Raphael Nemenoff, PhD

Stearman RA, 1, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn, PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE , Nemenoff RA, Malkinson AM, Geraci MW. Analysis of Orthologous Gene Expression Between Human and Carcinogen-Induced Murine Model of Pulmonary Adenocarcinoma. 2005 Am. J. Pathol. 167, 1763-75

Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW , Bonventre JV, Nemenoff RA, Malkinson AM. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice. 2006 Am. J. Physiol. In press.

Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MCM. The EGAP N-Terminal Acetyltransferase Complex is Essential for Embryonic Development by Regulating Cell Proliferation.2006 Circ.Research. in press

Winn RA, Marek L, Han S-Y, Rodriguez K, Rodriguez N, Acosta H, Mirus J, Barry NP, Hurteau G, Bren-Mattison Y, Nemenoff RA Heasley LE. Restoration of Wnt-7a Expression Reverses Non-Small Cell Lung Cancer Cell Transformation Through Frizzled-9 Mediated Growth Inhibition and Promotion of Cellular Differentiation. 2005, J. Biol. Chem., 280, 19625-19634

Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA Malkinson AM Attenuation of he pulmonary inflammatory response following butylated hdroytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice. 2006 Am. J. Physiol. 290, l1260-66

Winn RA, Van Scoykk M, Hammond M, Rodriguez K, Crosso JT, Heasley LE, Nemenoff RA. Antitumorigenic effect of Wnt7a and Fzd9 in Non-Small Cell Lung Cancer Cells is Mediated through ERK-5 Dependent Activation of PPARgamma 2006 J. Biol. Chem. 281, 26943-26950

Thurman JM, Lendernk AM, Royer PA,Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RH Holers VM. C3a is required for the production of CXC Chemokines by Tubular Epithelial Cells after Renal IIschemica/Reperfusion 2007. J. Immunol. 178, 1819-1828

Nemenoff RA, Winn RA Role of Nuclear Receptors in Lung Tumorigenesis. 2005 Eur. J. Cancer 41 2561-2568

Wnzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA Wesier-Evans MCM. The EGAP N-Terminal Acetyltransferase Complex is Essential for Embryonic Development by Regulating Cell Proliferation. 2006 Circ. Research 98, 846-855

Kaplan-Albuquerque N, Van Putten V, Nemenoff RA. Depletion of SRF by RNA interference mimics the Mitogenic Effects of PDGF-BB in VAscular Smooth Muscle Cells. 2005 Circ. Res. 97, 427-433

Stearman RA, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Nemenoff, RA, Malkinson AM, Geraqci MW. Analysis of orthologous gene expression between human and carcinogen-induced murine modle of pulmonaary adeoncarcinoma 2006. Am. J. Pathol. 167, 1763-75

Nemenoff RA Peroxisome Proliferator-Activate Receptor-gamma in Lung Cancer: Defining specific versus "off-target" effectors. 2007 Journal of Thoracic Oncology 2 989-992

Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. (2007) C3a is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renacl Ischemia/Reperfusion. Journal of Immunology 178, 1819-1828

Bren-Mattison Y, Meyer AM, VanPutten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic effects of PPARgamma in NSCLC are mediated by suppression of COX-2 vis NF-kB. 2008, Molecular Pharmacology in press

Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Mak TW, Weiser-Evans MCM. Targeted Deletion of PTEN in Smooth Muscle Cells Results in Vascular Remodeling and Recruitment of Progenitor Cells Through Induction of SDF-1?. 2008. Circ. Res. 102, 1036-45.

Nemenoff RA,Meyer AM, Hudich TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn RA, Weiser-Evans M, Geraci MW, Keith RL. Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of PPAR?. 2008 Cancer Prevention Res. 1, 349-56. PMID: 19138979

Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA. Antitumorigenic Effects of Peroxisome Proliferator-Activated Receptor-g (PPARg) in Non-small Cell Lung Cancer Cells (NSCLC) are Mediated by Suppression of COX-2 via Inhibition of NF-?B. 2008. Mol Pharm. 73, 709-717.

Nemenoff RA, Weiser-Evans M, Winn RA. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-??Ligands in Lung Cancer, 2008. PPAR Res.

Wang X-Q, Li H, Van Putten V, Winn RA, Heasley LE Nemenoff RA. Oncogenic K-Ras Regulates Proliferation and Cell Junctions in Lung Epithelial Cells Through Induction of COX-2 and Activation of MMP-9. 2009. Mol Biol Cell. 20, 791-800.

Marek L, Ware KE, Fritzsche A, Hercule P, Helton WA, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, HeasleyLE.. Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells. 2009 Mol. Pharm. 75:196-207.

