Dianna Quan, MD
Professor, Neurology

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Medical School:
  • MD, Columbia University College of Physicians and Surgeons
Undergraduate School:
  • AB, University of Chicago (IL)
Internship:
  • Hospital of the University of Pennsylvania
Residency:
  • Hospital of the University of Pennsylvania, Chief Resident, Neurology
Fellowships:
  • Hospital of the University of Pennsylvania, Neuromuscular Medicine
Languages: English
Department: Neurology

Professional Titles

  • Director, Electromyography Laboratory
  • Director, Neuromuscular Medicine Fellowship

Recognition & Awards

  • Top Doc, 5280 (2023)
    Clinical excellence award given to greater metropolitan Denver physicians by their peers
  • Regional Top Doctor, Castle Connolly (2013)
    Awarded to physicians in the mountain West for clinical excellence 2013-2022

Teaching

  • Professor (2013)
    School of Medicine, Neurology

Publications

  • Jacoby E, Quan D, Todd E, Rafaels N, Smith H, Crooks K. Prevalence of pathogenic transthyretin gene variants in the Rocky Mountain West region. Accepted for presentation at the American Association of Neuromuscular and Electrodiagnostic Medicine. Phoenix, AZ, Nov 2023.
  • Luigetti M, Quan D, BerkJL, Conceição I, Misumi Y, Chao CC, Bender S, Aldinc E, Vest J, Adams D. Impact of Baseline Polyneuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study. Presented at the Peripheral Nerve Society, Copenhagen, Denmark, June 2023
  • Sperry B, Quan D, Mauricio E, Small R, Ananthasubramaniam K, Egolum U, Roblin S, Yureneva E, Chou LN, Jay P, Capocell K, Freimer M. Effect of RNAi on cardiomyopathy and polyneuropathy outcomes in patients with V122I variant hereditary transthyretin-mediated (hATTR or ATTRv) amyloidosis. Presented at the American College of Cardiology, New Orleans, LA, March 2023.
  • Quan D, Obici L, Berk JL, Ando Y, Aldinc E, White MT, Adams D. Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial. Amyloid. 2023 Mar;30(1):49-58. PubMed PMID: 36120830
  • Antozzi C, Guptill J, Bril V, Gamez J, Meuth SG, Nowak RF, Quan D, Sevilla T, Jouvin MH, Jin J, Karcher K, Ramchandren S, Sun H, Ling L, Zhu YW, Arroyo S. Safety and Efficacy of Nipocalimab in Patients with Generalized Myasthenia Gravis: Results from the Randomized Phase 2 Vivacity-MG study. Neurology 2023 (in press).
  • Barroso FA, Coelho T, Dispenzieri A, Conceição I, Waddington-Cruz M, Wixner J, Maurer MS, Rapezzi C, Planté-Bordeneuve V, Kristen AV, González-Duarte A, Chapman D, Stewart M, Amass L; THAOS investigators. Characteristics of patients with autonomic dysfunction in the Transthyretin Amyloidosis Outcomes Survey (THAOS). Amyloid. 2022 Sep;29(3):175-183. doi: 10.1080/13506129.2022.2043270. Epub 2022 Apr 22. PMID: 35451899.
  • Coelho T, Conceição I, Waddington-Cruz M, Keohane D, Sultan MB, Chapman D, Amass L; THAOS investigators. A natural history analysis of asymptomatic TTR gene carriers as they develop symptomatic transthyretin amyloidosis in the Transthyretin Amyloidosis Outcomes Survey (THAOS). Amyloid. 2022 Jun 22:1-9. doi: 10.1080/13506129.2022.2070470. Epub ahead of print. PMID: 35730447.
  • Dispenzieri A, Coelho T, Conceição I, Waddington-Cruz M, Wixner J, Kristen AV, Rapezzi C, Planté-Bordeneuve V, Gonzalez-Moreno J, Maurer MS, Grogan M, Chapman D, Amass L; THAOS investigators. Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS): 14-year update. Orphanet J Rare Dis. 2022 Jun 18;17(1):236. doi: 10.1186/s13023-022-02359-w. PMID: 35717381; PMCID: PMC9206752.
  • Adams D, Tournev IL, Taylor MS, Coelho T, Planté-Bordeneuve V, Berk JL, González-Duarte A, Gillmore JD, Low SC, Sekijima Y, Obici L, Chen C, Badri P, Arum SM, Vest J, Polydefkis M; HELIOS-A Collaborators. Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial. Amyloid. 2022 Jul 23:1-9. doi: 10.1080/13506129.2022.2091985. Epub ahead of print. PMID: 35875890.
  • Quan D, Obici L, Berk JL, Ando Y, Aldinc E, White MT, Adams D. Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial. Amyloid. 2022 Sep 18;:1-10. [Epub ahead of print] PubMed PMID: 36120830
  • Stevens D, Quan D. “Diabetic neuropathies.” In: McDermott and Trujillo, eds., Diabetes Secrets, 1st edition. Philadelphia: Elsevier 2022
