Laurence Chan, MD, PhD, MS

Research Interests

My research interests include mechanism of allograft rejection and the safety and effectiveness of new therapeutic protocols for kidney transplantation. Application of NMR and other molecular biomarkers in allograft rejection and study of the effects of different immunosuppressive drugs on cellular metabolism.

Publications

• . Chan L, Mulgaokar S, Schiavelli R, Ambuhl P, Arns W, Walker R: Improved health related quality of life in renal transplant patientssuffering fromgastrointestinal complaints when converted from Mycophenolate Mofetil to enteric coated mycophenolate sodium. Transplantation 81: (9) May 15, 2006 (in press)
• Levi ME, Mandava M, Chan L: Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered Leflunomide. Transplant Infectious Diseases 8:38-43, 2006
• Gibney EM, Cagle L, Freed B, Warnell SE, Chan L, Wiseman AC. Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification. Nephrology Dialysis and Transplantation. (In Press).
• Terasaki P, Ozawa M, Castro R, Lee S, Cook D, Abdelnoor A, Bow L, Chan L et al: Chronic rejection of solid organ grafts report: A propective chronic rejection study. 13th International Histocompatibility Working Group. IHWS 13: 2005.
• Rivard C, Wang W, Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern and Steven C Herbert . Elsevier Press, New York, 2006
• Chan L, Wang W, Wiseman A, Alkesh J, Kam I: Outcomes and complications in Kidney Transplantation. “Diseases of the Kidney and Urinary Tract, VIII Edition” Edited by Schrier RW Schrier; Lippincott Williams and Wilkins, Baltimore, 2006
• Jost Klawitter, Christopher J. Rivard, Juan M. Capasso Nestor E. Almeida, Tomas Berl and Laurence Chan: Early Metabonomic Response to Hypertonicity in Inner Medullary Collecting Duct (IMCD3) Cells. Am Society of Nephrology 2005.
• . Chan L, Cooper M, Abecassis M, Munir L: Excellent renal function in de novo kidney transplant recipients treated with Certican, Basiliximab and reduced Tacrolimus exposure. World Transplant Congress, 2006
• Uwe Christians, Taveesak Pokaiyavanickul, Laurence Chan: Tacrolimus. In “Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic Drug Monitoring” 4th Edition. Lippincott, Williams and Williams
• Chan L, S Mulgaonkar, R Walker, W Arns, P Ambühl, Ruben Schiavelli: Patient-reported gastrointestinal symptom burden and health-related quality of life following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium. Transplantation 81:1290-1297, 2006
• Budde K, Knoll G, Curtis J, Chan L. Long-term safety and efficacy after conversion of maintenance renal transplant recipients from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPA, myfortic). Clin Nephrol. 2006 Aug;66(2):103-11.
• Gibney EM, Cagle LR, Freed B, Warnell SE, Chan L, Wiseman AC. Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification. Nephrol Dial Transplant. 2006 Sep;21(9):2625-9
• Levi ME, Mandava N, Chan LK, Weinberg A, Olson JL. Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered leflunomide. Transpl Infect Dis. 2006 Mar;8(1):38-43.
