Xiayuan Liang, MD

Professional Titles

• Professor
• Director of Hematopathology Fellowship
• Medical Director of Hematopathology, Flow Cytometry, and Cytopathology at Children's Hospital Colorado

Recognitions

• Summit award for excellence in teaching and the education of pathologists, University of Colorado School of Medicine, Department of Pathology (2017)
• Summit award for excellence in teaching and the education of pathologists, University of Colorado School of Medicine, Department of Pathology (2013)
• Summit award for excellence in teaching and the education of pathologists,, University of Colorado School of Medicine, Department of Pathology (2011)
• Summit award for excellence in teaching and the education of pathologists, University of Colorado School of Medicine, Department of Pathology (2009)
• Teaching award from Foundation to CURE Childhood Cancer, Foundation to CURE Childhood Cancer (2009)

Publications

• Liang X, Jones A, Giller R, Swisshelm K, McGavran L, Meltesen L, Carstens B, McGranahan AN, Albano EA. Primary high grade B-cell lymphoma of the breast with concurrent IGH-BCL2 and MYC translocations in an adolescent patient. Pediatr Devel Pathol.2011;14:402-406.
• Liang X, Greffe B, Cook B, Giller R, Graham DK, Wang M. Gray zone lymphomas in pediatric patients. Pediatr Deve Pathol.2011;14:57-63.
• Ball JB, Khan SY, McLaughlin NJD, Kelher MR, Nuss R, Cole L, Liang X, Silliman CC. Secretory phospholipase A2 releases pro-inflammatory lipids from sickled Red Blood Cells that cause neutrophil-mediated cytotoxicity of pulmonary endothelial cells. In press: Pediatric Blood and Cancer.
• Silliman CC, Dzieciatkowska M, Moore EE, Kelher MR, Banerjee A, Liang X, Land KJ, Hansen KC: Proteomic Analyses of Human Plasma: Venus versus Mars. In press: Transfusion.
• Salstrom JL, Kent M, Liang X, Wang M. Toddlers with anasarca and severe anemia: a lesson in preventative medicine. Current Opinion Pediatrics. 2012;24:129-133.
• Harr JN, Moore EE, Wohlauer MV, Fragoso M, Gamboni-Robertson F, Liang X, Banerjee A, Silliman CC: Activated Platelets in Heparinized Shed Blood: The “Second-Hit” of Acute Lung Injury in Trauma/Hemorrhagic Shock Models. In press: Shock.
• Brandao LN, Winges A, Christoph S, Sather S, McGranahan A, Liang X, Gao D, DeRyckere D, Graham DK. Inhibition of Mer TK increase the chemosensitivity and decreases the oncogenic potential in T-cell acute lymphoblastic leukemia. Blood Cancer J. 2013 Feb [Epub ahead of print]
• Ball JB, Khan SY, McLaughlin NJD, Kelher MR, Nuss R, Cole L, Liang X, Silliman CC. A two-event in vitro model of acute chest syndrome: the role of secretary phospholipase A2 and neutrophils. Pedia Blood &Cancer. 2012;58(3)399-405.
• Silliman CC, Dzieciatkowska M, Moore EE, Kelher MR, Banerjee A, Liang X, Land KJ, Hansen KC: Proteomic analyses of human plasma: Venus versus Mars. Transfusion. 2012;52(2):417-424.
• Salstrom JL, Kent M, Liang X, Wang M. Toddlers with anasarca and severe anemia: a lesson in preventative medicine. Current Opinion Pediatrics. 2012;24:129-133.
• Brock K, Goldenberg N, Graham DK, Liang X, Hays T. Moderate aplastic anemia in Children: Preliminary outcomes for treatment versus observation from a single-institutional experience. J Ped Hemtol Oncol. 2012 Nov 1 [Epub ahead of print]
• Rhee-Anagnost M, Lovell MA, Liang X. Assessment of benign lymphoid aggregates in pediatric bone marrow specimens. Platform Presentation. Annual Meeting, Society for Pediatric Pathologists. Baltimore, MD, March, 2013.
• Lee K, McGranahan A, Winkler T, Liang X. CD34-HLA-DR- Is Most Commonly Seen in Children with Acute Megakeryoblastic Leukemia In Addition to Acute Promyelocytic Leukemia: A Potential Diagnostic Pitfall. Platform Presentation, 102nd Annual Meeting, United States and Canadian Academy of Pathology. Baltimore, MD, March, 2013.
