentraut SF, Curtis VF, Wang RX, Saeedi BJ, Ehrentraut H, Onyiah JC, Kelly CJ, Campbell EL, Glover LE, Kominsky DJ, Colgan SP. Perturbation of neddylation-dependent NF-?B responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation. Mol Biol Cell. 2016 Sep 28. [Epub ahead of print] PubMed PMID: 27682585

Campbell EL, Kao DJ, Colgan SP. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol Rev. 2016 Sep;273(1):112-20. PubMed PMID: 27558331

Kitzenberg D, Colgan SP, Glover LE. Creatine kinase in ischemic and inflammatory disorders. Clin Transl Med. 2016 Dec;5(1):31. PubMed PMID: 27527620

Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP: Control of interferon-aA by CD73: Implications for mucosal inflammation. J Immunol 2008, In press.

Glover LE, Lee JS, Colgan SP. Oxygen metabolism and barrier regulation in the intestinal mucosa. J Clin Invest. 2016 Oct 3;126(10):3680-3688. PubMed PMID: 27500494

Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?. J Immunol. 2016 Aug 15;197(4):1425-34. PubMed PMID: 27402702

27. Louis NA, Campbell E, Colgan SP. Methods and protocols to study neutrophil adhesion and chemotaxis. In: Quinn M, DeLeo F and Bokoch G, editors. Neutrophil Methods and Protocols. Methods in Molecular Biology. Humana Press, Totowa, NJ. 2007. p. 257-272.

Taylor CT, Colgan SP: Hypoxia and gastrointestinal disease. J Mol Med, 2008; 85: 1295-1300.

Eltzschig HK, MacManus CF, Colgan SP: Neutrophils as sources of extracellular nucleotides: Functional consequences at the vascular interface. Trends Cardio Med, 2008, In press.

6th Annual Advances in Inflammatory Bowel Diseases

Robinson AM, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor (HIF) prolyl hydroxylation inhibition. Gastroenterol, 2008; 134: 145-155. Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Tazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VAJ. Hypoxia-independent activation of HIF-1 by Enterbacteriaceae and their siderophores. Gastroenterol, 2008; 134:756-767. Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP: Control of interferon-aA by CD73: Implications for mucosal inflammation. J Immunol 2008; 180:4246-55. Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, Sjöblom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J: Hypoxia inducible factor-1 (HIF-1) mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J 2009; 23: 204-13. Eltzschig HK, Kohler D, Eckle T, Kong T, Robson SC, Colgan SP: Central role of Sp1-regulated CD39 in hypoxia / ischemia protection. Blood 2009; 113: 224-32. Weissmuller T, Campbell EL, Rosenberger P, Scully M, Beck PL, Furuta GT, Colgan SP: PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases. J Clin Invest 2008; 118: 3682-93. Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ: Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers. J Controlled Release, 2008, In press. Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP. Selective induction of integrin ß1 by hypoxia-inducible factor: Implications for wound healing. FASEB J, 2009, In press. Li J, Liu Q, Khoury J, Colgan SP, Ibla JC. Adenosine signaling medicates small ubiquitin-like protein (SUMO-1) modification of I?Ba during hypoxia and re-oxygenation. J Biol Chem 2009, In press. Frick J-S, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP: Contribution of aensoine A2B receptors to inflammatory parameters of experimental colitis. J Immunol 2009, In press.

Onyiah JC, Colgan SP. Cytokine responses and epithelial function in the intestinal mucosa. Cell Mol Life Sci. 2016 Nov;73(22):4203-4212. PubMed PMID: 27271753

111. Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP. Selective induction of integrin ß1 by hypoxia-inducible factor: Implications for wound healing. FASEB J, 2009: 23: 1338-1346. PMID: 19103643

113. Frick J-S, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP: Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol 2009: 182: 4957-4964. PMID: 19342675

85. Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, Colgan SP: HIF-dependent regulation of platelet activating factor receptor as a route for Gram positive bacterial translocation across epithelia. Mol Biol Cell 2010: 21, 538-546. PMID: 20032301