• Chan L, Jani A, Wang W, Wiseman A, Kam I: Outcomes and complications in Kidney Transplantation In Disease of the Kidney and Unrinary Tract, edited by Rober W Schrier
• Chan L, Cibrik D, Munir L, Shaw LM: No pharmacokinetic interaction evident in de novo kidney transplant recipients treated with everolimus, basiliximab and reduced tacrolimus exposure. Am J Transplantation
• Multicenter randomized study of the use of Eeverolimus with Tacrolimus demonstrates its effectiveness. Chan L et al Transplantation Volume 88- 6, 2008
• Metabonomic Response to Hypertonicity in Inner Medullary Collecting Duct Cells. Jost Klawwitter, Christtopher Rivard. Juan Capasso, Nestor Almeida, Tomas berl and Laurence Chan. Nephron Physiology (in Press)
• Cristopher Rivard, Wang W and Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern and Steven C Herbert
• Chan L, Wiseman A, Wang W. Jani A and Kam I: Outcomes and complications of renal transplantation. “Diseases of the Kidney and Urinary Tract, VIII Edition” by R W Schrier, Lippincott Williams and Wilkins, Baltimore, 2007
• Lei Zhang, Daniel Chan, Alex Wiseman, Laurence Chan : Short report on NMR imaging of Human Islet labeled with Naoparticles. American Journal of Transplantation Vol 2 Suppl 2: 518, 1445, 2007
• Volker Schmitz, Jost Klawitter, James Hendrick-Peart, Manuel Haschke, Laurence Chan: Urine metabolites reflect effects of immunosuppression on rat kidney. American Journal of Transplantation Vol 2 Suppl 2:418, 1052, 2007
• Volker Schmitz, Jost Klawitter, James Hendrick-Peart, Manuel Haschke, Laurence Chan: Urine metabolites reflect effects of immunosuppression on rat kidney. American Journal of Transplantation Vol 2 Suppl 2:418, 1052, 2007
• Volker Schmitz, Jost Klawitter, James Hendrick-Peart, Manuel Haschke, Laurence Chan: Urine metabolites reflect effects of immunosuppression on rat kidney. American Journal of Transplantation Vol 2 Suppl 2:418, 1052, 2007
• L Chan, A Andres, M Hart, K Gugliuzza, R Parasuraman, R Peddi. New onset diabetes mellitus was lower in enteric-coated mycophenolate sodium treated de novo renal transplant recipients with reduced Tacrolimus target levels than with standard Tacrolimus levels: Results of a 6-month randomized study. American Transplant Congress, June 1, 2008.
• A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity. Klawitter J, Rivard CJ, Brown LM, Capasso JM, Almeida NE, Maunsbach AB, Pihakaski-Maunsbach K, Berl T, Leibfritz D, Christians U, Chan L. Nephron Physiol. 2008;109(1):p1-10. Epub 2008.
• Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness. Chan L, Greenstein S, Hardy MA, Hartmann E, Bunnapradist S, Cibrik D, Shaw LM, Munir L, Ulbricht B, Cooper M; CRADUS09 Study Group. Transplantation. 2008 27;85(6):821-6.
• Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U. Nephron Exp Nephrol. 2009;111(4):e80-91. Epub 2009 Mar 17.
• Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Chem Res Toxicol. 2009 Jan;22(1):118-28.
• Improvement in 3-month patient-reported gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in renal transplant patients. Bolin P, Tanriover B, Zibari GB, Lynn ML, Pirsch JD, Chan L, Cooper M, Langone AJ, Tomlanovich SJ. Transplantation. 15;84(11):1443-51.
• Everolimus concentration is associated with risk reduction for acute rejection in de novo renal transplant recipients. Laurence Chan, Erica Hartmann, Diane Cibrik, Matthew Cooper and Leslie Shaw. Clinical Transplantation.
• Validation of unique molecular signature for acute kidney transplant rejection revealed in peripheral blood by whole genome gene expression.
• New onset diabetes mellitus was lower in enteric coated mycophenolate sodium treated de novo renal transplant recipients with reduced tacrolimus target levels. American TRansplant Congress 2008
• Michelle Chonchol and Laurence Chan: Chronic Kidney Disease: Manifestation and Pathogenesis. IN Renal and Electrolytes Disorders. Ed. R. W. Schrier. Lippincott Williams and Wilkins, Baltimore,
• Uwe Christians, Taveesak Pokaiyavanickul, Laurence Chan: Tacrolimus. In “Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic Drug Monitoring” 4th Edition. Lippincott, Williams and Williams
• Rivard C, Wang W, Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern and Steven C Herbert . Elsevier Press, New York,
• Laurence Chan:Kidney Transplantation – current issues. In Textbook of Nephrology, Edited by Professor Hai Yin Wang, Beijing University.
