K. Joseph Hurt, MD, PhD

Professional Titles

• Associate Professor

Research Interests

I direct the Preterm Labor Research Laboratory, a basic science group dedicated to finding new treatments to prevent preterm birth and the complications of prematurity.

Publications

• G Lagoda, S Sezen, KJ Hurt, AL Burnett. FK506 neuroprotection via thioredoxin and anti-apoptotic pathways in a nerve crush injury model. J Sex. Med. 2011 Dec; 8(12): 3325-34.
• Hurt KJ, Roe G, Abman SH. Hydrogen sulfide is a potent vasodilator in an ovine model of fetal pulmonary hypertension. Pediatric Academic Societies 2012.
• Rachael Crnich, K. Joseph Hurt, Kelsey Breen, Steven H. Abman. Ontogeny of Hydrogen Sulfide Synthesizing Enzyme Expression in the Developing Lung and the Effects of Chronic Intrauterine Pulmonary Hypertension. Pediatric Academic Societies 2012.
• Hurt KJ, K Breen, S Abman. The small molecule gasotransmitter hydrogen sulfide is a potent uterine tocolytic. Women’s Reproductive Health Research Scholar Annual Scientific Meeting. (2011)
• Lagoda G, Sezen SF, Hurt KJ, Cabrini MR, Mohanty DK, Burnett AL. Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. FASEB J. 2013 Sep 27. [Epub ahead of print] PubMed PMID: 24076963
• Gwen Lagoda, Sena F. Sezen, KJ Hurt, Marcelo R. Cabrini, Dillip K. Mohanty and Arthur L. Burnett. Novel Nitric Oxide Releasing Compound Corrects Dysregulated PDE5 Expression in Nitric Oxide Synthase Knockout Mouse Penis. Sexual Medicine Society of North America. (2011)
• SF Sezen, KJ Hurt, B Musicki, G Lagoda, SH Snyder, and AL Burnett. Protein kinase-A dependent phosphorylation of neuronal nitric oxide synthase: novel mechanism for regulation of neuronal nitric oxide synthase activated penile erection. American Urological Association. (2011)
• Women's Health Research Day (UCD) - Poster: Physiologic mechanisms of hydrogen sulfide (H2S) inhibition of uterine contractility
• SGI - platform talk: Characterization of hydrogen sulfide signaling in mouse myometrium
• RMRSS - platform talk: Endogenous hydrogen sulfide inhibits calcium signaling in mouse myometrium.
• KJ Hurt, editor. Pocket OB-Gyn, Lippincott Williams & Wilkins: Philadelphia. 2013. In press.
• SGI - poster: Hormonal regulation of hydrogen sulfide-producing enzymes in the mouse uterus
• Women's Health Research Day (UCD) - Poster: Hormonal regulation of gasotransmitter enzymes in the mouse reproductive tract
• "Neurology OBGyn" in Pocket OBGyn, 1st Ed. KJ Hurt, ed. LWW: Philadelphia. 2014
• Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection. Hurt KJ, Sezen SF, Lagoda GF, Musicki B, Rameau GA, Snyder SH, Burnett AL. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16624-9. doi: 10.1073/pnas.1213790109. PMID:23012472
• Rodriguez AN, DeWitt P, Fisher J, Broadfoot K, Hurt KJ. Psychometric characterization of the obstetric communication assessment tool for medical education: a pilot study. Int J Med Educ. 2016 Jun 11;7:168-79. PubMed PMID: 27289202
• Python JL, Wakefield BW, Kondo KL, Bang TJ, Stamm ER, Hurt KJ. Ultrasound-Guided Percutaneous Management of Splenic Ectopic Pregnancy. J Minim Invasive Gynecol. 2016 Sep-Oct;23(6):997-1002. PubMed PMID: 27221066
• McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016;8(4):386-99. PubMed PMID: 27160391
• Iwanaga R, Orlicky DJ, Arnett J, Guess MK, Hurt KJ, Connell KA. Comparative histology of mouse, rat, and human pelvic ligaments. Int Urogynecol J. 2016 Nov;27(11):1697-1704. PubMed PMID: 27091643
• Carlson NS, Hernandez TL, Hurt KJ. Parturition dysfunction in obesity: time to target the pathobiology. Reprod Biol Endocrinol. 2015 Dec 18;13(1):135. PubMed PMID: 26684329
• Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN. Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap. Biol Open. 2015 Aug 14;4(9):1154-62. PubMed PMID: 26276101
• Carlson NS, Corwin EJ, Hernandez TL, Holt E, Lowe NK, Hurt KJ. Association between provider type and cesarean birth in healthy nulliparous laboring women: A retrospective cohort study. Birth. 2018 Jan 31. [Epub ahead of print] PubMed PMID: 29388247
• Pancreatic cancer in pregnancy presenting with thromboembolic events: case report and review of the literature. Accepted to Gynecologic and Obstetric Investigation.
• Reinl EL, Zhao P, Wu W, Ma X, Amazu C, Bok R, Hurt KJ, Wang Y, England SK. Na -Leak Channel, Non-Selective (NALCN) Regulates Myometrial Excitability and Facilitates Successful Parturition. Cell Physiol Biochem. 2018;48(2):503-515. PubMed PMID: 30021195
• Wakefield BW, Masterson CMC, Borges MT, Hurt KJ. Pancreatic Cancer in Pregnancy Presenting with Thromboembolic Events: Case Report and Review of the Literature. Gynecol Obstet Invest. 2018;83(4):404-409. PubMed PMID: 29886492
• Carlson NS, Corwin EJ, Hernandez TL, Holt E, Lowe NK, Hurt KJ. Association between provider type and cesarean birth in healthy nulliparous laboring women: A retrospective cohort study. Birth. 2018 Jun;45(2):159-168. PubMed PMID: 29388247
• Fore MS, Allshouse AA, Carlson NS, Hurt KJ. Outcomes of trial of labor after cesarean birth by provider type in low-risk women. Birth. 2019 Dec 10. [Epub ahead of print] PubMed PMID: 31823421
• Vyas V, Guerra DD, Bok R, Powell T, Jansson T, Hurt KJ. Adiponectin links maternal metabolism to uterine contractility. FASEB J. 2019 Dec;33(12):14588-14601. PubMed PMID: 31665924