Colgan SP, Campbell EL, Kominsky DJ. Hypoxia and Mucosal Inflammation. Annu Rev Pathol. 2016 May 23;11:77-100. PubMed PMID: 27193451

112. Liu Q, Li J, Khoury J, Colgan SP, Ibla JC. Adenosine signaling mediates small ubiquitin-like protein (SUMO-1) modification of I?Ba during hypoxia and re-oxygenation. J Biol Chem 2009: 284: 13686-13695. PMID: 19297320

114. Ahmad A, Ahmad S, Glover LE, Miller S, Shannon JM, Guo X, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2a in pulmonary endothelial cells. Proc Nat Acad Sci, 2009: 106: 10684-10689. PMID: 19541651

115. Henes J, Schmitt MA, Morote-Garcia JC, Mirakaj V, Kohler D, Glover LE, Eldh T, Walter U, Karhausen J, Colgan SP, Rosenberger P. Crucial role of vasodilator-stimulated phosphoprotein (VASP) for alveolar-capillary barrier function during acute lung injury. FASEB J 2009: 23, 4244-4255. PMID: 1969021

117. Hirota S, Fines K, Ng J, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully M, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL: Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterol, 2010, In press.

118. Schingnitz U, Hartman K, MacManus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol, 2010, In press.

33. Filep JG and Colgan SP: Neutrophil – Endothelial Cell Interactions, In: Charles Serhan, Peter Ward and Derek Gilroy, editors. Fundamentals of Inflammation, Cambridge University Press, New York, NY. 2010.

32. Eltzschig HK, Rivera-Nieves J, Colgan SP: Targeting adenosine A2B receptors during gastrointestinal inflammation and ischemia. Expert Opin Thera Targets 13: 1267-1277, 2009 PMID: 1976954

31. Fillon S, Robinson ZD, Colgan SP, Furuta GT. Epithelial function in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am 2009: 29: 171-78, xii-xiii

30. Zemans RL, Colgan SP, Downey GP: Transepithelial migration of neutrophils: Mechansisms and implications for acute lung injury. Am J Resp Cell Mol Biol 2009: 40: 519-535.

34. Kominsky DJ, Campbell EL, Colgan SP: Metabolic shifts in immunity and inflammation. J. Immunol, 2010, In press.

35. Colgan, SP and Taylor CT: Hypoxia: An alarm signal during intestinal inflammation. Nature Rev Gastroenterology and Hepatology, 2010, In press.

Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, Colgan SP: HIF-dependent regulation of platelet activating factor receptor as a route for Gram positive bacterial translocation across epithelia. Mol Biol Cell 2010: 21, 538-546. PMID: 20032301

117. Hirota S, Fines K, Ng J, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully M, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL: Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterol, 2010: 139, 259-269. PMID: 20347817.

118. Schingnitz U, Hartman K, MacManus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol, 2010: 184, 5271-5279. PMID: 20348420.

119. Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP: Resolvin E1-induced alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Nat Acad Sci 2010: 107, 14298-14303. PMID: 20660763.

122. Glover LE, Irizarry K, Scully M, Campbell EL, Bowers B, Aherne C, Kominsky DJ, MacManus CF, Colgan SP. IFN? Attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1ß. J Immunol, 2010; 186: 1790-1798. PMID: 21199896

121. Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010; 183: 330-340. PMID: 20813891

120. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, Macdonald JA, Beck PL: NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis. 2010; In press. PMID: 20872834

33. Filep JG and Colgan SP: Neutrophil – Endothelial Cell Interactions, In: Charles Serhan, Peter Ward and Derek Gilroy, editors. Fundamentals of Inflammation, Cambridge University Press, New York, NY. 2010.