• Laurence Chan, Erica hartmann, Diane Cribik, Matthew Cooper, Leslie Shaw. Everolimus concentration is associated with risk reduction for acute rejection. J Am Soc Nephrology. 2008
• Empowering New Transplant Registry Studies: Design, Methods and center Specific Information of the Myfortic Observational Renal Transplant Study Registry. W Irish, C Doria, S Greenstein, L Chan. American Transpant Congress 2009.
• Kidney Transplantation: Donor and Recipient Evaluation. In Manual of Nephrology. Ed. K. N Lai. Imperial College Press/World Scientific Publisher
• Clincal Manual of Kidney Transplantation. Kyu-Bok Choi, Seung-Hun Lee and Laurence Chan Ilchkak Press, Seoul, Korea
• Chan L, Hartman E, Cibrik D, Cooper M, Shaw L Optimal everolimus concentration is associated with risk reduction for acute rejection in de novo renal transplant recipients. Transplantation 2010
• Cooper James, Wiseman Alex, Chan Laurence: Bortezomib Use in Chronic Antibody-Mediated Allograft Dysfunction. Clinical Transplantation. 19: 13-18, 2010.
• Klem P, Cooper JE, Weiss AS, Gralla J, Owen P, Chan L, Wiseman AC. Reduced dose rabbit anti-thymocyte globulin induction for prevention of acute rejection in high-risk kidney transplant recipients. Transplantation. 2009 Oct 15;88(7):891-6. Transplantation. 2009 Oct 15;88(7):891-6.
• Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L. Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol. 2009;111(4):e80-91. Epub 2009 Mar 17.
• Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem Res Toxicol. 2009 Jan;22(1):118-28.
• Chonchol Michel and Chan Laurence: Chronic kidney Disease: Manifestations and pathogenesis. In Renal and Electrolytes Disporders. Ed by Robert W Schrier. Lippincott Williams & Wilkins.
• Chan L, Greenstein S, Hardy MA, Hartmann E, Bunnapradist S, Cibrik D, Shaw LM, Munir L, Ulbricht B, Cooper M; CRADUS09 Study Group. Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness. Transplantation. 2009 Mar 27;85(6):821-6.
• Chan L, Irish W, Doria C, Greenstein S: Distinct Effects of delayed Graft functionand acute rejection on Graft Failure following kidney transplantation. American Transplant Journal. American Transplant Congress 2010.
• Rivard C, Wang W, Chan L: Hypernatremic and Hyperosmolar States. In ?The Kidney: Physiology and Pathophysiology ,? edited by Robert J Alpern and Steven C Herbert . Elsevier Press, New York, Book chapter
• Kidney Transplantation: Donor and Recipient Evaluation. In Manual of Nephrology. Ed. K. N Lai. Imperial College Press/World Scientific Publisher
• Clincal Manual of Kidney Transplantation. Kyu-Bok Choi, Seung-Hun Lee and Laurence Chan Ilchkak Press, Seoul, Korea
• Empowering New Transplant Registry Studies: Design, Methods and center Specific Information of the Myfortic Observational Renal Transplant Study Registry. W Irish, C Doria, S Greenstein, L Chan. American Transpant Congress 2009.
• Report from an 80 transplant centers multi-regional kidney paired donation program. American Transplant Congress, 2010
• Chan L, Hartmann E, Cibrik D, Cooper M, Shaw LM. Optimal everolimus concentration is associated with risk reduction for acute rejection in de novo renal transplant recipients. Transplantation. 2010 Jul 15;90(1):31-7.PMID: 20517177
• Cooper JE, Chan L, Wiseman AC: Bortezomib Use in Chronic Antibody-Mediated Allograft Dysfunction: Updates and Additional Cases. Clinical Transplantation 2010: 39, 395-399,
• Arns W, Nashan B, Vincentes F, Banas B, Budde K, Chan : Sotrastaurin, a novel small molecule inhibiting proteinkinase C: randomized Phase II study in renal-transplant Recipients. American Journal of Transplantation (In Press)
• Rivard C, Wang W and Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern. Elsevier Press, New York, (In Press).
