Kimber Simmons, MD, MPH/MSPH

Professional Titles

• Assistant Professor

Publications

• Simmons KM, Alkanani AK, McDaniel KA, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One. 2016 Nov 15;11(11):e0166213. PubMed PMID: 27846247
• Simmons KM, Gottlieb PA, Michels AW. Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes. Curr Diab Rep. 2016 Oct;16(10):97. PubMed PMID: 27558810
• Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2016 Feb;169:44-8.e1. PubMed PMID: 26561381
• Simmons KM, Michels AW. Alternate Ways to Quantify Antibodies. Diabetes Technol Ther. 2015 Dec;17(12):854-6. PubMed PMID: 26544921
• Nakayama M, Simmons KM, Michels AW. Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep. 2015 Dec;15(12):113. PubMed PMID: 26458384
• Gonzalez Ballesteros LF, Ma NS, Gordon RJ, Ward L, Backeljauw P, Wasserman H, Weber DR, DiMeglio LA, Gagne J, Stein R, Cody D, Simmons K, Zimakas P, Topor LS, Agrawal S, Calabria A, Tebben P, Faircloth R, Imel EA, Casey L, Carpenter TO. Unexpected widespread hypophosphatemia and bone disease associated with elemental formula use in infants and children. Bone. 2017 Apr;97:287-292. PubMed PMID: 28167344
• Smith MJ, Simmons KM, Cambier JC. B cells in type 1 diabetes mellitus and diabetic kidney disease. Nat Rev Nephrol. 2017 Oct 17;13(11):712-720. PubMed PMID: 29038537
• Simmons KM, Steck AK. Islet Autoantibody Testing – Current Utility, Future Prospects in Predicting and Diagnosing Type 1 Diabetes. Clinical Laboratory News. 2017.
• Simmons KM, Michels AW. Type 1 diabetes: A predictable disease. World J Diabetes. 2015 Apr 15;6(3):380-90. PubMed PMID: 25897349
• Hoetzer GL, Irmiger HM, Keith RS, Westbrook KM, DeSouza CA. Endothelial nitric oxide synthase inhibition does not alter endothelial progenitor cell colony forming capacity or migratory activity. J Cardiovasc Pharmacol. 2005 Sep;46(3):387-9. PubMed PMID: 16116346
• Mahmud FH, Elbarbary NS, Fröhlich-Reiterer E, Holl RW, Kordonouri O, Knip M, Simmons K, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2018 Oct;19 Suppl 27:275-286. PubMed PMID: 30066458
• CITR Research Group. 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR). Cell Transplant. 2009;18(7):753-67. PubMed PMID: 19796497
• Smith MJ, Simmons KM, Cambier JC. B cells in type 1 diabetes mellitus and diabetic kidney disease. Nat Rev Nephrol. 2017 Oct 17;13(11):712-720. PubMed PMID: 29038537
• Alejandro R, Barton FB, Hering BJ, Wease S. 2008 Update from the Collaborative Islet Transplant Registry. Transplantation. 2008 Dec 27;86(12):1783-8. PubMed PMID: 19104422
• Simmons K, Michels AW. Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov;40(4):797-811. PubMed PMID: 25437293
• Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ. Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. PubMed PMID: 30844073
• Simmons KM, Michels AW. Is it Time to Screen the General Population for Type 1 Diabetes? US Endocrinology. 2015;11(1):10–6.
• Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK. Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes. Int J Mol Sci. 2019 Aug 8;20(16). PubMed PMID: 31398795
• Simmons KM, Youngkin E, Alkanani A, Miao D, McDaniel K, Yu L, Michels AW. Screening children for type 1 diabetes-associated antibodies at community health fairs. Pediatr Diabetes. 2019 Nov;20(7):909-914. PubMed PMID: 31376227
• Simmons KM, Alkanani AA, McDaniel K, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One.
• Zaharieva DP, Addala A, Simmons KM, Maahs DM. Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions. Curr Obes Rep. 2020 Oct 27. [Epub ahead of print] PubMed PMID: 33108635
• Triolo TM, Pyle L, Seligova S, Yu L, Simmons K, Gottlieb P, Evans-Molina C, Steck AK. Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes. J Transl Autoimmun. 2021;4:100089. PubMed PMID: 33748733
• Zaharieva DP, Addala A, Simmons KM, Maahs DM. Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions. Curr Obes Rep. 2020 Dec;9(4):412-423. PubMed PMID: 33108635
