David Fullerton, MD

Professional Titles

• Chief

Recognitions

• America's Top Doctors, Castle Connolly (2007)
  
• Recipient, Best Doctors in America (2006)
  
• Recipient, Best Doctors in America (2007)
  
• America's Top Doctors, Castle Connolly (2011)
  
• Recipient, Best Doctors in America (2011)
  
• America's Top Doctors, Castle Connolly (2008)
  
• America's Top Doctors, Castle Connolly (2009)
  
• Recipient, Best Doctors in America (2009)
  
• America's Top Doctors, Castle Connolly (2006)
  
• Award for Excellence in Mentoring and Advising, University of Colorado, Academy of Medical Educators (2009)
  

Publications

• Fullerton DA: An endangered species. J Thoracic Cardiovasc Surg 2010;139:4-12
• Mauchley D, Meng X, Johnson T, Teitelbaum J, Babu A, Fullerton DA, Weyant MJ: Heat shock protein 27: induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vivo. J Thorac Cardiovasc Surg 2010;139:1019-1025.
• Mauchley D, Meng X, Johnson T, Fullerton DA, Weyant MJ: Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2). J Thorac Cardiovasc Surg 2010;139:591-599.
• Mauchley D, Meng X, Babu A, Gamboni-Robertson F, Yang X, Banerjee A, Fullerton DA, Weyant MJ. Gastroduodenal reflux induces group IIa secretory phospholipase A(2) expression and activity in murine esophagus. Dis Esophagus 2010;23:430-436.
• Benson DD, Kelher MR, Meng X, Fullerton DA, Lee JH, Silliman CC, Barnett CC, Jr: Gender-specific transfusion affects tumor-associated neutrophil:macrophage ratios in murine pancreatic adenocarcinoma. J Gastrointest Surg 2010;14:1560-1565.
• Li J, Jin C, Cleveland JC Jr, Ao L, Xu D, Fullerton DA, Meng X: Enhanced inflammatory responses to Toll-like receptor 2/4 stimulation in type I diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol 2010;16:90.
• Su X, Sykes JB, Ao L, Raeburn CD, Fullerton DA, Meng X: Extra-cellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue. Cytokine 2010; 51:60-61.
• Lee J, Meng X, Weyant MJ, Reece JB, Cleveland JC Jr, Fullerton DA: Stenotic aortic valves have dysfunctional mechanisms of anti-inflammation: Implications for aortic stenosis. J Thorac Cardiovasc Surg 2011;141:481-486.
• Bell MT, Reece TB, Smith PD, Mares J, Weyant MJ, Cleveland JC Jr, Freeman KA, Fullerton DA, Puskas F. Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion. J Vis Exp. 2014 Mar 3;(85). PubMed PMID: 24637534
• Steinberg BA, Zhao Y, He X, Hernandez AF, Fullerton DA, Thomas KL, Mills R, Klaskala W, Peterson ED, Piccini JP. Management of postoperative atrial fibrillation and subsequent outcomes in contemporary patients undergoing cardiac surgery: insights from the Society of Thoracic Surgeons CAPS-Care Atrial Fibrillation Registry. Clin Cardiol. 2014 Jan;37(1):7-13. PubMed PMID: 24353215
• Bell MT, Puskas F, Agoston VA, Cleveland JC Jr, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10;128(11 Suppl 1):S152-6. PubMed PMID: 24030400
• Bell MT, Puskas F, Bennett DT, Herson PS, Quillinan N, Fullerton DA, Reece TB. Dexmedetomidine, an a-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. J Thorac Cardiovasc Surg. 2014 Jan;147(1):500-6. PubMed PMID: 24035379
• Piccini JP, Zhao Y, Steinberg BA, He X, Mathew JP, Fullerton DA, Hegland DD, Hernandez AF, Mills RM, Klaskala W, Peterson ED. Comparative effectiveness of pharmacotherapies for prevention of atrial fibrillation following coronary artery bypass surgery. Am J Cardiol. 2013 Oct 1;112(7):954-60. PubMed PMID: 23850476
• Bell MT, Agoston VA, Freeman KA, Puskas F, Herson PS, Mares J, Fullerton DA, Reece TB. Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia. J Vasc Surg. 2013 Jul 10. [Epub ahead of print] PubMed PMID: 23850057
• Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA. ox-LDL induces PiT-1 expression in human aortic valve interstitial cells. J Surg Res. 2013 Sep;184(1):6-9. PubMed PMID: 23849774
• Nadlonek N, Lee JH, Reece TB, Weyant MJ, Cleveland JC Jr, Meng X, Fullerton DA. Interleukin-1 Beta induces an inflammatory phenotype in human aortic valve interstitial cells through nuclear factor kappa Beta. Ann Thorac Surg. 2013 Jul;96(1):155-62. PubMed PMID: 23735716
• Smith PD, Puskas F, Fullerton DA, Meng Z, Cho D, Cleveland JD Jr, Weyant MJ, Reece TB: Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg 2011;141:245-260.
• Zeng Q, Song R, Ao L, Weyant MJ, Lee J, Xu D, Fullerton DA, Meng X. Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and nuclear factor-?B activation. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1580-90. PubMed PMID: 23640488
• Ward ST, Smith D, Andrei AC, Hicks GL Jr, Shemin RJ, Calhoon JH, Reed C, Verrier ED, Fullerton DA, Lee R. Comparison of cardiothoracic training curricula: integrated six-year versus traditional programs. Ann Thorac Surg. 2013 Jun;95(6):2051-4; discussion 2054-6. PubMed PMID: 23602065
• Su X, Ao L, Shi Y, Johnson TR, Fullerton DA, Meng X: Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem 2011 (in press).
• Sadaria MR, Yu JA, Meng X, Fullerton DA, Reece TB, Weyant MJ. Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway. Anticancer Res. 2013 Apr;33(4):1337-42. PubMed PMID: 23564770
• Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1644-50. PubMed PMID: 23564307
• Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC Jr, Weyant MJ, Fullerton DA, Reece TB. Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. Ann Thorac Surg. 2013 May;95(5):1647-53. PubMed PMID: 23541432
• Sadaira MR, Meng X, Fullerton DA, Reece TB, Shah RR, Grover FL, Weyant MJ: Secretory phospholipase A(2) inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. Ann Thorac Surg 2011 (in press).
• Fullerton DA, Grover FL. Prosthetic valve endocarditis. In: Selke FW, del Nido P, Swanson SJ (Eds) Sabiston and Spencer’s Surgery of the Chest. 8th ed. Philadephia, PA: WB Saunders Co; 2010.
• Steinberg BA, Zhao Y, He X, Hernandez AF, Fullerton DA, Thomas KL, Klaskala W, Peterson ED, Piccini JP: Management of postoperative atrial fibrillation and subsequent outcomes in contemporary patients undergoing cardiac surgery: insights from the Society of Thoracic Surgeons CAPS-Care Atrial Fibrillation Registry. Clin Cardiol 2014;37:7-13.
• Bell MT, Reece TB, Smith PD, Mares J, Weyant MJ, Cleveland JC Jr, Freeman KA, Fullerton DA, Puskas F: Reproducible paraplegia by thoracic aortic occlusion in a murin model of spinal cord ischemia-reperfusion. J Vis Exp 2014;85
• Venardos N, Nadlonek N, Meng X, Fullerton DA: Differential Inflammatory Responses Mediate Aortic Valve Calcification. J Surg Res 2014; 190:1-8
