Raphael Nemenoff, PhD

Publications

• Nemenoff RA, Winn RA. Role of Nuclear Receptors in Lung Tumorigenesis. 2005 Eur. J. Cancer, 41, 2561-8
• Kaplan-Albuquerque N, Bogaert Y, Van Putten V, Weiser-Evans MC, Nemenoff RA. Vasconstrictors and PDGF Mediate Distinct Patterns of Gene Expression in Vascular Smooth Muscle Cells. 2005 J. Biol. Chem.,280, 19966-19976.
• Kaplan-Albuquerque N, Van PuttenV, Nemenoff RA. Depletion of SRF by RNA interference Mimics the Mitogenic Effects of PDGF-BB in Vascular Smooth Muscle Cells. 2005 Circ. Res. 97, 427-433
• Wick M, Blaine S, Van Putten V, Saavedra M, Nemenoff RA. Lung Krüppel-Like Factor (LKLF) is a Transcriptional Activator of the Cytosolic Phospholipase A2 a Promoter. 2005 Biochem. J. 387(part 1) 239-246
• Bren-Mattison Y, Van Putten V, Chan D, Winn R, Nemenoff RA. Peroxisome Proliferator-Activated Receptor-g (PPARg) Inhibits Tumorigenesis by Reversing the Undifferentiated Phenotype of Metastatic Non-small Cell lung Cancer Cells . 2005 Oncogene 24: 1412-1422
• Stearman RA, 1, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn, PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE , Nemenoff RA, Malkinson AM, Geraci MW. Analysis of Orthologous Gene Expression Between Human and Carcinogen-Induced Murine Model of Pulmonary Adenocarcinoma. 2005 Am. J. Pathol. 167, 1763-75
• Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW , Bonventre JV, Nemenoff RA, Malkinson AM. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice. 2006 Am. J. Physiol. In press.
• Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MCM. The EGAP N-Terminal Acetyltransferase Complex is Essential for Embryonic Development by Regulating Cell Proliferation.2006 Circ.Research. in press
• Winn RA, Marek L, Han S-Y, Rodriguez K, Rodriguez N, Acosta H, Mirus J, Barry NP, Hurteau G, Bren-Mattison Y, Nemenoff RA Heasley LE. Restoration of Wnt-7a Expression Reverses Non-Small Cell Lung Cancer Cell Transformation Through Frizzled-9 Mediated Growth Inhibition and Promotion of Cellular Differentiation. 2005, J. Biol. Chem., 280, 19625-19634
• Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA Malkinson AM Attenuation of he pulmonary inflammatory response following butylated hdroytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice. 2006 Am. J. Physiol. 290, l1260-66
• Winn RA, Van Scoykk M, Hammond M, Rodriguez K, Crosso JT, Heasley LE, Nemenoff RA. Antitumorigenic effect of Wnt7a and Fzd9 in Non-Small Cell Lung Cancer Cells is Mediated through ERK-5 Dependent Activation of PPARgamma 2006 J. Biol. Chem. 281, 26943-26950
• Thurman JM, Lendernk AM, Royer PA,Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RH Holers VM. C3a is required for the production of CXC Chemokines by Tubular Epithelial Cells after Renal IIschemica/Reperfusion 2007. J. Immunol. 178, 1819-1828
• Nemenoff RA, Winn RA Role of Nuclear Receptors in Lung Tumorigenesis. 2005 Eur. J. Cancer 41 2561-2568
• Wnzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA Wesier-Evans MCM. The EGAP N-Terminal Acetyltransferase Complex is Essential for Embryonic Development by Regulating Cell Proliferation. 2006 Circ. Research 98, 846-855
• Kaplan-Albuquerque N, Van Putten V, Nemenoff RA. Depletion of SRF by RNA interference mimics the Mitogenic Effects of PDGF-BB in VAscular Smooth Muscle Cells. 2005 Circ. Res. 97, 427-433
• Stearman RA, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Nemenoff, RA, Malkinson AM, Geraqci MW. Analysis of orthologous gene expression between human and carcinogen-induced murine modle of pulmonaary adeoncarcinoma 2006. Am. J. Pathol. 167, 1763-75
• Nemenoff RA Peroxisome Proliferator-Activate Receptor-gamma in Lung Cancer: Defining specific versus "off-target" effectors. 2007 Journal of Thoracic Oncology 2 989-992
• Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. (2007) C3a is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renacl Ischemia/Reperfusion. Journal of Immunology 178, 1819-1828
• Bren-Mattison Y, Meyer AM, VanPutten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic effects of PPARgamma in NSCLC are mediated by suppression of COX-2 vis NF-kB. 2008, Molecular Pharmacology in press
• Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Mak TW, Weiser-Evans MCM. Targeted Deletion of PTEN in Smooth Muscle Cells Results in Vascular Remodeling and Recruitment of Progenitor Cells Through Induction of SDF-1?. 2008. Circ. Res. 102, 1036-45.