Neil JR, Johnson KM, Nemenoff RA, Schiemann WP, COX-2 Inactivates Smad Signaling and Enhances EMT Stimulated by TGF-? Through a PGE2-Dependent Mechanism. 2008 Carcinogenesis; 29, 2227-35.

Weiser-Evans MCM, Wang X-Q, Amin J, Van Putten V, Choudhary R, Winn RAM Scheinman R, Simpson P, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. 2009. Cancer Res. In press

Weiser-Evans MCM, Wang X-Q, Amin J, Van Putten V, Choudhary R, Winn RAM Scheinman R, Simpson P, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. 2009. Cancer Res. 69: 1733-8. PMID: 19208832.

Qin Z, Konaniah, ES, Neltner B, Nemenoff RA, Hui DY, Weintraub NL. Participation of ATP7A in macrophage mediated oxidation of low density lipoprotein. 2010. J. Lipid Res. In Press.

Tennis, MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin and Its Synthetic Analogues are Small-Molecule Agonists of Frizzled 9 Mediating Growth Inhibition of Non Small Cell Lung Cancer Cells.. 2010. Neoplasia in press.

Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MCM, Nemenoff RA. Peroxisome Proliferator-Activated Receptor-?(PPAR?) Inhibits Transformed Growth of Non- Small Cell Lung Cancer Cells Through Selective Suppression of Snail. 2010. Neoplasia, in Press

Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC. Smooth Muscle-specific Deletion of PTEN Promotes Phenotypic Modulation, Inflammatory Cytokine Production, and Enhances Neointima Formation Following Vascular Injury. 2010. Cardiovascular Res. In press.

Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MCM, Nemenoff RA. Peroxisome Proliferator-Activated Receptor-?(PPAR?) Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells Through Selective Suppression of Snail. 2010. Neoplasia 12:224-234

Spiegel D, Nemenoff RA. Recombinant human erythropoietin dosing errors due to concentrated EPO. 2010. Clin Nephrol. 73: 446-8.

Meng L, VanPutten V, Qu L, Nemenoff RA, Shang MY Cai SQ, Li X. Altered expression of genes profiles modulated by a combination of astagali radix and angelicae sinensis in obstructed kidney. 2010. Plant Med. 76: 1431-38.

Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC. Smooth Muscle-specific Deletion of PTEN Promotes Phenotypic Modulation, Inflammatory Cytokine Production, and Enhances Neointima Formation Following Vascular Injury. 2010. Cardiovascular Res. 86: 274-82

Tennis, MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA. Prostacyclin and Its Synthetic Analogues are Small-Molecule Agonists of Frizzled 9 Mediating Growth Inhibition of Non Small Cell Lung Cancer Cells.. 2010. Neoplasia 12: 244-53

Tennis MA, VanScoyk M, Freeman S, Vandervest K, Nemenoff R, Winn RA. Sprouty-4 inhibits transformed cell growth, migration and invasion, and EMT and is regulated by Wnt7A through PPAR? in NSCLC. 2010. Molecular Cancer Research. 8: 833-43

Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MCM, Nemenoff RA. Serum Response Factor Regulates Expression of PTEN through a Micro-RNA Network in Vascular Smooth Muscle Cells. 2011 Arterioscler Thromb Vasc Biol, 12: 2909-19

Li H, Sorenson AL, Sorenson AL, Poczobutt J, Amin J, Sullivan T, Crossno JT Jr., WeiserEvans MCM, Nemenoff RA. Activation of PPAR? in Myeloid Cells Promotes Lung Cancer Progression and Metastasis. 2011. PLOS1, 6: e28133.

Andres-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff RA, He Z, Ishimoto T, Simpson PA, Weiser-Evans MCM, Bacalja J, Faubel S. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. 2011 Am J Physiol Renal Physiol, 301: F907-16.

Nemenoff RA, Horita H, OstrikerAC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MCM. SDF-1{alpha} Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. 2011 Arterioscler Thromb Vasc Biol, 31: 1300-8 .

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, et al. Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism. Circ Res 2012.

Author's View: Activation of PPARc in myeloid cells promotes lung cancer progression and metastasis. Oncoimmunology 3, 2012

Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, et al. Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells. J Thorac Cardiovasc Surg. 2012. 6:1479-85.

Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, et al. Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg. 2012;144:1185-91.

Nemenoff R. Activation of PPARgamma in myeloid cells promotes lung cancer progression and metastasis. Oncoimmunology. 2012;1:403-4. PMCID: 3382846

Li H, Weiser-Evans MC, Nemenoff R. Anti- and Protumorigenic Effects of PPARgamma in Lung Cancer Progression: A Double-Edged Sword. PPAR Res. 2012;2012:362085. 3425863

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, and McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. 2012 Circ Res 110: 739-748.