  • Bhai SF, Brown A, Gajewski B, Kimminau KS, Waitman LR, Pasnoor M, Barohn RJ; PAIN-CONTRoLS Study Team. A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living. Muscle Nerve. 2022 Oct;66(4):404-410.
  • Adams D, Polydefkis M, González-Duarte A, Wixner J, Kristen AV, Schmidt HH, Berk JL, Losada López IA, Dispenzieri A, Quan D, Conceição IM, Slama MS, Gillmore JD, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei MM, Planté-Bordeneuve V, Attarian S, Mauricio E, Brannagan TH 3rd, Ueda M, Aldinc E, Wang JJ, White MT, Vest J, Berber E, Sweetser MT, Coelho T. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study. Lancet Neurol. 2021 Jan;20(1):49-59. PubMed PMID: 33212063
  • Shefner JM, Andrews JA, Genge A, Jackson C, Lechtzin N, Miller TM, Cockroft BM, Meng L, Wei J, Wolff AA, Malik FI, Bodkin C, Brooks BR, Caress J, Dionne A, Fee D, Goutman SA, Goyal NA, Hardiman O, Hayat G, Heiman-Patterson T, Heitzman D, Henderson RD, Johnston W, Karam C, Kiernan MC, Kolb SJ, Korngut L, Ladha S, Matte G, Mora JS, Needham M, Oskarsson B, Pattee GL, Pioro EP, Pulley M, Quan D, Rezania K, Schellenberg KL, Schultz D, Shoesmith C, Simmons Z, Statland J, Sultan S, Swenson A, Berg LHVD, Vu T, Vucic S, Weiss M, Whyte-Rayson A, Wymer J, Zinman L, Rudnicki SA. A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):287-299. PubMed PMID: 32969758
  • Caponetti AG, Rapezzi C, Gagliardi C, Milandri A, Dispenzieri A, Kristen AV, Wixner J, Maurer MS, Garcia-Pavia P, Tournev I, Planté-Bordeneuve V, Chapman D, Amass L. Sex-Related Risk of Cardiac Involvement in Hereditary Transthyretin Amyloidosis: Insights From THAOS. JACC Heart Fail. 2021 Oct;9(10):736-746. PubMed PMID: 34391735
  • Kang X, Quan D. Electrodiagnostic Assessment of Motor Neuron Disease. Neurol Clin. 2021 Nov;39(4):1071-1081. PubMed PMID: 34602215
  • Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ; NeuroNEXT NN103 BeatMG Study Team. Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study. Neurology. 2021 Dec 2;98(4):e376–89. doi: 10.1212/WNL.0000000000013121. Epub ahead of print. PMID: 34857535; PMCID: PMC8793103.
  • Caponetti AG, Rapezzi C, Gagliardi C, Milandri A, Dispenzieri A, Kristen AV, Wixner J, Maurer MS, Garcia-Pavia P, Tournev I, Planté-Bordeneuve V, Chapman D, Amass L; THAOS Investigators. Sex-Related Risk of Cardiac Involvement in Hereditary Transthyretin Amyloidosis: Insights From THAOS. JACC Heart Fail. 2021 Oct;9(10):736-746.
  • Nativi-Nicolau J, Siu A, Dispenzieri A, Maurer MS, Rapezzi C, Kristen AV, Garcia-Pavia P, LoRusso S, Waddington-Cruz M, Lairez O, Witteles R, Chapman D, Amass L, Grogan M; THAOS Investigators. Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey. JACC CardioOncol. 2021 Oct 19;3(4):537-546.
  • Gentile L, Tournev I, Amass L, Chapman D, Mazzeo A; THAOS investigators. Phenotypic Differences of Glu89Gln Genotype in ATTR Amyloidosis From Endemic Loci: Update From THAOS. Cardiol Ther. 2021 Dec;10(2):481-490.
  • Waddington-Cruz M, Wixner J, Amass L, Kiszko J, Chapman D, Ando Y; THAOS investigators. Characteristics of Patients with Late- vs. Early-Onset Val30Met Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey (THAOS). Neurol Ther. 2021 Dec;10(2):753-766.
  • Kang X, Quan D. Electrodiagnostic Assessment of Motor Neuron Disease. Neurol Clin. 2021 Nov;39(4):1071-1081.
  • Shefner JM, Andrews JA, Genge A, Jackson C, Lechtzin N, Miller TM, Cockroft BM, Meng L, Wei J, Wolff AA, Malik FI, Bodkin C, Brooks BR, Caress J, Dionne A, Fee D, Goutman SA, Goyal NA, Hardiman O, Hayat G, Heiman-Patterson T, Heitzman D, Henderson RD, Johnston W, Karam C, Kiernan MC, Kolb SJ, Korngut L, Ladha S, Matte G, Mora JS, Needham M, Oskarsson B, Pattee GL, Pioro EP, Pulley M, Quan D, Rezania K, Schellenberg KL, Schultz D, Shoesmith C, Simmons Z, Statland J, Sultan S, Swenson A, Berg LHVD, Vu T, Vucic S, Weiss M, Whyte-Rayson A, Wymer J, Zinman L, Rudnicki SA. A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Sep 24;:1-13. [Epub ahead of print] PubMed PMID: 32969758
