Kathryn Horwitz, PhD

Publications

• MOLEC ENDO 19(13): 574-587
• jcem 90(2): 1181-1188
• J CLIN ONC 23(4): 931-932
• BR CA RES & TREAT 94(2): 171-183
• POSTDOCS, MENTOR, TEACHER, GUIDE; JUNIOR FACULTY, DITTO
• ENDOCRINOLOGY 147: 700-713
• CANCER RES 65(21): 9779-9788
• MOL CELL BIO 26(5): 1722-1730
• CANCER RES
• Harvell DME, Richer JK, Allred DC, Sartorius CA and Horwitz KB. Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture. ENDOCRINOLOGY, 147: 700-713, 2006
• Chadli M, Graham JD, Abel MG, Jackson TA, Gordon DF, Wood WM, Felts SJ, Horwitz KB and Toft DO. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. MOLECULAR AND CELL BIOLOGY, 26(5): 1722-1730, 2006.
• Tung L, Abdel-Hafiz H, Shen T, Harvell DME, Nitao LK, Richer JK, Sartorius SA, Takimoto GS, and Horwitz KB. Progesterone receptors (PR)-B and PR-A regulated transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. MOLECULAR ENDOCRINOLOGY, 20 (11): 2656-2670, 2006
• Harrell JC, Dye WW, Allred DC, Jedlicka P, Spoelstra NS, Sartorius CA and Horwitz KB. A new model of estrogen receptor positive, estrogen dependent breast cancer metastasis: Altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. CANCER RESEARCH, 66 (18): 9308-9315, 2006.
• Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X and Yee D. Insulin receptor substrates mediate distinct biological responses to IGF-IR activation in breast cancer cells. BRITISH J OF CANCER, 95: 1220-1228, 2006.
• Jones MC, Fusi L, Higham JH, Abdel-Hafiz H, Horwitz KB, Lam EWF and Brosens JJ. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 103 (44): 16272-16277, 2006.
• Jacobsen BM, Harrell JC, Jedlicka P, Borges VF, Garcia MV and Horwitz, KB. Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. CANCER RESEARCH, 66 (16): 8274-8279, 2006.
• Spoelstra NS, Manning NG, Higashi Y, Darling D, Singh M, Shroyer S, Broaddus RR, Horwitz KB and Richer JK. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. CANCER RESEARCH, 66(7) 3893-3902, 2006.
• Harvell DME, Spoelstra NS, Singh M, Finlayson C, Phang T, Hunter L, Dye WW, Borges VB, Elias AD, Horwitz KB and Richer JK. Molecular signatures of response to neoadjuvant endocrine therapies for breast cancers. BREAST CANCER RESEARCH & TREATMENT, in press 2008.
• Harvell DME, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VB, Elias AD and Horwitz KB. Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: Tamoxifen agonist effects dominate in the presence of an aromatase inhibitor. BREAST CANCER RESEARCH & TREATMENT, in press, 2008
• Harrell JC, Dye WW, Harvell DME, Pinto M, Sartorius CA and Horwitz KB. Estrogen insensitivity in a model of estrogen receptor-positive breast cancer lymph node metastasis. CANCER RESEARCH, 67:10582-91, 2007
• Harrell JC, Sartorius CA, Dye WW, Jacobsen BM and Horwitz KB. ZsGreen labeling of breast cancer cells to visualize metastasis. CLONTECHNIQUES XXII, No 2. 23-25, 2007
• Harrell JC, Dye WW, Sartorius CA and Horwitz KB. Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: A comparison of experimental breast cancers and their lymph node metastases. CLINICAL AND EXPERIMENTAL METASTASIS, eprint ahead of pub DOI 10.1007/s10585-007-9105-7, 2007
• Horwitz KB, Dye WW, Harrell JC, Kabos P and Sartorius CA. Rare steroid receptor negative basal-like tumorigenic cells in luminal subtype human breast cancers, Submitted, 2008
• Singh M, Spoelstra NS, Shroyer KK, Torkko KC, Clark HR, Darling DS, Horwitz KB, Broaddus RR and Richer JK. ZEB1 expression in Type I vs. Type II endometrial cancers. MODERN PATHOLOGY, Submitted, 2008.
• Christensen KL, Micalizzi DS, Coletta RD, Jedlicka P, Harrell JC, Horwitz KB, Billheimer D, Heichman K, Welm A, and Ford HL. The developmental regulator Six1 promotes an epithelial to mesenchymal transition, induces metastasis, and predicts poor prognosis in many human cancers, Submitted, 2008
• Harrell JC, Dye WW, Sartorius CA and Horwitz KB. Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: A comparison of experimental breast cancers and their lymph node metastases. CLINICAL AND EXPERIMENTAL METASTASIS 25:81-88, 2008.