• Bia M, Adey DB, Bloom RD, Chan L, Kulkarni S, Tomlanovich S. KDOQI US commentary on the 2009 KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Kidney Dis. 2010 Aug;56(2):189-218.
• Weir MR, Mulgaonkar S, Chan L, Shidban H, Waid TH, Preston D, Kalil RN, Pearson TC.Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trial. Kidney Int. 2010 Dec 29.PMD:21191361
• Langone AJ, Chan L, Bolin P, Cooper M. Enteric-Coated Mycophenolate Sodium Versus Mycophenolate Mofetil in Renal Transplant Recipients Experiencing Gastrointestinal Intolerance: A Multicenter, Double-Blind, Randomized Study. Transplantation. 2011 Jan 17.
• Cooper JE, Gralla J, Cagle L, Goldberg R, Chan L, Wiseman AC. Inferior Kidney Allograft Outcomes in Patients with de novo Donor Specific Antibodies are Due to Acute Rejection Episodes. Transplantation (In Press)
• Cooper JE, Huskey J, Chan L, Wiseman AC. Preemptive retransplant for BK virus nephropathy without concurrent transplant nephrectomy. Transplantation. 2010 Aug 15;90(3):331-2
• Wiseman AC, CE Cooper, Chan L. Clinical aspects of kidney Transplantation. Dieases of Kidney and Urinary System.
• Imed Helal and Laurence Chan: Steroid and Calcineurin inhibitor sparing protocols in kidney transplantation. Transplantation Proceedings 2011.(In Press)
• I Helal and L Chan: Steroid and Calcineurin Inhibitor-sparing protocols in kidney transplantation. Transplantation Proc. Vol 43: 472-477, 2011
• L Chan: Pharmacologic recruitment of T regulatory cells. Kidney International. (In Press)
• DR Lee, JM Kong, KI Cho, L Chan: Impact of Vitamin D on Proteinuria, Insulin Resistance, and Cardiovascular Parameters in Kidney Transplant Recipients.Transplantation Proc Vol43: 3723-3729, 2011
• J Cooper, A Wiseman, L Chan: Bortezomib use in chronic antibody mediated allograft rejection- updates. Clinical Transplants 2011.
• JE Cooper, J Gralla, L Cagle, Goldberg R, L Chan, A Wiseman: Inferior kidney allograft outcomes in patients with de novo donor-specific antibodies are due to acute rejection episodes. Transplantation 27: 1103-9, 2011
• Langone AJ, Chan L, Bolin P, Cooper M. Enteric-Coated Mycophenolate Sodium Versus Mycophenolate Mofetil in Renal Transplant Recipients Experiencing Gastrointestinal Intolerance: A Multicenter, Double-Blind, Randomized Study. Transplantation. 91: 1593-1600, 2011
• Arns W, Nashan B, Vincentes F, Banas B, Budde K, Cibrik D, Chan L:Sotrastaurin, a novel small molecule inhibiting proteinkinase C: randomized Phase II study in renal-transplant Recipients. American Journal of Transplantation 11(7), 1444-55, 2011.
• Narayanab M, Shihab F, Pankewyez O, Wiland A, McCague K, Chan L African American One Year Outcomes from the MORE Registry Study. American Society of Nephrology Congress 2011. Transplantation ( in press)
• Chan L, Johnston T, Tedesco-Silva H, Cibrik, Shibhab F, Zibari GB, Walker R. Effect of Gender Mismatches on Renal Function after Kidney Transplant. American Transplant Congress 2011. Am J Transplantation (in press)
• Rivard C, Wang W and Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern. Elsevier Press, New York.
• Laurence Chan: Harnessing regulatory T cells for therapeutic purposes. www.nature.com/ki/journal/v81/n10/ Kidney International. 81: 935-936; .2012.