  • Barohn RJ, Gajewski B, Pasnoor M, Brown A, Herbelin LL, Kimminau KS, Mudaranthakam DP, Jawdat O, Dimachkie MM, Iyadurai S, Stino A, Kissel J, Pascuzzi R, Brannagan T, Wicklund M, Ahmed A, Walk D, Smith G, Quan D, Heitzman D, Tobon A, Ladha S, Wolfe G, Pulley M, Hayat G, Li Y, Thaisetthawatkul P, Lewis R, Biliciler S, Sharma K, Salajegheh K, Trivedi J, Mallonee W, Burns T, Jacoby M, Bril V, Vu T, Ramchandren S, Bazant M, Austin S, Karam C, Hussain Y, Kutz C, Twydell P, Scelsa S, Kushlaf H, Wymer J, Hehir M, Kolb N, Ralph J, Barboi A, Verma N, Ahmed M, Memon A, Saperstein D, Lou JS, Swenson A, Cash T. Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial. JAMA Neurol. 2020 Aug 17. [Epub ahead of print] PubMed PMID: 32809014
  • González-Duarte A, Berk JL, Quan D, Mauermann ML, Schmidt HH, Polydefkis M, Waddington-Cruz M, Ueda M, Conceição IM, Kristen AV, Coelho T, Cauquil CA, Tard C, Merkel M, Aldinc E, Chen J, Sweetser MT, Wang JJ, Adams D. Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis. J Neurol. 2020 Mar;267(3):703-712. PubMed PMID: 31728713
  • Guptill J, Antozzi C, Bril V, Gamez J, Meuth S, Munoz Blanco JL, Nowak R, Quan D, Sevilla T, Szczudlik A, Hegarty B, Jouvin MH, Jin J, Arroyo S. Vivacity-MG: A phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of nipocalimab administered to adults with generalized myasthenia gravis. Poster presented at the American Association of Neuromuscular and Electrodiagnostic Medicine, Virtual Meeting, October 2020.
  • Quan D, Dixon S. “Electromyography and nerve conduction studies.” In: West and Kolfenbach, eds., Rheumatology Secrets, 4rd edition. Philadelphia: Elsevier 2020, pp. 85-88
  • Kennedy A, Kaplan J, Quan D. A 40-Year-Old Man With Dizziness, Confusion, and Neuropathy 2020, https://reference.medscape.com/viewarticle/923933
  • Shefner JM, Cudkowicz ME, Hardiman O, Cockcroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA. A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2019;0(0):1-11. PubMed PMID: 31081694
  • Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. The authors reply. Crit Care Med. 2018 Apr;46(4):e347-e348. PubMed PMID: 29538131
  • Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017 Oct 10. [Epub ahead of print] PubMed PMID: 29019851
  • Fleming J, Quan D. A case of congenital spinal muscular atrophy with pain due to a mutation in TRPV4. Neuromuscul Disord. 2016 Sep 16. [Epub ahead of print] PubMed PMID: 27751652
  • Kelmenson DA, Quan D, Nordon-Craft A, Malone D, Schenkman M, Moss M. Electrophysiological abnormalities can differentiate pre-hospital discharge functional status in critically ill patients with normal strength. Intensive Care Med. 2016 Sep;42(9):1504-5. PubMed PMID: 27334267
  • Adams D, Polydefkis M, González-Duarte A, Wixner J, Kristen AV, Schmidt HH, Berk JL, Losada López IA, Dispenzieri A, Quan D, Conceição IM, Slama MS, Gillmore JD, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei MM, Planté-Bordeneuve V, Attarian S, Mauricio E, Brannagan TH, Ueda M, Aldinc E, Wang JJ, White MT, Vest J, Berber E, Sweetser MT, Coelho T, on behalf of the patisiran Global OLE study group. Long-term efficacy and safety of patisiran in patients with hereditary transthyretin amyloidosis with polyneuropathy: Interim 1-year results from an open-label extension study. Lancet Neurology (accepted Sept. 21, 2020).
  • Stevens D, Quan D. “Diabetic Neuropathies.” In: McDermott, ed., Diabetes Secrets. Philadelphia: Elsevier (in press).
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Professional Memberships

  • American Academy of Neurology, Fellow
  • American Association of Neuromuscular & Electrodiagnostic Medicine, Fellow
  • Colorado Society of Clinical Neurologists, Member
  • American Neurological Association, Fellow

Practice Locations

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Neurology, Board Certification
  • Neuromuscular Medicine, Board Certification
  • American Board of Electrodiagnostic Medicine, Board Certification (0001)
Conditions & Treatments
  • Brain and Nervous System - Neuromuscular Diseases
  • Brain and Nervous System

General Information

Medical Schools:
  • MD, Columbia University College of Physicians and Surgeons (0001)
Undergraduate Schools:
  • AB, University of Chicago (IL) (0001)
Internships:
  • Hospital of the University of Pennsylvania (0001)
Residency Programs:
  • Hospital of the University of Pennsylvania, Chief Resident, Neurology (0001)
Fellowships:
  • Hospital of the University of Pennsylvania, Neuromuscular Medicine (0001)
Languages: English
Department: Neurology
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