• Nemenoff RA,Meyer AM, Hudich TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn RA, Weiser-Evans M, Geraci MW, Keith RL. Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of PPAR?. 2008 Cancer Prevention Res. 1, 349-56. PMID: 19138979
• Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic Effects of Peroxisome Proliferator-Activated Receptor-g (PPARg) in Non-small Cell Lung Cancer Cells (NSCLC) are Mediated by Suppression of COX-2 via Inhibition of NF-?B. 2008. Mol Pharm. 73, 709-717.
• Nemenoff RA, Weiser-Evans M, Winn RA. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-??Ligands in Lung Cancer, 2008. PPAR Res.
• Wang X-Q, Li H, Van Putten V, Winn RA, Heasley LE Nemenoff RA. Oncogenic K-Ras Regulates Proliferation and Cell Junctions in Lung Epithelial Cells Through Induction of COX-2 and Activation of MMP-9. 2009. Mol Biol Cell. 20, 791-800.
• Marek L, Ware KE, Fritzsche A, Hercule P, Helton WA, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, HeasleyLE.. Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells. 2009 Mol. Pharm. 75:196-207.
• Neil JR, Johnson KM, Nemenoff RA, Schiemann WP, COX-2 Inactivates Smad Signaling and Enhances EMT Stimulated by TGF-? Through a PGE2-Dependent Mechanism. 2008 Carcinogenesis; 29, 2227-35.
• Weiser-Evans MCM, Wang X-Q, Amin J, Van Putten V, Choudhary R, Winn RAM Scheinman R, Simpson P, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. 2009. Cancer Res. In press
• Weiser-Evans MCM, Wang X-Q, Amin J, Van Putten V, Choudhary R, Winn RAM Scheinman R, Simpson P, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. 2009. Cancer Res. 69: 1733-8. PMID: 19208832.
• Qin Z, Konaniah, ES, Neltner B, Nemenoff RA, Hui DY, Weintraub NL. Participation of ATP7A in macrophage mediated oxidation of low density lipoprotein. 2010. J. Lipid Res. In Press.
• Tennis, MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin and Its Synthetic Analogues are Small-Molecule Agonists of Frizzled 9 Mediating Growth Inhibition of Non Small Cell Lung Cancer Cells.. 2010. Neoplasia in press.
• Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MCM, Nemenoff RA. Peroxisome Proliferator-Activated Receptor-?(PPAR?) Inhibits Transformed Growth of Non- Small Cell Lung Cancer Cells Through Selective Suppression of Snail. 2010. Neoplasia, in Press
• Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC. Smooth Muscle-specific Deletion of PTEN Promotes Phenotypic Modulation, Inflammatory Cytokine Production, and Enhances Neointima Formation Following Vascular Injury. 2010. Cardiovascular Res. In press.
• Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MCM, Nemenoff RA. Peroxisome Proliferator-Activated Receptor-?(PPAR?) Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells Through Selective Suppression of Snail. 2010. Neoplasia 12:224-234
• Spiegel D, Nemenoff RA. Recombinant human erythropoietin dosing errors due to concentrated EPO. 2010. Clin Nephrol. 73: 446-8.
• Meng L, VanPutten V, Qu L, Nemenoff RA, Shang MY Cai SQ, Li X. Altered expression of genes profiles modulated by a combination of astagali radix and angelicae sinensis in obstructed kidney. 2010. Plant Med. 76: 1431-38.
• Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC. Smooth Muscle-specific Deletion of PTEN Promotes Phenotypic Modulation, Inflammatory Cytokine Production, and Enhances Neointima Formation Following Vascular Injury. 2010. Cardiovascular Res. 86: 274-82
• Tennis, MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin and Its Synthetic Analogues are Small-Molecule Agonists of Frizzled 9 Mediating Growth Inhibition of Non Small Cell Lung Cancer Cells.. 2010. Neoplasia 12: 244-53
• Tennis MA, VanScoyk M, Freeman S, Vandervest K, Nemenoff R, Winn RA. Sprouty-4 inhibits transformed cell growth, migration and invasion, and EMT and is regulated by Wnt7A through PPAR? in NSCLC. 2010. Molecular Cancer Research. 8: 833-43
• Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MCM, Nemenoff RA. Serum Response Factor Regulates Expression of PTEN through a Micro-RNA Network in Vascular Smooth Muscle Cells. 2011 Arterioscler Thromb Vasc Biol, 12: 2909-19
• Li H, Sorenson AL, Sorenson AL, Poczobutt J, Amin J, Sullivan T, Crossno JT Jr., WeiserEvans MCM, Nemenoff RA. Activation of PPAR? in Myeloid Cells Promotes Lung Cancer Progression and Metastasis. 2011. PLOS1, 6: e28133.
• Andres-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff RA, He Z, Ishimoto T, Simpson PA, Weiser-Evans MCM, Bacalja J, Faubel S. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. 2011 Am J Physiol Renal Physiol, 301: F907-16.
• Nemenoff RA, Horita H, OstrikerAC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MCM. SDF-1{alpha} Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. 2011 Arterioscler Thromb Vasc Biol, 31: 1300-8 .
• Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, et al. Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism. Circ Res 2012.
• Author's View: Activation of PPARc in myeloid cells promotes lung cancer progression and metastasis. Oncoimmunology 3, 2012
• Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, et al. Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells. J Thorac Cardiovasc Surg. 2012. 6:1479-85.
• Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, et al. Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg. 2012;144:1185-91.
• Nemenoff R. Activation of PPARgamma in myeloid cells promotes lung cancer progression and metastasis. Oncoimmunology. 2012;1:403-4. PMCID: 3382846
• Li H, Weiser-Evans MC, Nemenoff R. Anti- and Protumorigenic Effects of PPARgamma in Lung Cancer Progression: A Double-Edged Sword. PPAR Res. 2012;2012:362085. 3425863
• Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, and McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. 2012 Circ Res 110: 739-748.
• Majka SM MH, sullivan T, Erickson PF, Kong R, Weiser-Evans M, Nemenoff RA, Modldovan R, Moarandi SA, Davis JA, Klemm DJ. Adipose lineage specification of bone marrow-derived myeloid cells. Adipocyte. 2012;1:216-29
• Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation. Immunity. 2014 Jan 16;40(1):66-77. PubMed PMID: 24412613
• Poczobutt JM, Gijon M, Amin J, Hanson D, Li H, Walker D, Weiser-Evans M, Lu X, Murphy RC, Nemenoff RA. Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. PLoS One. 2013;8(11):e79633. PubMed PMID: 24244531
• Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC. Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension. J Am Heart Assoc. 2013 May 31;2(3):e000188. PubMed PMID: 23727701
• Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. J Allergy Clin Immunol. 2014 Dec 9. [Epub ahead of print] PubMed PMID: 25498313
• Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL. Homeoprotein Six2 Promotes Breast Cancer Metastasis via Transcriptional and Epigenetic Control of E-Cadherin Expression. Cancer Res. 2014 Dec 15;74(24):7357-70. PubMed PMID: 25348955
• Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells. Mol Pharmacol. 2014 Nov;86(5):570-9. PubMed PMID: 25169989
• Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE. Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma. Mol Cancer Res. 2014 Oct;12(10):1460-9. PubMed PMID: 24966347
• Ostriker A, Horita HN, Poczobutt J, Weiser-Evans MC, Nemenoff RA. Vascular smooth muscle cell-derived transforming growth factor-ß promotes maturation of activated, neointima lesion-like macrophages. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):877-86. PubMed PMID: 24526697
• Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16;40(1):66-77. PubMed PMID: 24412613
• Ostriker A, HoritaH, Poczobutt J, Weiser-Evans MCM, Nemenoff RA. Smooth Muscle Cell-derived TGF-ß Promotes Maturation of Activated, Neointima Lesion-Like Macrophages Arterioscler Thromb Vasc Biol. 2014, in press
• Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781
• Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2015 Dec 1. [Epub ahead of print] PubMed PMID: 26620676
• Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. J Allergy Clin Immunol. 2015 Feb;135(2):517-527.e12. PubMed PMID: 25498313
• Poczobutt JM, De S, Vadav VK, Nguyen T, Li H, Sipple T, Weiser-Evans MCM, NemenoffRAExpression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer J. Immunol. 2016 in press
• Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16;6(1):e287. PubMed PMID: 28092369
• Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC. Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4. Circ Res. 2017 Jan 20;120(2):296-311. PubMed PMID: 27834190
• Ranjit S, Dobrinskikh E, Montford J, Dvornikov A, Lehman A, Orlicky DJ, Nemenoff R, Gratton E, Levi M, Furgeson S. Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis. Kidney Int. 2016 Nov;90(5):1123-1128. PubMed PMID: 27555119
• Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Cytosolic phospholipase A(2)a increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins Other Lipid Mediat. 2016 Nov;126:1-8. PubMed PMID: 27554058
• Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 1;200(1):3-22. PubMed PMID: 29255085
• Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone Marrow-Derived cPLA2a Contributes to Renal Fibrosis Progression. J Lipid Res. 2017 Dec 11. [Epub ahead of print] PubMed PMID: 29229740
• Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967
• Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090
• Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff RA, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2017 Oct 25;:ajprenal.00040.2017. [Epub ahead of print] PubMed PMID: 29070568
• Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Cancer Immunol Res. 2017 Sep;5(9):767-777. PubMed PMID: 28819064
• Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16;6(1):e287. PubMed PMID: 28092369
• Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC. Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4. Circ Res. 2017 Jan 20;120(2):296-311. PubMed PMID: 27834190
• Thurman JM, Nemenoff RA. Never make assumptions: the complicated role of complement in urinary tract infections. Kidney Int. 2016 Sep;90(3):469-71. PubMed PMID: 27521106
• Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 4;7:10830. PubMed PMID: 26940659
• Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891
• Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K. CD8( ) T cells modulate autosomal dominant polycystic kidney disease progression. Kidney Int. 2018 Dec;94(6):1127-1140. PubMed PMID: 30249452
• Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey E, Nemenoff R, Karam SD. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018 Nov 1;24(21):5368-5380. PubMed PMID: 30042205
• Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 Sep 1;78(17):4971-4983. PubMed PMID: 29997230
• Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP. Adenoviral vectors transduce alveolar macrophages in lung cancer models. Oncoimmunology. 2018;7(6):e1438105. PubMed PMID: 29872579
• Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA. Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4 T lymphocytes in tumors that express MHC class II. Oncoimmunology. 2018;7(5):e1423182. PubMed PMID: 29721380
• Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. JCI Insight. 2018 Feb 22;3(4). [Epub ahead of print] PubMed PMID: 29467331
• Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 1;200(1):3-22. PubMed PMID: 29255085
• Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 Feb;59(2):380-390. PubMed PMID: 29229740
• Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967
• Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090
• Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff R, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F356-F366. PubMed PMID: 29070568
• Poczobutt JM, De S, Yadav VK, Nguyen TT, Li H, Sippel TR, Weiser-Evans MC, Nemenoff RA. Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer. J Immunol. 2016 Mar 15;196(6):2847-59. PubMed PMID: 26873985
• Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781
• Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2016 Apr;94(4):443-55. PubMed PMID: 26620676
• Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling. Arterioscler Thromb Vasc Biol. 2019 Dec 19;:ATVBAHA119313757. [Epub ahead of print] PubMed PMID: 31852223
• Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA. Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer. Front Immunol. 2019;10:954. PubMed PMID: 31134065
• Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA. Tumor-intrinsic response to IFN? shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Sci Alliance. 2019 Jun;2(3). PubMed PMID: 31133614
• Sippel TR, Johnson AM, Li HY, Hanson D, Nguyen TT, Bullock BL, Poczobutt JM, Kwak JW, Kleczko EK, Weiser-Evans MC, Nemenoff RA. Activation of PPAR? in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFß1. Mol Cancer Res. 2019 Aug;17(8):1748-1758. PubMed PMID: 31088909
• Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843
• Montford JR, Bauer C, Dobrinskikh E, Hopp K, Levi M, Weiser-Evans M, Nemenoff R, Furgeson SB. Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F732-F742. PubMed PMID: 30649890
• Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891
• Ng TL, Johnson A, Nemenoff RA, Hsieh E, Osypuk AA, van Bokhoven A, Li H, Camidge DR, Schenk EL. Brief Report: Prospective observational study showing early pulmonary function changes associated with brigatinib initiation. J Thorac Oncol. 2020 Dec 8. [Epub ahead of print] PubMed PMID: 33307191
• Thurman JM, Laskowski J, Nemenoff RA. Complement and Cancer-A Dysfunctional Relationship?. Antibodies (Basel). 2020 Nov 5;9(4). PubMed PMID: 33167384
• Lu S, Jolly AJ, Strand KA, Dubner AM, Mutryn MF, Moulton KS, Nemenoff RA, Majesky MW, Weiser-Evans MC. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. JCI Insight. 2020 Dec 3;5(23). PubMed PMID: 33119549
• Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1854-1869. PubMed PMID: 32580634
• Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 Aug 3;130(8):4039-4054. PubMed PMID: 32369457
• Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment. J Thorac Oncol. 2021 Oct;16(10):1694-1704. PubMed PMID: 34048945
• Gurule NJ, McCoach CE, Hinz TK, Merrick DT, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff RA, Tan AC, Doebele RC, Heasley LE. A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer. NPJ Precis Oncol. 2021 May 17;5(1):41. PubMed PMID: 34001994
• Jolly AJ, Lu S, Strand KA, Dubner AM, Mutryn MF, Nemenoff RA, Majesky MW, Moulton KS, Weiser-Evans MCM. Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodeling. Cardiovasc Res. 2021 May 14. [Epub ahead of print] PubMed PMID: 33989378
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341
• Johnson AM, Kleczko EK, Nemenoff RA. Eicosanoids in Cancer: New Roles in Immunoregulation. Front Pharmacol. 2020;11:595498. PubMed PMID: 33364964
• Ng TL, Johnson A, Nemenoff RA, Hsieh E, Osypuk AA, van Bokhoven A, Li H, Camidge DR, Schenk EL. Prospective Observational Study Revealing Early Pulmonary Function Changes Associated With Brigatinib Initiation. J Thorac Oncol. 2021 Mar;16(3):486-491. PubMed PMID: 33307191
• Thurman JM, Laskowski J, Nemenoff RA. Complement and Cancer-A Dysfunctional Relationship?. Antibodies (Basel). 2020 Nov 5;9(4). PubMed PMID: 33167384
• Lu S, Jolly AJ, Strand KA, Dubner AM, Mutryn MF, Moulton KS, Nemenoff RA, Majesky MW, Weiser-Evans MC. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. JCI Insight. 2020 Dec 3;5(23). PubMed PMID: 33119549
• Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1854-1869. PubMed PMID: 32580634
• Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 Aug 3;130(8):4039-4054. PubMed PMID: 32369457
• Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 Apr;8(1). PubMed PMID: 32312906
• Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cell Signal. 2020 Jul;71:109605. PubMed PMID: 32194168
• Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. J Immunol. 2020 Apr 15;204(8):2295-2307. PubMed PMID: 32179637
• Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):394-403. PubMed PMID: 31852223
• Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 Apr;8(1). PubMed PMID: 32312906
• Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cell Signal. 2020 Jul;71:109605. PubMed PMID: 32194168
• Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. J Immunol. 2020 Apr 15;204(8):2295-2307. PubMed PMID: 32179637
• Nemenoff RA, Kleczko EK, Hopp K. Renal double negative T cells: unconventional cells in search of a function. Ann Transl Med. 2019 Dec;7(Suppl 8):S342. PubMed PMID: 32016060
• Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):394-403. PubMed PMID: 31852223
• Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2022 Nov 24. [Epub ahead of print] PubMed PMID: 36422996
• Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA. Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer. Front Immunol. 2019;10:954. PubMed PMID: 31134065
• Seal S, Wrobel J, Johnson AM, Nemenoff RA, Schenk EL, Bitler BG, Jordan KR, Ghosh D. On clustering for cell-phenotyping in multiplex immunohistochemistry (mIHC) and multiplexed ion beam imaging (MIBI) data. BMC Res Notes. 2022 Jun 20;15(1):215. PubMed PMID: 35725622
• Hopp K, Catenacci VA, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson GC, Jackman MR, Miller M, Steele CN, Serkova NJ, MacLean PS, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease. iScience. 2022 Jan 21;25(1):103697. PubMed PMID: 35059607
• Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F105-F119. PubMed PMID: 34866403
• Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment. J Thorac Oncol. 2021 Oct;16(10):1694-1704. PubMed PMID: 34048945
• Gurule NJ, McCoach CE, Hinz TK, Merrick DT, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff RA, Tan AC, Doebele RC, Heasley LE. A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer. NPJ Precis Oncol. 2021 May 17;5(1):41. PubMed PMID: 34001994
• Jolly AJ, Lu S, Strand KA, Dubner AM, Mutryn MF, Nemenoff RA, Majesky MW, Moulton KS, Weiser-Evans MCM. Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling. Cardiovasc Res. 2022 May 6;118(6):1452-1465. PubMed PMID: 33989378
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341
• Ng TL, Johnson A, Nemenoff RA, Hsieh E, Osypuk AA, van Bokhoven A, Li H, Camidge DR, Schenk EL. Prospective Observational Study Revealing Early Pulmonary Function Changes Associated With Brigatinib Initiation. J Thorac Oncol. 2021 Mar;16(3):486-491. PubMed PMID: 33307191
• Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner. JCI Insight. 2023 Nov 22;8(22). PubMed PMID: 37991018
• Corey Z, Schechter E, Nemenoff RA. Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation. Cell Chem Biol. 2023 Sep 21;30(9):1004-1006. PubMed PMID: 37738950
• Dubner AM, Lu S, Jolly AJ, Noble T, Hinthorn T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MCM. Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research-Brief Report. Arterioscler Thromb Vasc Biol. 2023 Nov;43(11):2223-2230. PubMed PMID: 37706321
• Dubner AM, Lu S, Jolly AJ, Strand KA, Mutryn MF, Hinthorn T, Noble T, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner. bioRxiv. 2023 Jul 19. PubMed PMID: 37503181
• Schubert L, Le AT, Hinz TK, Navarro AC, Nelson-Taylor SK, Nemenoff RA, Heasley LE, Doebele RC. A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes. Biol Open. 2023 Aug 15;12(8). PubMed PMID: 37470475
• Kleczko EK, Nguyen DT, Marsh KH, Bauer CD, Li AS, Monaghan MT, Berger MD, Furgeson SB, Gitomer BY, Chonchol MB, Clambey ET, Zimmerman KA, Nemenoff RA, Hopp K. Immune checkpoint activity regulates polycystic kidney disease progression. JCI Insight. 2023 Jun 22;8(12). PubMed PMID: 37345660
• Schubert L, Le AT, Hinz TK, Navarro A, Nelson-Taylor SK, Nemenoff RA, Heasley LE, Doebele RC. A Rapid, Functional sgRNA Screening Method for Generating Murine RET and NTRK1 Fusion Oncogenes. bioRxiv. 2023 Apr 6. PubMed PMID: 37066347
• Jolly AJ, Lu S, Dubner AM, Strand KA, Mutryn MF, Pilotti-Riley A, Danis EP, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis. JCI Insight. 2023 May 8;8(9). PubMed PMID: 36976650
• Sisler DJ, Hinz TK, Le AT, Kleczko EK, Nemenoff RA, Heasley LE. Evaluation of KRAS(G12C) inhibitor responses in novel murine KRAS(G12C) lung cancer cell line models. Front Oncol. 2023;13:1094123. PubMed PMID: 36845684
• Kleczko EK, Hinz TK, Nguyen TT, Gurule NJ, Navarro A, Le AT, Johnson AM, Kwak J, Polhac DI, Clambey ET, Weiser-Evans M, Merrick DT, Yang MC, Patil T, Schenk EL, Heasley LE, Nemenoff RA. Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. NPJ Precis Oncol. 2023 Feb 4;7(1):15. PubMed PMID: 36739466
• Kleczko EK, Poczobutt JM, Navarro AC, Laskowski J, Johnson AM, Korpela SP, Gurule NJ, Heasley LE, Hopp K, Weiser-Evans MCM, Gottlin EB, Bushey RT, Campa MJ, Patz EF Jr, Thurman JM, Nemenoff RA. Upregulation of complement proteins in lung cancer cells mediates tumor progression. Front Oncol. 2022;12:1045690. PubMed PMID: 36686777
• Kleczko EK, Le AT, Hinz TK, Nguyen TT, Navarro A, Hu CJ, Selman AM, Clambey ET, Merrick DT, Lu S, Weiser-Evans M, Nemenoff RA, Heasley LE. Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response. Cancer Lett. 2023 Mar 1;556:216062. PubMed PMID: 36657561
• Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2023 Jan 10;8(1). PubMed PMID: 36422996

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• Nephrology