34. Kominsky DJ, Campbell EL, Colgan SP: Metabolic shifts in immunity and inflammation. J. Immunol, 2010: 184: 4062-4068. PMID: 20368286

35. Colgan, SP and Taylor CT: Hypoxia: An alarm signal during intestinal inflammation. Nature Rev Gastroenterology and Hepatology, 2010,: 7: 281-287. PMID: 20368740

MacManus CF, Campbell EL, Keely S, Burgess A, Kominsky DJ and Colgan SP. Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization. FASEB J. 2011: 25:1856-64. PMID 21350119

Goldstein JI, Kominsky DJ, Jacobson N, Bowers B, Regalia K, Austin GL, Yousefi M, Falta MT, Fontenot AP, Gerich ME, Golden-Mason L, Colgan SP: Defective leukocyte CM-CSF receptor (CD116) expression and function in Inflammatory Bowel Disease. Gastroenterol 2011: 141: 208-216. PMID 21557945

Kominsky DJ, Keely S, Macmanus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-Inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011: 186: 6505-14. PMID 21515785

Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, de Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via ß-catenin signaling. Proc Nat Acad Sci 2011: 108: 15990-15995. PMID 21880956

Eckle T, Hartmann K, Bonney S, Reithel S,1 Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP and Eltzschig HK. The circadian rhythm protein Per2 mediates a metabolic switch critical for myocardial adaptation to ischemia. Nature Med, In press.

Colgan SP. Targeting hypoxia in inflammatory bowel disease. J Investig Med. 2016 Feb;64(2):364-8. PubMed PMID: 26098381

Fu Q, Colgan SP, Shelley CS. Hypoxia: The Force that Drives Chronic Kidney Disease. Clin Med Res. 2016 Mar;14(1):15-39. PubMed PMID: 26847481

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016 May 27;291(22):11800-8. PubMed PMID: 27044749

Glover LE and Colgan SP: Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterol, 2011: 140: 1748-1755. PMID 21530741

Campbell EL, Serhan CN, Colgan SP: Antimicrobial aspects of inflammatory resolution in the mucosa: A role for pro-resolving mediators. J. Immunol, 2011: 187: 3475-3481. PMID 21934099

Colgan SP and Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Ann Rev Physiol, 2012: 74: 153-175. PMID 21942704

Ehrentraut S and Colgan SP: Implications of protein post-translational modifications in IBD. Inflamm Bowel Dis, 2012, In press.

Kelly CJ, Colgan SP, Frank DN. Of microbes and meals: The health consequences of dietary endotoxemia. Nutr Clin Prac, 2012, In press.

Kelly CJ and Colgan SP: Targeting hypoxia to augment mucosal barrier function. J. Epith. Biol Pharm., 2012, In press.

Keely S, Kelly CJ, Weissmueller T, Burgess A, Wagner BD, Harris JK, Colgan SP. Activated fluid transport regulated bacterial-epithelial interactions and significantly shifts the murine colonic microbiome. Gut Microbes 2012: 3: 250-260. PMID 22614705

Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP and Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch critical for myocardial adaptation to ischemia. Nature Med 2012: 18: 774-782. PMID 22504483

Clambey ET, McNamee EN, Westrich JA, Glover LE, Cambier J, Stenmark KR, Colgan SP and Eltzschig HK. Hypoxia-inducible factor-1 alpha dependent induction of FoxP3 drives regulatory T cell expansion during inflammatory hypoxia. Proc Nat Acad Sci 2012: 109: 2784-2793. PMID 22988108

Ehrentraut SF, Kominsky DJ, Glover LE, Campbell EL, Kelly CJ, Bowers BE, Bayless AJ, Colgan SP Central role for endothelial human deneddylase-1 / SENP8 in fine tuning of the vascular inflammatory response. J Immunol, 2013: 190: 392-400. PMID 23209320.

Kominsky DJ, Keely S, Macmanus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-Inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011: 186: 6505-14. PMID 21515785

Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK: Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol, 2013; In press. PMID 23187315.

Kelly CJ, Colgan SP. Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity. Cell Host Microbe. 2016 Apr 13;19(4):427-8. PubMed PMID: 27078062

Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. Fundamental role for HIF-1a in constitutive expression of human ß defensin-1. Mucosal Immunol, 2013; In press.

Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK: CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J, 2013: In press.

