As a materials engineer working in a clinical environment, for the past 5 years and ongoing, I am investigating the how and why spinal instrumentation fails in-vivo. Combining my background in materials engineering, synthesis, and corrosion research I set up a program at the University of Colorado, School of Medicine to investigate microbial influenced corrosion of orthopedic alloys. My discoveries from data collected via my ongoing retrieval of patient hardware include: 1) the association between intrinsic device material properties and detrimental patient outcomes; 2) the presence of bacteria local to the hardware and diagnosed infection and metallosis (leaching of biomedical alloy elements into the surrounding tissues). I discovered that the standard clinical method for bacterial identification rarely matches the bacteria sonicated directly from hardware removed from a patient. Using my experience in metallurgical methodologies combined with genetic analysis from sonicated hardware I created the infrastructure to establish the link between diseases such as metallosis and infection to the microbial milieu on the implanted hardware. I am an active member of American Standards and Testing and Materials International (ASTM) and International Standards Organization (ISO), being involved with the development of standards used to retrieve devices and hardware from patients for study (ASTM F561-19 - Standard Practice for Retrieval and Analysis of Medical Devices, and Associated Tissues and Fluids) as well as standards for materials synthesized and used in medicine (ASTM committees F04.02 – Subcommittee on Orthopedic Devices; F42.07.03 - Subcommittee on Medical/Biological; ISO/TC 150/WG 16 – Antimicrobial properties of implants) thus, giving me the experience and knowledge concerning the design and testing for orthopedic devices. I developed high energy/high speed synthesis techniques using solid/solid reaction methods to synthesize biomedical alloys and ceramics using solid state redox reactions (3 Patents). This understanding gives me unique insight as to how materials interact with the tissue microbiome which, in outside industries, is termed Microbial Influenced Corrosion (MIC). My work is accepted in the clinical world with publications such as a book chapter used for the AAOS Board Certification for all surgeons – Ayers and Singh. Core Sciences: Biomaterials. In: Jay R. Lieberman, MD, (ed) AAOS Comprehensive Review, 2020. Overall, as the sole researcher in this area during this time, I published 2 book chapters including the biomaterials chapter and Reed A. Ayers, Evalina Levina Burger, Christopher J. Kleck, Vikas Patel, Metallurgy of Spinal Instrumentation in “Advances in Metallic Biomaterials Technology” Mitsuo Niinomi, Takayuki Narushima, Masaki nakai (eds.). Springer Series in Biomaterials Science and Engineering, Springer-Verlag Gmbh Heidelberg (June, 2015).