• Lee K, McGranahan A, Winkler T, Liang X. Characterization of Anatomic Distribution of Acute Leukemia Relapse in Pediatric Patients. Poster Presentation, 102nd Annual Meeting, United States and Canadian Academy of Pathology. Baltimore, MD, March, 2013.
• Yin L, Lovell MA, Wilson ML, Wei Q, Liang X. Distinct GATA1 Point Mutations in Identical Twin Boys with Down Syndrome and Transient Abnormal Myelopoiesis from a Triplet Pregnancy. Poster Presentation, 102nd Annual Meeting, United States and Canadian Academy of Pathology. Baltimore, MD, March, 2013.
• Yin L, Xu J, Li M, Zhang Q, Reddy V, Liu H, Zhou Q, Chu P, Huang Q, Gao Z, Wang H, Liang X, Pan Z. Oct2 and Bob1 Expression in Lineage Determination of B-Cell Lymphomas Negative for Conventional B-Cell Markers. Poster Presentation, 102nd Annual Meeting, United States and Canadian Academy of Pathology. Baltimore, MD, March, 2013.
• Garth A, Will M, Liang X, Schowinsky JR. Novel description of prospective diagnosis of congenital acute leukemia on initial processing of banked umbilical cord blood and potential implications for testing laboratories. Poster presentation, 54th Annual Meeting, American Society of Hematology. Atlanta, GA. December, 2012.
• Ken MW, Oliveira JL, Breaux Jr. CW. Liang X, Hoyer JD, Swanson K, Silliman C. Hemoglobin Grand Junction: A novel mutation associated with hemolytic anemia. Poster presentation, Annual meeting, American Society of Hematology/Oncology. New Orleans, LA. May, 2012.
• McDaniel V, Henderson C, Graham D, Maloney K, Meltesen L, Liang X, Swisshelm K, McGavran L. A rare case of acute myeloid leukemia with an inversion (8)(p11.22q13). Poster presentation, American Cytogenetic Conference. San Antonio, TX. April, 2012.
• Linger RMA, Lee-Sherick AB, DeRyckere D, Cohen R, McGranaham A, Brandao L, Winges A, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, and Graham DK. Mer receptor tyrosine kinase is a therapeutic target in pre-B cell acute lymphoblastic leukemia. Blood. 2013;122:1599-1609.
• Liang X, Branchford B, Greffe B, McGavran L, Carstens B, Meltesen L, Albano EA, Quinones R, Cook B, Graham DK. Dual ALK and MYC rearrangements leading to aggressive variant of anaplastic large cell lymphoma. J Pediatr Hematol Oncol. 2013,35:209-213.
• Brandao LN, Winges A, Christoph S, Sather S, McGranahan A, Liang X, Gao D, DeRyckere D, Graham DK. Inhibition of Mer TK increase the chemosensitivity and decreases the oncogenic potential in T-cell acute lymphoblastic leukemia. Blood Cancer J. 2013 Jan 25;3:e101. doi: 10.1038/bcj.2012.46.
• Lee-Sherick AB, Eisenman KM, Sather S, McGranahan A, Armistead PM, McGary CS, Hunsucker SA, Schlegel J, Martinson H, Cara Cannon1, Keating AK, Shelton Earp HS, Liang X, DeRyckere D, Graham DK. Aberrant Mer receptor tyrosine kinase expression contributes to oncogenesis in acute myloid leukemia. Oncogene. 2013,14;32:5359-5368.
• Brock K, Goldenberg N, Graham DK, Liang X, Hays T. Moderate aplastic anemia in Children: Preliminary outcomes for treatment versus observation from a single-institutional experience. J Ped Hemtol Oncol. 2013;35:148-152.
• Liang X, Pillai J, Wilson CS. Coexistence of hyaline vascular Castleman disease-like features with lymphoma. ASCP Case Reports. March 2014
• Correlation of imprint and aspiration cytology with histology in mediastinal lymphoma and thymoma in Diagnostic Pediatric Cytopathology and Histopathologic Correlation edited by Chou P, Gattuso P, Reddy V, and Reyes-Mugica. Cambridge University Press.
• Ken MW, Oliveira JL, Breaux Jr. CW. Liang X, Hoyer JD, Swanson K, Silliman C. Hemoglobin Grand Junction: a novel hyperunstable hemoglobin variant. Hemoglobin. 2014;38:8-12.
