James Jaggers, MD
Professor, Surgery-Cardiothoracic

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Medical School:
  • MD, University of Nebraska College of Medicine (1988)
Undergraduate Schools:
  • BS, Chadron State College (NE) (1984)
  • BA, University of Nebraska Medical Center (NE) (1988)
Residency:
  • Oregon Health & Science University, Surgery (1993)
Fellowships:
  • University of Colorado, Thoracic and Cardiac (1996)
  • University of Colorado (Children's Hospital Colorado) Program, Congenital Cardiac Surgery (1996)
Languages: English
Department: Surgery-Cardiothoracic

Professional Titles

  • Barton-Elliman Chair in Pediatric Cardiothoracic Surgery
  • Co-Medical Director, The Children’s Hospital of Colorado Heart Institute
  • Section Chief Congenital Heart Surgery UC SOM

Recognition & Awards

  • Top Doctors in Denver, 5280 Magazine (2019)
  • Distinguished Alumnus Award, Chadron State College (2019)
  • Top Doctors in Denver, 5280 Magazine (2018)
  • Top Doctors in Denver, 5280 Magazine (2017)
  • Top Doctors in Denver, 5280 Magazine (2016)
  • Top Doctors in Denver, 5280 Magazine (2015)
  • Top Doctors in Denver, 5280 Magazine (2014)
  • Top Doctors in Denver, 5280 Magazine (2013)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
  • Top Doctors in Denver, 5280 Magazine (2012)
  • Top Doctors in Denver, 5280 Magazine (2011)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
  • Meritorious Service Award, AmSECT Pediatric Conference, American Society of Extracorporeal Technology (2006)
  • 1st Place, C Walton Lillehei Resident Forum Session, American Association for Thoracic Surgery (2006)

Teaching

  • Professor (2010)
    School of Medicine, Surgery
  • Program Director for Congenital Cardiac Surgery Residency (2019)
    School of Medicine, Surgery