• Simmons KM, Sosenko JM, Warnock M, Geyer S, Ismail HM, Elding Larsson H, Steck AK. One-Hour Oral Glucose Tolerance Tests for the Prediction and Diagnostic Surveillance of Type 1 Diabetes. J Clin Endocrinol Metab. 2020 Nov 1;105(11). PubMed PMID: 32844178
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02 . Diabetes. 2020 Aug;69(8):1763-1769. PubMed PMID: 32439825
• Rydin AA, Spiegel G, Frohnert BI, Kaess A, Oswald L, Owen D, Simmons KM. Medical management of children with type 1 diabetes on low-carbohydrate or ketogenic diets. Pediatr Diabetes. 2021 May;22(3):448-454. PubMed PMID: 33470021
• Mitchell AM, Baschal EE, McDaniel KA, Simmons KM, Pyle L, Waugh K, Steck AK, Yu L, Gottlieb PA, Rewers MJ, Nakayama M, Michels AW. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 2022 Sep 22;7(18). PubMed PMID: 35998036
• He L, Jia X, Rasmussen CG, Waugh K, Miao D, Dong F, Frohnert B, Steck AK, Simmons KM, Rewers M, Yu L. High-Throughput Multiplex Electrochemiluminescence Assay Applicable to General Population Screening for Type 1 Diabetes and Celiac Disease. Diabetes Technol Ther. 2022 Jul;24(7):502-509. PubMed PMID: 35238620
• Steck AK, Dong F, Geno Rasmussen C, Bautista K, Sepulveda F, Baxter J, Yu L, Frohnert BI, Rewers MJ, Rewers M, Barbour A, Bautista K, Baxter J, Felipe-Morales D, Dong F, Dormond-Brooks P, Driscoll K, Frohnert B, Rasmussen CG, Gesualdo P, Hoffman M, Karban R, Sepulveda F, Shorrosh H, Simmons K, Steck A, Taki I, Waugh K, Yu L, Liu E, Gallant M, McQueen RB, Norris JM. CGM Metrics Predict Imminent Progression to Type 1 Diabetes: Autoimmunity Screening for Kids (ASK) Study. Diabetes Care. 2022 Feb 1;45(2):365-371. PubMed PMID: 34880069
• Simmons KM, Sosenko JM, Warnock M, Geyer S, Ismail HM, Elding Larsson H, Steck AK. One-Hour Oral Glucose Tolerance Tests for the Prediction and Diagnostic Surveillance of Type 1 Diabetes. J Clin Endocrinol Metab. 2020 Nov 1;105(11). PubMed PMID: 32844178
• Triolo TM, Pyle L, Seligova S, Yu L, Simmons K, Gottlieb P, Evans-Molina C, Steck AK. Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes. J Transl Autoimmun. 2021;4:100089. PubMed PMID: 33748733
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02 . Diabetes. 2020 Aug;69(8):1763-1769. PubMed PMID: 32439825
• Rydin AA, Spiegel G, Frohnert BI, Kaess A, Oswald L, Owen D, Simmons KM. Medical management of children with type 1 diabetes on low-carbohydrate or ketogenic diets. Pediatr Diabetes. 2021 May;22(3):448-454. PubMed PMID: 33470021
• Simmons KM, Youngkin E, Alkanani A, Miao D, McDaniel K, Yu L, Michels AW. Screening children for type 1 diabetes-associated antibodies at community health fairs. Pediatr Diabetes. 2019 Nov;20(7):909-914. PubMed PMID: 31376227
• Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ. Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. PubMed PMID: 30844073
• Ramos EL, Dayan CM, Chatenoud L, Sumnik Z, Simmons KM, Szypowska A, Gitelman SE, Knecht LA, Niemoeller E, Tian W, Herold KC. Teplizumab and ß-Cell Function in Newly Diagnosed Type 1 Diabetes. N Engl J Med. 2023 Oct 18. [Epub ahead of print] PubMed PMID: 37861217
• Simmons KMW, Frohnert BI, O'Donnell HK, Bautista K, Geno Rasmussen C, Gerard Gonzalez A, Steck AK, Rewers MJ. Historical Insights and Current Perspectives on the Diagnosis and Management of Presymptomatic Type 1 Diabetes. Diabetes Technol Ther. 2023 Nov;25(11):790-799. PubMed PMID: 37695674
• O'Donnell HK, Rasmussen CG, Dong F, Simmons KM, Steck AK, Frohnert BI, Bautista K, Rewers MJ, Baxter J. Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes. Diabetes Care. 2023 Dec 1;46(12):2155-2161. PubMed PMID: 37673098
• Frost HM, Geno Rasmussen C, Shorrosh H, Pyle L, Bautista K, Frohnert BI, Stahl M, Simmons K, Steck AK, Jia X, Yu L, Rewers M. Prevalence of SARS-CoV-2 Antibodies Among Healthy Children From Colorado From 2020 to 2021: A Brief Report. J Prim Care Community Health. 2023 Jan-Dec;14:21501319231189147. PubMed PMID: 37501515
• Simmons KM, Sims EK. Screening and Prevention of Type 1 Diabetes: Where Are We?. J Clin Endocrinol Metab. 2023 Nov 17;108(12):3067-3079. PubMed PMID: 37290044