Majka SM MH, sullivan T, Erickson PF, Kong R, Weiser-Evans M, Nemenoff RA, Modldovan R, Moarandi SA, Davis JA, Klemm DJ. Adipose lineage specification of bone marrow-derived myeloid cells. Adipocyte. 2012;1:216-29

Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation. Immunity. 2014 Jan 16;40(1):66-77. PubMed PMID: 24412613

Poczobutt JM, Gijon M, Amin J, Hanson D, Li H, Walker D, Weiser-Evans M, Lu X, Murphy RC, Nemenoff RA. Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. PLoS One. 2013;8(11):e79633. PubMed PMID: 24244531

Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC. Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension. J Am Heart Assoc. 2013 May 31;2(3):e000188. PubMed PMID: 23727701

Ostriker A, HoritaH, Poczobutt J, Weiser-Evans MCM, Nemenoff RA. Smooth Muscle Cell-derived TGF-ß Promotes Maturation of Activated, Neointima Lesion-Like Macrophages Arterioscler Thromb Vasc Biol. 2014, in press

Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. J Allergy Clin Immunol. 2014 Dec 9. [Epub ahead of print] PubMed PMID: 25498313

Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL. Homeoprotein Six2 Promotes Breast Cancer Metastasis via Transcriptional and Epigenetic Control of E-Cadherin Expression. Cancer Res. 2014 Dec 15;74(24):7357-70. PubMed PMID: 25348955

Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells. Mol Pharmacol. 2014 Nov;86(5):570-9. PubMed PMID: 25169989

Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE. Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma. Mol Cancer Res. 2014 Oct;12(10):1460-9. PubMed PMID: 24966347

Ostriker A, Horita HN, Poczobutt J, Weiser-Evans MC, Nemenoff RA. Vascular smooth muscle cell-derived transforming growth factor-ß promotes maturation of activated, neointima lesion-like macrophages. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):877-86. PubMed PMID: 24526697

Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16;40(1):66-77. PubMed PMID: 24412613

Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781

Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16;6(1):e287. PubMed PMID: 28092369

Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC. Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4. Circ Res. 2017 Jan 20;120(2):296-311. PubMed PMID: 27834190

Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2015 Dec 1. [Epub ahead of print] PubMed PMID: 26620676

Ranjit S, Dobrinskikh E, Montford J, Dvornikov A, Lehman A, Orlicky DJ, Nemenoff R, Gratton E, Levi M, Furgeson S. Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis. Kidney Int. 2016 Nov;90(5):1123-1128. PubMed PMID: 27555119

Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Cytosolic phospholipase A(2)a increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins Other Lipid Mediat. 2016 Nov;126:1-8. PubMed PMID: 27554058

Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. J Allergy Clin Immunol. 2015 Feb;135(2):517-527.e12. PubMed PMID: 25498313

Thurman JM, Nemenoff RA. Never make assumptions: the complicated role of complement in urinary tract infections. Kidney Int. 2016 Sep;90(3):469-71. PubMed PMID: 27521106

Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 4;7:10830. PubMed PMID: 26940659

Poczobutt JM, De S, Yadav VK, Nguyen TT, Li H, Sippel TR, Weiser-Evans MC, Nemenoff RA. Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer. J Immunol. 2016 Mar 15;196(6):2847-59. PubMed PMID: 26873985

Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781

Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2016 Apr;94(4):443-55. PubMed PMID: 26620676

Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 1;200(1):3-22. PubMed PMID: 29255085

Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone Marrow-Derived cPLA2a Contributes to Renal Fibrosis Progression. J Lipid Res. 2017 Dec 11. [Epub ahead of print] PubMed PMID: 29229740

Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090

Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff RA, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2017 Oct 25;:ajprenal.00040.2017. [Epub ahead of print] PubMed PMID: 29070568

Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Cancer Immunol Res. 2017 Sep;5(9):767-777. PubMed PMID: 28819064

Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16;6(1):e287. PubMed PMID: 28092369

Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC. Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4. Circ Res. 2017 Jan 20;120(2):296-311. PubMed PMID: 27834190

Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891

Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K. CD8( ) T cells modulate autosomal dominant polycystic kidney disease progression. Kidney Int. 2018 Dec;94(6):1127-1140. PubMed PMID: 30249452

Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey E, Nemenoff R, Karam SD. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018 Nov 1;24(21):5368-5380. PubMed PMID: 30042205

Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 Sep 1;78(17):4971-4983. PubMed PMID: 29997230

Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP. Adenoviral vectors transduce alveolar macrophages in lung cancer models. Oncoimmunology. 2018;7(6):e1438105. PubMed PMID: 29872579

Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA. Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4 T lymphocytes in tumors that express MHC class II. Oncoimmunology. 2018;7(5):e1423182. PubMed PMID: 29721380

Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. JCI Insight. 2018 Feb 22;3(4). [Epub ahead of print] PubMed PMID: 29467331

Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 1;200(1):3-22. PubMed PMID: 29255085

Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 Feb;59(2):380-390. PubMed PMID: 29229740

Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090

Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff R, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL. IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F356-F366. PubMed PMID: 29070568

Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling. Arterioscler Thromb Vasc Biol. 2019 Dec 19;:ATVBAHA119313757. [Epub ahead of print] PubMed PMID: 31852223

Poczobutt JM, De S, Vadav VK, Nguyen T, Li H, Sipple T, Weiser-Evans MCM, NemenoffRAExpression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer J. Immunol. 2016 in press

Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA. Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer. Front Immunol. 2019;10:954. PubMed PMID: 31134065

Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA. Tumor-intrinsic response to IFN? shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Sci Alliance. 2019 Jun;2(3). PubMed PMID: 31133614

Sippel TR, Johnson AM, Li HY, Hanson D, Nguyen TT, Bullock BL, Poczobutt JM, Kwak JW, Kleczko EK, Weiser-Evans MC, Nemenoff RA. Activation of PPAR? in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFß1. Mol Cancer Res. 2019 Aug;17(8):1748-1758. PubMed PMID: 31088909

Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843

Montford JR, Bauer C, Dobrinskikh E, Hopp K, Levi M, Weiser-Evans M, Nemenoff R, Furgeson SB. Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F732-F742. PubMed PMID: 30649890

Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891

Ng TL, Johnson A, Nemenoff RA, Hsieh E, Osypuk AA, van Bokhoven A, Li H, Camidge DR, Schenk EL. Brief Report: Prospective observational study showing early pulmonary function changes associated with brigatinib initiation. J Thorac Oncol. 2020 Dec 8. [Epub ahead of print] PubMed PMID: 33307191

Thurman JM, Laskowski J, Nemenoff RA. Complement and Cancer-A Dysfunctional Relationship?. Antibodies (Basel). 2020 Nov 5;9(4). PubMed PMID: 33167384

Lu S, Jolly AJ, Strand KA, Dubner AM, Mutryn MF, Moulton KS, Nemenoff RA, Majesky MW, Weiser-Evans MC. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. JCI Insight. 2020 Dec 3;5(23). PubMed PMID: 33119549

Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1854-1869. PubMed PMID: 32580634

Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 Aug 3;130(8):4039-4054. PubMed PMID: 32369457

Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 Apr;8(1). PubMed PMID: 32312906

Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cell Signal. 2020 Jul;71:109605. PubMed PMID: 32194168

Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. J Immunol. 2020 Apr 15;204(8):2295-2307. PubMed PMID: 32179637

Nemenoff RA, Kleczko EK, Hopp K. Renal double negative T cells: unconventional cells in search of a function. Ann Transl Med. 2019 Dec;7(Suppl 8):S342. PubMed PMID: 32016060

Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):394-403. PubMed PMID: 31852223

Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment. J Thorac Oncol. 2021 Oct;16(10):1694-1704. PubMed PMID: 34048945

Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA. Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer. Front Immunol. 2019;10:954. PubMed PMID: 31134065

Gurule NJ, McCoach CE, Hinz TK, Merrick DT, Van Bokhoven A, Kim J, Patil T, Calhoun J, Nemenoff RA, Tan AC, Doebele RC, Heasley LE. A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer. NPJ Precis Oncol. 2021 May 17;5(1):41. PubMed PMID: 34001994

Jolly AJ, Lu S, Strand KA, Dubner AM, Mutryn MF, Nemenoff RA, Majesky MW, Moulton KS, Weiser-Evans MCM. Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodeling. Cardiovasc Res. 2021 May 14. [Epub ahead of print] PubMed PMID: 33989378

Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881

Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341

Johnson AM, Kleczko EK, Nemenoff RA. Eicosanoids in Cancer: New Roles in Immunoregulation. Front Pharmacol. 2020;11:595498. PubMed PMID: 33364964

Ng TL, Johnson A, Nemenoff RA, Hsieh E, Osypuk AA, van Bokhoven A, Li H, Camidge DR, Schenk EL. Prospective Observational Study Revealing Early Pulmonary Function Changes Associated With Brigatinib Initiation. J Thorac Oncol. 2021 Mar;16(3):486-491. PubMed PMID: 33307191