• Guerra DD, Bok R, Vyas V, Orlicky DJ, Lorca RA, Hurt KJ. Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17541-17546. PubMed PMID: 31405982
• Diko S, Guiahi M, Nacht A, Connell KA, Reeves S, Bailey BA, Hurt KJ. Prevention and Management of Severe Obstetric Anal Sphincter Injuries (OASIs): a National Survey of Nurse- Midwives. Int Urogynecol J. 2019 Mar 15. [Epub ahead of print] PubMed PMID: 30877353
• Guerra DD, Hurt KJ. Gasotransmitters in pregnancy: from conception to uterine involution†. Biol Reprod. 2019 Jul 1;101(1):4-25. PubMed PMID: 30848786
• Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Taurine alleviates repression of betaine-homocysteine S -methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ß-synthase-deficient homocystinuria. FASEB J. 2019 May;33(5):6339-6353. PubMed PMID: 30768359
• Guerra DD, Bok R, Breen K, Vyas V, Jiang H, MacLean KN, Hurt KJ. Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium. Reprod Sci. 2020 Aug 20. [Epub ahead of print] PubMed PMID: 32820455
• Wakefield B, Diko S, Gilmer R, Connell KA, DeWitt PE, Hurt KJ. Accuracy of obstetric laceration diagnoses in the electronic medical record. Int Urogynecol J. 2020 Aug 13. [Epub ahead of print] PubMed PMID: 32789812
• Monni G, Atzori L, Corda V, Dessolis F, Iuculano A, Hurt KJ, Murgia F. Metabolomics in Prenatal Medicine: A Review. Front Med (Lausanne). 2021;8:645118. PubMed PMID: 34249959
• Diko S, Sheeder J, Guiahi M, Nacht A, Reeves S, Connell KA, Hurt KJ. Identification of obstetric anal sphincter injuries (OASIs) and other lacerations: a national survey of nurse-midwives. Int Urogynecol J. 2020 May 12. [Epub ahead of print] PubMed PMID: 32399907
• Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. PubMed PMID: 33485059
• Guerra DD, Bok R, Breen K, Vyas V, Jiang H, MacLean KN, Hurt KJ. Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium. Reprod Sci. 2021 Jan;28(1):79-90. PubMed PMID: 32820455
• Ozemek C, Hildreth KL, Blatchford PJ, Hurt KJ, Bok R, Seals DR, Kohrt WM, Moreau KL. Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2020 Apr 1;128(4):739-747. PubMed PMID: 32134713
• Porter AC, Gumina DL, Armstrong M, Maclean KN, Reisdorph N, Galan HL, Stabler SP, Bailey BA, Hobbins JC, Hurt KJ. Maternal Amino Acid Profiles to Distinguish Constitutionally Small versus Growth-Restricted Fetuses Defined by Doppler Ultrasound: A Pilot Study. Am J Perinatol. 2020 Sep;37(11):1084-1093. PubMed PMID: 32120425
• Guerra DD, Bok R, Cari EL, Nicholas C, Orlicky DJ, Johnson J, Hurt KJ. Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response. Biol Reprod. 2020 May 26;102(6):1281-1289. PubMed PMID: 32101284
• Murgia F, Corda V, Serrenti M, Usai V, Santoru ML, Hurt KJ, Passaretti M, Monni MC, Atzori L, Monni G. Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans. Metabolites. 2020 Feb 11;10(2). PubMed PMID: 32053951
• Under review at AJOG: A Nested Case-Control Study of Maternal Steroid Hormones as Preterm Birth Biomarkers: The Healthy Start Study
• Under review at Intern Urogyn J: Obstetric anal sphincter injuries and other delivery trauma: a US National Survey of obstetrician–gynecologists
• Under review at Repro Sci: Theme with Variations: The Pathophysiology of Labor Dystocia
• Guerra DD, Bok R, Lorca RA, Hurt KJ. Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase. Br J Pharmacol. 2020 Jun;177(12):2765-2778. PubMed PMID: 31975425
• Fore MS, Allshouse AA, Carlson NS, Hurt KJ. Outcomes of trial of labor after cesarean birth by provider type in low-risk women. Birth. 2020 Mar;47(1):123-134. PubMed PMID: 31823421
• Mayne GB, DeWITT PE, Ringham B, Warrener AG, Christians U, Dabelea D, Hurt KJ. A Nested Case-Control Study of Allopregnanolone and Preterm Birth in the Healthy Start Cohort. J Endocr Soc. 2022 Dec 15;7(2):bvac179. PubMed PMID: 36632210
• Kissler K, Hurt KJ. The Pathophysiology of Labor Dystocia: Theme with Variations. Reprod Sci. 2022 Jul 11. [Epub ahead of print] PubMed PMID: 35817950
• Bunn JG, Sheeder J, Schulkin J, Diko S, Estin M, Connell KA, Hurt KJ. Obstetric anal sphincter injuries and other delivery trauma: a US national survey of obstetrician-gynecologists. Int Urogynecol J. 2022 Jun;33(6):1463-1472. PubMed PMID: 35113178
• Diko S, Guiahi M, Nacht A, Connell KA, Reeves S, Bailey BA, Hurt KJ. Prevention and Management of Severe Obstetric Anal Sphincter Injuries (OASIs): a National Survey of Nurse- Midwives. Int Urogynecol J. 2020 Mar;31(3):591-604. PubMed PMID: 30877353
• Simon NT, Niblock FC, Rabaza CA, Hoss ML, Sheeder JK, Hurt KJ. Family medicine physician identification of obstetric lacerations: a US national survey. Int Urogynecol J. 2023 Dec 11. [Epub ahead of print] PubMed PMID: 38078914
• Roper JC, Thakar R, Hurt KJ, Sultan AH. Diagnosis, management and training in perineal trauma: a UK national survey of obstetricians. Int Urogynecol J. 2023 Dec;34(12):2873-2883. PubMed PMID: 37498432
• Kissler K, Hurt KJ. The Pathophysiology of Labor Dystocia: Theme with Variations. Reprod Sci. 2023 Mar;30(3):729-742. PubMed PMID: 35817950
• Roper JC, Thakar R, Hurt KJ, Sultan AH. Diagnosis, management and training in perineal trauma: a national survey of UK midwives. Brit J Midwifery. 2023. 31(6):316-324. Online at https://www.britishjournalofmidwifery.com/content/research/diagnosis-management-and-training-in-perineal-trauma-a-national-survey-of-uk-midwives