• Langone A, Doria C, Greenstein S, Narayanan M, Chan L : Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure Levels? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. Clinical Transplantation, 2013 Jan 27 (1): 15-24.
• Narayanab M, Shihab F, Pankewyez O, Wiland A, McCague K, Chan L African American One Year Outcomes from the MORE Registry Study. American Society of Nephrology Congress 2011. Transplantation Int ( in press)
• Chan L, Johnston T, Tedesco-Silva H, Cibrik, Shibhab F, Zibari GB, Walker R. Effect of Gender Mismatches on Renal Function after Kidney Transplant. American Transplant Congress . J Transplantation (in press)
• Outcomes in african american kidney transplant patients receiving tacrolimus and mycophenolic Acid immunosuppression. Narayanan M, Pankewycz O, El-Ghoroury M, Shihab F, Wiland A, McCague K, Chan L. Transplantation. 2013 Feb 27;95(4):566-72. doi: 10.1097/TP.0b013e318277
• Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS. Chan L, Andres A, Bunnapradist S, Gugliuzza K, Parasuraman R, Peddi VR, Cassuto E, Hart M. J Transplant. 2012;2012:941640. doi: 10.1155/2012/941640. Epub 2012 Nov 25. PMID: 23227307 [PubMed] Free PMC Article
• Association of mycophenolic acid dose with efficacy and safety events in kidney transplant patients receiving tacrolimus: an analysis of the Mycophenolic acid Observational REnal transplant registry. Doria C, Greenstein S, Narayanan M, Ueda K, Wiland A, McCague K, Sankari B, Chan L. Clin Transplant. 2012 Nov;26(6):E602-11. doi: 10.1111/ctr.12035. Epub 2012 Nov 2. PMID: 23121178 [PubMed - in process] Free PMC Article
• Association of mycophenolic acid dose with efficacy and safety events in kidney transplant patients receiving tacrolimus: an analysis of the Mycophenolic acid Observational REnal transplant registry. Doria C, Greenstein S, Narayanan M, Ueda K, Wiland A, McCague K, Sankari B, Chan L. Clin Transplant. 2012 Nov;26(6):E602-11. doi: 10.1111/ctr.12035. Epub 2012 Nov 2. PMID: 23121178 [PubMed - in process] Free PMC Article
• Association of clinical events with everolimus exposure in kidney transplant patients receiving reduced cyclosporine. Shihab FS, Cibrik D, Chan L. Clin Transplant. 2012 Dec 12. doi: 10.1111/ctr.12045. [Epub ahead of print]PMID: 23230975 [PubMed - as supplied by publisher]
• Chan L, L Rostang, B Bresnahan, Helderman JH, MB Harler MB, Vincentes: Likelihood of improving or sustaining renal function over four years with Belatacpt or CsA: insight frm BENNEFIT over 4 yars. Insight from the BENEFITs likeliy over four years Long-term expensive cause over. J Am Soc Nephrol, 23: PO 1042, 2012.
• Narayanan M, Pankewwycz O, Shihab F, Wiland A,McCague K, Chan L: Does African American ethnicity affect kidney transplant outcomes at four years? American Transplantation Congress, 2013.
• Laurence Chan, Fuad Shihab, Oleh Pankewycz, Cataldo Doria, Anne Wiland, Kevin Mccague, Anthony Langone : Mycophenolic Acid Dosing: Effect on Efficacy to 4 years after Kidney Transplantation in Mycophenolic Acid Observation Renal Transplant (MORE) Study, American Transplantation Congress, 2013.
• Langone A, Doria C, Greenstein S, Narayanan M, Chan L : Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure Levels? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. Clinical Transplantation, 15, May, 2013.
• Narayanan M, Pankewycz O, El-Ghoroury M, Shihab F, Wiland A, McCague K, Chan L. Outcomes in African American kidney transplant patients receiving tacrolimus and mycophenolic acid immunosuppression. Transplantation. 2013 Feb 27;95(4):566-72. doi: 10.1097/TP.0b013e318277438f.