• Bennet D, Reece TB; Smith P, Grandhi M, Rove J, Justison G, Fullerton D, Mitchell JD, Zamora M, Weyant MJ: Ex-Vivo Lung Perfusion Allows for Successful Transplantation of Donor Lungs from Hanging Victims. Ann Thorac Surg 2014;98:1051-1056.
• Slimani H, Yufeng Z, Yousif N, Ao L, Fullerton D, Dinarello C, Meng X: P504Critical role IL-37 to ameliorate endotoxemic cardiac depression in aging mice: a critical role of suppression cardiodepressant cytokines. Cardiovasc Res. 2014;103 Suppl 1:S92. doi: 10.1093/cvr/cvu091.177
• Tommaso CL, Fullerton DA, Feldman T, Dean LS, Hijazi ZM, Horlick E, Weiner BH, Zahn E, Cigarroa JE, Ruiz CE, Bavaria J, Mack MJ, Cameron DE, Bolman RM 3rd, Miller DC, Moon MR, Mukherjee D, Trento A, Aldea GS, Bacha EA: SCAI/AATS/ACC/STS operator and institutional requirements for transcatheter valve repair and replacement. Part II. Mitral valve. J Thorac Cardiovasc Surg. 2014;148:387-400
• Bennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJ: Cancer Stem Cell Phenotype Is Supported by Secretory Phospholipase A2 in Human Lung Cancer Cells. Ann Thorac Surg. 2014; 98:435-439.
• Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng X.: Human Myocardium Releases Heat Shock Protein 27 (HSP27) after Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 through Toll-like Receptor (TLR)-2 and TLR4. Mol Med. 2014;20:280-289.
• Song R, Ao L, Zhao KS, Zheng D, Venardos N, Fullerton DA, Meng X.: Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway. Inflamm Res. 2014; 63:703-710.
• Tommaso CL, Fullerton DA, Feldman T, Dean LS, Hijazi ZM, Horlick E, Weiner BH, Zahn E, Cigarroa JE, Ruiz CE, Bavaria J, Mack MJ, Cameron DE, Bolman RM 3rd, Miller DC, Moon MR, Mukherjee D, Trento A, Aldea GS, Bacha EA: SCAI/AATS/ACC/STS operator and institutional requirements for transcatheter valve repair and replacement. Part II. Mitral valve. Ann Thorac Surg 2014;98:765-777.
• Tommaso CL, Fullerton DA, Feldman T, Dean LS, Hijazi ZM, Horlick E, Weiner BH, Zahn E, Cigarroa JE, Ruiz CE, Bavaria J, Mack MJ, Cameron DE, Bolman RM 3rd, Miller DC, Moon MR, Mukherjee D, Trento A, Aldea GS, Bacha EA: SCAI/AATS/ACC/STS operator and institutional requirements for transcatheter valve repair and replacement. Part II. Mitral valve. Catheter Cardiovasc Interv. 2014;84:567-580.
• Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton DA, Meng X.: Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction.: PLoS One. 2014 May 8;9(5):e95400. DOI: 10.1371/journal.pone.0095400. eCollection 2014
• Shemin RJ, Fullerton DA, Mayer JE Jr, Wright DC, Iknonmidis: Manpower: What is the Future. Semin Thorac Cardiovasc Surg 2014;26:255-71
• Mares JM, Foley LS, Bell MT, Bennett DT, Freeman KA, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Puskas F, Reece TB: Erythropoietin activates the phosphorylated cAMP (adenosine 3’5’ cyclic monophosphate) response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2014 Nov 13. pii: S0022-5223(14)01787-5. doi: 10.1016/j.jtcvs.2014.11.011. [Epub ahead of print] PMID:25500291
• Lee JH, Choi WP, Weyant MJ, Cleveland JC, Meng X, Fullerton DA: Interleukin-1 beta mediates a phenotypic change in human aortic valve interstitial cells: Implications for calcific aortic stenosis. J Am Coll Surg 2010;211:S30.
• Fullerton DA, Sundt TM: Process versus outcome: The sugar window. Ann Thorac Surg 2014;98:1902-1904
• Freeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC Jr, Weyant MJ, Mares J, Meng X, Puskas F, Reece TB: Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor. J Thorac Cardiovasc Surg. 2014 Oct 15. pii: S0022-5223(14)01542-6. doi: 10.1016/j.jtcvs.2014.10.037. [Epub ahead of print] PMID:25454921
• Calhoon JH, Baisden C, Holler B, Hicks GL, Bove EL, Wright CD, Merrill WH, Fullerton DA: Thoracic surgical resident education: a costly endeavor. Ann Thorac Surg 2014;98:2012-2015.
• Fullerton DA, Sundt TM: Process versus outcome: The sugar window. J Cardiovasc Surg 2014;148:2458-2460
• Song R, Fullerton DA, Ao L, Zheng D, Zhao KS, Meng X: BMP-2 and TGF-B1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med 2014 ( in press).
• Slimani H, Shai Y, Yousif NG, Ao L, Zeng Q, Fullerton DA, Meng X: Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endoxemia. Crit Care 2014;18:527.
• Wang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng X: Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch 1-NF-kB pathway in BMP-2 expression. Biochem Biophus Acta 2014;1843:2744-2753.
• Tommaso CL, Fullerton DA, Feldman T, Dean LS, Hijazi ZM, Horlick E, Weiner BH, Zahn E, Cigarroa JE, Ruiz CE, Bavaria J, Mack MJ, Cameron DE, Bolman RM 3rd, Miller DC, Moon MR, Mukherjee D, Trento A, Aldea GS, Bacha EA: SCAI/AATS/ACC/STS operator and institutional requirements for transcatheter valve repair and replacement. Part II. Mitral valve. J Am Coll Cardiol. 2014;64:1515-26.
• Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X, Herson PS, Reece TB: Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res 2014 (in press).
• Howell KW, Meng X, Fullerton DA, Chunhua J, Lihua A, Reece TB, Cleveland JC: Toll-like receptor 4 mediates oxidized-LDL-induced macrophage differentiation to foam cells. J Am Coll Surg 2010;211:S140.
• Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X, Herson PS, Reece TB: Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res 2015;195:21-8.
• Mares JM, Foley LS, Bell MT, Bennett DT, Freeman KA, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Puskas F, Reece TB: Erythropoietin activates the phosphorylated cAMP (adenosine 3’5’ cyclic monophosphate) response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2015;149:920-924.
• Bennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJ: C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3. J Thorac Cardiovasc Surg 2015;149:369-375.
• Fullerton DA: 50th Anniversary Landmark Commentary on Adkins PC, Orthner HF. The Society of Thoracic Surgeons Manpower Survey for 1976: a summary. Ann Thorac Surg 1979;28:407-12. Ann Thorac Surg. 2015;100:776.
• Li J, Ao L, Zhai Y, Cleveland JC, Fullerton DA, Meng X: Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and injury. Int J Clin Exp Med. 2015;8:10537-10547
• Bennett DT, Zamora M, Reece TB, Mitchell JD, Cleveland JC Jr, Grover FL, Babu AN, Meguid RA, Fullerton DA, Weyant MJ: Continued Utility of Single-Lung Transplantation in Select Populations: Chronic Obstructive Pulmonary Disease. Ann Thorac Surg. 2015;100:437-42.
• Yao Q, Song R, Ao L, Zhan Q, Cleveland JC Jr, Yu X, Fullerton DA, Meng X: Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochem Biophys Acta. 2015;1852:1940-9.
