Linda Barbour, MD
Professor, Medicine-Endocrinology/Metabolism/Diabetes

Research Interests

Publications

• Szmuilowicz ED, BARBOUR LA, Brown FM, Durnwald C, Feig D, O’Malley G, Polsky S, Aleppo G. CGM Metrics for Pregnancies Complicated by Diabetes: Critical Appraisal of Current Evidence. J Diab Sci Tech, in press, 2024.
• Nicklas JM, Pyle L, Soares A, Leiferman JA, Bull SS, Tong S, Caldwell AE, Santoro N, BARBOUR LA. The Fit After Baby randomized controlled trial: An mHealth postpartum lifestyle intervention for women with elevated cardiometabolic risk, PLOS One, in press, 2024.
• Rainford M, BARBOUR LA, Birch D, Catalano P, Daniels E, Gremont C, Marshall NE, Wharton K, Thornburg K. Barriers to Implementing Good Nutrition in Pregnancy and Early Childhood: Creating Equitable National Solutions Running title: Blueprint for Nutrition in Pregnancy. In Press, Annals of the New York Academy of Sciences, 2024.
• Valent AM, BARBOUR LA. Thyroid Disease in Pregnancy. In Lockwood CJ, Copel JA, Dugoff L, Louis J, Moore TR, Silver RM, Resnik R. Creasy and Resnik’s Study Guide for Maternal-Fetal Medicine, 194-197, Elsevier 2024.
• Warrfuel J, BARBOUR LA, Son Shannon. Diabetic Ketoacidosis and Euglycemic Diabetic Ketoacidosis in Pregnancy. Topics in Obstetrics and Gynecology, 2024 Feb; 44 (3):1-8.
• Abushamat LA, Sayres L, Jeffers R, Nielsen C, Barbour LA, Zaman A. Unmasking Barriers in the Delivery of Preconception Counseling and Contraception Provision for Patients With Type 1 or Type 2 Diabetes. Clin Diabetes. 2023 Fall;41(4):567-572. PubMed PMID: 37849518
• Hernandez TL, Farabi SS, Fosdick BK, Hirsch N, Dunn EZ, Rolloff K, Corbett JP, Haugen E, Marden T, Higgins J, Friedman JE, Barbour LA. Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Mellitus Results in Similar Newborn Adiposity. Diabetes Care. 2023 Nov 1;46(11):1931-1940. PubMed PMID: 37643311
• Valent AM, BARBOUR LA. Thyroid Disease in Pregnancy. In Lockwood CJ, Moore TR, Copel JA, Silver R, Resnik R, Dugoff L, Louis J (editors). Creasy & Resnik’s Maternal-Fetal Medicine: Principles and Practice. 9th ed. Philadelphia: Elsevier; 2023, 1187-1213.
• Hamidi OP, Barbour LA. Endocrine Emergencies During Pregnancy: Diabetic Ketoacidosis and Thyroid Storm. Obstet Gynecol Clin North Am. 2022 Sep;49(3):473-489. PubMed PMID: 36122980
• Sugino KY, Hernandez TL, Barbour LA, Kofonow JM, Frank DN, Friedman JE. A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus. Front Endocrinol (Lausanne). 2022;13:921464. PubMed PMID: 35966074
• Heyborne K, Barbour L. Risk of Adverse Pregnancy Outcomes Among US Individuals With Gestational Diabetes by Race and Ethnicity. JAMA. 2022 Jul 26;328(4):396-397. PubMed PMID: 35881130
• Marshall NE, Abrams B, Barbour LA, Catalano P, Christian P, Friedman JE, Hay WW Jr, Hernandez TL, Krebs NF, Oken E, Purnell JQ, Roberts JM, Soltani H, Wallace J, Thornburg KL. The importance of nutrition in pregnancy and lactation: lifelong consequences. Am J Obstet Gynecol. 2022 May;226(5):607-632. PubMed PMID: 34968458
• Rodel RL, Farabi SS, Hirsch NM, Rolloff KP, McNair B, Hernandez TL, Krebs NF, Barbour LA, Young BE. Human milk imparts higher insulin concentration in infants born to women with type 2 diabetes mellitus. J Matern Fetal Neonatal Med. 2022 Dec;35(25):7676-7684. PubMed PMID: 34465258
• Rodel RL, Farabi SS, Hirsch NM, Rolloff KP, McNair B, Hernandez TL, Krebs NF, Barbour LA, Young BE. Human milk imparts higher insulin concentration in infants born to women with type 2 diabetes mellitus. J Matern Fetal Neonatal Med. 2021 Aug 31;:1-9. [Epub ahead of print] PubMed PMID: 34465258
• Castillo-Castrejon M, Yamaguchi K, Rodel RL, Erickson K, Kramer A, Hirsch NM, Rolloff K, Jansson T, Barbour LA, Powell TL. Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity. Mol Cell Endocrinol. 2021 Jul 15;532:111319. PubMed PMID: 33989714
• Valent AM, Barbour LA. Management of Women with Polycystic Ovary Syndrome During Pregnancy. Endocrinol Metab Clin North Am. 2021 Mar;50(1):57-69. PubMed PMID: 33518186
• Farabi SS, Barbour LA, Hernandez TL. Sleep-disordered breathing in pregnancy: a developmental origin of offspring obesity?. J Dev Orig Health Dis. 2021 Apr;12(2):237-249. PubMed PMID: 32425147
• Abushamat L, BARBOUR LA. Management of Diabetes in Pregnancy. In: McDermott, M.T. editor. Diabetes Secrets. Pennsylvania: Elsevier Saunders; Nov 25, 2021.