Colgan SP and Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Ann Rev Physiol, 2012: 74: 153-175. PMID 21942704

Ehrentraut S and Colgan SP: Implications of protein post-translational modifications in IBD. Inflamm Bowel Dis, 2012: 18: 1378-1388. PMID 22223542

Kelly CJ and Colgan SP: Targeting hypoxia to augment mucosal barrier function. J. Epith. Biol Pharm. 2012: 5 (Suppl 1-M10), 67-76.

Kelly CJ, Colgan SP, Frank DN. Of microbes and meals: The health consequences of dietary endotoxemia. Nutr Clin Prac, 2012: 27: 215-225. PMID 21942704.

Colgan SP, Ehrentraut SF, Glover LE, Kominsky DJ, Campbell EL: Immunology in Colorado (Special Issue) Contributions of neutrophils to resolution of inflammation. Immunol Res 2013: 55: 75-82. PMID 22968707.

Colgan SP, Fennimore BP, Ehrentraut SF: Adenosine and gastrointestinal inflammation. J Mol Med 2013: 91: 157-164. PMID 23296303.

Ju C, Colgan SP, Eltzschig HK. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med (Berl). 2016 Jun;94(6):613-27. PubMed PMID: 27094811

Colgan SP. Swimming through the gut: Implications of fluid transport on the microbiome . (Invited editorial). Dig Dis Sci 2013; In press. PMID 23361577.

Colgan SP, Curtis VF, Campbell EL: The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis 2013; In press.

Colgan SP, Glover LE: Microenvironmental control of permeability in mucosal inflammation. Proceedings of the 2012 Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia. Tissue Barriers, 2013, In press.

Taylor CT, Colgan SP. Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol. 2017 Dec;17(12):774-785. PubMed PMID: 28972206

Chun C, Zheng L, Colgan SP. Tissue metabolism and host-microbial interactions in the intestinal mucosa. Free Radic Biol Med. 2017 Apr;105:86-92. PubMed PMID: 27687211

Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 2017 Sep;10(5):1133-1144. PubMed PMID: 28098246

Wang RX, Colgan SP. Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Med. 2017 Dec;58:93-101. PubMed PMID: 28232096

Lanis JM, Kao DJ, Alexeev EE, Colgan SP. Tissue metabolism and the inflammatory bowel diseases. J Mol Med (Berl). 2017 Sep;95(9):905-913. PubMed PMID: 28528514

McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug;187(8):1772-1786. PubMed PMID: 28618253

Colgan SP, Campbell EL. Oxygen metabolism and innate immune responses in the gut. J Appl Physiol (1985). 2017 Nov 1;123(5):1321-1327. PubMed PMID: 28705991

Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 Oct;85(10). PubMed PMID: 28717030

Neudecker V, Colgan SP, Eltzschig HK. Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside. J Mol Med (Berl). 2017 Sep;95(9):899-903. PubMed PMID: 28780611

Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2017 Aug 16. [Epub ahead of print] PubMed PMID: 28812548

Nguyen N, Fernando SD, Biette KA, Hammer JA, Capocelli KE, Kitzenberg DA, Glover LE, Colgan SP, Furuta GT, Masterson JC. TGF-ß1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis. Mucosal Immunol. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28832026

Hall CHT, Campbell EL, Colgan SP. Neutrophils as Components of Mucosal Homeostasis. Cell Mol Gastroenterol Hepatol. 2017 Nov;4(3):329-337. PubMed PMID: 28884136

Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol. 2017 Oct 15;199(8):2976-2984. PubMed PMID: 28893958

Glover LE, Colgan SP. Epithelial Barrier Regulation by Hypoxia-Inducible Factor. Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S233-S236. PubMed PMID: 28945477

Alexeev EE, Lanis JM, Kao DJ, Battista KD, Campbell EL, Kelly CJ, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP. Microbiota-derived indole metabolites promote intestinal homeostasis and serve as biomarkers of human inflammatory bowel disease. Am J Pathol, 2018, In press.

