Laurel Lenz, PhD

Publications

• Rayamajhi M, Humann J, Kearney S, Hill KK, and Lenz LL. (2010) “Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections.” Virulence. 1(5):421-425. PMC2957886
• Lei J, Lenz LL, and Cambier JC. (2010) “Cellular Reactive Oxygen Species Inhibit MPYS Induction of IFNb” PLoS ONE 5(12):e15142. PMC3000824
• Boudreau J, Stephenson K, Wang F, Ashkar A, Mossman K, Lenz LL, Rosenthal K, Bramson J, Lichty B, and Wan Y (2011) “IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.” Cancer Res. 71(7):2497-506.
• Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DWH, and Lenz LL (2011) “Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry.” JoVE, in press.
• A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. Schmidt RL, Filak HC, Lemon JD, Potter TA, Lenz LL. PLoS Pathog. 2011 Nov;7(11):e1002368. Epub 2011 Nov 3
• MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. J Immunol. 2011 Sep 1;187(5):2595-601. Epub 2011 Aug 3.
• Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11578-83. Epub 2011 Jun 27.
• Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. Manira Rayamajhia, Christine Delgado, Tracy V. Condon, David W. Riches and Laurel L. Lenz. Mucosal Immunology. in press
• Nitric oxide increases susceptibility of TLR-activated macrophages to spreading Listeria monocytogenes. Caroline Cole; Stacey Thomas; Holly Filak; Peter M Henson; Laurel L. Lenz. Immunity. in press
• Listeria monocytogenes interactions with the innate and adaptive immune system. Matthew A Williams, Rebecca L Schmidt, Laurel L. Lenz. Trends Immunol. in press
• Cole C, Thomas S, Filak H, Henson PM, and Lenz LL. (2012) “Nitric oxide increases susceptibility of Toll-Like Receptor-activated macrophages to spreading Listeria monocytogenes.” Immunity 36:807-20. **Highlighted article in Immunity and Nat. Med.
• Rayamajhi M, Delgado C, Condon TV, Riches DW, and Lenz LL. (2012) “Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax” Mucosal Immunol. 5:444-54.
• Williams MA, Schmidt R, and Lenz LL (2012) “Listeria monocytogenes interactions with the innate and adaptive immune system.” Trends Immunol. 33:488-96.
• Schmidt RL and Lenz LL (2012) “Distinct Licensing of IL-18 and IL-1ß Secretion in Response to NLRP3 Inflammasome Activation.” PLoS ONE 7(9): e45186
• Kearney S, Delgado C, and Lenz LL (2013) “Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections.” Immunol Res. 55:187-200.
• Kearney SJ, Delgado C, Eshleman E, Hill K, O’Connor B, and Lenz LL (2012) “Type I IFNs silence myeloid cell ifngr1 expression via the Egr3/Nab1 co-repressor” J. Immunol. In Revision.
• Mills CD, Thomas AC, Lenz LL, Munder M. Macrophage: SHIP of Immunity. Front Immunol. 2014;5:620. PubMed PMID: 25538705
• Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15;193(10):4757-60. PubMed PMID: 25381356
• Eshleman EM, Lenz LL. Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol. 2014;5:431. PubMed PMID: 25309533
• Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar;58(6):e115-8. PubMed PMID: 24336756
• “Macrophages at the Fork in the Road to Health or Disease” Charles D. Mills, Laurel L. Lenz, and Klaus Ley, Eds
• Mills CD, Lenz LL, Ley K. Macrophages at the fork in the road to health or disease. Front Immunol. 2015;6:59. PubMed PMID: 25762997
• Eshleman EM and Lenz LL. “Induction and consequences of the type I IFN response to Listeria monocytogenes.” In Bacterial Activation of Type I Interferons. Dane Parker, Ed.
• Mills CD, Lenz LL, and Harris RA. (2015) “A Breakthrough: Macrophage-Directed Cancer Immunotherapy.” Cancer Res. In press.