• Soderborg TK, Carpenter CM, Janssen RC, Weir TL, Robertson CE, Ir D, Young BE, Krebs NF, Hernandez TL, Barbour LA, Frank DN, Kroehl M, Friedman JE. Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota. Front Endocrinol (Lausanne). 2020;11:603021. PubMed PMID: 33329403
• Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 Nov 20. [Epub ahead of print] PubMed PMID: 33216249
• Farabi SS, Barbour LA, Hernandez TL. Sleep-disordered breathing in pregnancy: a developmental origin of offspring obesity?. J Dev Orig Health Dis. 2020 May 19;:1-13. [Epub ahead of print] PubMed PMID: 32425147
• Nicklas JM, Leiferman JA, Lockhart S, Daly KM, Bull SS, Barbour LA. Development and Modification of a Mobile Health Program to Promote Postpartum Weight Loss in Women at Elevated Risk for Cardiometabolic Disease: Single-Arm Pilot Study. JMIR Form Res. 2020 Apr 9;4(4):e16151. PubMed PMID: 32271149
• Shomaker LB, Gulley LD, Clark ELM, Hilkin AM, Pivarunas B, Tanofsky-Kraff M, Nadeau KJ, Barbour LA, Scott SM, Sheeder JL. Protocol for a pilot randomized controlled feasibility study of brief interpersonal psychotherapy for addressing social-emotional needs and preventing excess gestational weight gain in adolescents. Pilot Feasibility Stud. 2020;6:39. PubMed PMID: 32206334
• Valent, A, BARBOUR LA. Diabetes in Pregnancy. In: McDermott, M.T., editor. Endocrine Secrets, 7th Edition. Pennsylvania: Elsevier Saunders; 2020, 67-86.
• Donnelly, M, BARBOUR LA. Thyroid Disease in Pregnancy. In McDermott MT (ed). Endocrine Secrets, 7th Edition. Pennsylvania: Elsevier Saunders; 2020, 345-358.
• Soderborg TK, Carpenter CM, Janssen RC, Weir TL, Robertson CE, Ir D, Young BE, Krebs NF, Hernandez TL, Barbour LA, Frank DN, Kroehl M, Friedman JE. Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota. Front Endocrinol (Lausanne). 2020;11:603021. PubMed PMID: 33329403
• Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 Dec;25(4):367-387. PubMed PMID: 33216249
• Nicklas JM, Leiferman JA, Lockhart S, Daly KM, Bull SS, Barbour LA. Development and Modification of a Mobile Health Program to Promote Postpartum Weight Loss in Women at Elevated Risk for Cardiometabolic Disease: Single-Arm Pilot Study. JMIR Form Res. 2020 Apr 9;4(4):e16151. PubMed PMID: 32271149
• Shomaker LB, Gulley LD, Clark ELM, Hilkin AM, Pivarunas B, Tanofsky-Kraff M, Nadeau KJ, Barbour LA, Scott SM, Sheeder JL. Protocol for a pilot randomized controlled feasibility study of brief interpersonal psychotherapy for addressing social-emotional needs and preventing excess gestational weight gain in adolescents. Pilot Feasibility Stud. 2020;6:39. PubMed PMID: 32206334
• Farabi SS, Barbour LA, Heiss K, Hirsch NM, Dunn E, Hernandez TL. Obstructive Sleep Apnea is Associated with Altered Glycemic Patterns in Pregnant Women with Obesity. J Clin Endocrinol Metab. 2019 Feb 22. [Epub ahead of print] PubMed PMID: 30794722
• Barbour LA, Feig DS. Metformin for Gestational Diabetes Mellitus: Progeny, Perspective, and a Personalized Approach. Diabetes Care. 2019 Mar;42(3):396-399. PubMed PMID: 30787061
• Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462. PubMed PMID: 30367045
• Barbour LA, Hernandez TL. Maternal Lipids and Fetal Overgrowth: Making Fat from Fat. Clin Ther. 2018 Oct;40(10):1638-1647. PubMed PMID: 30236792
• Wexler DJ, Powe CE, Barbour LA, Buchanan T, Coustan DR, Corcoy R, Damm P, Dunne F, Feig DS, Ferrara A, Harper LM, Landon MB, Meltzer SJ, Metzger BE, Roeder H, Rowan JA, Sacks DA, Simmons D, Umans JG, Catalano PM. Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Obstet Gynecol. 2018 Aug;132(2):496-505. PubMed PMID: 29995731
• Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR. A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. Am J Obstet Gynecol. 2018 Oct;219(4):367.e1-367.e7. PubMed PMID: 29959933
• Barbour LA, Farabi SS, Friedman JE, Hirsch NM, Reece MS, Van Pelt RE, Hernandez TL. Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy. Obesity (Silver Spring). 2018 Aug;26(8):1347-1356. PubMed PMID: 29931812