• Bell MT, Puskas F, Bennett DT, Cleveland JC Jr, Herson PS, Mares JM, Meng X, Weyant MJ, Fullerton DA, Reece TB: Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion. Brain Res. 2015;1618:55-60.
• Venardos N, Bennett D, Weyant MJ, Reece TB, Meng X, Fullerton DA: Matrix Gla protein regulates calcification of the aortic valve. J Surg Res. 2015;199:1-6.
• Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC Jr, Weyant MJ, Meng X, Puskas F, Reece TB: Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression. Ann Thorac Surg. 2015;100:41-6
• Aly A, Meng X, Li J, Sadaria M, Saad A, Ao L, Fullerton DA, Raeburn C: DITPA, a thyroid hormone analog, reduces infarct size and attenuates the inflammatory response following myocardial ischemia. J Surg Res 2011;165:266.
• Zhai Y, Ao L, Cleveland JC, Zeng Q, Reece TB, Fullerton DA, Meng X: Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion. PLoS One. 2015; 30;10:e0121853
• Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X: Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways. Int J Biol Sci. 2015; 20;11:482-93.
• Austin EW, Yousif NG, Li J, Ao L, Reece TB, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X: Ghrelin reduces myocardial injury following global hypothermic ischemia/reperfusion via suppression of the myocardial inflammatory response. J Surg Res 2011;165:192.
• Lee JH, Meng X, Reece TB, Weyant MJ, Cleveland JC Jr, Fullerton DA: The p38 mitogen-activated protein kinase mediates osteogenic transformation of human aortic valve interstitial cells by interleukin-1 beta: implications for aortic stenosis. J Surg Res 2011;165:192.
• Fullerton DA. Invited Commentary to Ikonomidis JS, The Society of Thoracic Surgeons Practice and Access Task Force: 2014 Workforce Report. Ann Thorac Surg 2016;102: 2126.
• Howell KW, Cleveland JC Jr, Meng X, Ao L, Su X, Schwartz RS, Fullerton DA: Interleukin 6 production during cardiac surgery correlates with increasing age. J Surg Res 2016;201:76-81
• Deng XS, Meng X, Song R, Fullerton D, Jaggers J: Rapamycin decreases the osteogenic response in aortic valve interstitial cells through the Stat3 pathway. Ann Thorac Surg 2016;102:1229-1238
• Kim MS, Bracken J, Eshuis P, Chen SY, Fullerton D, Cleveland J, Messenger JC, Carroll JD: Use of short roll C-arm computed tomography and fully automated 3D tools to guide transcatheter aortic valve replacement. Int J Cardiovasc Imaging 2016;32:1145-1152
• Allen MS, Calhoon JH, Fullerton D, Shemin R, Naunheim K, Verrier E, Doty J, Mathisen DJ: Outcome of the Joint Council of Thoracic Surgery Education’s Early Review Course Project. Ann Thorac Surg 2016;101:1564-1568
• Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng X: Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: role of extracellular HSP27 and TLR4. Mol Med 2016; (Epub ahead of print)
• Hijazi ZM, Ruiz CE, Zahn E, Ringel R, Aldea GS, Bacha EA, Bavaria J, Bolman RM 3rd, Cameron DE, Dean LS, Feldman T, Fullerton D, Horlick E, Mack MJ, Miller DC, Moon MR, Mukherjee D, Tranto A, Tommaso CL: SCAI/AATS/ACC/STS Operator and Institutional Requirements for Transcathether Valve Repair and Replacement, Part III: Pulmonic Valve. J Am Coll Cardiol 2015;65:2556-2563.
• Lee J, Meng X, Weyant MJ, Reece JB, Cleveland JC Jr, Fullerton DA: Stenotic aortic valves have dysfunctional mechanisms of anti-inflammation: Implications for aortic stenosis. J Thorac Cardiovasc Surg 2011;141:481-486.
• 161. Smith PD, Puskas F, Fullerton DA, Meng Z, Cho D, Cleveland JD Jr, Weyant MJ, Reece TB: Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg 2011;141:245-260.
• 162. Su X, Ao L, Shi Y, Johnson TR, Fullerton DA, Meng X: Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem 2011;286:12213-20.
• Zhan Q, Song r, Li F, Zeng Q, Xu D, Fullerton DA, Meng X: Double-stranded RNA up-regulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-non-canonical NF-kB pathway. Am J Physiol Cell Physiol 2017; 312:C407-C417.
• Cheng H, Yao Q, Song R, Zhai Y, Wang W, Fullerton DA, Meng X. Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells. J Surg Res. 2017;213:243-250
• Li F, Song R, Ao L, Reece TB, Cleveland JC Jr, Dong N, Fullerton DA, Meng X. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017; 37:1339-1351
• Song R, Fullerton DA, Ao L, Zhao KS, Reece TB, Cleveland JC Jr, Meng X. Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves. J Am Heart Assoc. 2017; 24;6 pii: e005364
• Song R, Fullerton DA, Ao L, Zhao KS, Meng X. An epigenetic regulatory loop controls pro-osteogenic activation by TGF-ß1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. J Biol Chem. 2017;292:8657-8666.
• Zeng Q, Song R, Fullerton DA, Ao L, Zhai, Y, Li S, Ballak, DB, Cleveland JC JR, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X: Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Nat Acad Sci USA 114:1631-1636, 2017.
• Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X: Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine 2017;95:55-63.
• Hui H, Zhai Y, Ao L, Cleveland JC Jr, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017;8:15663-15676.
• Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X. IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitia. Mol Med. 2017;23:83-91.
• Li F, Yao Q, Ao L, Cleveland JC Jr, Dong N, Fullerton DA, Meng X. Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9. J Mol Med 2017;95:739-751.
• Yao Q, Song R, Ao L, Cleveland JC Jr, Fullerton DA, Meng X: Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017;312:C697-C706.
• Deng X-S, Meng X, Venardos N, Song R, Yamanaka K, Fullerton D, Jaggers J: Autophagy negatively regulates pro-osteogenic activity in human aortic valve interstitial cells. J Surg Res 2017; 218:285-291.
• Foley LS, Fullerton DA, Mares J, Sungelo M, Weyant MJ, Cleveland JC Jr, Reece TB: Erythropoietin’s beta common receptor mediates neuroprotection in spinal cord neurons. Ann Thorac Surg 2017;104:1909-1914.
• Bhagat R, Bronsert MR, Ward AN, Martin J, Juarez-Colunga E, Glebova NO, Henderson WG, Fullerton D, Weyant MJ, Mitchell JD, Meguid RA. National analysis of uplanned readmissions after thoracoscopic versus open lung cancer resection. Ann Thorac Surg 2017; 104:1782-1790.
• Yamanaka K, Eldeiry M, Aftab M, Foley LS, Mares J, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB: Pretreatment with diazoxide attenuates injury in a mouse model of spinal cord ischemia. J Am Coll Surg 2017;225:S33
• Fullerton, DA Rwanda is rising. J Thorac Cardiovasc Surg 2018;155:2553