Publications

  • Schäfer M, Di Maria MV, Jaggers J, Stone ML, Campbell DN, Ivy DD, Mitchell MB. Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation. JTCVS Open. 2023 Dec;16:836-843. PubMed PMID: 38204687
  • Iguidbashian J, Malone LJ, Browne LP, Nguyen M, Frank B, Schafer M, Campbell DN, Mitchell MB, Jaggers J, Stone ML. Regional Arch Measurements Differ Between Imaging Modalities in Infants With Aortic Coarctation. Ann Thorac Surg. 2023 Dec 10. [Epub ahead of print] PubMed PMID: 38072352
  • Overbey D, Jaggers J, Beckerman Z. Discussion to: Infant heart transplant following donation after circulatory death using normothermic regional perfusion and distant transport, first reported case in North America. JTCVS Tech. 2023 Oct;21:205-206. PubMed PMID: 37854827
  • Schäfer M, Mitchell MB, Frank BS, Barker AJ, Stone ML, Jaggers J, von Alvensleben JC, Hunter KS, Friesen RM, Ivy DD, Jacobsen R, Di Maria MV. Myocardial strain-curve deformation patterns after Fontan operation. Sci Rep. 2023 Jul 24;13(1):11912. PubMed PMID: 37488167
  • Deng XS, Meng X, Fullerton D, Stone M, Iguidbashian J, Jaggers J. Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells. J Surg Res. 2023 Jun;286:118-126. PubMed PMID: 36822134
  • Stone ML, Schäfer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2023 Feb;44(2):463-471. PubMed PMID: 36370189
  • Iguidbashian J, Feng Z, Colborn KL, Barrett CS, Newman SR, Harris M, Campbell DN, Mitchell MB, Jaggers J, Stone ML. Open Chest Duration Following Congenital Cardiac Surgery Increases Risk for Surgical Site Infection. Pediatr Cardiol. 2022 Dec 30. [Epub ahead of print] PubMed PMID: 36583758
  • Venardos N, Mangham C, Morgan GJ, Zablah JE, Jaggers J, Stone ML. Two-Stage Biventricular Repair of Complex Aortic Atresia. Ann Thorac Surg. 2022 Apr 1. [Epub ahead of print] PubMed PMID: 35378089
  • Malone LJ, Browne LP, Morgan GJ, Lovell MA, Campbell DN, Jaggers JJ, Leahy RA, Mitchell MB, Mong DA, Weinman JP, Zablah JE, Stone ML. Computed Tomographic Angiography Provides Reliable Coronary Artery Evaluation in Infants With Pulmonary Atresia Intact Ventricular Septum. Semin Thorac Cardiovasc Surg. 2022 Oct 14. [Epub ahead of print] PubMed PMID: 36244628
  • Stone ML, Schäfer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2022 Nov 12. [Epub ahead of print] PubMed PMID: 36370189
  • Iguidbashian J, Yoeli D, Everitt MD, Campbell DN, Mitchell MB, Jaggers J, Stone ML. Pediatric Heart Transplant Waiting List Times in the US During the COVID-19 Pandemic. JAMA Netw Open. 2022 Oct 3;5(10):e2234874. PubMed PMID: 36206002
  • Schäfer M, Di Maria MV, Stone ML, Jaggers J, Mitchell MB. Reply from authors: The unbearable weight of shape and flow quality. JTCVS Open. 2022 Jun;10:352-353. PubMed PMID: 36004238
  • Iguidbashian KG, Robison J, Khailova L, Jaggers J, Ing R, Lawson S, Osorio Lujan SM, Klawitter J, Davidson JA. Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass. Pediatr Res. 2022 Nov;92(5):1274-1281. PubMed PMID: 35681098
  • Stone ML, Schäfer M, DiMaria MV, von Alvensleben JC, Campbell DN, Jaggers J, Mitchell MB. Diastolic inflow is associated with inefficient ventricular flow dynamics in Fontan patients. J Thorac Cardiovasc Surg. 2022 Mar;163(3):1195-1207. PubMed PMID: 34429192
  • Ramos SA, Morton JJ, Yadav P, Reed B, Alizadeh SI, Shilleh AH, Perrenoud L, Jaggers J, Kappler J, Jimeno A, Russ HA. Generation of functional human thymic cells from induced pluripotent stem cells. J Allergy Clin Immunol. 2022 Feb;149(2):767-781.e6. PubMed PMID: 34331993
  • Freddo AM, Mathur S, Dunlevy H, Jaggers J, Khanna A. Endocarditis Caused by Candida parapsilosis Presenting With Severe Thrombocytopenia in a Patient With Tetralogy of Fallot. World J Pediatr Congenit Heart Surg. 2022 Mar;13(2):245-247. PubMed PMID: 34310898
  • Davidson JA, Robison J, Khailova L, Frank BS, Jaggers J, Ing RJ, Lawson S, Iguidbashian J, Ali E, Treece A, Soranno DE, Osorio-Lujan S, Klawitter J. Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F20-F32. PubMed PMID: 35532069
  • Venardos N, Mangham C, Morgan GJ, Zablah JE, Jaggers J, Stone ML. Two-Stage Biventricular Repair of Complex Aortic Atresia. Ann Thorac Surg. 2022 Apr 2. [Epub ahead of print] PubMed PMID: 35378089
  • Schäfer M, Frank BS, Grady RM, Eghtesady P, Mitchell MB, Jaggers J, Ivy DD. Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging. J Thorac Cardiovasc Surg. 2022 Aug;164(2):331-341. PubMed PMID: 34872760
  • Jaggers J, Downs EA. Commentary: Resident education in congenital heart surgery: Is this the best we can do?. J Thorac Cardiovasc Surg. 2022 Jan;163(1):262-263. PubMed PMID: 33894993