• Singh M, Spoelstra NS, Howe JA, Torkko KC, Clark HR, Darling DS, Shroyer KK, Horwitz KB, Broaddus RR and Richer JK. ZEB1 expression in Type I vs. Type II endometrial cancers: a marker of aggressive disease. MODERN PATHOLOGY, 21: 912-923, 2008
• Harvell DME, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VB, Elias AD and Horwitz KB. Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: Tamoxifen agonist effects dominate in the presence of an aromatase inhibitor. BREAST CANCER RESEARCH & TREATMENT, 112: 489-501, 2008
• Horwitz KB, Dye WW, Harrell JC, Kabos P and Sartorius CA. Rare steroid receptor negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts, PROC NAT ACAD SCI, 105(15): 5774-5779, 2008
• Horwitz KB and Sartorius CA. COMMENTARY: Progestins in hormone replacement therapies reactivate cancer stem cells in occult breast cancers: a hypothesis. J CLIN ENDO & METAB, 93(9): 3295-3298, 2008
• Horwitz KB. Update of estrogen plus progestin therapy for menopausal hormone replacement and an explanation for the associated increased risk of breast cancer. MOLEC ENDOCR, 22: 2743-2750, 2008
• Abdel-Hafiz H, Dudevoir M, and Horwitz KB. Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation. J BIOL CHEM, in press, 2009
• Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Baron AE, Harrell JC, Horwitz KB, Billheimer D, Heichman K, Welm A, Schiemann WP and Ford HL. The Six1 homeoprotein induces epithelial to mesenchymal transition and breast cancer metastasis via Transforming Growth Factor-?, JOURNAL CLINICAL INVESTIGATION, 119(9): 2528-2531, 2009
• Jacobsen BM, Jambal P, Schittone SA and Horwitz KB. ALU-like repeats in promoters are position dependent co-response elements (coRE) that enhance or repress transcription by dimeric and monomeric progesterone receptors. MOLECULAR ENDOCRINOLOGY, 23(7); 989-1000, 2009
• Abdel-Hafiz H, Dudevoir M, and Horwitz KB. Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation. J BIOL CHEM, 284(14): 9099-9108, 2009
• Spillman MA, Sartorius CA, Harrell JC, Manning NG, Jacobsen BM and Horwitz KB. Estrogen enhances tumor growth and metastases in human ovarian cancer nude mouse xenograft models. AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, Hunter Prize Thesis Award, American Gynecological & Obstetrics Society; Submitted
• Breast Cancer Res Treat. 2011 Feb 22. [Epub ahead of print]PMID:21340479 Badtke MM, Jambal P, Dye WW, Spillman MA, Post MD, Horwitz KB, Jacobsen BM. Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint.
• Cancer Res. 2010 Nov 1;70(21):8927-36. Epub 2010 Oct 19.PMID:20959477 Spillman MA, Manning NG, Dye WW, Sartorius CA, Post MD, Harrell JC, Jacobsen BM, Horwitz KB. Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis.
• Breast Cancer Res Treat. 2010 Jul 28. [Epub ahead of print]PMID: 20665103 Kabos P, Haughian JM, Wang X, Dye WW, Finlayson C, Elias A, Horwitz KB, Sartorius CA. Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.
• Kabos P, Haughian JM, Wang X, Dye WW, Finlayson C, Elias A, Horwitz KB and Sartorius CA. Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant cell subpopulation in luminal breast cancers. BREAST CANCER RESEARCH AND TREATMENT, 128:45-55, 2011
• Badtke MM, Jambal P, Dye WW, Spillman MS, Post MD, Horwitz KB and Jacobsen BM Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint. BREAST CANCER RESEARCH AND TREATMENT, in press 2011
• Pinto MP, Jacobsen BM and Horwitz KB. An immunohistochemical method to study breast cancer cell subpopulations and their growth regulation by hormones in three-dimensional cultures. FRONTIERS IN CANCER ENDOCRINOLOGY 2(15): 1-6, 2011
• Haughian JM, Pinto MP, Harrell JC, Bliesner BS, Joensuu K, Dye WW, Sartorius CA, Tan A-C, Heikkilä PS, Perou CM and Horwitz KB. Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch, PROC OF THE NATIONAL ACADEMY OF SCIENCES (USA), 109 (8): 2742-2747, 2012
• Jacobsen BM and Horwitz KB. Progesterone receptors, their isoforms and progesterone regulated transcription. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012 in press
• Harvell DME, Kim J, O’Brien J, Tan A-C, Borges VF, Schedin P, Jacobsen BM, and Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone, submitted 2011
• Abdel-Hafiz H and Horwitz KB. Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation, in press, 2012
• Badtke MM, Jambal P, Dye WW, Spillman MS, Post MD, Horwitz KB and Jacobsen BM Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint. BREAST CANCER RESEARCH AND TREATMENT, 131 (1): 75-87, 2012
• Haughian JM, Pinto MP, Harrell JC, Bliesner BS, Joensuu K, Dye WW, Sartorius CA, Tan A-C, Heikkilä PS, Perou CM and Horwitz KB. Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch, PROC OF THE NATIONAL ACADEMY OF SCIENCES (USA), 109 (8): 2742-2747, 2012
• Jacobsen BM and Horwitz KB. Progesterone receptors, their isoforms and progesterone regulated transcription. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 357: 18-29, 2012
• Harvell DME, Kim J, O’Brien J, Tan A-C, Borges VF, Schedin P, Jacobsen BM, and Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone, HORMONES AND CANCER, in press 2013
• Abdel-Hafiz H and Horwitz KB. Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation, in press 2012
• Joensuu K, Leidenius M, Kero M, Andersson LC, Horwitz KB, Heikkilä P. ER, PR, HER2, Ki67 and CK5 in early and late relapsing breast cancer -- Reduced CK5 expression in metastases, BREAST CANCER: BASIC AND CLINICAL RESEARCH, 7: 23-34, 2013
• Jambal, P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, Spillman MA, Horwitz KB and Jacobsen BM. Estrogen switches pure mucinous breast cancer to aggressive invasive lobular carcinoma with mucinous features. BREAST CANCER RESEARCH AND TREATMENT, in press, 2013