• Yamanaka K, Eldeiry M, Mares J, Ryan TJ, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury. J Thorac Cardiovasc Surg 2018;155:2505-2516.
• Bhagat R, Bronsert MR, Juarez-Colunga E, Weyant MJ, Mitchell JD, Glebova NO, Henderson WG, Fullerton D, Mequid RA: Postoperative complications drive unplanned readmissions after esophagectomy for cancer. Ann Thorac Surg 2018; 105: 1476-1482.
• Eldeiry M, Ghincea C, Aftab M, Cleveland JC Jr, Fullerton D, Reece TB: Innominate versus axillary artery cannulation for the hemiarch repair. J Surg Res 2018; 232:234-239.
• Venardos N, Deng X-S, Yao Q, Weyant MJ, Reece TB, Meng X, Fullerton DA: Simvastatin reduces the TLR4-induced Inflammatory response in human aortic valve interstitial cells. J Surg Res 2018
• Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Roda G, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Pretreatment with diazoxide attenuates spinal cord ischemia-reperfusion injury through STAT3 pathway. Ann Thorac Surg 2018
• Kohtz PD, Halpern AL, Eldeiry MA, Hazel K, Kalatardi S, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ: Toll-like receptor-4 is a mediator of proliferation in esophageal adenocarcinoma. Ann Thorac Surg 2018
• Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Mares J, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Synergistic reduction of apoptosis with diazoxide and erythropoietin in spinal cord ischemic injury. Ann Thorac Surg 2018
• Fullerton, DA: Maintenance of Certification and the Social Contract. Ann Thorac Surg 2019;107:17-18
• Sadaira MR, Meng X, Fullerton DA, Reece TB, Shah RR, Grover FL, Weyant MJ: Secretory phospholipase A(2) inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. Ann Thorac Surg 2011;91:1539-1545
• Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Roda G, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Pretreatment with diazoxide attenuates spinal cord ischemia-reperfusion injury through STAT3 pathway. Ann Thorac Surg 2019;107:733-739.
• Kohtz PD, Halpern AL, Eldeiry MA, Hazel K, Kalatardi S, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ: Toll-like receptor-4 is a mediator of proliferation in esophageal adenocarcinoma. Ann Thorac Surg 2019;107:233-241.
• Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Mares J, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Synergistic reduction of apoptosis with diazoxide and erythropoietin in spinal cord ischemic injury. Ann Thorac Surg 2018; 106:1751-1758.
• Eldeiry M, Ghincea C, Aftab M, Cleveland JC Jr, Fullerton D, Reece TB: Innominate versus axillary artery cannulation for the hemiarch repair. J Surg Res 2018; 232:234-239.
• Smith PD, Puskas F, Meng X, Cho D, Cleveland JC Jr, Weyant MJ, Watkins MT, Fullerton DA, Reece TB: Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia. J Surg Res 2011 (in press).
• Abdhashem-Aly AA, Meng X, Li J, Sadaria MR, Ao L, Wennergern J, Fullerton DA, Raeburn CD: DITPA, a thyroid hormone analog, reduces infarct size and attenuates the inflammatory response following myocardial ischemia. J Surg Res 2011;171:379-385.
• Sadaria MR, Smith PD, Fullerton DA, Justison GA, Lee JH, Puskas F, Grover FL, Clevleand JC Jr, Reece TB, Weyant MJ: Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusion. Ann Thorac Surg 2011;92:478-484.
• Sadaria MR, Yu J, Meng X, Reppert AE, Reece TB, Fullerton DA, Weyant MJ: Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells. J Thorac Cardiovasc Surg 2011;142:1152-1160.
• Howell KW, Meng X, Fullerton DA, Jin C, Reece TB, Cleveland JC Jr: Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells. J Surg Res 2011; 171:e27-31.
• Fullerton DA: Invited Critique. Critical Care Competence. Arch Surg 2011;146:1260.
• Yu J, Sadaria MR, Meng X, Mitra S, Ao L, Fullerton DA, Weyant MJ: Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A(2) inhibition. J Thorac Cardiovasc Surg 2012;143:405-411.
• Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Meng X, Weyant MJ, Fullerton DA, Reece TB. Synergetic induction of NGF With Diazoxide and Erythropoietin Attenuates Spinal Cord Ischemic Injury. J Surg Res. 2019;233:124-131.
• Aly A, Meng X, Li J, Sadaria M, Saad A, Ao L, Fullerton DA, Raeburn C: DITPA, a thyroid hormone analog, reduces infarct size and attenuates the inflammatory response following myocardial ischemia. J Surg Res 2011;165:266
• Halpern AL, Kohtz, PD, Rove JY, Ao L, Meng X, Fullerton DA, Weyant MJ: Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma. Mol Cell Biochem 2019; 456:145-156.
• Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J: MMP-12-Induced pro-osteogenic responses in human aortic valve interstitial cells. J Surg Res 2019 (in press).
• Bhagat R, Bronsert MR, Henderson WG, Scott CD, Weyant MJ, Mitchell JD, Fullerton DA, Meguid RA: Analysis of discharge destination after open vs minimally invasive surgery for lung cancer. Ann Thorac Surg 2019 (in press).
• Halpern AL, Boshier PR, White AM, Houk AK, Helmkamp L, Mitchell JD, Meguid RA, Low DE, Fullerton DA, Weyant MJ: A comparison of frailty measures at listing to predict outcomes following lung transplantation. Ann Thorac Surg 2019;109:233-240.
• Colson YL, Putnam, JB, Yang SC, Fann JI, Vaporciyan AA, Dearani JA, Jones DR, Allen MS, Meyers BF, Wright CD, Shemin RJ, Baumgartner WA, Fullerton DA: The ABTS 10-year maintenance of certification exam improves and validates knowledge acquisition. Ann Thorac Surg 2019;108:1895-1900.
• Ghincea CV, Reece TB, Eldeiry M, Roda GF, Bronsert MR, Jarret MF, Pal JD, Cleveland JC Jr, Fullerton DA, Aftab M: Predictors of acute kidney injury following aortic arch surgery. J Surg Res 2019;242:40-46.
• Austin EW, Yousif NG, Li J, Ao L, Reece TB, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X: Ghrelin reduces myocardial injury following global hypothermic ischemia/reperfusion via suppression of the myocardial inflammatory response. J Surg Res 2011;165:192.
• Halpern AL, Kohtz PD, Helmkamp L, Eldeiry M, Hodges MM, Scott CD, Mitchell JD, Aftab M, Pal JD, Cleveland JC Jr, Reece TB, Mequid RA, Fullerton DA, Weyant MJ: Improved mortality associated with the use of extracorporeal membrane oxygenation. Ann Thorac Surg 2019; 108:350-357.
• Halpern AL, Kohtz PD, Rove JY, Ao L, Meng X, Fullerton DA, Weyant MJ: Inhibition of secretary phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma. Mol Cell Biochem 2019;456:145-156.
• Lee JH, Meng X, Reece TB, Weyant MJ, Cleveland JC Jr, Fullerton DA: The p38 mitogen-activated protein kinase mediates osteogenic transformation of human aortic valve interstitial cells by interleukin-1 beta: implications for aortic stenosis. J Surg Res 2011;165:192.
• Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA: Simvastatin Downregulates Osteogenic Response in Cultured Human Aortic Valve Interstitial Cells. J Thorac Cardiovasc Surg 2019 (in press).
• Song R, Zhai Y, Ao L, Fullerton DA, Meng X: MicroRNA-204 deficiency in human aortic valves elevates valvular osteogenic activity. Int J Mol Sciences 2019, 21, 76;doi:10.3390/ijms21010076
• Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia after cardiopulmonary bypass is associated with increased morbidity and mortality. Ann Thorac Surg 2019; (in press).
• Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res 2019; (in press).
• Lee JH, Meng X, Reece TB, Weyant MJ, Cleveland JC Jr, Fullerton DA: Oxidized low-density lipoprotein transforms aortic valve interstitial cells into an osteogenic phenotype implying its role in aortic stenosis. J Am Coll Surg 2011;213:S33
• Yu J, Sadaria MR, Meng X, Mitra S, Ao L, Fullerton DA, Weyant MJ: Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A(2) inhibition. J Thorac Cardiovasc Surg 2012;143:405-411.
• Benson DD, Meng X, Fullerton DA, Moore EE, Lee JH, Ao L, Silliman CC, Barnett CC Jr: Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1067-R1075
• Tommaso CL, Bolman RM 3rd, Feldman T, Bavaria J, Acker MA, Aldea G, Cameron DE, Dean LS, Fullerton DA, Hijazi ZM, Horlick E, Miller DC, Moon MR, Ringel R, Ruiz CE, Trento A, Weiner BH, Zahn EM: SCAI/AATS/ACCF/STS Multisociety expert consensus statement: operator and institutional requirements for transcatheter valve repair and replacement: Part 1 TAVR. J Thorac Cardiovasc Surg 2012:1254-1263.
• Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia after cardiopulmonary bypass is associated with increased morbidity and mortality. Ann Thorac Surg 2020;110:50-57
• Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res
• Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X: TLR4 stimulation promotes human AVIC fibrogenic activity through upregulation of neurotrophin 3 production. Int J Mol Sci 2020; 21. Pii: E1276. PMID 32074942
• The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X: Mechanistic roles of matrillin-2 and Klotho in modulating the inflammatory activity of human aortic valve cells. Cells 2020; 9 pii: E385. PMID: 32046115
• Griffin BR, Teixeira JP, Ambruso S, Bronsert M, Pal JD, Cleveland JC, Reece TB, Fullerton DA, Faubel S, Aftab M: Stage 1 acute kidney injury is independently associated with infection following cardiac surgery. J Thorac Cardiovasc Surg
• Vigneshwar NG, Kohtz PD, Lucas MT, Bronsert M, Weyant MJ, Masood M, Itoh A, Rove JY, Reece TB, Cleveland JC, Pal JD, Fullerton DA, Aftab M: Clinical predictors of in-hospital mortality in venoarterial extracorporeal membrane oxygenation. J Card Surg 2020;35:2512-2521
• Bell MT, Puskas F, Smith PD, Argoston VA, Fullerton DA, Meng X, Weyant MJ, Reece TB: Attenuation of spinal cord ischemia-reperfusion injury by specific alpha-2a receptor activation with dexmetedomidine. J Vasc Surg 2012 (Epub ahead of print).
• Gergen AK, Kohtz PK, Halpern AL, Li A, Meng X, Reece TB, Fullerton DA, Weyant MJ: Activation of toll-like receptor 2 promotes proliferation of human lung adenocarcinoma cells. Anticancer Res 2020;40:5361-5369
• Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ: Secretory phospholipase A2 IIa mediated expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci
• Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M: Creatine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg 2020
• Ghincea CV, Anderson DA, Ikeno Y, Roda GF, Eldeiry M, Bronsert MR, Anukst K, Fullerton DA, Reece TB, Aftab M: Utility of neuromonitoring in hypothermic circulatory arrest cases for early detection of stroke: Listening through the noise. J Thorac Cardiovasc Surg 2020
• Zhang P, The E, Nedujmaran B, Ao L, Jarett MJ, Xu D, Fullerton DA, Meng X: Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve insterstitial cells through prarcrine up-regulation of TLR2 level. Int J Biol Sci 2020; 16:3062-3074
• Venardos N, Reece TB, Cleveland JC Jr, Aftab M, Pal J, Fullerton DA, Rove JY: Training for multiple arterial grafting: a thoracic surgery resident survey. Ann Thorac Surg 2020
• Shah PB, Welt FGP, Mahmud E, Phillips A, Kleiman NS, Young MN, Sherwook M, Batchelor W, Wang DD, Davidson L, Wyman J, Kadavath S, Sxerlip M, Mermiller J, Fullerton D, Anwaruddin S: Triage considerations for patient referred for structural heart disease intervention during the COVID-19 pandemic: an ACC/SCAI position statement. Catheter Cardiovascular Interv 2020: 96:659-663
• Shah PB, Welt FGP, Mahmud E, Phillips A, Kleiman NS, Young MN, Sherwook M, Batchelor W, Wang DD, Davidson L, Wyman J, Kadavath S, Sxerlip M, Mermiller J, Fullerton D, Anwaruddin S: Triage considerations for patient referred for structural heart disease intervention during the COVID-19 pandemic: an ACC/SCAI position statement. JACC Cardiovascular Interv 2020;13:1484-1488
• Halpern AL, Boshier PR, White AM, Houk AK, Helmkamp L, Mitchell JD, Meguid RA, Low DE, Fullerton DA, Weyant MJ: A comparison of frailty measures at listing to predict outcomes after lung transplantation. Ann Thorac Surg 2020
• Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA: Wnt signaling mediates pro-inflammatory activity in human aortic valve interstitial cells. Ann Thorac Surg 2020
• Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA: Simvastatin Downregulates Osteogenic Response in Cultured Human Aortic Valve Interstitial Cells. J Thorac Cardiovasc Surg
• Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ: Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res 2020
• Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ: Statins inhibit toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res 2020.
• Bhagat R, Bronsert MR, Henderson WG, Scott CD, Weyant MJ, Mitchell JD, Fullerton DA, Meguid RA: Analysis of discharge destination after open vs minimally invasive surgery for lung cancer. Ann Thorac Surg 2020; 109:375-382
• Nadlonek N, Weyant MJ, Yu J, Cleveland JC Jr, Reece TB, Meng X, Fullerton DA: Radiation induces osteogenesis in human aortic valve interstitial cells. J Thorac Cardiovasc Surg 2012;144:1466-1470.
• Song R, Zeng Q, Ao L, Yu J, Cleveland JC, Zhao K-S, Fullerton DA, Meng X: Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor 2. Art Throm Vasc Biol 2012;32:2711-20.
• Yu J, Li H, Nemenoff R, Meng X, Mitchell JD, Fullerton DA, Weyant MJ: sPLA2 IIa expression correlates with sPLA2 IIa inhibition-mediated cell death in K-Ras mutant lung cancer cells. J Thorac Cardiovasc Surg 2012;144:1479-1485.