  • Stone ML, Schäfer M, DiMaria MV, von Alvensleben JC, Campbell DN, Jaggers J, Mitchell MB. Diastolic inflow is associated with inefficient ventricular flow dynamics in Fontan patients. J Thorac Cardiovasc Surg. 2022 Mar;163(3):1195-1207. PubMed PMID: 34429192
  • Jaggers J, Downs EA. Commentary: Resident education in congenital heart surgery: Is this the best we can do?. J Thorac Cardiovasc Surg. 2022 Jan;163(1):262-263. PubMed PMID: 33894993
  • Freddo AM, Mathur S, Dunlevy H, Jaggers J, Khanna A. Endocarditis Caused by Candida parapsilosis Presenting With Severe Thrombocytopenia in a Patient With Tetralogy of Fallot. World J Pediatr Congenit Heart Surg. 2022 Mar;13(2):245-247. PubMed PMID: 34310898
  • Schäfer M, Stone ML, Jaggers J, Browne LP, Mitchell MB. Commentary: In vortices veritas-quantitative approach. J Thorac Cardiovasc Surg. 2022 Mar;163(3):964-966. PubMed PMID: 32768303
  • Schäfer M, Stone ML, Jaggers J, Browne LP, Mitchell MB. Commentary: In vortices veritas-quantitative approach. J Thorac Cardiovasc Surg. 2022 Mar;163(3):964-966. PubMed PMID: 32768303
  • Wojcik BM, Rajab TK, Newman S, Jaggers J, Mitchell MB. COVID-19 Testing, Surgical Prioritization, and Reactivation in a Congenital Cardiac Surgery Program. World J Pediatr Congenit Heart Surg. 2021 Jan;12(1):150-151. PubMed PMID: 33179577
  • Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2021 Jan 1;322:158-167. PubMed PMID: 32853667
  • Schäfer M, Frank BS, Grady RM, Eghtesady P, Mitchell MB, Jaggers J, Ivy DD. Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging. J Thorac Cardiovasc Surg. 2021 Nov 16. [Epub ahead of print] PubMed PMID: 34872760
  • Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 Sep 22;17(10):89. PubMed PMID: 34553313
  • Persson JN, Holstein J, Silveira L, Irons A, Rajab TK, Jaggers J, Twite MD, Scahill C, Kohn M, Gold C, Davidson JA. Validation of Point-of-Care Ultrasound to Measure Perioperative Edema in Infants With Congenital Heart Disease. Front Pediatr. 2021;9:727571. PubMed PMID: 34497787
  • Lin Y, Davis TJ, Zorrilla-Vaca A, Wojcik BM, Miyamoto SD, Everitt MD, Campbell DN, Jaggers JJ, Rajab TK. Neonatal heart transplant outcomes: A single institutional experience. J Thorac Cardiovasc Surg. 2021 Nov;162(5):1361-1368. PubMed PMID: 34099271
  • Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
  • Schäfer M, Di Maria MV, Jaggers J, Stone ML, Ivy DD, Barker AJ, Mitchell MB. High-degree Norwood neoaortic tapering is associated with abnormal flow conduction and elevated flow-mediated energy loss. J Thorac Cardiovasc Surg. 2021 Dec;162(6):1791-1804. PubMed PMID: 33653609
  • Deng XS, Meng X, Fullerton D, Stone M, Jaggers J. Complement Upregulates Runx-2 to Induce Profibrogenic Change in Aortic Valve Interstitial Cells. Ann Thorac Surg. 2021 Dec;112(6):1962-1972. PubMed PMID: 33545156
  • Stone ML, Schäfer M, von Alvensleben JC, Browne LP, Di Maria M, Campbell DN, Jaggers J, Mitchell MB. Increased Aortic Stiffness and Left Ventricular Dysfunction Exist After Truncus Arteriosus Repair. Ann Thorac Surg. 2021 Sep;112(3):809-815. PubMed PMID: 33307069
  • Wojcik BM, Rajab TK, Newman S, Jaggers J, Mitchell MB. COVID-19 Testing, Surgical Prioritization, and Reactivation in a Congenital Cardiac Surgery Program. World J Pediatr Congenit Heart Surg. 2021 Jan;12(1):150-151. PubMed PMID: 33179577
  • Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2021 Jan 1;322:158-167. PubMed PMID: 32853667
  • Rajab TK, Jaggers J, Campbell DN. Heart transplantation following donation after cardiac death: History, current techniques, and future. J Thorac Cardiovasc Surg. 2021 Apr;161(4):1335-1340. PubMed PMID: 32245667
  • Stone ML, Schäfer M, von Alvensleben JC, Browne LP, Di Maria M, Campbell DN, Jaggers J, Mitchell MB. Increased Aortic Stiffness and Left Ventricular Dysfunction Exist After Truncus Arteriosus Repair. Ann Thorac Surg. 2020 Dec 8. [Epub ahead of print] PubMed PMID: 33307069
  • Jaggers J. Commentary: Surgical options for right ventricular outflow tract reconstruction: Innovate or die. J Thorac Cardiovasc Surg. 2020 Nov;160(5):1289-1290. PubMed PMID: 32900479
  • Khailova L, Robison J, Jaggers J, Ing R, Lawson S, Treece A, Soranno D, Osorio Lujan S, Davidson JA. Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest. J Inflamm (Lond). 2020;17:27. PubMed PMID: 32817746
  • Schäfer M, Stone ML, Jaggers J, Browne LP, Mitchell MB. Commentary: In vortices veritas-quantitative approach. J Thorac Cardiovasc Surg. 2020 Jun 27. [Epub ahead of print] PubMed PMID: 32768303
  • Rajab TK, Jaggers J. Extracardiac Fontan Operation: How I Teach It. Ann Thorac Surg. 2020 Oct;110(4):1119-1122. PubMed PMID: 32693037
  • Rajab TK, Jaggers J, Campbell DN. Heart transplantation following donation after cardiac death: History, current techniques, and future. J Thorac Cardiovasc Surg. 2020 Mar 31. [Epub ahead of print] PubMed PMID: 32245667
  • Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1032-H1040. PubMed PMID: 32167782
  • Rajab TK, Jaggers J, Campbell DN. Donation after circulatory death determination pediatric heart transplantation and 10-year outcomes. J Heart Lung Transplant. 2020 May;39(5):491-492. PubMed PMID: 32146106
  • Schäfer M, Browne LP, Jaggers J, Barker AJ, Morgan GJ, Ivy DD, Mitchell MB. Abnormal left ventricular flow organization following repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2020 Oct;160(4):1008-1015. PubMed PMID: 31924354
  • Schäfer M, Barker AJ, Morgan GJ, Jaggers J, Stone ML, Browne LP, Ivy DD, Mitchell MB. Increased systolic vorticity in the left ventricular outflow tract is associated with abnormal aortic flow formations in Tetralogy of Fallot. Int J Cardiovasc Imaging. 2020 Apr;36(4):691-700. PubMed PMID: 31907684
  • Jaggers J, Stone M. Commentary: Intraventricular conduit repair for double-outlet right ventricle with noncommitted ventricular septal defect-How bright is the light at the end of the tunnel?. J Thorac Cardiovasc Surg. 2020 Jun;159(6):2404-2405. PubMed PMID: 31669028
  • Schäfer M, Barker AJ, Jaggers J, Morgan GJ, Stone ML, Truong U, Browne LP, Malone L, Ivy DD, Mitchell MB. Abnormal aortic flow conduction is associated with increased viscous energy loss in patients with repaired tetralogy of Fallot. Eur J Cardiothorac Surg. 2020 Mar 1;57(3):588-595. PubMed PMID: 31535124
  • Jaggers J, Stone M. Commentary: Intraventricular conduit repair for double-outlet right ventricle with noncommitted ventricular septal defect-How bright is the light at the end of the tunnel?. J Thorac Cardiovasc Surg. 2019 Sep 17. [Epub ahead of print] PubMed PMID: 31669028
  • Davidson JA, Khailova L, Treece A, Robison J, Soranno DE, Jaggers J, Ing RJ, Lawson S, Lujan SO. Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest. Sci Rep. 2019 Oct 2;9(1):14175. PubMed PMID: 31578351
  • Schäfer M, Younoszai A, Truong U, Browne LP, Mitchell MB, Jaggers J, Campbell DN, Hunter KS, Ivy DD, Di Maria MV. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. J Thorac Cardiovasc Surg. 2019 Feb;157(2):699-707. PubMed PMID: 30396734
  • Schäfer M, Barker AJ, Jaggers J, Morgan GJ, Stone ML, Truong U, Browne LP, Malone L, Ivy DD, Mitchell MB. Abnormal aortic flow conduction is associated with increased viscous energy loss in patients with repaired tetralogy of Fallot. Eur J Cardiothorac Surg. 2019 Sep 18. [Epub ahead of print] PubMed PMID: 31535124
  • Jaggers J. Commentary: This is your brain, and this is your brain on deep hypothermic cardiac arrest. J Thorac Cardiovasc Surg. 2019 Sep;158(3):893-894. PubMed PMID: 31430845
  • Lueth ET, Gist KM, Burkett DA, Landeck BF, Brinton JT, Meier MR, Coffin JM, Schafer M, Jaggers J, Mitchell MB. Retrospective Comparison of the Supported and Unsupported Bovine Jugular Vein Conduit in Children. Ann Thorac Surg. 2019 Aug;108(2):567-573. PubMed PMID: 30974093
  • Schäfer M, Browne LP, von Alvensleben JC, Mitchell MB, Morgan GJ, Ivy DD, Jaggers J. Ventricular interactions and electromechanical dyssynchrony after Ross and Ross-Konno operations. J Thorac Cardiovasc Surg. 2019 Aug;158(2):509-517. PubMed PMID: 30928217
  • Schäfer M, DiMaria MV, Jaggers J, Mitchell MB. Suboptimal neoaortic arch geometry correlates with inefficient flow patterns in hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2019 Sep;158(3):e113-e116. PubMed PMID: 30926198
  • Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J. MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells. J Surg Res. 2019 Mar;235:44-51. PubMed PMID: 30691826
  • Schäfer M, Younoszai A, Truong U, Browne LP, Mitchell MB, Jaggers J, Campbell DN, Hunter KS, Ivy DD, Di Maria MV. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. J Thorac Cardiovasc Surg. 2019 Feb;157(2):699-707. PubMed PMID: 30396734
  • Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. Shock. 2019 Mar;51(3):328-336. PubMed PMID: 29664834
  • SooHoo MM, Patel SS, Jaggers J, Faubel S, Gist KM. Acute Kidney Injury Defined by Fluid Corrected Creatinine in Neonates After the Norwood Procedure. World J Pediatr Congenit Heart Surg. 2018 Sep;9(5):513-521. PubMed PMID: 30157730
  • Schäfer M, Browne LP, Truong U, Jaggers JJ, Mitchell MB, Malone L, Morgan G, Chatfield K, McLennan D, Turbendian H, Vargas D, Fonseca B, DiMaria M, Shah A, Ivy MP, Barker AJ, Hunter KS, Wilson N, Ivy DD, Campbell DN. Aortic stiffness in adolescent Turner and Marfan syndrome patients. Eur J Cardiothorac Surg. 2018 Nov 1;54(5):926-932. PubMed PMID: 29684119
  • Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia after Infant Cardiothoracic Surgery. Shock. 2018 Apr 16. [Epub ahead of print] PubMed PMID: 29664834
