Dale Brown, PhD

Sr. Instructor, Pediatrics-Critical Care Medicine

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Graduate School
  • PhD, Rice University (1979)
Undergraduate School
  • AB, Rice University (TX) (1973)
Fellowships
  • University of California (San Diego) Program, Pharmacology (1984)
Languages
English
Department
Pediatrics-Critical Care Medicine

Publications

  • Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT Jr, Long CS, Garrington TP, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan;304(2):H269-81. PubMed PMID: 23125215
  • Brown RD, Li M, Stewart CT, McKeon BA, Walker LA, Buttrick PM, Stenmark KR. The inflammatory-fibrotic phenotype of right ventricular cardiac fibroblasts in hypoxia-induced pulmonary hypertension. FASEB J. 26:1059.11.
  • Brown RD, Li M, Stewart CT, McKeon BA, Stenmark KR. Cardiac fibroblasts contribute to the inflammatory-fibrotic signature of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 185:A3458.
  • Li M, Horn T, McKeon BA, Nelson NG, Brown RD, Frid MG, McKinsey TA, Stenmark KR. Rat genetic strain differences in right ventricular remodeling in response to hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 185:A4756
  • Walker LA, Brown RD, Bull TM, Stenmark KR, Buttrick PM. Pulmonary hypertension induced right ventricular failure: Species comparison of global and local inflammatory responses. FASEB J 26:873.24.
  • Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
  • Brown RD, Riddle SR, Cockrum RR, Thomas MG, Stenmark KR (2014). Genomic signatures of right ventricular remodeling in neonatal calves with severe pulmonary hypertension: Implications for human pediatrics. Am J Respir Crit Care Med 189:A2345.
  • Brown RD, El-Kasmi KC, Stenmark KR, Buttrick PM, Walker LA (2014). The right ventricular fibroblast secretome drives cardiomyocyte dysfunction and macrophage activation. Am J Respir Crit Care Med 189:A2344
  • Neary JM, Garry FB, Holt TN, Brown RD, Stenmark KR, Enns RM, Thomas MG. The altitude at which a calf is born and raised influences the rate at which mean pulmonary arterial pressure increases with age. J Anim Sci. 2015 Oct;93(10):4714-20. PubMed PMID: 26523564
  • Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
  • Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA 3rd, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015 Apr 15;6:6863. PubMed PMID: 25873470
  • Brown RD*, Canovas A, Riddle S, Neary JM, Islas-Trejo A, Krafsur GM, Cockrum RR, Enns RM, Medrano J, Thomas MG, Stenmark KR. Natural History Of Pulmonary Hypertension: Transcriptome Analysis Of Right Ventricular Remodeling And Failure In Beef Cattle Exposed To Chronic Hypoxia. Am J Respir Crit Care Med 191;2015:A1041.
  • Neary JM, Brown RD, Holt TN, Stenmark KR, Enns RM, Thomas MG, Garry FB. Static and dynamic components of right ventricular afterload are negatively associated with calf survival at high altitude. J Anim Sci. 2016 Oct;94(10):4172-4178. PubMed PMID: 27898844
  • Bartels K, Brown RD, Fox DL, Bull TM, Neary JM, Dorosz JL, Fonseca BM, Stenmark KR. Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension. Anesth Analg. 2016 May;122(5):1280-6. PubMed PMID: 26974020
  • Krafsur GM, Brown RD, Neary JM, Holt T, Gould DH, Riddle S, Canovas A, Medrano J, Enns RM, Cockrum RR, Thomas MG, Stenmark KR. Natural History Of Pulmonary Hypertension: Adaptive Versus Maladaptive Physiologic Responses And Cardiopulmonary Remodeling In Beef Cattle Exposed To Chronic Hypoxia. Am J Respir Crit Care Med 191;2015:A5535.