• Zeng Q, Jin C, Ao L, Cleveland JD, Jr, Rui S, Xu D, Fullerton DA, Meng X: Cross-talk between the toll-like receptor 4 and Notch 1 pathway augments the inflammatory response in the interstitial cells of stenotic aortic valves. Circulation 2012;126:S222-S230.
• Venardos N, Reece TB, Cleveland JC Jr, Aftab M, Pal J, Fullerton DA, Rove JY: Training for multiple arterial grafting: A Thoracic Surgery Resident survey. Ann Thorac Surg 2021;111:190-1907
• Tommaso CL, Bolman RM 3rd, Feldman T, Bavaria J, Acker MA, Aldea G, Cameron DE, Dean LS, Fullerton DA, Hijazi ZM, Horlick E, Miller DC, Moon MR, Ringel R, Ruiz CE, Trento A, Weiner BH, Zahn EM: SCAI/AATS/ACCF/STS Multisociety expert consensus statement: operator and institutional requirements for transcatheter valve repair and replacement: Part 1 TAVR. Ann Thorac Surg 2012;93:2093-2110.
• Smith PD, Puskas F, Meng X, Lee JH, Cleveland JC Jr, Weyant MJ, Fullerton DA, Reece TB: The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury. Circulation 2012;126:S110-117.
• Yu JA, Kalatardi S, Dohse J, Sadaraia MR, Meng X, Fullerton DA, Weyant MJ: Group IIa SPLA2 inhibition attenuates NF-kB activity and promotes apoptosis of lung cancer cells. Anticancer Res 2012; 32:3601-3607.
• Tommaso CL, Bolman RM 3rd, Feldman T, Bavaria J, Acker MA, Aldea G, Cameron DE, Dean LS, Fullerton DA, Hijazi ZM, Horlick E, Miller DC, Moon MR, Ringel R, Ruiz CE, Trento A, Weiner BH, Zahn EM: SCAI/AATS/ACCF/STS Multisociety expert consensus statement: operator and institutional requirements for transcatheter valve repair and replacement: Part 1 TAVR. J Am Coll Cardiol 2012;59:2028-42.
• Wohlauer M, Moore EE, Silliman CC, Fragoso M, Gamboni J, Harr J, Accurso F, Wright F, Haenel J, Fullerton D, Banerjee A: Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhage shock via inhibition of matrix metalloproteinase-13. Crit Care Med 2012 40:2647-53.
• Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, Weyant MJ: Knockdown of secretory phospholipase lipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg 2012;144:1185-91.
• Tommaso CL, Bolman RM 3rd, Feldman T, Bavaria J, Acker MA, Aldea G, Cameron DE, Dean LS, Fullerton DA, Hijazi ZM, Horlick E, Miller DC, Moon MR, Ringel R, Ruiz CE, Trento A, Weiner BH, Zahn EM: SCAI/AATS/ACCF/STS Multisociety expert consensus statement: operator and institutional requirements for transcatheter valve repair and replacement: Part 1 TAVR. Catheter Cardiovasc Interv 2012;80;1-17.
• Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC, Weyant MJ, Fullerton DA, Reece TB: Preservation of Motor Function Following Spinal Cord Ischemia and Reperfusion Through Microglial Inhibition. Ann Thorac Surg 2013 (in press).
• Ward S, Hicks G, Calhoon J, Verrier ED, Shemin R, Smith D, Fullerton DA, Lee R: A comparison of cardiothoracic training curricula; integrated six year vs traditional programs. Ann Thorac Surg 2013 (in press).
• Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA: Simvastatin Downregulates Osteogenic Response in Cultured Human Aortic Valve Interstitial Cells. J Thorac Cardiovasc Surg 2021;161:e261-e271.
• Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA: Wnt signaling mediates pro-inflammatory activity in human aortic valve interstitial cells. Ann Thorac Surg 2021;112:519-525.
• Mack MJ, Fullerton DA, Fann JI: The answers you get depend on the questions you ask: Insights from the recent EXCEL Trial controversy. Ann Thorac Surg 2021;111:1743-1745
• Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB: Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg 2021; Jan 12 (online ahead of print).
• Fullerton DA. Aortic Valve Replacement. In: Kaiser LR, Kron IL, Spray TL, eds. Mastery of Cardiothoracic Surgery. 3nd Edition. New York, NY: Wolters Kluwer Health, Inc., 2013
• Gergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X Fullerton DA, Weyant MJ: Expression of adhesion molecules in a gastroduodenal reflux murine model. Ann Thorac Surg 2021 (online ahead of print).
• Fullerton DA, Meng X. Dysfunctional mechanisms of anti-inflammation in aortic stenosis. In: Gabriel EA and Gabriel SA (Eds.), Inflammatory Response in Cardiovascular Surgery, Springer, 2013
• Nadlonek NA, Lee JH, Meng X, Fullerton DA: Ox-LDL induces expression of Pit-1 in human aortic valve interstitial cells. J Surg Res 2013;179:285-6
• Extracellular Soluble Biglycan Induces Osteogenic Phenotypic Changes in Human Aortic Valve Interstitial Cells via Smad-Dependent and -Independent Pathways Rui Song, David A Fullerton, Lihua Ao, Kesen Zhao, and Xianzhong Meng Circulation 126: A13511, 2012.
• Therapeutic Potential of Interleukine-37 for Suppression of Aortic Valve Inflammatory and Osteogenic Responses Qingchun Zeng, Jilin Li, Chunhua Jin, Rui Song, Lihua Ao, Joseph C. Cleveland, Jr., David A. Fullerton, and Xianzhong Meng Circulation 126: A11803, 2012.
• Ikeno Y, Ghincea CV, Roda GF, Cheng L, Meng X, Wyant MJ, Cleveland JC Jr, Fullerton DA, Aftab M, Reece TB: Reactive oxygen species mediate nicorandil-induced metabolic tolerance to spinal cord injury. Ann Thorac Surg 2021;112:38-44.
• Ikeno Y, Ghincea CV, Roda GF, Cheng L, Meng X, Wyant MJ, Cleveland JC Jr, Fullerton DA, Aftab M, Reece TB: Reactive oxygen species mediate nicorandil-induced metabolic tolerance to spinal cord injury. Ann Thorac Surg 2021;112:38-44.
• Venardos N, Gergen AK, Jarrett M, Weyant MJ, Reece TB, Meng X, Fullerton DA: Warfarin induces calcification of the aortic valve via ERK1/2 and B-catenin Signaling. Ann Thorac Surg 2021; online ahead of print
• Gergen AL. White AM, Mitchell JD< Meguid RA, Fullerton DA, Scott CD, Weyant MJ: Introduction of robotic surgery leads to increased rate of segmentectomy in patient with lung cancer. J Thorac Dis 2021;13:762-767.
• A Novel Role of Intercellular Adhesion Molecule-1 Signaling via Notch1 in Mediating Bone Morphogenetic Protein-2 Expression in Human Aortic Valve Interstitial Cells Dong Wang, Qingchun Zeng, Rui Song, Lihua Ao, Joseph C Cleveland Jr, Jr, David A Fullerton, and Xianzhong Meng Circulation 126: A13589, 2012.
• Toll-Like Receptor 4 Dependent Macrophage Activation is Critical in Spinal Cord Ischemia-Reperfusion Injury Marshall T Bell, Ferenc Puskas, Viktor A Agoston, Joseph C Cleveland, David A Fullerton, Fabia Gamboni, Paco Herson, Xianzhong Meng, Phillip D Smith, Michael J Weyant, and T. Brett Reece Circulation 126: A17512, 2012.
• Zhao P, Yao Q, Shang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng X: Single-cell RNA-seq reveals a critical role for novel pro-inflammatory EndMT in mediating adverse remodeling in coronary-on-a-chip. Sci Adv 2021;7:eabg1694. PMID: 34417174.