  • Di Maria MV, Mulvahill M, Jaggers J, Ivy DD, Younoszai AK. Predictive value of presuperior cavopulmonary anastomosis cardiac catheterization at increased altitude. Congenit Heart Dis. 2018 Mar;13(2):311-318. PubMed PMID: 29431283
  • Jaggers J. Primum non nocere when the treatment is worse than the disease. J Thorac Cardiovasc Surg. 2018 Apr;155(4):1769-1770. PubMed PMID: 29397151
  • Sandhu A, Ruckdeschel E, Sauer WH, Collins KK, Kay JD, Khanna A, Jaggers J, Campbell D, Mitchell M, Nguyen DT. Perioperative electrophysiology study in patients with tetralogy of Fallot undergoing pulmonary valve replacement will identify those at high risk of subsequent ventricular tachycardia. Heart Rhythm. 2018 May;15(5):679-685. PubMed PMID: 29330130
  • Ehrmann DE, Mulvahill M, Harendt S, Church J, Stimmler A, Vichayavilas P, Batz S, Rodgers J, DiMaria M, Jaggers J, Barrett C, Kaufman J. Toward standardization of care: The feeding readiness assessment after congenital cardiac surgery. Congenit Heart Dis. 2018 Jan;13(1):31-37. PubMed PMID: 29148256
  • Ehrmann DE, Mulvahill M, Harendt S, Church J, Stimmler A, Vichayavilas P, Batz S, Rodgers J, DiMaria M, Jaggers J, Barrett C, Kaufman J. Toward standardization of care: The feeding readiness assessment after congenital cardiac surgery. Congenit Heart Dis. 2017 Nov 17. [Epub ahead of print] PubMed PMID: 29148256
  • Davidson JA, Urban TT, Baird C, Tong S, Woodruff A, Twite M, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. J Pediatr. 2017 Nov;190:49-55.e2. PubMed PMID: 29144270
  • Deng XS, Meng X, Venardos N, Song R, Yamanaka K, Fullerton D, Jaggers J. Autophagy negatively regulates pro-osteogenic activity in human aortic valve interstitial cells. J Surg Res. 2017 Oct;218:285-291. PubMed PMID: 28985862
  • Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
  • Jaggers J. New tricks for old dogs. J Thorac Cardiovasc Surg. 2017 May;153(5):1153-1154. PubMed PMID: 28283229
  • Lawson DS, Eilers D, Osorio Lujan S, Bortot M, Jaggers J. Hemolysis generation from a novel, linear positive displacement blood pump for cardiopulmonary bypass on a six kilogram piglet: a preliminary report. Perfusion. 2017 May;32(4):264-268. PubMed PMID: 27856841
  • Clopton RG, Friesen R, Partrick D, Wilson N, Jaggers J, Ivy DD, Schwartz LI, Ing RJ. The Anesthetic Challenges of Lung Biopsy-Associated Intrathoracic Hemorrhage in a Child With Suprasystemic Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2017 Jun;21(2):172-177. PubMed PMID: 27815350
  • McRobb CM, Ing RJ, Lawson DS, Jaggers J, Twite M. Retrospective analysis of eliminating modified ultrafiltration after pediatric cardiopulmonary bypass. Perfusion. 2017 Mar;32(2):97-109. PubMed PMID: 27708000
  • Ohye RG, Jaggers JJ, Sade RM. Must Surgeons in Training Programs Allow Residents to Operate on Their Patients to Satisfy Board Requirements?. Ann Thorac Surg. 2016 Jan;101(1):18-23. PubMed PMID: 26694262
  • Lawson DS, Eilers D, Osorio Lujan S, Bortot M, Jaggers J. Hemolysis generation from a novel, linear positive displacement blood pump for cardiopulmonary bypass on a six kilogram piglet: a preliminary report. Perfusion. 2016 Nov 16. [Epub ahead of print] PubMed PMID: 27856841
  • Clopton RG, Friesen R, Partrick D, Wilson N, Jaggers J, Ivy DD, Schwartz LI, Ing RJ. The Anesthetic Challenges of Lung Biopsy-Associated Intrathoracic Hemorrhage in a Child With Suprasystemic Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2016 Nov 3. [Epub ahead of print] PubMed PMID: 27815350
  • McRobb CM, Ing RJ, Lawson DS, Jaggers J, Twite M. Retrospective analysis of eliminating modified ultrafiltration after pediatric cardiopulmonary bypass. Perfusion. 2016 Oct 5. [Epub ahead of print] PubMed PMID: 27708000
  • Deng XS, Meng X, Song R, Fullerton D, Jaggers J. Rapamycin Decreases the Osteogenic Response in Aortic Valve Interstitial Cells Through the Stat3 Pathway. Ann Thorac Surg. 2016 Oct;102(4):1229-38. PubMed PMID: 27209607
  • Zanotti G, Gupta R, Reece TB, Campbell DN, Jaggers J, Babu A. Aortic Valve Sparing Root Replacement With Unroofing and Reconstruction of an Anomalous Right Coronary Artery. Ann Thorac Surg. 2016 May;101(5):1980-2. PubMed PMID: 27106435
  • Ohye RG, Jaggers JJ, Sade RM. Must Surgeons in Training Programs Allow Residents to Operate on Their Patients to Satisfy Board Requirements?. Ann Thorac Surg. 2016 Jan;101(1):18-23. PubMed PMID: 26694262
  • Deng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers J. Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation. Ann Thorac Surg. 2015 Jan;99(1):62-71. PubMed PMID: 25442996