  • Riddle SR, Li M, Zhang H, Brown RD, Frid MG, Flockton A, McKeon BA, Thomas MG, Canovas A, Islas-Trejo A, Medrano J, Serkova NJ, Davis D, El Kasmi K, Stenmark KR. Aerobic Glycolysis Is A Critical Metabolic Adaptation In Pro-Inflammatory Adventitial Fibroblasts Isolated From The Remodeled Pulmonary Artery Of Animals With Pulmonary Hypertension. Am J Respir Crit Care Med 191;2015:A5137.
  • Schäfer M, Myers C, Brown RD, Frid MG, Tan W, Hunter K, Stenmark KR. Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment. Curr Hypertens Rep. 2016 Jan;18(1):4. PubMed PMID: 26733189
  • Brown RD, Hunter KS, Bartels K, Stenmark KR. Early Hemodynamic and echocardiographic indicators of right ventricular dysfunction in neonatal calves with pulmonary hypertension. 2016. Amer J Crit Care Med. 193:A3901 (abstract)
  • Krafsur GM, Brown RD, Riddle S, Frid M, Poth J, Gould D, Neary J, Holt T, Garry F, Stenmark K. 2016 High-energy ration feeding in steers at low elevation:A natural animal model of irreversible pulmonary hypertension, pulmonary arterio-venous remodeling, and heart failure. Amer. J Resp Crit Care Med 193:A3905 (abstract)
  • Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. PubMed PMID: 28555642
  • Krafsur GM, Brown RD, Holt TN, Gould DH, Garry F, Riddle S, Neary JM, Enns RM, Thomas MG, Stenmark KR. Intense feeding and fattening regimens augment pulmonary hypertension, pulmonary venous and cardiac remodeling in beef cattle:A natural large animal model of pulmonary hypertension with left ventricular dysfunction. Am J Respir Crit Care Med 2017:195:A7216
  • Joseph P, Gottehrer-Cohen A, Maron BA, Brown RD, Stenmark KR, Loscalzo J, Oldham WM. Mechanism of taurine accumulation and metabolic regulation in pulmonary hypertension. Am J Respir Crit Care Med 2017; 195:A7211
  • Krafsur GM, Neary J, Garry F, Holt T, Gould D, Mason G, Thomas MG, Enns RM, Tuder R, Brown RD*, Stenmark KR* * Co-Senior Authors EXPRESS: Cardiopulmonary Remodeling in Fattened Beef Cattle: A Naturally Occurring Large Animal Model of Obesity-Associated Pulmonary Hypertension with Left Heart Disease Pulm Circ, Aug 20 2018. https://doi.org/10.1177/2045894018796804
  • M. G. Thomas G. M. Krafsur, T. N. Holt, R. M. Enns, S. E. Speidel, F.B. Garry, A. Canovas, J. M. Medrano, R.D. Brown, K.R. Stenmark, J.M. Neary. Genetics of Brisket Disease in beef cattle: A not so high altitude problem. Proc. Assoc. Advmt. Anim. Breed. Genet. 22:293-300.
  • G.M. Krafsur, R.D. Brown, T.N. Holt, D.H. Gould, F. Garry, S. Riddle, J. Neary, M. Enns, M. Thomas, K.R. Stenmark. Biomarkers of inflammation and metabolic stress in a bovine model of pulmonary hypertension with left ventricular fibrosis and pulmonary venous remodeling. Am J Respir Crit Care Med 2018;197:A3748.
  • Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
  • Bruns DR, Tatman PD, Kalkur RS, Brown RD, Stenmark KR, Buttrick PM, Walker LA. The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation. PLoS One. 2019;14(8):e0220573. PubMed PMID: 31374110
  • Krafsur GM, Neary JM, Garry F, Holt T, Gould DH, Mason GL, Thomas MG, Enns RM, Tuder RM, Heaton MP, Brown RD, Stenmark KR. Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease. Pulm Circ. 2019 Jan-Mar;9(1):2045894018796804. PubMed PMID: 30124135
  • Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
  • Brown RD, Riddle SR, Campbell N, Frump AL, Lahm T, Graham BB, Stenmark KR. A novel transcriptomic signature distinguishes right ventricular adaptation at the outset of hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 199:A2801