• Gergen AK, Jarret MJ, Anqi L, Meng X, Akshay P, Fullerton DA, Weyant MJ: Toll-like receptor 4 mediates reflux-induced inflammation in murine reflux model. Sem Thorac Cardiovasc Surg 2021; (in press).
• Suarez-Pierre A, Choudhury R, Carroll AM, King RW, Iguidbashian J, Cotton J, Colborn K, Kennealey PT, Cleveland JR JC, Pomfret E, Fullerton DA: Measuring the effect of the COVID-19 pandemic on solid organ transplantation. Am J Surg 2021 (in press).
• Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ: Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res; in press
• Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ: Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res; in press
• Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X: Monocytes augment inflammatory responses in human aortic valve interstitial cells via ß2-integrin/ICAM-1-mediated signaling. Imflamm Res 2022; 71:681-694.
• Venardos N, Gergen AK, Jarrett M, Weyant MJ, Reece TB, Meng X, Fullerton DA: Warfarin induces calcification of the aortic valve via ERK1/2 and B-catenin Signaling. Ann Thorac Surg 2022;113:824-835.
• Gergen AK, Kemp C, Ghincea CV, Feng Z, Cleveland JC Jr, Pal JD, Rove JY, Fullerton DA, Aftab M, Reece TB: Challenging paradigm limits of retrograde cerebral perfusion during lower body circulatory arrest. J Surg Res 2023;283:699-704.
• Suarez-Pierre A, Iguidbashian JP, Stuart C, King RW, Cotton J, Carroll AM, Cleveland JC Jr, Fullerton DA, Pal JD: Appraisal of donation after circulatory death: How far could we expand the heart donor pool? Ann Thorac Surg 2022;114:676-682.
• Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng X: Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity. Front Cardiovasc Med 2023; 10:1293866.
• Suarez-Pierre A, Iguidbashian J, Kirsch MJ, Cotton JL, Quinn C, Fullerton AD, Reece TB, Hoffman JRH, Cleveland JC Jr, Rove JY: Importance of social vulnerability on long-term outcomes after heart transplantation. Am J Transplant 2023; 10:1580-1589.
• Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M: Creatine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg 2022;163:1378-1387.
• The E, Zhai Y, Yao Q, Ao L, Li S, Fullerton DA, Dinarello CA, Meng X: Recombinant IL-37 exerts an anti-inflammatory effect on human aortic valve interstitial cells through extracellular and intracellular actions. Int J Biol Sci 2023;19:3908-3919.
• Suarez-Pierre A, Iguidbashian J, Vigneshwar N, Breithaupt J, Fullerton DA, Reece TB, Hoffman JRH, Cleveland JC Jr, Rove JY: Variability in heart yield from donation after brain death between organ procurement organizations: An opportunity for improvement. ASAIO J 2023;69:e322-e332
• Li X, Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Yu KJ, Meng X: Up-regulation of myocardial klotho expression to promote cardiac functional recovery in old mice following endotoxemia. Res Sq 2023;May 22:rs.3.re-2949854.
• Deng XS, Meng X, Fullerton DA, Stone M, Iguidbashian J, Jaggers J: Complement cross talks with H-K-ATPase to upregulate Runx2 in human aortic valve interstitial cells. J Surg Res 2023; 286:118-126.
• Suarez-Pierre A, Iguidbashian J, Kirsch MJ, Cain MT, Aftab M, Reece TB, Fullerton DA, Robe JY, Cleveland JC Jr, Hoffman JRH: Association of cardiac preservation solution with short-term outcomes after heart transplantation: J Cardiovasc Med 2024:25:158-164.
• Iguidashian J, Cotton J, King RW, Carroll AM, Gergen AK, Meguid RA, Fullerton DA, Suarez-Pierre A: Survival following lung transplantation: A population -based nested case-control study. J Card Surg 2022; 37:1153-1160.
• Iguidbashian JP, King RW, Carroll AM, Cotton JL, Stuart C, Fullerton DA, Meguid RA, Suarez-Pierre A: Conditional survival in lung transplantation: An organ procurement and transplantation network database analysis. ASAIO J 202369:e333-341.
• Suarez-Pierre A, Iguidashian J, Stuart C, King RW, Cotton J, Carroll AM, Cleveland JC, Fullerton DA, Pal JD: Appraisal of donation after circulatory death: How far could we expand the heart donor pool? Ann Thorac Surg 2022;114:676-682.
• 309. Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Xianzhong M: Elevated expression of TLR2 in aging hearts exacerbates cardiac inflammatory response and adverse remodeling following ischemia and reperfusion injury. Frontiers Immunol April 14, 2022.
• Gergen AK, Jarret MJ, Anqi L, Meng X, Akshay P, Fullerton DA, Weyant MJ: Toll-like receptor 4 mediates reflux-induced inflammation in murine reflux model. Sem Thorac Cardiovasc Surg 2022; 34:1324-1335.
• Valle JA, Fullerton DA, Cleveland JC Jr, Messenger JC, Carroll JD: Reply: Rational dispersion of TAVR: The role of training centers. J Am Coll Cardiol 2022:37:1153-1160.
• Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X: Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med 2022; 28:5.
• Gergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJ: Simvastin inhibits histologic changes associated with gastroduodenal reflux in a murine model. Dig Dis Sci 2022;67:4732-4741.
• Suarez-Pierre A, Choudhury R, Carroll AM, King RW, Iguidbashian J, Cotton J, Colborn KL, Kennealey PT, Cleveland JC, Pomfret E, Fullerton DA: Measuring the effect of the COVID-19 pandemic on solid organ transplantation. Am J Surg 2022, 224:437-442.
• Vigneshwar NG, Masood MF, Vasic I, Krause M, Bartels K, Lucas MT, Bronsert M, Selzman CH, Thompson S, Rove JY, Cleveland JC Jr, Pal JD, Fullerton DA, Aftab M: Venovenous extracorporeal membrane oxygenation support in patients with COVID-19 respiratory failure: A multicenter study. JTCVS Open 2022, 12: 211-220.
• The E, de Graff DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X: interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci USA 2022;119:e2202577119.
• Zhai Y, Ao L, Yal Q, The E, Fullerton DA, Meng X: Elevated expression of TLR2 in aging hearts exacerbates cardiac inflammatory response and adverse remodeling following ischemia and reperfusion injury. Front Immunol 2022;13: 891570.
• Pratap A, Li A, Westbrook L, Gergen AK, Mitra S, Chauhan A, Cheng L, Weyant MJ, McCarter M, Wani S, Meguid RA, Cohen M, Fullerton DA, Meng X: Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/B-catenin pathway. J Gastrointest Oncol 2022;13:2082-2104.
• Kemp C, Ghincea CV, Feng Z, Gergen AK, Cleveland JC Jr, Rove JY, Aftab M, Fullerton DA, Reece TB: Evaluating the risk of spinal cord ischemia in zone 2 frozen elephant trunk replacement. Am J Surg 2022;224:1057-1061.