  • Peng E, Campbell DN, Jaggers J, Mitchell MB. Three-Sinus Repair of Elastin Arteriopathy Associated Supravalvar Pulmonary Stenosis With Bilateral Branch Pulmonary Artery Involvement. Ann Thorac Surg. 2015 Aug;100(2):741-3. PubMed PMID: 26234860
  • Peng E, Howley L, Cromblehome TM, Jaggers J. Ex-utero intrapartum treatment as a novel bridging strategy to surgery in hypoplastic left heart syndrome with intact atrial septum-cross-circulation revisited. J Thorac Cardiovasc Surg. 2015 Mar;149(3):935-7. PubMed PMID: 25595375
  • Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-dimensional echocardiography enhances diagnostic accuracy of supramitral ring. Echocardiography. 2015 Jun;32(6):1048-50. PubMed PMID: 25496227
  • Deng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers J. Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation. Ann Thorac Surg. 2015 Jan;99(1):62-71. PubMed PMID: 25442996
  • Peng E, Howley L, Cromblehome TM, Jaggers J. Ex-utero intrapartum treatment as a novel bridging strategy to surgery in hypoplastic left heart syndrome with intact atrial septum-cross-circulation revisited. J Thorac Cardiovasc Surg. 2014 Nov 24. [Epub ahead of print] PubMed PMID: 25595375
  • Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-Dimensional Echocardiography Enhances Diagnostic Accuracy of Supramitral Ring. Echocardiography. 2014 Dec 12. [Epub ahead of print] PubMed PMID: 25496227
  • Goot BH, Jaggers J, Anagnost MR, Collins KK. Multivalvular Replacement and Ventricular Arrhythmias in a Female Child With Congenital Polyvalvular Disease. World J Pediatr Congenit Heart Surg. 2014 Jun 23;5(3):463-466. [Epub ahead of print] PubMed PMID: 24958053
  • Gist KM, Schuchardt EL, Moroze MK, Kaufman J, Cruz Ed, Campbell DN, Mitchell MB, Jaggers J, Collins KK, McCanta AC. Tachyarrhythmia following Norwood operation: a single-center experience. World J Pediatr Congenit Heart Surg. 2014 Apr;5(2):206-10. PubMed PMID: 24668965
  • McFerson MC, McCanta AC, Pan Z, Collins KK, Jaggers J, da Cruz EM, Kaufman J. Tachyarrhythmias after the Norwood procedure: relationship and effect of vasoactive agents. Pediatr Cardiol. 2014 Apr;35(4):668-75. PubMed PMID: 24240783
  • McFerson MC, McCanta AC, Pan Z, Collins KK, Jaggers J, da Cruz EM, Kaufman J. Tachyarrhythmias After the Norwood Procedure: Relationship and Effect of Vasoactive Agents. Pediatr Cardiol. 2013 Nov 17. [Epub ahead of print] PubMed PMID: 24240783
  • Hauck A, da Cruz EM, Jaggers J, Jone PN. Tricuspid Atresia Associated with Truncus Arteriosus versus Aortopulmonary Window: Combining Fetal and Postnatal Echocardiography to Make the Diagnosis. Echocardiography. 2013 Sep 4. [Epub ahead of print] PubMed PMID: 24033694
  • Mejak BL, Ing RJ, McRobb C, Ellis WC, Lawson DS, Twite MD, Jaggers J. Cryoprecipitate and platelet administration during modified ultrafiltration in children less than 10 kg undergoing cardiac surgery. J Extra Corpor Technol. 2013 Jun;45(2):107-11. PubMed PMID: 23930379
  • Kaufmnan J, Twite M, Barrett C, Peyton C, Koehler J, Rannie M, Kahn MG, Schofield S, Ing RJ, Jaggers J, Hyman D, da Cruz EM. A handoff protocol from the cardiovascular operating room to cardiac ICU is associated with improvements in care beyond the immediate postoperative period. Jt Comm J Qual Patient Saf. 2013 Jul;39(7):306-11. PubMed PMID: 23888640
  • Turek JW, Andersen ND, Lawson DS, Bonadonna D, Turley RS, Peters MA, Jaggers J, Lodge AJ. Outcomes before and after implementation of a pediatric rapid-response extracorporeal membrane oxygenation program. Ann Thorac Surg. 2013 Jun;95(6):2140-6; discussion 2146-7. PubMed PMID: 23506632
  • Barrett CS, Jaggers JJ, Cook EF, Graham DA, Yarlagadda VV, Teele SA, Almond CS, Bratton SL, Seeger JD, Dalton HJ, Rycus PT, Laussen PC, Thiagarajan RR. Pediatric ECMO outcomes: comparison of centrifugal versus roller blood pumps using propensity score matching. ASAIO J. 2013 Mar-Apr;59(2):145-51. PubMed PMID: 23438777
  • Gist KM, Barrett CS, Graham DA, Crumback SL, Schuchardt EL, Erickson B, Jaggers J. Pulmonary artery interventions after Norwood procedure: does type or position of shunt predict need for intervention?. J Thorac Cardiovasc Surg. 2013 Jun;145(6):1485-92. PubMed PMID: 23398647
  • Stewart RD, Pasquali SK, Jacobs JP, Benjamin DK, Jaggers J, Cheng J, Mavroudis C, Jacobs ML. Reply: To PMID 22450074. Ann Thorac Surg. 2013 Feb;95(2):775. PubMed PMID: 23336910
  • Chen XJ, Smith PB, Jaggers J, Lodge AJ. Bioprosthetic pulmonary valve replacement: contemporary analysis of a large, single-center series of 170 cases. J Thorac Cardiovasc Surg. 2013 Dec;146(6):1461-6. PubMed PMID: 23122698
