I study children with stroke, and try to understand the mechanisms behind why children have strokes. Specifically, I investigate the potential of hypercoagulable and inflammatory biomarkers in prognosticating outcome and recurrence in childhood-onset arterial ischemic stroke.
Teaching
Site Director (CHCO), Vascular Fellowship
(2020)
School of Medicine,
Neurology
Bedside teacher, child neurology
(2020)
School of Medicine,
Pediatrics
Director of Education, Section of Child Neurology
(2022)
School of Medicine,
Pediatrics
COMPASS Guide
(2021)
School of Medicine,
Other
Publications
Robert G. Kowalski, MD, MS1,2; Brandi Schimpf BSN RN CEN3; David Ornelas, RN3; Sharon N. Poisson, MD1; Eduardo Carrera, MD1; Timothy J. Bernard, MD4; Benzi M. Kluger, MD, MS1; Matthew R.G. Taylor, MD, PhD5; Stefan H. Sillau, PhD1; William J. Jones, MD1. Seizures as Stroke Mimics in Ultra-Early Treatment on a Mobile Stroke Unit: A Pilot Study. International Stroke Conference 2022.
Mastej EJ, Leppert MH, Poisson S, Ritchey Z, Barry M, Rundek T, Liebeskind DS, Mirsky D, Bernard TJ, Stence NV. Thalamic Volume Loss Is Greater in Children Than in Adults Following Middle Cerebral Artery Territory Arterial Ischemic Stroke. J Child Neurol. 2022 Oct;37(10-11):882-888. PubMed PMID: 36069041
Beslow LA, Agner SC, Santoro JD, Ram D, Wilson JL, Harrar D, Appavu B, Fraser SM, Rossor T, Torres MD, Kossorotoff M, Zuñiga Zambrano YC, Hernández-Chávez M, Hassanein SMA, Zafeiriou D, Dowling MM, Kopyta I, Stence NV, Bernard TJ, Dlamini N. International Prevalence and Mechanisms of SARS-CoV-2 in Childhood Arterial Ischemic Stroke During the COVID-19 Pandemic. Stroke. 2022 Aug;53(8):2497-2503. PubMed PMID: 35380052
Houska N, Schafer M, Chatfield KC, Bernard TJ, Ing RJ. Anesthetic Considerations for Children With Multisystem Smooth Muscle Dysfunction Syndrome and Review of the Literature. J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt B):3205-3211. PubMed PMID: 35568655
Davila-Williams D, Barry M, Vargas C, Vossough A, Bernard TJ, Rafay MF. Cerebral Arteriopathies of Childhood - Current Approaches. Semin Pediatr Neurol. 2022 Oct;43:101004. PubMed PMID: 36344018
Ritchey Z, Bernard TJ, Fenton LZ, Maloney JA, Mirsky DM, Neuberger I, Sriram I, Seinfeld J, Stence NV. Stroke Recurrence in Children with Vertebral Artery Dissecting Aneurysm. AJNR Am J Neuroradiol. 2022 Jun;43(6):913-918. PubMed PMID: 35550284
Troy E, Sillau S, Bernard TJ, Rao S. Incidence and Clinical Outcomes of Streptococcus anginosus in Acute Complicated Sinusitis: A Pediatric Cohort. J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):168-171. PubMed PMID: 31925948
Beslow LA, Linds AB, Fox CK, Kossorotoff M, Zuñiga Zambrano YC, Hernández-Chávez M, Hassanein SMA, Byrne S, Lim M, Maduaka N, Zafeiriou D, Dowling MM, Felling RJ, Rafay MF, Lehman LL, Noetzel MJ, Bernard TJ, Dlamini N. Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2. Ann Neurol. 2021 Apr;89(4):657-665. PubMed PMID: 33332607
Felling RJ, Rafay MF, Bernard TJ, Carpenter JL, Dlamini N, Hassanein SMA, Jordan LC, Noetzel MJ, Rivkin MJ, Shapiro KA, Slim M, deVeber G. Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study. Ann Neurol. 2020 Jun;87(6):840-852. PubMed PMID: 32215969
Troy E, Sillau S, Bernard TJ, Rao S. Incidence and Clinical Outcomes of Streptococcus anginosus in Acute Complicated Sinusitis: A Pediatric Cohort. J Pediatric Infect Dis Soc. 2020 Jan 11. [Epub ahead of print] PubMed PMID: 31925948
Rafay MF, Shapiro KA, Surmava AM, deVeber GA, Kirton A, Fullerton HJ, Amlie-Lefond C, Weschke B, Dlamini N, Carpenter JL, Mackay MT, Rivkin M, Linds A, Bernard TJ. Spectrum of cerebral arteriopathies in children with arterial ischemic stroke. Neurology. 2020 Jun 9;94(23):e2479-e2490. PubMed PMID: 32457211
Roach ES, Bernard T, deVeber G. Defining a Pediatric Stroke Center. Pediatr Neurol. 2020 Nov;112:11-13. PubMed PMID: 32835896
Beslow LA, Linds AB, Fox CK, Kossorotoff M, Zuñiga Zambrano YC, Hernández-Chávez M, Hassanein SMA, Byrne S, Lim M, Maduaka N, Zafeiriou D, Dowling MM, Felling RJ, Rafay MF, Lehman LL, Noetzel MJ, Bernard TJ, Dlamini N. Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2. Ann Neurol. 2020 Dec 17. [Epub ahead of print] PubMed PMID: 33332607