Campbell EL, Colgan SP. Control and dysregulation of the redox signaling in the gastrointestinal tract. Nat Rev Gastro Hepatol, 2017, In press. PMID In press.

Campbell EL, Colgan SP. Control and dysregulation of redox signalling in the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2018 Nov 15. [Epub ahead of print] PubMed PMID: 30443019

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell. 2018 Oct 8;34(4):659-673.e6. PubMed PMID: 30270124

Colgan SP, Campbell EL. Oxygen metabolism and innate immune responses in the gut. J Appl Physiol (1985). 2017 Nov 1;123(5):1321-1327. PubMed PMID: 28705991

Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 Oct;85(10). PubMed PMID: 28717030

Neudecker V, Colgan SP, Eltzschig HK. Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside. J Mol Med (Berl). 2017 Sep;95(9):899-903. PubMed PMID: 28780611

Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2018 Mar;11(2):357-368. PubMed PMID: 28812548

Nguyen N, Fernando SD, Biette KA, Hammer JA, Capocelli KE, Kitzenberg DA, Glover LE, Colgan SP, Furuta GT, Masterson JC. TGF-ß1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis. Mucosal Immunol. 2018 Mar;11(2):415-426. PubMed PMID: 28832026

Hall CHT, Campbell EL, Colgan SP. Neutrophils as Components of Mucosal Homeostasis. Cell Mol Gastroenterol Hepatol. 2017 Nov;4(3):329-337. PubMed PMID: 28884136

Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol. 2017 Oct 15;199(8):2976-2984. PubMed PMID: 28893958

Colgan SP, Furuta GT, Taylor CT. Hypoxia and Innate Immunity: Keeping Up with the HIFsters. Annu Rev Immunol. 2020 Jan 21. [Epub ahead of print] PubMed PMID: 31961750

Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2019 Dec 2. [Epub ahead of print] PubMed PMID: 31792360

Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C. Hypoxia-Inducible Factor-2a Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2019 Sep 17. [Epub ahead of print] PubMed PMID: 31529728

Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562

Shearn CT, Fennimore B, Orlicky DJ, Gao YR, Saba LM, Battista KD, Aivazidis S, Assiri M, Harris PS, Michel C, Merrill GF, Schmidt EE, Colgan SP, Petersen DR. Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response. Free Radic Biol Med. 2019 Nov 1;143:101-114. PubMed PMID: 31377417

Masterson JC, Biette KA, Hammer JA, Nguyen N, Capocelli KE, Saeedi BJ, Harris RF, Fernando SD, Hosford LB, Kelly CJ, Campbell EL, Ehrentraut SF, Ahmed FN, Nakagawa H, Lee JJ, McNamee EN, Glover LE, Colgan SP, Furuta GT. Epithelial HIF-1a/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. J Clin Invest. 2019 Jul 2;129(8):3224-3235. PubMed PMID: 31264974

Kelly CJ, Alexeev EE, Farb L, Vickery TW, Zheng L, Eric L C, Kitzenberg DA, Battista KD, Kominsky DJ, Robertson CE, Frank DN, Stabler SP, Colgan SP. Oral vitamin B(12) supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice. Gut Microbes. 2019;10(6):654-662. PubMed PMID: 31062653

Campbell EL, Colgan SP. Control and dysregulation of redox signalling in the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2019 Feb;16(2):106-120. PubMed PMID: 30443019

Gally F, Sasse SK, Kurche J, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion O, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant, rs35705950, resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2020 Dec 15. [Epub ahead of print] PubMed PMID: 33320836

Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2020 Oct 1. [Epub ahead of print] PubMed PMID: 33004979

Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 Sep 15;31(20):2249-2258. PubMed PMID: 32726170

Lee JS, Wang RX, Goldberg MS, Clifford GP, Kao DJ, Colgan SP. Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function. iScience. 2020 Jun 26;23(6):101226. PubMed PMID: 32554188

Hall CHT, Lee JS, Murphy EM, Gerich ME, Dran R, Glover LE, Abdulla ZI, Skelton MR, Colgan SP. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology. 2020 Sep;159(3):984-998.e1. PubMed PMID: 32433978

