Virginia Winn, MD, PhD

Research Interests

I have been involved with research related to pregnancy for the past 11 years. I have extensive training in all aspects of clinical translational research and am the Co-Director of the Child and Maternal Health component (CMH) of the Clinical and Translational Sciences Institute (CCTSI). My role is to oversee and coordinate the labor and delivery component of clinical research as part of the CCTSI.

Publications

• Winn, VD, M. Gormley and SJ Fisher (2011) The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 1(1):100-108.
• Andrea Schanz, M.D.; Virginia D Winn, MD PhD; Robyn North, MBChB PhD; Marion Blumenstein, Dr rer nat; Christian Heiss, MD; Alexandra P Hess, MD; Jan S Kruessel, MD; Michael MCMaster, PhD; Susan J Fisher, PhD Preeclampsia is Associated with Elevated CXCL12 Levels in Placental Syncytiotrophoblasts and Maternal Blood European Journal of Obstetrics & Gynecology and Reproductive Biology (in press)
• Barbra M. FISHER, MD, PhD; Janice SCOTT, BA; Jan HART, MSPH; Virginia D. WINN, MD, PhD; Ronald S. GIBBS, MD; Anne M. LYNCH, MB, BCh, BAO, MSPH BEHAVIORS AND PERCEPTIONS REGARDING SEASONAL AND H1N1 INFLUENZA VACCINATION DURING PREGNANCY AJOG (in press)
• The impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface. Winn, VD, Gormley M, Fisher SJ, Pregnancy Hypertension Jan 1;1(1):100-108 PMID: 21743843
• Hoffman MC, Rumer KK, Kramer A, Lynch AM, Winn VD. Maternal and fetal alternative complement pathway activation in early severe preeclampsia. Am J Reprod Immunol. 2014 Jan;71(1):55-60. PubMed PMID: 24128411
• Friend SF, Peterson LK, Treacy E, Stefanski AL, Sosinowski T, Pennock ND, Berger AJ, Winn VD, Dragone LL. The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation. PLoS One. 2013;8(10):e75200. PubMed PMID: 24124476
• Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophobalsts and maternal blood. Schanz A, Winn VD, Fisher SJ, Blumenstein M, Heiss C, Hess AP, Kruessel JS, McMaster M, North RA. Eur. J. Obstet. Gynecol. Reprod. Biol. 157(1):32-7 PMID 21450389
• Behaviors and perceptions regarding seasonal and H1N1 influenza vaccination during pregnancy. Fisher BM, Scott J, Hart J, Winn VD, Gibbs RS, Lynch AM. Am. J. Obstet. Gynecol. 204(6 sup1):S107-11. PMID 21419386
• Armstrong-Wells J, Post MD, Donnelly M, Manco-Johnson MJ, Fisher BM, Winn VD. Patterns of placental pathology in preterm premature rupture of membranes. J Dev Orig Health Dis. 2013 Jun;4(3):249-255. PubMed PMID: 23828732
• Anitbody Response to H1N1 Vaccine and Infection. Fisher BM et al. PlosOne (in press)
• Rumer KK, Uyenishi J, Hoffman MC, Fisher BM, Winn VD. Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia. Reprod Sci. 2013 Jun;20(6):646-53. PubMed PMID: 23171684
• Arthritis Amelioration by Pregnancy is Associated with SSA3 levels. Shaw et al. J. Clin. Exp. Immunol. (accepted).
• Fisher, B, J Scott, J Hart, VD Winn, R Gibbs and A Lynch. Behaviors, Attitudes, and Perceptions Regarding Seasonal and H1N1 Influenza Vaccination During the 2009-2010 Season. 37th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology August 5-7, 2010 Santa Fe, New Mexico.
• Fisher, B, J Scott, J Hart, VD Winn, R Gibbs and A Lynch. Course of Influenza-like Illness at the University of Colorado Hospital (UCH). 37th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology August 5-7, 2010, Santa Fe, NM.