Barry M, Hallam DK, Bernard TJ, Amlie-Lefond C. What is the Role of Mechanical Thrombectomy in Childhood Stroke?. Pediatr Neurol. 2019 Jun;95:19-25. PubMed PMID: 30795888
Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, DeBaun MR, deVeber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke. 2019 Mar;50(3):e51-e96. PubMed PMID: 30686119
Ritchey Z, Mirsky DM, Weitzenkamp D, Bernard TJ, Herson PS, Stence NV. Age-associated hippocampal volume changes in childhood arterial ischemic stroke. Childs Nerv Syst. 2019 Feb;35(2):295-300. PubMed PMID: 30535770
Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2019 Jun;39(6):1005-1014. PubMed PMID: 29283314
Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018 Nov;49(11):2590-2596. PubMed PMID: 30355212
Goldenberg NA, Everett AD, Graham D, Bernard TJ, Nowak-Göttl U. Proteomic and other mass spectrometry based "omics" biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: current state, unmet needs, and future directions. Proteomics Clin Appl. 2014 Dec;8(11-12):828-36. PubMed PMID: 25379629
Baird LC, Smith ER, Ichord R, Piccoli DA, Bernard TJ, Spinner NB, Scott RM, Kamath BM. Moyamoya Syndrome Associated with Alagille Syndrome: Outcome after Surgical Revascularization. J Pediatr. 2014 Oct 30. [Epub ahead of print] PubMed PMID: 25465847
Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ, VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014 Dec;45(12):3597-605. PubMed PMID: 25388419
Goldenberg NA, Bernard TJ, Hillhouse J, Armstrong-Wells J, Galinkin J, Knapp-Clevenger R, Jacobson L, Marcovina SM, Manco-Johnson MJ. Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children. Haematologica. 2013 May;98(5):802-7. PubMed PMID: 23349301
Lambers M, Goldenberg NA, Kenet G, Kirkham FJ, Manner D, Bernard T, Mesters RM, Junker R, Stoll M, Nowak-Göttl U. Role of reduced ADAMTS13 in arterial ischemic stroke: a pediatric cohort study. Ann Neurol. 2013 Jan;73(1):58-64. PubMed PMID: 23225307
Pearson V, Ruzas C, Krebs NF, Goldenberg NA, Manco-Johnson MJ, Bernard TJ. Overweight and Obesity Are Increased in Childhood-Onset Cerebrovascular Disease. J Child Neurol. 2012 May 30. [Epub ahead of print] PubMed PMID: 22647484
Kedia S, Stence N, Manco-Johnson M, Armstrong-Wells J, Bernard TJ. Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke?. Headache. 2012 Apr;52(4):674-8. PubMed PMID: 22404149
Beslow LA, Kasner SE, Smith SE, Mullen MT, Kirschen MP, Bastian RA, Dowling MM, Lo W, Jordan LC, Bernard TJ, Friedman N, DeVeber G, Kirton A, Abraham L, Licht DJ, Jawad AF, Ellenberg JH, Lautenbach E, Ichord RN. Concurrent validity and reliability of retrospective scoring of the Pediatric National Institutes of Health Stroke Scale. Stroke. 2012 Feb;43(2):341-5. PubMed PMID: 22076000
Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012 Feb;43(2):371-7. PubMed PMID: 22156694
Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260102
Clinical Interests
My many clinical interests include childhood stroke, childhood CSVT, and general neurology
Care Philosophy
I want all of my patients and their families to know that their child is getting the best care possible. In order to support this goal, I strive to listen to the needs of the family and patient, and educate them about their child's disease.
Personal Interests
In my spare time, I enjoy skiing, golfing, and spending time with my 16 year old twins.
Volunteer Activities
Top-100 fundraiser, Courage Classic Bike Ride
Public Speaking Yes
I enjoy giving talks about pediatric stroke, and the importance of dedicated pediatric stroke specialists
General Information
Medical Schools:
MD, University of Rochester School of Medicine and Dentistry
(2001)
Graduate Schools:
MSCS, University of Colorado Health Sciences Center
(2013)
Undergraduate Schools:
BA, Middlebury College (VT)
(1994)
Internships:
University of Colorado (Children's Hospital Colorado) Program
(2002)
Residency Programs:
University of Colorado (Children's Hospital Colorado) Program, Child Neurology (2006)