• Knez V, Carstens B, Swissheim L, McGranham A, Liang X. Heterogeneity of abnormal RUNX1 leading to clinicopathological variations in childhood B-lymphoblastic leukemia. Am J Clin Pathol. 2015;144:305-314.
• Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, DeRocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Guiterrez-Hartmann A, Liang X, Pluthero FC, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutatins in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015;47:535-538.
• Yin L, Lovell MA, Wilson ML, Wei Q, Liang X. Distinct GATA1 point mutations in monozygotic twins with Down syndrome and transient abnormal myelopoiesis from a triplet pregnancy: A case report and review of literature. Am J of Clin Pathol. 2016 Dec 27. pii: aqw190. doi: 10.1093/ajcp/aqw190. [Epub ahead of print]
• Knez V, Pan Z, Post MD, Wang D, Ryder J, Carstens B, Swisshelm K, Liang X. Novel case of B-lymphoblastic leukemia with RUNX1 amplification in pregnancy with a review of literature. ASC P Case Report. 2016. In press.
• Moreira DC, Ng CJ, Quinones R, Liang X, Czaja A, Chung D, and Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS13 loss in idiopathic systemic capillary leak syndrome. J Thromb Haemost. 2016 Dec;14(12):2353-2355. doi: 10.1111/jth.13506. Epub 2016 Oct 24.
• Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao X, Liang X, Wang HY, Pan Z. Oct2 and Bob1 are sensitive and specific markers in lineage determination of B-cell lymphomas with no expression of conventional B-cell markers. Histopathology. 2016. 2016 Nov;69(5):775-783. doi: 10.1111/his.13017. Epub 2016 Aug 5.
• Liang X, Chou P. Imprint and aspiration cytology of the lung, pleura, and mediastinum including thymus in Diagnostic Pediatric Cytopathology and Histopathologic Correlation edited by Chou P, Gattuso P, Reddy V, and Reyes-Mugica. Cambridge University Press. 2016:203-240.
• B Siegele, B Carstens, X Liang. Enteric Epstein Barr virus (EBV)-negative post-transplant lymphoproliferative disorder (PTLD) in a patient with a history of EBV gastroenteritis and markedly elevated serum EBV DNA levels. Platform presentation. 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology. Long Beach, CA. October, 2015.
• Wang D, X Liang, Pan Z, Post MD, Wang D, Ryder J, Carstens B, Swisshelm K, Knez V. Novel case of B-lymphoblastic leukemia with RUNX1 amplification in pregnancy. Poster presentation. CAP’15. Nashville, TN. October, 2015.
• B Siegele and X Liang. Kikuchi-Fujimoto disease can be distinguished from clinicopathologic mimics in the presence of leukopenia and neutropenia. Poster presentation. Annual Meeting of Society for Pediatric Pathology. MA, March, 2015.
• J Rosser, A Svensson, Q Wei, Y Shi, J Yuan, N Miltgen, X Liang. Clinicopathologic characterization of acute myeloid leukemia with mutated NPM1 and CEBPA in pediatric patients – A single institution experience. Poster presentation. 104th Annual Meeting, United States and Canadian Academy of Pathology. Boston, MA, March, 2015. Mod Path. 2015:28 (Supplement 2):375A.
• J Rosser, B Carstens, K Swisshelm, X Liang. Vacuolated variant of B-lymphoblastic leukemia is associated with ETV6-RUNX1 in children. Poster presentation. 104th Annual Meeting, United States and Canadian Academy of Pathology. Boston, MA, March, 2015. Mod Path. 2015:28 (Supplement 2):375A.
• Knez V, Liu X, Schowinsky J, Pan Z, Wang D, Lorsbach R, Lu C, Luedke C, Haag M, Carstens B, Swisshelm K, Yang L, Jug R, Wang E, Liang X. Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: A multi-institutinal study. Leukemia and Lymphoma. DOI: 10.1080/10428194.2018.1508667.