Wang RX, Lee JS, Campbell EL, Colgan SP. Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11648-11657. PubMed PMID: 32398370

Colgan SP. Resolvins resolve to heal mucosal wounds. Proc Natl Acad Sci U S A. 2020 May 19;117(20):10621-10622. PubMed PMID: 32371481

Liu G, Baird AW, Parsons MJ, Fan K, Skerrett-Byrne DA, Nair PM, Makanyengo S, Chen J, Neal R, Goggins BJ, Tay H, Mathe A, Soh WS, Minahan K, Hansbro PM, Nixon B, McCaughan GW, Holtmann G, Colgan SP, Keely S. Platelet activating factor receptor acts to limit colitis-induced liver inflammation. FASEB J. 2020 Jun;34(6):7718-7732. PubMed PMID: 32293760

deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME. Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. Hypoxia (Auckl). 2020;8:1-12. PubMed PMID: 32104717

Colgan SP, Furuta GT, Taylor CT. Hypoxia and Innate Immunity: Keeping Up with the HIFsters. Annu Rev Immunol. 2020 Apr 26;38:341-363. PubMed PMID: 31961750

Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 Mar;13(2):230-244. PubMed PMID: 31792360

Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C. Hypoxia-Inducible Factor-2a Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2020 Jun;71(6):2105-2117. PubMed PMID: 31529728

Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2021 Dec 16. [Epub ahead of print] PubMed PMID: 34916594

Dowdell AS, Colgan SP. Metabolic Host-Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD). Pharmaceuticals (Basel). 2021 Jul 22;14(8). PubMed PMID: 34451805

Trikha SRJ, Lee DM, Ecton KE, Wrigley SD, Vazquez AR, Litwin NS, Thomas KN, Wei Y, Battson ML, Johnson SA, Kuhn KA, Colgan SP, Gentile CL, Weir TL. Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance. Gut Microbes. 2021 Jan-Dec;13(1):1940791. PubMed PMID: 34313540

Wang RX, Henen MA, Lee JS, Vögeli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec;13(1):1938380. PubMed PMID: 34190032

Cartwright IM, Colgan SP. In vitro Monitoring of Extracellular pH in Real-Time. J Vis Exp. 2021 Jun 3;(172). PubMed PMID: 34152309

Colgan SP. HIF2 keeps paces in tight hypoxic spaces. Blood. 2021 Jun 17;137(24):3323-3324. PubMed PMID: 34137846

Cartwright IM, Colgan SP. Lung neutrophils on a paleo diet: lean, mean inflammatory machines. J Clin Invest. 2021 May 17;131(10). PubMed PMID: 33998602

Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 May 18;118(20). PubMed PMID: 33972436

Wallimann T, Hall CHT, Colgan SP, Glover LE. Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial. Nutrients. 2021 Apr 23;13(5). PubMed PMID: 33922654

Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 May;35(5):e21552. PubMed PMID: 33826788

Lee JS, Wang RX, Alexeev EE, Colgan SP. Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut Microbes. 2021 Jan-Dec;13(1):1-20. PubMed PMID: 33583319

Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA, Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Sci Transl Med. 2021 Feb 3;13(579). PubMed PMID: 33536281

Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021 Jan 25;6(2). PubMed PMID: 33320836

Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2021 Mar;14(2):479-490. PubMed PMID: 33004979

Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 Sep 27;40(13):111409. PubMed PMID: 36170839

Steiner CA, Cartwright IM, Taylor CT, Colgan SP. Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis. Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C866-C878. PubMed PMID: 35912990

de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. IL-38 Gene Deletion Worsens Murine Colitis. Front Immunol. 2022;13:840719. PubMed PMID: 35693797

Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 Dec;112(6):1543-1553. PubMed PMID: 35674095

Kitzenberg DA, Lee JS, Mills KB, Kim JS, Liu L, Vázquez-Torres A, Colgan SP, Kao DJ. Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics. mBio. 2022 Jun 28;13(3):e0048022. PubMed PMID: 35575513