• Mameli C, Triolo TM, Chiarelli F, Rewers M, Zuccotti G, Simmons KM. Lessons and gaps in the prediction and prevention of type 1 diabetes. Pharmacol Res. 2023 Jul;193:106792. PubMed PMID: 37201589
• Fröhlich-Reiterer E, Elbarbary NS, Simmons K, Buckingham B, Humayun KN, Johannsen J, Holl RW, Betz S, Mahmud FH. ISPAD Clinical Practice Consensus Guidelines 2022: Other complications and associated conditions in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2022 Dec;23(8):1451-1467. PubMed PMID: 36537532
• Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Erratum. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 2024;47:1276-1298. Diabetes Care. 2024 Nov 1;47(11):2033. PubMed PMID: 39240700
• Karakus KE, Fleury T, Baschal EE, McDaniel KA, Choi H, Armstrong TK, Yu L, Simmons KM, Michels AW. Clinical Features and HLA Genetics Differ in Children at Type 1 Diabetes Onset by Hispanic Ethnicity. J Clin Endocrinol Metab. 2024 Sep 4. [Epub ahead of print] PubMed PMID: 39231249
• Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Correction to: Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetologia. 2024 Sep;67(9):2012-2014. PubMed PMID: 39230637
• Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Elding Larsson H, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 2024 Aug 1;47(8):1276-1298. PubMed PMID: 38912694
• Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark Å, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetologia. 2024 Sep;67(9):1731-1759. PubMed PMID: 38910151
• Mehta S, Ryabets-Lienhard A, Patel N, Breidbart E, Libman I, Haller MJ, Simmons KM, Sims EK, DiMeglio LA, Gitelman SE, Griffin KJ, Tonyushkina KN. Pediatric Endocrine Society Statement on Considerations for Use of Teplizumab (Tzield™) in Clinical Practice. Horm Res Paediatr. 2024 Apr 30;:1-12. [Epub ahead of print] PubMed PMID: 38663372
• Sooy MGQ, Pyle L, Alonso GT, Broncucia HC, Rewers A, Gottlieb PA, Simmons KMW, Rewers MJ, Steck AK. Lower Prevalence of Diabetic Ketoacidosis at Diagnosis in Research Participants Monitored for Hyperglycemia. J Clin Endocrinol Metab. 2024 Mar 12. [Epub ahead of print] PubMed PMID: 38470864
• Ramos EL, Dayan CM, Chatenoud L, Sumnik Z, Simmons KM, Szypowska A, Gitelman SE, Knecht LA, Niemoeller E, Tian W, Herold KC. Teplizumab and ß-Cell Function in Newly Diagnosed Type 1 Diabetes. N Engl J Med. 2023 Dec 7;389(23):2151-2161. PubMed PMID: 37861217
• Simmons KMW, Frohnert BI, O'Donnell HK, Bautista K, Geno Rasmussen C, Gerard Gonzalez A, Steck AK, Rewers MJ. Historical Insights and Current Perspectives on the Diagnosis and Management of Presymptomatic Type 1 Diabetes. Diabetes Technol Ther. 2023 Nov;25(11):790-799. PubMed PMID: 37695674
• O'Donnell HK, Rasmussen CG, Dong F, Simmons KM, Steck AK, Frohnert BI, Bautista K, Rewers MJ, Baxter J. Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes. Diabetes Care. 2023 Dec 1;46(12):2155-2161. PubMed PMID: 37673098
• Frost HM, Geno Rasmussen C, Shorrosh H, Pyle L, Bautista K, Frohnert BI, Stahl M, Simmons K, Steck AK, Jia X, Yu L, Rewers M. Prevalence of SARS-CoV-2 Antibodies Among Healthy Children From Colorado From 2020 to 2021: A Brief Report. J Prim Care Community Health. 2023 Jan-Dec;14:21501319231189147. PubMed PMID: 37501515
• Simmons KM, Sims EK. Screening and Prevention of Type 1 Diabetes: Where Are We?. J Clin Endocrinol Metab. 2023 Nov 17;108(12):3067-3079. PubMed PMID: 37290044
• Mameli C, Triolo TM, Chiarelli F, Rewers M, Zuccotti G, Simmons KM. Lessons and gaps in the prediction and prevention of type 1 diabetes. Pharmacol Res. 2023 Jul;193:106792. PubMed PMID: 37201589

Practice Locations

Barbara Davis Center for Diabetes Pediatric Clinic - CU Anschutz Medical Campus
1775 Aurora Ct
Suite A140
Aurora, CO 80045
303-724-2323

Children's Hospital Colorado North Campus - Broomfield
469 State Highway 7
Broomfield, CO 80023
720-478-5000

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Center Affiliations

• Barbara Davis Center for Childhood Diabetes

Specialty Information

Specialties

• Pediatrics, Board Certification (2013)
• Pediatric Endocrinology, Board Certification (2017)