  • Petrou CL, D'Ovidio TJ, Bölükbas DA, Tas S, Brown RD, Allawzi A, Lindstedt S, Nozik-Grayck E, Stenmark KR, Wagner DE, Magin CM. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro. J Mater Chem B. 2020 Aug 21;8(31):6814-6826. PubMed PMID: 32343292
  • Jennings KJ, Krafsur GM, Brown RD, Holt TN, Coleman SJ, Spiedel SE, Enns RM, Stenmark KR, Thomas MG. Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle. Trans Anim Sci 3 (Suppl 1):1669-1672.
  • Jennings KJ, Krafsur GM, Brown RD, Holt TN, Coleman SJ, Speidel SE, Enns RM, Stenmark KR, Thomas MG. Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle. Transl Anim Sci. 2019 Dec;3(Suppl 1):1669-1672. PubMed PMID: 32704934
  • Brown RD, Fini MA, Stenmark KR. Band on the run: insights into right ventricular reverse remodelling. Cardiovasc Res. 2020 Aug 1;116(10):1651-1653. PubMed PMID: 32289148
  • Zhang H, Brown RD, Stenmark KR, Hu CJ. RNA-Binding Proteins in Pulmonary Hypertension. Int J Mol Sci. 2020 May 26;21(11). PubMed PMID: 32466553
  • Zhang H, Brown RD, Williams J, Delaney C, Stenmark KR. Hypoxic remodeling of neonatal pulmonary artery and myocardium. IN: Hypoxic respiratory failure in the newborn - From origins to clinical management. eds, S Dakshinamurti, S Abman, P-Y Cheung, S Lakshminrusimha, P McNamara, W Milson, CRC Press (Taylor & Frances Publishers, Boca Raton, FL). In press, 2020
  • Brown RD, Allawzi A, Petrou C, Magin CM, GrayckEN, Stenmark KR. Activation of Pulmonary and Cardiac Cell Populations in Response to Environmental Hypoxia or Lung Injury Using Transgenic Mouse Strains Expressing Phenotype-Sensitive Fluorescent Reporter Proteins. Am J Respir Crit Care Med 201:A3870, 2020
  • Brown RD, Applegate TJ, Krafsur GM, Boon JA, Zhang H, Holt TN, Abrams BA, Gustafson DL, Bartels K, Garry FA, Stenmark KR. Therapeutic Actions of the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Hypoxia-Induced Pulmonary Hypertension. Am J Respir Crit Care Med 201:A3873, 2020
  • Applegate TJ, Krafsur GM, Boon JA, Zhang H, Li M, Holt TN, Ambler SK, Abrams BA, Gustafson DL, Bartels K, Garry FB, Stenmark KR, Brown RD. Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension. Front Physiol. 2021;12:712583. PubMed PMID: 34552503
  • Kumar S, Frid MG, Zhang H, Li M, Riddle S, Brown RD, Yadav SC, Roy MK, Dzieciatkowska ME, D'Alessandro A, Hansen KC, Stenmark KR. Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages. JCI Insight. 2021 Nov 8;6(21). PubMed PMID: 34499621
  • Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021;12:640718. PubMed PMID: 33868271
  • Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17ß-Estradiol and estrogen receptor a protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. J Clin Invest. 2021 Mar 15;131(6). PubMed PMID: 33497359
  • Zhang H, Brown RD, Williams J, Delaney C, Stenmark KR. Hypoxic remodeling of neonatal pulmonary artery and myocardium. Chapter 20, pp. 111-118. doi: 10.1201/9780367494018-20. IN: Hypoxic Respiratory Failure in the Newborn: From Origins to Clinical Management. Ed, Dakshinamurti S. CRC Press, 2021. ISBN 9780367493998

Professional Memberships

  • Member, American Society for Pharmacology and Experimental Therapeutics
  • Affiliate, American Thoracic Society
  • Member, North American Vascular Biology Organization
  • Member, American Association for the Advancement of Science

Practice Locations

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Conditions & Treatments
  • Critical Care

School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

School
General
Students