Professional Memberships

• American College of Obstetricians and Gynecologists, Fellow
• The Kelly Society for Hopkins Gyn/OB, Member
• Society for Maternal Fetal Medicine, Member
• Society for Reproductive Investigation, Member

Practice Locations

UCHealth Maternal-Fetal Medicine Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 3rd Fl
Aurora, CO 80045
720-848-1060

UCHealth Maternal-Fetal Medicine Clinic - Lone Tree
9548 Park Meadows Drive
2nd Floor, Suite 100
Lone Tree, CO 80124
720-848-5146

Parker Perinatal Center
9397 Crown Crest Blvd
Suite 310
Parker, CO 80138
303-315-6100 option 2

CU John C. Hobbins Perinatal Center
1875 Lawrence Street
Suite 350
Denver, CO 80202
303-315-6100

Littleton Perinatal Center
7720 South Broadway
Suite 190
Littleton, CO 80122
303-315-6100

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

Specialties

• Obstetrics and Gynecology, Board Certification (2012)
• Maternal and Fetal Medicine, Board Certification (2019)

Conditions & Treatments

• Pregnancy and Reproduction - High-Risk Pregnancy
• Pregnancy and Reproduction - Maternal and Fetal Health
• Pregnancy and Reproduction - Prenatal Testing
• Pregnancy and Reproduction - Prenatal Care
• Pregnancy and Reproduction