Kurt Beam, PhD

Distinguished Professor, Physiology & Biophysics


Publications

  • Sheridan, DC, Moua, O, Lorenzon, NM and Beam, KG. Bimolecular Fluorescence Complementation and Targeted Biotinylation Provide Insight into the Topology of the Skeletal Muscle Ca2+ Channel ?1a Subunit. Channels 6:26-40, 2012. Eltit. JM, Bannister, RA, Moua, O, Altamirano, F, Hopkins, PM, Pessah, IN, Molinski, TF, López, JR, Beam, KG, and Allen, PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc. Natl. Acad. Sci. U.S.A., 109:7923-7928, 2012. PMCID: PMC3356662 Cherednichenko, G, Zhang, R, Bannister, RA, Timofeyev, V, Li, N, Fritsch, EB, Feng, W, Barrientos, GC, Schebb, NH, Hammock, BD, Beam, KG, Chiamvimonvat, N, and Pessah, IN. Triclosan impairs excitation–contraction coupling and Ca2+ dynamics in striated muscle. Proc. Natl. Acad. Sci. U.S.A., 109:14158-63, 2012. PMCID: PMC3435154 Polster, A, Ohrtman, JD, Beam, KG, and Papadopoulos, S. Fluorescence Resonance Energy Transfer (FRET) Indicates that Association with the Type I Ryanodine Receptor (RyR1) Causes Reorientation of Multiple Cytoplasmic Domains of the Dihydropyridine Receptor (DHPR) ?1S Subunit. J. Biol. Chem., 287:41560-68, 2012. PMCID: PMC3510851 Szpyt, J, Lorenzon, N, Perez, CF, Norris, E, Allen, PD, Beam, K, and Samsó, M. 3D Localization of the Alpha and Beta Subunits and of the II-III loop in the Skeletal Muscle L-type Ca2+ Channel. J. Biol. Chem. 287:43853-61, 2012. PMCID: in process. Bannister, RA and Beam, KG. (2013). Impaired gating of an L-type Ca2+ channel carrying a mutation linked to malignant hyperthermia. Biophys. J., in press.
  • Bannister RA, Beam KG. Impaired gating of an L-Type Ca(2 ) channel carrying a mutation linked to malignant hyperthermia. Biophys J. 2013 May 7;104(9):1917-22. PubMed PMID: 23663834
  • Bannister RA, Beam KG. Ca(V)1.1: The atypical prototypical voltage-gated Ca²? channel. Biochim Biophys Acta. 2013 Jul;1828(7):1587-97. PubMed PMID: 22982493
  • Polster A, Perni S, Bichraoui H, Beam KG. Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2 channels. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):602-6. PubMed PMID: 25548159
  • Ohrtman JD, Romberg CF, Moua O, Bannister RA, S. Rock Levinson SR, Beam, KG. Apparent lack of physical or functional interaction between CaV1.1 and its distal C-terminus. 2015. J. Gen. Physiol., in press.
  • Ohrtman JD, Romberg CF, Moua O, Bannister RA, Levinson SR, Beam KG. Apparent lack of physical or functional interaction between CaV1.1 and its distal C terminus. J Gen Physiol. 2015 Apr;145(4):303-14. PubMed PMID: 25779869
  • Polster A, Perni S, Bichraoui H, Beam KG. Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2 channels. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):602-6. PubMed PMID: 25548159
  • Bannister RA, Sheridan DC, and Beam KG. Distinct components of retrograde CaV1.1-RyR1 coupling revealed by a lethal mutation in RyR1. Biophysical J., in press, 2015.
  • Polster A, Nelson BR, Olson EN, Beam KG. Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10986-91. PubMed PMID: 27621462
  • Bannister RA, Sheridan DC, Beam KG. Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1. Biophys J. 2016 Feb 23;110(4):912-21. PubMed PMID: 26910427
  • Perni S, Lavorato M, Beam KG. De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca(2 ) release. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13822-13827. PubMed PMID: 29229815
  • Polster A, Perni S, Filipova D, Moua O, Ohrtman JD, Bichraoui H, Beam KG, Papadopoulos S. Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain. J Gen Physiol. 2018 Feb 5;150(2):293-306. PubMed PMID: 29284662
  • Polster A, Nelson BR, Papadopoulos S, Olson EN, Beam KG. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. J Gen Physiol. 2018 Feb 21. [Epub ahead of print] PubMed PMID: 29467163
  • Polster A, Dittmer PJ, Perni S, Bichraoui H, Sather WA, Beam KG. Stac Proteins Suppress Ca(2 )-Dependent Inactivation of Neuronal l-type Ca(2 ) Channels. J Neurosci. 2018 Oct 24;38(43):9215-9227. PubMed PMID: 30201773
  • Polster A, Nelson BR, Papadopoulos S, Olson EN, Beam KG. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. J Gen Physiol. 2018 Apr 2;150(4):613-624. PubMed PMID: 29467163
  • Polster A, Perni S, Filipova D, Moua O, Ohrtman JD, Bichraoui H, Beam KG, Papadopoulos S. Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain. J Gen Physiol. 2018 Feb 5;150(2):293-306. PubMed PMID: 29284662
  • Stefano Perni, Kurt G. Beam. Recruitment and modulation of neuronal moltage-Gated Ca2+ channels and endoplasmic Ca2+-release channels into ER-PM junctions formed by Junctophilins and STIM1. In preparation (2019).
  • Alexander Polster, Philip M. Hopkins, Kurt G. Beam. Multiple sites of interaction may be involved in the regulation of CaV1.1 by Stac3. Biophysical Journal 116:523a.
  • Stefano Perni, Kurt G. Beam. Interactions of Junctophilins and STIM1 with ER calcium-releasing channels. Biophysical Journal 116:400a.
  • Stefano Perni, Kurt G. Beam: Neuronal Junctophilin 3 can replace Junctophilin 2 In voltage-induced calcium Release. Gordon Conference on Muscle Excitation-Contraction Coupling, Il Ciocco, Italy, May 2019.
  • Stefano Perni, Kurt G. Beam: Interactions of neuronal junctophilins and STIM1 with ER and PM Ca2+ channels. Gordon Conference on Muscle Excitation-Contraction Coupling, Il Ciocco, Italy, May 2019.
  • Perni S, Beam K. Neuronal junctophilins recruit specific Ca(V) and RyR isoforms to ER-PM junctions and functionally alter Ca(V)2.1 and Ca(V)2.2. Elife. 2021 Mar 26;10. PubMed PMID: 33769283
  • Flucher BE, Beam KG. . The skeletal muscle calcium channel. In: Voltage-Gated Calcium Channels (Zamponi, GW and Weiss, N., eds.) Springer Nature Books, in press.
  • Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. J Gen Physiol. 2022 Dec 5;154(12). PubMed PMID: 36305844
  • Dayal A, Perni S, Franzini-Armstrong C, Beam KG, Grabner M. The distal C terminus of the dihydropyridine receptor ß(1a) subunit is essential for tetrad formation in skeletal muscle. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2201136119. PubMed PMID: 35507876
  • Perni S, Beam K. Junctophilins 1, 2, and 3 all support voltage-induced Ca2 release despite considerable divergence. J Gen Physiol. 2022 Sep 5;154(9). PubMed PMID: 35089322
  • Feng W, Lopez JR, Antrobus S, Zheng J, Uryash A, Dong Y, Beqollari D, Bannister RA, Hopkins PM, Beam KG, Allen PD, Pessah IN. Putative malignant hyperthermia mutation Ca(V)1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance. J Biol Chem. 2023 Aug;299(8):104992. PubMed PMID: 37392848