• Wilberger A, Liang X. Primary non-anaplastic peripheral natural killer/T-cell lymphoma in pediatric patients – an unusual distribution pattern of subtypes. Ped Dev Pathol. 2018 Oct 18:1093526618807110. doi: 10.1177/1093526618807110. [Epub ahead of print]
• Li T, Montgomery N, Liang X. Table and Algorithms in Hematopathology – Tables and Algorithms Series. MDher+, 2018.
• Liang X. Diffuse Large B-Cell Lymphoma. In: Pediatric Pathology. Chinese Clinical Pathology Fascicle Series. (Editors: Lejian He and Larry Wang), People’s Publisher, Beijing, China, in press
• Liang X. Burkitt Lymphoma. In: Pediatric Pathology. Chinese Clinical Pathology Fascicle Series. (Editors: Lejian He and Larry Wang), People’s Publisher, Beijing, China, in press
• Liang X. ALK-Positive Anaplastic Large Cell Lymphoma. In: Pediatric Pathology. Chinese Clinical Pathology Fascicle Series. (Editors: Lejian He and Larry Wang), People’s Publisher, Beijing, China, in press
• Liang X. Extranodal NK/T-Cell Lymphoma. In: Pediatric Pathology. Chinese Clinical Pathology Fascicle Series. (Editors: Lejian He and Larry Wang), People’s Publisher, Beijing, China, in press
• Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, Gossling M, Wright C. Vitamin K deficiency presenting in an infant with an anterior mediastinal mass: a case report and review of the literature. Case Rep Pediatr. 2017;2017:7628946. doi: 10.1155/2017/7628946. Epub 2017 Feb 9
• Liang X. Follicular Lymphoma, Pediatric Type. In: Pediatric Pathology. Chinese Clinical Pathology Fascicle Series. (Editors: Lejian He and Larry Wang), People’s Publisher, Beijing, China, in press
• X Liang, AC Wilberger. Extranodal NK/T-cell lymphoma of the small intestine in a pediatric patient. Poster Presentation. The 19th Meeting of the European Association of Hematopathology. Edinburgh, Scotland, UK. Sept 29-Oct 4, 2018.
• S Lummus, KE Capocelli, JG Black, MA Lovell, C Galambos, Gary Mierau, E Wartchow, X Liang. INI1-Deficient Thymic Carcinoma in Young Children: A New Member of Rhabdoid Tumor Family. Poster presentation. Fall Meeting of Society for Pediatric Pathology. Denver, Colorado. September, 2017.
• D Olson, C Galambos, VH. Savell, X Liang. ALK+ Histiocytosis: Two Atypical Presentations in an Already Atypical Disease. Poster presentation. Fall Meeting of Society for Pediatric Pathology. Denver, Colorado. September, 2017.
• V Knez, J Schowinsky, M Haag, B Carstens, X Liang. Congenital and non-congenital-infantile leukemia case series comparison. Poster presentation. Fall Meeting of Society for Pediatric Pathology. Denver, Colorado. September, 2017.
• D Olson, MA Lovell, X Liang, J Picarsic, K Swisshelm, C Galambos. Clonal Evolution of Myelomonocytic Leukemia into a Low-Grade Histiocytic Cerebral Mass. Poster presentation. Fall Meeting of Society for Pediatric Pathology. Denver, Colorado. September, 2017.
• V Knez, X Liang. G-CSF Double-edged sword. SH/EAHP Workshop 2017. Molecular Genetics of Hematopoietic Neoplasms. Case presentation. Chicago, IL. September, 2017.
• V Knez, B Carstens, K Swisshelm, M Haag. X Liang. Noonan syndrome associated B-ALL. SH/EAHP Workshop 2017. Molecular Genetics of Hematopoietic Neoplasms. Case presentation. Chicago, IL. September, 2017.
• AC Wilberger, X Liang. Extranodal NK/T-Cell Lymphoma, Nasal type in pediatric patients: A single institution experience versus literature data. Poster presentation. Annual Meeting of Society for Pediatric Pathology. San Antonio, TX, March, 2017.
• V Knez, X Liang. Distinct patterns of cytogenetic abnormalities in lymphoblastic lymphoma and lymphoblastic leukemia of childhood. Poster presentation. Annual Meeting of Society for Pediatric Pathology. San Antonio, TX. March, 2017.
• CA Thomas, X Liang. Early T-Precursor (ETP) Acute Lymphoblastic Leukemia/Lymphoma (ALL) versus Non-ETP ALL in Children and Young Adults: Clinicopathologic Differences. Poster presentation. 107th Annual Meeting, United States and Canadian Academy of Pathology. Vancouver, BC. Canada. March, 2018.
