Rytis Prekeris, PhD
Professor, Cell & Developmental Biology


  • Hoffman HK, Prekeris R. Roles of the actin cytoskeleton in ciliogenesis. J Cell Sci. 2022 May 15;135(10). PubMed PMID: 35575063
  • Han KJ, Mikalayeva V, Gerber SA, Kettenbach AN, Skeberdis VA, Prekeris R. Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation. Life Sci Alliance. 2022 Sep;5(9). PubMed PMID: 35512830
  • McCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CG. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022 Jul 1;33(8). PubMed PMID: 35476505
  • Duncan ED, Han KJ, Trout MA, Prekeris R. Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration. J Cell Biol. 2022 Apr 4;221(4). PubMed PMID: 35293963
  • Farmer T, Prekeris R. New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation. Mol Biol Cell. 2022 Mar 1;33(3). PubMed PMID: 35179994
  • Duncan ED, Lencer E, Linklater E, Prekeris R. Methods to Study the Unique SOCS Box Domain of the Rab40 Small GTPase Subfamily. Methods Mol Biol. 2021;2293:163-179. PubMed PMID: 34453716
  • Lencer E, Prekeris R, Artinger KB. Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. Elife. 2021 Aug 16;10. PubMed PMID: 34397384
  • Linklater ES, Duncan ED, Han KJ, Kaupinis A, Valius M, Lyons TR, Prekeris R. Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration. J Cell Biol. 2021 Jul 5;220(7). PubMed PMID: 33999101
  • Gibieža P, Peterman E, Hoffman HK, Van Engeleburg S, Skeberdis VA, Prekeris R. Rab14/MACF2 complex regulates endosomal targeting during cytokinesis. Mol Biol Cell. 2021 Apr 1;32(7):554-566. PubMed PMID: 33566684
  • Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021 Feb 8;56(3):325-340.e8. PubMed PMID: 33561422
  • Jewett CE, Appel BH, Prekeris R. The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development. Biol Open. 2020 Oct 23;9(10). PubMed PMID: 32973079
  • Turn RE, East MP, Prekeris R, Kahn RA. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis. Mol Biol Cell. 2020 Aug 15;31(18):2070-2091. PubMed PMID: 32614697
  • Peterman E, Valius M, Prekeris R. CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. J Cell Sci. 2020 May 14;133(9). PubMed PMID: 32184265
  • Peterman E, Prekeris R. The postmitotic midbody: Regulating polarity, stemness, and proliferation. J Cell Biol. 2019 Dec 2;218(12):3903-3911. PubMed PMID: 31690620
  • Peterman E, Gibieža P, Schafer J, Skeberdis VA, Kaupinis A, Valius M, Heiligenstein X, Hurbain I, Raposo G, Prekeris R. The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation. Nat Commun. 2019 Jul 18;10(1):3181. PubMed PMID: 31320617
  • Antanaviciute I, Gibieža P, Prekeris R, Skeberdis VA. Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle. Medicina (Kaunas). 2018 Jul 30;54(4). PubMed PMID: 30344284
  • Jewett CE, Prekeris R. Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis. Traffic. 2018 May 16. [Epub ahead of print] PubMed PMID: 29766620
  • Das L, Gard JMC, Prekeris R, Nagle RB, Morrissey C, Knudsen BS, Miranti CK, Cress AE. Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer. Mol Cancer Res. 2018 Aug;16(8):1319-1331. PubMed PMID: 29759989
  • Gibieža P, Prekeris R. Rab GTPases and cell division. Small GTPases. 2018 Mar 4;9(1-2):107-115. PubMed PMID: 28471300
  • Dionne LK, Peterman E, Schiel J, Gibieža P, Skeberdis VA, Jimeno A, Wang XJ, Prekeris R. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation. J Cell Sci. 2017 Dec 1;130(23):4051-4062. PubMed PMID: 29196475
  • Gibieža P, Prekeris R. Rab GTPases and cell division. Small GTPases. 2017 May 4;:1-9. [Epub ahead of print] PubMed PMID: 28471300
  • Peterman E, Prekeris R. Understanding post-mitotic roles of the midbody during cell differentiation and polarization. Methods Cell Biol. 2017;137:173-186. PubMed PMID: 28065304
  • Jacob A, Linklater E, Bayless BA, Lyons T, Prekeris R. The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion. J Cell Sci. 2016 Dec 1;129(23):4341-4353. PubMed PMID: 27789576
  • Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci. 2016 Oct 1;129(19):3562-3573. PubMed PMID: 27562068
  • Mangan AJ, Sietsema DV, Li D, Moore JK, Citi S, Prekeris R. Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells. Nat Commun. 2016 Aug 3;7:12426. PubMed PMID: 27484926
  • Prekeris R. Analyzing the functions of Rab11-effector proteins during cell division. Methods Cell Biol. 2015;130:19-34. PubMed PMID: 26360025
  • Blasky AJ, Mangan A, Prekeris R. Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis. Annu Rev Cell Dev Biol. 2015 Nov 13;31:575-91. PubMed PMID: 26359775
  • Prekeris R. Cut or NoCut: the role of JADE1S in regulating abscission checkpoint. Cell Cycle. 2015;14(20):3219. PubMed PMID: 26327571
  • Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther. 2015 Oct;14(10):2215-27. PubMed PMID: 26206334
  • Song M, Giza J, Proenca CC, Jing D, Elliott M, Dincheva I, Shmelkov SV, Kim J, Schreiner R, Huang SH, Castrén E, Prekeris R, Hempstead BL, Chao MV, Dictenberg JB, Rafii S, Chen ZY, Rodriguez-Boulan E, Lee FS. Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Dev Cell. 2015 Jun 22;33(6):690-702. PubMed PMID: 26004511
  • Dionne LK, Wang XJ, Prekeris R. Midbody: from cellular junk to regulator of cell polarity and cell fate. Curr Opin Cell Biol. 2015 Aug;35:51-8. PubMed PMID: 25950842
  • Mangan A, Prekeris R. 3D time-lapse analysis of Rab11/FIP5 complex: spatiotemporal dynamics during apical lumen formation. Methods Mol Biol. 2015;1298:181-6. PubMed PMID: 25800842
  • Jacob A, Prekeris R. The regulation of MMP targeting to invadopodia during cancer metastasis. Front Cell Dev Biol. 2015;3:4. PubMed PMID: 25699257
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Department: Cell & Developmental Biology
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