• . 152. Shihab FS, Cibrik D, Chan L, Association of clinical events with everolimus exposure in kidney transplant patients receiving reduced cyclosporine. Clin Transplant. 2013 Mar-Apr;27(2):217-26. doi: 10.1111/ctr.12045.
• 153. Langone A, Doria C, Greenstein S, Narayanan M, Ueda K, Sankari B, Pankewycz O, Shihab F, Chan L.Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. Clin Transplant. 2013 Jan-Feb;27(1):15-24. doi: 10.1111/j.1399-0012.2012.01694.x. Epub 2012 Aug 2. PMID:22861144.[PubMed - indexed for MEDLINE]
• .154. Narayanan M, Pankewycz O, Shihab F, Wiland A, McCague K, Chan L. Long-term outcomes in African American kidney transplant recipients under contemporary immunosuppression: a four-yr analysis of the Mycophenolic acid Observational REnal transplant (MORE) study. Clin Transplant. 2013 Dec 24. doi: 10.1111/ctr.12294. [Epub ahead of print] PMID: 24372743 [PubMed - as supplied by publisher]
• Rivard C, Wang W and Chan L: Hypernatremic and Hyperosmolar States. In “The Kidney: Physiology and Pathophysiology ,” edited by Robert J Alpern. Elsevier Press, New York, (2013).
• . AC Wiseman, Cooper J, Chan L: Clinical Aspects of Kidney Transplantation. Schrier,s Dieseases of the Kidney. Lippincott Williams and Wilkins, Baltimore, (2013)
• Cooper J, Wiseman AC, Chan L: A Patient with Kidney transplant. Manual of Nephrology. Edited by R. W. Schrier. Lippincott Williams and Wilkins, Baltimore, (2014)
• Todd Ing, Angela Hadsell and Laurence Chan Nobel Laureates of Chinese Descent World Scientific Publishing, Imperial College (London University (in Press)
• Narayanan M, Pankewwycz O, Shihab F, Wiland A, McCague, Chan L: Does African American ethnicity affect kidney transplant outcomes at four years? American Transplantation Congress, 2013. 261. Laurence Chan, Fuad Shihab, Oleh Pankewycz, Cataldo Doria, Anne Wiland, Kevin Mccague, Anthony Langone : Mycophenolic Acid Dosing: Effect on Efficacy to 4 years after Kidney Transplantation in Mycophenolic Acid Observation Renal Transplant (MORE) Study, American Transplantation Congress, 2013. 262. Demetra Tsapepas, Anthony Langone, Laurence Chan. A longitudinal assessment of adherence with immunosuppressive therapy following kidney transplantation from the Mycophenolic Acid Observational REnal Transplant (MORE) Study . American Society of Nephrology. Renal Week 2013.