• X Liu, C Luedke, L Yang, CM Lu, R Jug, Z Pan, D Wang, R Lorsbach, Y Shi, V Knez, X Liang (co-senior author) , E Wang (co-senior author). Clinicopathological Study of 79 Cases of Infantile Leukemia: Where Should the Line for Congenital Leukemia be Drawn for Practical Purposes? Poster presentation. 107th Annual Meeting, United States and Canadian Academy of Pathology. Vancouver, BC. Canada. March, 2018.
• Lucas CG, Gilani A, Solomon DA, Liang X, Maher OM, Chamyan G, Kleinschmidt-Demasters BK, Perry A. ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system. Acta Neuropathol. 2019 Aug;138(2):335-337. PubMed PMID: 31119374
• Klein C, Kleinschmidt-DeMasters BK, Liang X, Stence N, Tuder RM, Moore BE. A Review of Neuropathological Features of Familial and Adult Hemophagocytic Lymphohistiocytosis. J Neuropathol Exp Neurol. 2019 Mar 1;78(3):197-208. PubMed PMID: 30726926
• Sopfe J, Endres A, Campbell K, Hayes K, Trout AT, Liang X, Lorsbach R, O'Brien MM, Cost CR. Castleman disease in pediatrics: Insights on presentation, treatment, and outcomes from a two-site retrospective cohort study. Pediatr Blood Cancer. 2019 May;66(5):e27613. PubMed PMID: 30680887
• Knez V, Liu X, Schowinsky J, Pan Z, Wang D, Lorsbach R, Lu C, Luedke C, Haag M, Carstens B, Swisshelm K, Yang LH, Jug R, Wang E, Liang X. Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study. Leuk Lymphoma. 2019 Apr;60(4):1006-1013. PubMed PMID: 30188223
• Wilberger AC, Liang X. Primary Nonanaplastic Peripheral Natural Killer/T-Cell Lymphoma in Pediatric Patients-An Unusual Distribution Pattern of Subtypes. Pediatr Dev Pathol. 2019 Mar-Apr;22(2):128-136. PubMed PMID: 30334665
• Knez V, Bao L, Carstens B, and Liang X. Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in patients of childhood. Leuk Lymphoma. 2020;61:2129-2135 (32427530).
• Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D'Alessandro A, Ryon J, Hansen KC, Gamboni F, Moore EE, Peltz ED, Cohen MJ, Jones KL, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Eitel A, Hom P, Silliman CC. Succinate activation of SUCNR1 predisposes severely injured patients to neutrophil-mediated ARDS. Ann Surg. 2020 Nov 18. doi: 10.1097/SLA.0000000000004644.
• Kaleigh Erin Lindholm, Liming Bao, Billie Carstens, Xiayuan Liang. Down Syndrome (DS) with B-Cell Acute Lymphoblastic Leukemia (B-ALL) versus Non-DS B-ALL in Children and Young Adults: Pathogenetic Differences. Poster Presentation. 109th Annual Meeting, United States and Canadian Academy of Pathology. Los Angeles, CA. March, 2020.
• Liu X, Zhao Y, Luedke C, Yang L, Lu CM, Jug R, Pan Z, Wang D, Lorsbach R, Shi Y, Knez V, Liang X, Wang E. Infantile Leukemia - What Factors Determine Its Distinct Biological Nature? Clinicopathological Study of 78 Cases. International J Lab Hematol. Int J Lab Hematol. 2021 Apr 13. doi: 10.1111/ijlh.13540. Online ahead of print (PMID: 33847065).
• Thiago Alves da Costa, Jacob N Peterson, Julie Lang, Jeremy Shulman, Xiayuan Liang, Brian M. Freed, Susan A. Boackle, Pilar Lauzurica, Raul M. Torres, and Roberta Pelanda. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. The Proceedings of the National Academy of Sciences. Proc Natl Acad Sci USA. 2021 Apr 20;118(16):e2021570118. doi:10.1073/pnas.2021570118 (PMID: 33850015).

Professional Memberships

• Society of Hematopathology, Member
• Society of Pediatric Pathology, Member

Practice Locations

• University of Colorado Hospital
• Children's Hospital Colorado

Specialty Information

• Anatomic and Clinical, Board Certification
• Hematology, Board Certification

• Cancers - Cancer Pathology
• Cancers