• Uyenishi, J, K Rumer, VD Winn, Siglec-6 is Overexpressed in Preeclamptic Placentas. 31st SMFM Annual Meeting, San Francisco, CA Feb.8-12th, 2011
• Fisher, B, J Scott, J Hart, AM Lynch, VD Winn, A Weinberg and RS Gibbs. Pandemic Influenza A H1N1 2009 infection versus vaccination: a cohort study comparing immune responses in pregnancy. 31st SMFM Annual Meeting, San Francisco, CA Feb.8-12th, 2011
• Rumer, KK, KM Morrison and VD Winn. Signaling Pathways Involved in Leptin-Mediated Human Trophoblast Invasion. 58th SGI Annual Meeting, Miami Beach, FL, March 16-19th, 2011
• Rumer, KK, LL Krause and VD Winn. The Effects of Leptin and its Receptors, LepR and Siglec-6, in First Trimester Human Placental Villous Explant Invasion. 58th SGI Annual Meeting, Miami Beach, FL, March 16-19th, 2011
• Fisher, B, M Post, J Scott, J Hart, AM Lynch, RS Gibbs and VD Winn. H1N1 Influenza and Pregnancy: Does Antenatal Illness Cause Placental Inflammation? 58th SGI Annual Meeting, Miami Beach, FL, March 16-19th, 2011
• Shaw, LA, AL Stefanski, LK Peterson, S Sakaguchi, VD Winn, LL Dragone. Amelioration of Arthritis by Pregnancy in SKG Mice Correspond with Alterations in SAA3 Levels. Keystone Symposium- Rheumatoid Arthritis: Molecular and Clinical Insights, Santa Fe, NM, January 19-24, 2012. LAS and ALS co-first authors VDW and LLD co-senior authors
• Maternal Serum PAPP-A2 Levels are Elevated in Early Onset Preeclampsia Both At Time of Diagnosis and in Early Gestation. Anita Kramer, Camille Hoffman, Anne Lynch and Virginia D. Winn, SGI Annual Meeting March 22, 2012 San Diego ORAL
• Donnelly M, Todd E, Wheeler M, Winn VD and Kamnasaran D. (2012) Prenatal diagnosis and identification of heterozygous frameshift mutation in PRRX1 in an infant with agnathia-otocephaly. Prenat Diagn. 2012 Jun 5:1-3. doi: 10.1002/pd.3910. [Epub ahead of print] PMID: 22674740
• Shaw, LA, AL Stefanski, LK Peterson, KK Rumer, A Vondracek, TL Phang, S Sakaguchi, VD Winn* and LL Dragone. (2012) Pregnancy Amelioration of Arthritis in SKG Mice Corresponds with Alterations in Serum Amyloid A3 levels. Am J Clin Exp Immunol, 1(1):12-19 (*co-senior author) PMID: 23097751
• Rumer, KK, J Uyenishi, MC Hoffman, BM Fisher and VD Winn. (2012) Siglec-6 expression is increased in placentas from pregnancies complicated by pre-term preeclampsia. Reproductive Sciences.Nov. 20 PMID: 23171684
• Rumer, KK, M Post, R Larivee, M Zink, J Uyenishi, A Kramer, D Teoh, K Bogart and VD Winn, (2012) Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion. Endocrine-Related Cancer 19(6):827-40.PMID 23089140
• Armstron-Wells, M Donnelly, M Post, B Fisher and VD Winn. Patterns of Placental Pathology in Preterm Premature Rupture of Membranes. Journal of Developmental Origins of Health and Disease.(accepted)
• Fisher, BM, JV Bockern, J Hart, AM Lynch, VD Winn, RS Gibbs and A Weinberg. Pandemic influenza A H1N1 2009 infection versus vaccination: a cohort study comparing immune responses in pregnancy. PLoS One. 2012;7(3):e33048. Epub 2012 Mar 22. PMID: 22457731

Professional Memberships

• American College of Obstetrics and Gynecologist, Member
• Society of Maternal-Fetal Medicine, Member
• Society of Gynecologic Investigation, Member
• Endocrinology Society, Member

Specialty Information

Specialties

• Obstetrics and Gynecology, Board Certification
• Maternal and Fetal Medicine, Board Certification

Conditions & Treatments

• Pregnancy and Reproduction - Maternal and Fetal Health
• Women's Health
• Pregnancy and Reproduction