• Clark SE, Filak HC, Guthrie BS, Schmidt RL, Jamieson A, Merkel P, Knight V, Cole CM, Raulet DH, Lenz LL. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection. PLoS Pathog. 2016 Jun 13;12(6):e1005708. PubMed PMID: 27295349
• Mills CD, Lenz LL, Harris RA. A Breakthrough: Macrophage-Directed Cancer Immunotherapy. Cancer Res. 2016 Feb 1;76(3):513-6. PubMed PMID: 26772756
• Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017;8:470. PubMed PMID: 28484464
• Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL. Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS Pathog. 2017 May;13(5):e1006388. PubMed PMID: 28542482
• Ortiz A and Lenz LL. A Listeria-derived polypeptide promotes in vivo activation of NK cells for anti-tumor therapy. ImmunoHorizons 2017 1:53-62. doi: 10.4049/immunohorizons.1700013
• Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462. PubMed PMID: 30367045
• Alper S, Lenz LL. Editorial overview: Tuning the innate immune response to pathogens. Curr Opin Immunol. 2018 Oct;54:vi-ix. PubMed PMID: 30342707
• Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 1;10(1):2965. PubMed PMID: 31263097
• Crisler WJ, Lenz LL. Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection. Curr Opin Immunol. 2018 Oct;54:35-41. PubMed PMID: 29886270
• Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL. NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation. Front Immunol. 2019;10:2087. PubMed PMID: 31552035
• Crisler WJ, Eshleman EM, Lenz LL. Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFN? responsiveness. Life Sci Alliance. 2019 Oct;2(5). PubMed PMID: 31585982
• Clark SE, Schmidt RL, McDermott DS, Lenz LL. A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection. Cell Rep. 2018 May 29;23(9):2582-2594. PubMed PMID: 29847790
• Yang C, McDermot DS, Pasricha S, Brown AS, Bedoui S, Lenz LL, van Driel IR, Hartland EL. IFN? receptor down-regulation facilitates Legionella survival in alveolar macrophages. J Leukoc Biol. 2019 Dec 2. [Epub ahead of print] PubMed PMID: 31793076
• Larson SR, Bortell N, Illies A, Crisler WJ, Matsuda JL, Lenz LL. Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection. Front Immunol. 2020;11:590266. PubMed PMID: 33363536
• Clark SE, Schmidt RL, Aguilera ER, Lenz LL. IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung. Transl Res. 2020 Dec;226:70-82. PubMed PMID: 32634590
• Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020;11:238. PubMed PMID: 32153571
• Aguilera ER, Lenz LL. Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections. Front Immunol. 2020;11:105. PubMed PMID: 32117259
• Yang C, McDermot DS, Pasricha S, Brown AS, Bedoui S, Lenz LL, van Driel IR, Hartland EL. IFN? receptor down-regulation facilitates Legionella survival in alveolar macrophages. J Leukoc Biol. 2020 Feb;107(2):273-284. PubMed PMID: 31793076
• Eshleman EM, Bortell NN, McDermott DS, Crisler WJ, and Lenz LL (2020) “Myeloid cell IFNGR suffices for early resistance to Listeria monocytogenes.” Curr. Res. Immunol. 1:1-9 [https://doi.org/10.1016/j.crimmu.2020.01.001]
• Bortell N, Aguilera ER, Lenz LL. Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells. PLoS Pathog. 2021 Apr;17(4):e1009531. PubMed PMID: 33878120
• Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC. Mol Ther. 2021 Nov 15. [Epub ahead of print] PubMed PMID: 34793974
• Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Nov 15;27(22):6235-6249. PubMed PMID: 34518311
• Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2022 Mar 1;28(5):1013-1026. PubMed PMID: 34862244
• Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2022 Mar 2;30(3):1149-1162. PubMed PMID: 34793974
• Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Nov 15;27(22):6235-6249. PubMed PMID: 34518311
• Bortell N, Aguilera ER, Lenz LL. Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells. PLoS Pathog. 2021 Apr;17(4):e1009531. PubMed PMID: 33878120
• Vickery JM, Toperzer JD, Raab JE, Lenz LL, Colgan SP, Russo BC. Synaptopodin is necessary for Shigella flexneri intercellular spread. bioRxiv. 2023 Jun 26. PubMed PMID: 37163027