  • Auerbach SR, Smith JK, Gralla J, Mitchell MB, Campbell DN, Jaggers J, Pietra BA, Miyamoto SD. Graft survival is better without prior surgery in cardiac transplantation for functionally univentricular hearts. J Heart Lung Transplant. 2012 Sep;31(9):987-95. PubMed PMID: 22789137
  • Barrett CS, Jaggers JJ, Cook EF, Graham DA, Rajagopal SK, Almond CS, Seeger JD, Rycus PT, Thiagarajan RR. Outcomes of neonates undergoing extracorporeal membrane oxygenation support using centrifugal versus roller blood pumps. Ann Thorac Surg. 2012 Nov;94(5):1635-41. PubMed PMID: 22921236
  • Perry J, Jagger J, Parker G, Phillips EK, Gomaa A. Disposal of sharps medical waste in the United States: impact of recommendations and regulations, 1987-2007. Am J Infect Control. 2012 May;40(4):354-8. PubMed PMID: 21824683
  • Holst JA, Campbell DN, Jaggers J, Mitchell MB. Posterior pulmonary artery bifurcation side-to-side arterioplasty for branch pulmonary artery stenosis. J Thorac Cardiovasc Surg. 2012 Nov;144(5):1257-9. PubMed PMID: 22748692
  • Gist KM, Mitchell MB, Jaggers J, Campbell DN, Yu JA, Landeck BF 2nd. Assessment of the relationship between Contegra conduit size and early valvar insufficiency. Ann Thorac Surg. 2012 Mar;93(3):856-61. PubMed PMID: 22300627
  • Phillips EK, Simwale OJ, Chung MJ, Parker G, Perry J, Jagger JC. Risk of bloodborne pathogen exposure among Zambian healthcare workers. J Infect Public Health. 2012 Jun;5(3):244-9. PubMed PMID: 22632598
  • Fahy CJ, Ing RJ, Kern FH, O'Hare B, Redmond JM, Jaggers J. The anesthetic management and physiologic implications in infants with anomalous left coronary artery arising from the pulmonary artery. J Cardiothorac Vasc Anesth. 2012 Apr;26(2):286-90. PubMed PMID: 21441041
  • Stewart RD, Pasquali SK, Jacobs JP, Benjamin DK, Jaggers J, Cheng J, Mavroudis C, Jacobs ML. Contemporary Fontan operation: association between early outcome and type of cavopulmonary connection. Ann Thorac Surg. 2012 Apr;93(4):1254-60; discussion 1261. PubMed PMID: 22450074
  • Kiefer TL, Crowley AL, Jaggers J, Harrison JK. Coronary arteriovenous fistulae: the complexity of coronary artery-to-coronary sinus connections. Tex Heart Inst J. 2012;39(2):218-22. PubMed PMID: 22740735
  • Chen JG, Wright MC, Smith PB, Jaggers J, Mistry KP. Adaptation of a postoperative handoff communication process for children with heart disease: a quantitative study. Am J Med Qual. 2011 Sep-Oct;26(5):380-6. PubMed PMID: 21701043
  • Kaza AK, Colan SD, Jaggers J, Lu M, Atz AM, Sleeper LA, McCrindle BW, Lambert LM, Margossian R, Lacro RV, Richmond ME, Natarajan S, Minich LL. Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience. Ann Thorac Surg. 2011 Oct;92(4):1468-75; discussion 1475. PubMed PMID: 21872212
  • Wallace MC, Jaggers J, Li JS, Jacobs ML, Jacobs JP, Benjamin DK, O'Brien SM, Peterson ED, Smith PB, Pasquali SK. Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes. Ann Thorac Surg. 2011 May;91(5):1445-52. PubMed PMID: 21524453
  • Atz AM, Hawkins JA, Lu M, Cohen MS, Colan SD, Jaggers J, Lacro RV, McCrindle BW, Margossian R, Mosca RS, Sleeper LA, Minich LL. Surgical management of complete atrioventricular septal defect: associations with surgical technique, age, and trisomy 21. J Thorac Cardiovasc Surg. 2011 Jun;141(6):1371-9. PubMed PMID: 21163497
  • Turner II, Turek JW, Jaggers J, Herlong JR, Lawson DS, Lodge AJ. Anomalous aortic origin of a coronary artery: preoperative diagnosis and surgical planning. World J Pediatr Congenit Heart Surg. 2011 Jul 1;2(3):340-5. PubMed PMID: 23803983
  • Trivedi B, Smith PB, Barker PC, Jaggers J, Lodge AJ, Kanter RJ. Arrhythmias in patients with hypoplastic left heart syndrome. Am Heart J. 2011 Jan;161(1):138-44. PubMed PMID: 21167346
  • Pasquali SK, Hall M, Li JS, Peterson ED, Jaggers J, Lodge AJ, Marino BS, Goodman DM, Shah SS. Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database. Circulation. 2010 Nov 23;122(21):2123-30. PubMed PMID: 21060075
  • Baker-Smith CM, Milazzo AS, Frush DP, Jaggers J, Kirby ML, Kanter RJ, Barker PC. Double aortic arch with aortic atresia and left-sided type B interruption. Congenit Heart Dis. 2010 May-Jun;5(3):316-20. PubMed PMID: 20576054
  • Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med. 2010 May 27;362(21):1980-92. PubMed PMID: 20505177
  • Pasquali SK, Hall M, Li JS, Peterson ED, Jaggers J, Lodge AJ, Jacobs JP, Jacobs ML, Shah SS. Safety of aprotinin in congenital heart operations: results from a large multicenter database. Ann Thorac Surg. 2010 Jul;90(1):14-21. PubMed PMID: 20609740
  • Fudge JC Jr, Li S, Jaggers J, O'Brien SM, Peterson ED, Jacobs JP, Welke KF, Jacobs ML, Li JS, Pasquali SK. Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database. Pediatrics. 2010 Aug;126(2):315-22. PubMed PMID: 20624800
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Professional Memberships