Professional Memberships

• Society of Thoracic Surgeons, President Elect
• Western Thoracic Surgical Association, President
• The American Surgical Association, Membership Committee
• Residency Review Committee for Thoracic Surgery, Chair
• Thoracic Surgery Directors Association, President
• The American Geriatrics Society, Research Agenda Setting Council
• International Society of Heart Transplantation, Member
• Rocky Mountain Cardiac Surgical Society, Member
• Association for Academic Surgery, Member
• American Heart Association (AHA), Member
• Society of University Surgeons, Member
• American Association for the Advancement of Science, Member
• Society of Critical Care Medicine, Member
• The American Physiological Society, Member
• Surgical Infection Society, Member
• American College of Surgeons (ACS), Governor
• American Association for Thoracic Surgeons, Member
• Society of Clinical Surgery, Member
• Cardiac Surgery Biology Club, Member
• American Board of Thoracic Surgery, Chair, Cardiac Exam Committee
• Thoracic Surgery Foundation for Research and Education, Secretary

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Structural Heart and Valve Clinic - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation

• University of Colorado Hospital
• Children's Hospital Colorado
• Veterans Affairs Medical Center
• Denver Health Medical Center

Specialty Information

Specialties

• Thoracic and Cardiac, Board Certification (1991, 2011)
• Surgery, Board Certification (1988, 2008)
• Surgical Critical Care, Board Certification (1991, 2011)

Conditions & Treatments

• Heart and Circulation - Aneurysms
• Heart and Circulation - Congenital Heart Disease
• Heart and Circulation - Heart Valve Diseases
• Surgery - Transplant Surgery
• Surgery - Open Heart Surgery
• Surgery - Cardiothoracic Surgery
• Surgery - Heart Transplant Surgery
• Surgery - Adult Cardiac Surgery
• Heart and Circulation
• Surgery
• Surgery - Lung Transplant Surgery