Jim Lambert, PhD

Publications

• Effect of dietary vitamin D3 and calcium on the growth of androgen-insensitive human prostate tumor in a murine model Ray R, Banks M, Abuzahra H, Persons KS, Eddy VJ, Lambert JR, Holick MF. American Association of Cancer Research Advances in Prostate Cancer Research Conference. February 2012. Orlando, FL.
• Prostate derived factor/macrophage inhibitory cytokine/nonsteroidal anti-inflammatory drug activated gene: A mediator of prostatic inflammation Whitson RJ, Genova E, Torkko K, La Rosa FG, Kelly JA, Wilson S, Lambert JR, Lucia MS. American Association of Cancer Research Advances in Prostate Cancer Research Conference. February 2012. Orlando, FL
• Ray R, Lambert JR. 1a,25-Dihydroxyvitamin D3-3ß-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action. Bioorganic and Medicinal Chemistry Letters. 2011 Apr 15:21(8):2537-40
• Boyes SG, Rowe MD, Serkova NJ, Kim FJ, Lambert JR, Werahera PN. Plymer-modified gadolinium nanoparticles for targeted magnetic resonance imaging and therapy. NanoLife 2011 1(3-4):263-275
• 16. Ray R, Banks M, Abuzahra H, Eddy VJ, Person KS, Lucia MS, Lambert JR, Holick MF. Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model. Anticancer Research.2012 32(3): 727-731.
• From steroid receptors to cytokines: the thermodynamics of self-associating systems. Connaghan KD, Moody AD, Robblee JP, Lambert JR, Bain DL. Biophys Chem. 2011 Nov;159(1):24-32
• Hegyesi H, Lambert JR, Sandor N, Schilling B, Safrany G. Validation of Growth Differentiation Factor (GDF-15) as a radiation response gene and radiosensitizing target in mammary adenocarcinoma model. In Breast Cancer- Recent Advances in Biology, Imaging and Therapeutics. Edited by S. J. Done. InTech Press 2011
• Whitson RJ, Lucia MS, Lambert JR. Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2). J Cell Biochem. 2012 Dec 31 doi: 10.1002/jcb.24483
• Bain DL, Yang Q, Connaghan KD, Robblee JP, Miura MT, DeGala GD, Lambert JR, Maul NK. Glucocorticoid receptor-DNA interactions: Binding energetics ar the primary determinant of sequence-specific transcriptional activity. J. Molecular Biology. 2012 422(1): 18-32.
• Connaghan KD, Miura MT, Maluf NK, Lambert JR, Bain DL. Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control. Biophys. Chem. 2013 172C:8-17
• “Prostate derived factor/macrophage inhibitory cytokine/nonsteroidal anti-inflammatory drug activated gene: A mediator of prostatic inflammation” Whitson RJ, Genova E, Torkko K, La Rosa FG, Kelly JA, Wilson S, Lucia MS, Lambert JR. American Association of Cancer Research Advances in Prostate Cancer Research Conference. February 2012. Orlando, FL.
• “Effect of dietary vitamin D3 and calcium on the growth of androgen-insensitive human prostate tumor in a murine model” Ray R, Banks M, Abuzahra H, Persons KS, Eddy VJ, Lambert JR, Holick MF. American Association of Cancer Research Advances in Prostate Cancer Research Conference. February 2012. Orlando, FL.