• Barbour LA, Hernandez TL. Maternal Non-glycemic Contributors to Fetal Growth in Obesity and Gestational Diabetes: Spotlight on Lipids. Curr Diab Rep. 2018 May 9;18(6):37. PubMed PMID: 29744612
• Hernandez TL, Mande A, Barbour LA. Nutrition therapy within and beyond gestational diabetes. Diabetes Res Clin Pract. 2018 Nov;145:39-50. PubMed PMID: 29679625
• Riveros-Perez E, Hermesch AC, Barbour LA, Hawkins JL. Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations. Int J Womens Health. 2018;10:117-125. PubMed PMID: 29535558
• Dutton H, Borengasser SJ, Gaudet LM, Barbour LA, Keely EJ. Obesity in Pregnancy: Optimizing Outcomes for Mom and Baby. Med Clin North Am. 2018 Jan;102(1):87-106. PubMed PMID: 29156189
• Riveros-Perez E, Hermesch A, Barbour L, Hawkins J. Aplastic anemia in two consecutive pregnancies: obstetric and anesthetic management. Int J Obstet Anesth. 2018 Feb;33:71-75. PubMed PMID: 29108725
• Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan;105(1):234-236. PubMed PMID: 28049665
• Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan;39(1):122-9. PubMed PMID: 26628417
• McIntyre HD, Sacks DA, Barbour LA, Feig DS, Catalano PM, Damm P, McElduff A. Issues With the Diagnosis and Classification of Hyperglycemia in Early Pregnancy. Diabetes Care. 2016 Jan;39(1):53-4. PubMed PMID: 26519336
• Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240
• Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27876761
• Moore GS, Allshouse AA, Fisher BM, Kahn BF, Hernandez TL, Reece MS, Reynolds RM, Lee W, Barbour LA, Galan HL. Can Fetal Limb Soft Tissue Measurements in the Third Trimester Predict Neonatal Adiposity?. J Ultrasound Med. 2016 Sep;35(9):1915-24. PubMed PMID: 27417735
• Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016 Jul 14;11(7):e0159575. PubMed PMID: 27414406
• Lemas DJ, Young BE, Baker PR 2nd, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May;103(5):1291-300. PubMed PMID: 27140533
• Shapiro AL, Kaar JL, Crume TL, Starling AP, Siega-Riz AM, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study. Int J Obes (Lond). 2016 Jul;40(7):1056-62. PubMed PMID: 27133623
• Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia. 2016 May;59(5):895-906. PubMed PMID: 26843076
• Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan;39(1):122-9. PubMed PMID: 26628417
• McIntyre HD, Sacks DA, Barbour LA, Feig DS, Catalano PM, Damm P, McElduff A. Issues With the Diagnosis and Classification of Hyperglycemia in Early Pregnancy. Diabetes Care. 2016 Jan;39(1):53-4. PubMed PMID: 26519336
• Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240
• Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2016 Aug;11(4):264-71. PubMed PMID: 26198967
• Nicklas JM, Barbour LA. Optimizing Weight for Maternal and Infant Health - Tenable, or Too Late?. Expert Rev Endocrinol Metab. 2015;10(2):227-242. PubMed PMID: 26442123
• Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2015 Jul 22. [Epub ahead of print] PubMed PMID: 26198967
• Donnelly MA, Wood C, Casey B, Hobbins J, Barbour LA. Early severe fetal Graves disease in a mother after thyroid ablation and thyroidectomy. Obstet Gynecol. 2015 May;125(5):1059-62. PubMed PMID: 25710616
• Buschur E, Stetson B, Barbour LA. Diabetes In Pregnancy. . 2000. PubMed PMID: 25905241
• Abushamat L, BARBOUR LA. Management of Diabetes in Pregnancy. In: McDermott, M.T. editor. Diabetes Secrets. Pennsylvania: Elsevier Saunders; 2020, in press.
• Valent A, BARBOUR LA. Polycystic Ovarian Disease in Pregnancy. In Endocrinology and Metabolism Clinics of North America, Androgens in Women: Too Much, Too Little, Just Right, March 2021, in press.
• Valent A, BARBOUR LA. Thyroid Disease in Pregnancy. In Lockwood CJ, Moore TR, Copel JA, Silver R, Resnik R, Dugoff L, Louis J (editors). Creasy & Resnik’s Maternal-Fetal Medicine: Principles and Practice. 9th ed. Philadelphia: Elsevier.