Ornelas A, Dowdell AS, Lee JS, Colgan SP. Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function. Cells. 2022 Mar 10;11(6). PubMed PMID: 35326394

Glover LE, Colgan SP. Epithelial Barrier Regulation by Hypoxia-Inducible Factor. Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S233-S236. PubMed PMID: 28945477

Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2022 Feb;15(2):244-256. PubMed PMID: 34916594

Lee JS, Wang RX, Colgan SP. Microbial metabolite regulation of epithelial tight junctions and barrier. Gonzalez L, Editor. In Tight Junctions. Springer Publishers, New York, NY. 2022.

Colgan SP, Wang RX, Hall CHT, Bhagavatula G, Lee JS. Revisiting the “starved gut” hypothesis in inflammatory bowel disease. Immunometabolism 2022, In press.

Alexeev EE, Lanis JM, Kao DJ, Campbell EL, Kelly CJ, Battista KD, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP. Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol. 2018 May;188(5):1183-1194. PubMed PMID: 29454749

Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Hall CHT, Lu S, Weiser-Evans MC, Cartwright IM, Colgan SP. The TNF?ARE mouse as a model of intestinal fibrosis. Am J Pathol, 2023, S0002-9440. PMID: 37169343.

Seymour BJ, Trent B, Allen BE, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice. J Clin Invest. 2023 Dec 19. [Epub ahead of print] PubMed PMID: 38113112

Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 Nov 17;11(1):256. PubMed PMID: 37978573

Ornelas A, Welch N, Countess JA, Zhou L, Wang RX, Dowdell AS, Colgan SP. Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers. Gut Microbes. 2023 Dec;15(2):2267706. PubMed PMID: 37822087

Hall CHT, Lanis JM, Dowdell AS, Murphy EM, Bhagavatula G, Neuhart RM, Vijaya Sai KY, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. Mucosal Immunol. 2023 Dec;16(6):817-825. PubMed PMID: 37716510

Feng D, Xiang X, Guan Y, Guillot A, Lu H, Chang C, He Y, Wang H, Pan H, Ju C, Colgan SP, Tacke F, Wang XW, Kunos G, Gao B. Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models. J Clin Invest. 2023 Aug 1;133(15). PubMed PMID: 37338984

Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Nguyen TT, Hall CHT, Lu S, de Zoeten EF, Weiser-Evans MCM, Cartwright IM, Colgan SP. The TNF(?ARE) Mouse as a Model of Intestinal Fibrosis. Am J Pathol. 2023 Aug;193(8):1013-1028. PubMed PMID: 37169343

Vickery JM, Toperzer JD, Raab JE, Lenz LL, Colgan SP, Russo BC. Synaptopodin is necessary for Shigella flexneri intercellular spread. bioRxiv. 2023 Jun 26. PubMed PMID: 37163027

Cartwright IM, Colgan SP. The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. Front Immunol. 2023;14:1124774. PubMed PMID: 36742292

Colgan SP, Wang RX, Hall CHT, Bhagavatula G, Lee JS. Revisiting the "starved gut" hypothesis in inflammatory bowel disease. Immunometabolism (Cobham). 2023 Jan;5(1):e0016. PubMed PMID: 36644501

Taylor CT, Colgan SP. Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol. 2017 Dec;17(12):774-785. PubMed PMID: 28972206

Lee JS, Wang RX, Alexeev EE, Lanis JM, Battista KD, Glover LE, Colgan SP. Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem. 2018 Apr 20;293(16):6039-6051. PubMed PMID: 29487135

Onyiah JC, Schaefer REM, Colgan SP. A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression. J Innate Immun. 2018;10(3):228-238. PubMed PMID: 29791903

Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP. Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling. Mol Biol Cell. 2018 Nov 1;29(22):2687-2699. PubMed PMID: 30188771

Distinguished Professor, Medicine-Gastroenterology

Department

Publications

Practice Locations

School of Medicine

CU Anschutz

Fitzsimons Building