• Cooper JE, Gralla J, Klem P, Chan L, Wiseman AC. High dose intravenous immunoglobulin therapy for donor-specific antibodies in kidney transplant recipients with acute and chronic graft dysfunction. Transplantation. 2014 Jun 27;97(12):1253-9. PubMed PMID: 24937199
• Molecular Classifiers for acute Transplant rejection in peripheral blood by whole genome gene expression Profiling. Kurian et al. American Journal of Transplantation 14;1164-1172
• Switching study of kidney transplant recipients with tremor to LCP-Tacrolimus. Langone et al. Clin Transplant 29;796-805
• Nobel Laureates of Chinese Descent World Scientific Publishing Imperial College, London
• Langone A, Shihab F, Pankewycz O, Doria C, Wiland A, McCague K, Chan L. Long-term dosing patterns of enteric-coated mycophenolate sodium or mycophenolate mofetil with tacrolimus after renal transplantation. Clin Transplant. 2014 Sep;28(9):961-7. PubMed PMID: 24893821
• Tsapepas D, Langone A, Chan L, Wiland A, McCague K, Chisholm-Burns M. A longitudinal assessment of adherence with immunosuppressive therapy following kidney transplantation from the Mycophenolic Acid Observational REnal Transplant (MORE) study. Ann Transplant. 2014 Apr 17;19:174-81. PubMed PMID: 24743224
• Modena BD, Kurian SM, Gaber LW, Waalen J, Su AI, Gelbart T, Mondala TS, Head SR, Papp S, Heilman R, Friedewald JJ, Flechner SM, Marsh CL, Sung RS, Shidban H, Chan L, Abecassis MM, Salomon DR. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes. Am J Transplant. 2016 Jul;16(7):1982-98. PubMed PMID: 26990570
• Weir MR, Pearson TC, Patel A, Peddi VR, Kalil R, Scandling J, Chan L, Baliga P, Melton L, Mulgaonkar S, Waid T, Schaefer H, Youssef N, Anandagoda L, McCollum D, Lawson S, Gordon R. Long-term Follow-up of Kidney Transplant Recipients in the Spare-the-Nephron-Trial. Transplantation. 2017 Jan;101(1):157-165. PubMed PMID: 26950714
• Narayanan M, Pankewycz O, Shihab F, Wiland A, McCague K, Chan L. Long-term outcomes in African American kidney transplant recipients under contemporary immunosuppression: a four-yr analysis of the Mycophenolic acid Observational REnal transplant (MORE) study. Clin Transplant. 2014 Feb;28(2):184-91. PubMed PMID: 24372743
• Langone A, Steinberg SM, Gedaly R, Chan LK, Shah T, Sethi KD, Nigro V, Morgan JC. Switching STudy of Kidney TRansplant PAtients with Tremor to LCP-TacrO (STRATO): an open-label, multicenter, prospective phase 3b study. Clin Transplant. 2016 Sep;29(9):796-805. PubMed PMID: 26113208
• Rostaing L, Bunnapradist S, Grinyó JM, Ciechanowski K, Denny JE, Silva HT Jr, Budde K, Chan L .Strato Investigators Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial. Am J Kidney Dis. 2016 Apr;67(4):648-59. PubMed PMID: 26717860
• High dose IVIG therapy for donor specific antibodies in kidney transplant recipients with acute and chronic graft dysfunction: Update on previous reported cohorts. Clinical Transplantation. 2015
• Donor specific antibodies before and after kidney transplant: The University of Colorado Experience. Clinical Transplant 2014: 49:407-412
• Chronic Kidney Diseases: Manifestation and Pathogenesis Renal and Electrolyte Disorders 8th Edition Lippinton Williams and Wilkins Ed Robert Schrier
• Weir MR, Pearson TC, Patel A, Peddi VR, Kalil R, Scandling J, Chan L, Baliga P, Melton L, Gordon R. Long-term Follow-up of Kidney Transplant Recipients in the Spare-the-Nephron-Trial.Transplantation.2018Jan;101(1):157-165.doi: 10.1097/TP.001098.PMID: 26950714
• The Effect of Sirolimus on Native Total Kidney Volume After Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Pilot Study. 2018:OSVC;180605-2023, Transplant Proceedings
• . Chan L: Normal and Abnormal Magnesium Metabolism. In Renal and Electrolytes Disorders. Ed. R. W. Schrier. Lippincott Williams and Wilkins, Baltimore
• Nobel and Lasker Laureates of Chinese Descent Publisher: World Scientific and Imperial College of London -Nobel Foundation (2018) ISBN978-981-4704-60-1
• Nobel and Lasker Laureates of Chinese Descent. ISBN 9814704601
• Boxer Scholars and Nobel laureates

Practice Locations

UCHealth Transplant Center - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0005

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Nephrology
• Surgery

Conditions & Treatments

• Kidneys and Urinary System
• Kidneys and Urinary System - Kidney Disease
• Kidneys and Urinary System - Kidney Failure
• Surgery - Kidney Transplant Surgery
• Surgery
• Surgery - Living Kidney Donation