• Nordeen SK, Bona BJ, Jones DN, Lambert JR, Jackson TA. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm Cancer. 2013 Oct;4(5):293-300. PubMed PMID: 23836117
• Lambert JR, Whitson RJ, Iczkowski KA, La Rosa FG, Smith ML, Wilson RS, Smith EE, Torkko KC, Gari HH, Lucia MS. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate. Prostate. 2015 Feb;75(3):255-65. PubMed PMID: 25327758
• Connaghan KD, Miura MT, Maluf NK, Lambert JR, Bain DL. Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control. Biophys Chem. 2013 Feb;172:8-17. PubMed PMID: 23333595
• Bain DL, Connaghan KD, Maluf NK, Yang Q, Miura MT, De Angelis RW, Degala GD, Lambert JR. Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation. Nucleic Acids Res. 2014 Jan;42(2):691-700. PubMed PMID: 24064251
• Whitson RJ, Lucia MS, Lambert JR. Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2). J Cell Biochem. 2013 Jun;114(6):1424-33. PubMed PMID: 23280549
• Bain DL, De Angelis RW, Connaghan KD, Yang Q, Degala GD, Lambert JR. Dissecting Steroid Receptor Function by Analytical Ultracentrifugation. Methods Enzymol. 2015;562:363-89. PubMed PMID: 26412661
• De Angelis RW, Maluf NK, Yang Q, Lambert JR, Bain DL. Glucocorticoid Receptor-DNA Dissociation Kinetics Measured in Vitro Reveal Exchange on the Second Time Scale. Biochemistry. 2015 Sep 1;54(34):5306-14. PubMed PMID: 26267475
• Lambert JR, Whitson RJ, Iczkowski KA, La Rosa FG, Smith ML, Wilson RS, Smith EE, Torkko KC, Gari HH, Lucia MS. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate. Prostate. 2015 Feb 15;75(3):255-65. PubMed PMID: 25327758
• Bain DL, Connaghan KD, Maluf NK, Yang Q, Miura MT, De Angelis RW, Degala GD, Lambert JR. Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation. Nucleic Acids Res. 2014 Jan;42(2):691-700. PubMed PMID: 24064251
• A role for the non-conserved N-terminal domain of the TATA-binding proteinin the crosstalk between cell signaling pathways and steroid receptors. Lambert JR, Nordeen SK. AIMS Molecular Science. 2015; 2(2):64-72.
• Gari HH, Gearheart CM, Fosmire S, DeGala GD, Fan Z, Torkko KC, Edgerton SM, Lucia MS, Ray R, Thor AD, Porter CC, Lambert JR. Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers. Oncotarget. 2016 Mar 29;7(13):15757-71. PubMed PMID: 26909599
• Gari HH, DeGala GD, Ray R, Lucia MS, Lambert JR. PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion. Cancer Lett. 2016 Oct 1;380(2):505-12. PubMed PMID: 27452906
• Gari HH, DeGala GD, Lucia MS, Lambert JR. Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth. Oncogenesis. 2016 Aug 15;5(8):e255. PubMed PMID: 27526109
• Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2019 Jan;17(1):30-41. PubMed PMID: 30213797
• Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2019 Jan;17(1):30-41. PubMed PMID: 30213797
• Zhang W, Hu C, Wang X, Bai S, Cao S, Kobelski M, Lambert JR, Gu J, Zhan Y. Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. PLoS One. 2019;14(9):e0222812. PubMed PMID: 31539407
• Mukherjee N, Skees J, Todd KJ, West DA, Lambert KA, Robinson WA, Amato CM, Couts KL, Van Gulick R, MacBeth M, Nassar K, Tan AC, Zhai Z, Fujita M, Bagby SM, Dart CR, Lambert JR, Norris DA, Shellman YG. MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443. PubMed PMID: 32513939
• Dart CR, Mukherjee N, Amato CM, Goulding A, MacBeth M, Van Gulick R, Couts KL, Lambert JR, Norris DA, Robinson WA, Shellman YG. A Novel Regimen for Treating Melanoma: MCL1 Inhibitors and Azacitidine. Pharmaceuticals (Basel). 2021 Jul 30;14(8). PubMed PMID: 34451846
• Mukherjee N, Skees J, Todd KJ, West DA, Lambert KA, Robinson WA, Amato CM, Couts KL, Van Gulick R, MacBeth M, Nassar K, Tan AC, Zhai Z, Fujita M, Bagby SM, Dart CR, Lambert JR, Norris DA, Shellman YG. MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443. PubMed PMID: 32513939
• Mukherjee N, Dart C, Amato C, Honig-Frand A, Lambert J, Lambert K, Robinson W, Tobin R, McCarter M, Couts K, Fujita M, Norris D, Shellman Y. Expression differences in BCL2 family members between uveal and cutaneous melanomas account for varying sensitivity to BH3 mimetics. Journal of Investigative Dermatology.
• Mukherjee N, Dart CR, Amato CM, Honig-Frand A, Lambert JR, Lambert KA, Robinson WA, Tobin RP, McCarter MD, Couts KL, Fujita M, Norris DA, Shellman YG. Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics. J Invest Dermatol. 2022 Jul;142(7):1912-1922.e7. PubMed PMID: 34942200