  • American Association for Thoracic Surgery, Member
  • American College of Surgeons (ACS), Member
  • Congenital Heart Surgeons Society, Program Committee
  • International Society for Heart & Lung Transplantation, Member
  • Society of Thoracic Surgeons, Workforce on Congenital Heart Disease
  • European Association of Cardiothoracic Surgery, Member
  • World Society of Pediatric Cardiac Surgeons, Member
  • American Academy of Pediatrics (AAP), Specialty Fellow
  • American Heart Assocaition, Member
  • North Carolina Medical Society, Member
  • Southern Thoracic Surgical Association, Member
  • Society of University Surgeons, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado - Colorado Springs
4090 Briargate Pkwy
Colorado Springs, CO 80920
719-305-1234

Saint Joseph Hospital
1375 E. 19th Avenue
Denver, CO 80218
303-812-2000

UCHealth Anschutz Inpatient Pavilion 2 - Anschutz Medical Campus
12505 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
  • Saint Joseph Hospital
Center Affiliations

Specialty Information

Specialties
  • Surgery, Board Certification (1994)
  • Thoracic and Cardiac, Board Certification (1997, 2017)
  • Congenital Cardiac Surgery, Board Certification (2017)
  • Congenital Cardiac surgery, Board Certification (2009)
Conditions & Treatments
  • Heart and Circulation - Heart Valve Diseases
  • Heart and Circulation - Heart Diseases
  • Heart and Circulation - Congenital Heart Disease
  • Surgery - Cardiothoracic Surgery
  • Surgery - Adult Cardiac Surgery
  • Surgery - Heart Transplant Surgery
  • Surgery - Open Heart Surgery
  • Surgery - Cardiothoracic - Congenital Cardiac Surgery
  • Heart and Circulation - Adult Congenital Heart Disease
  • Heart and Circulation
  • Surgery
Clinical Interests
I am interested in complex congenital heart defects in newborns and infants, adult congenital cardiac surgery, pediatric cardiac transplantation, and surgery for Marfan Syndrome.

Care Philosophy
I utilize a multidisciplinary approach to determine the least invasive procedure to solve complex conditions, while ensuring the best possible outcomes.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, University of Nebraska College of Medicine (1988)
Undergraduate Schools:
  • BS, Chadron State College (NE) (1984)
  • BA, University of Nebraska Medical Center (NE) (1988)
Residency Programs:
  • Oregon Health & Science University, Surgery (1993)
Fellowships:
  • University of Colorado, Thoracic and Cardiac (1996)
  • University of Colorado (Children's Hospital Colorado) Program, Congenital Cardiac Surgery (1996)
Download CV
Languages: English
Department: Surgery-Cardiothoracic
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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