Xiyuan Bai, PhD

Publications

• Bai X, Gao J, Guan X, Narum DE, Fornis LB, Griffith DE, Gao B, Sandhaus RA, Huang H, Chan ED. Analysis of alpha-1-antitrypsin (AAT)-regulated, glucocorticoid receptor-dependent genes in macrophages reveals a novel host defense function of AAT. Physiol Rep. 2024 Jul;12(14):e16124. PubMed PMID: 39016119
• Chan ED, King PT, Bai X, Schoffstall AM, Sandhaus RA, Buckle AM. The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions. Int J Mol Sci. 2024 Feb 2;25(3). PubMed PMID: 38339082
• Malcolm KC, Ochoa AE, Congel JH, Hume PS, Corley JM, Wheeler EA, Bai X, Nick JA, Janssen WJ, Chan ED, Cool CD, Hisert KB. A Murine Model of Mycobacterium abscessus Infection Mimics Pathology of Chronic Human Lung Disease. Am J Respir Cell Mol Biol. 2024 Nov 26. [Epub ahead of print] PubMed PMID: 39589263
• Bai X, Verma D, Garcia C, Musheyev A, Kim K, Fornis L, Griffith DE, Li L, Whittel N, Gadwa J, Ohanjanyan T, Eggleston MJ, Galvan M, Freed BM, Ordway D, Chan ED. Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2023;13:1216492. PubMed PMID: 37965256
• Bai X, Schountz T, Buckle AM, Talbert JL, Sandhaus RA, Chan ED. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. Biochem Soc Trans. 2023 Jun 28;51(3):1361-1375. PubMed PMID: 37294003
• Bai X, Verma D, Garcia C, Musheyev A, Kim K, Fornis L, Griffith DE, Li L, Whittel N, Gadwa J, Ohanjanyan T, Eggleston MJ, Galvan M, Freed BM, Ordway D, Chan ED. Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2023;13:1216492. PubMed PMID: 37965256
• Bai X, Schountz T, Buckle AM, Talbert JL, Sandhaus RA, Chan ED. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. Biochem Soc Trans. 2023 Jun 28;51(3):1361-1375. PubMed PMID: 37294003
• Bai X, Bai A, Tomasicchio M, Hagman JR, Buckle AM, Gupta A, Kadiyala V, Bevers S, Serban KA, Kim K, Feng Z, Spendier K, Hagen G, Fornis L, Griffith DE, Dzieciatkowska M, Sandhaus RA, Gerber AN, Chan ED. a1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages. J Immunol. 2022 Nov 1;209(9):1746-1759. PubMed PMID: 36162872
• Schenkel AR, Mitchell JD, Cool CD, Bai X, Groshong S, Koelsch T, Verma D, Ordway D, Chan ED. Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or Pseudomonas aeruginosa Infection. Immune Netw. 2022 Jun;22(3):e27. PubMed PMID: 35799709
• Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19;12(1):6466. PubMed PMID: 35440617
• Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Mar 25;12(1):5207. PubMed PMID: 35338216
• Bai X, Stitzel JA, Bai A, Zambrano CA, Phillips M, Marrack P, Chan ED. Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol. 2017 Sep;57(3):324-333. PubMed PMID: 28398760
• Lee S, Choi DK, Kwak A, Kim S, Nguyen TT, Gil G, Kim E, Yoo KH, Kim IA, Lee Y, Jhun H, Chan ED, Bai X, Kim H, Kim YS, Kim S. IL-32-induced Inflammatory Cytokines Are Selectively Suppressed by a1-antitrypsin in Mouse Bone Marrow Cells. Immune Netw. 2017 Apr;17(2):116-120. PubMed PMID: 28458623
• Yang J, Han X, Liu A, Bai X, Xu C, Bao F, Feng S, Tao L, Ma M, Peng Y. Use of Digital Droplet PCR to Detect Mycobacterium tuberculosis DNA in Whole Blood-Derived DNA Samples from Patients with Pulmonary and Extrapulmonary Tuberculosis. Front Cell Infect Microbiol. 2017;7:369. PubMed PMID: 28848722
• An Bai, Michael Weaver, Fukai Bao, Edward D. Chan, Xiyuan Bai; Saccharomyces boulardii Produces a Factor That Inhibits Mycobacterium intracellulare Burden in Human Macrophages. Advances in Microbiology. Vol.6 No.13, November 2016
• Bai X, Oberley-Deegan RE, Bai A, Ovrutsky AR, Kinney WH, Weaver M, Zhang G, Honda JR, Chan ED. Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection. Respirology. 2016 Jul;21(5):951-7. PubMed PMID: 27012592
• Xiyuan Bai, Jerry A. Stitzel, An Bai, Cristian Zambrano, Matthew Phillips, Philippa Marrack, Edward D. Chan. Nicotine impairs macrophage control of Mycobacterium tuberculosis. The American Journal of Respiratory Cell and Molecular Biology in reviewing process