Paul Bunn, MD

Professional Titles

• James Dudley Chair in Cancer Research

Recognitions

• ASCO Karnofsky Award, ASCO (2016)
• Honoary Membership, Hungarian Respiratory Society (2018)
• The 400 Best Doctors in America, Good Housekeeping (2019)
• America's Top Doctors for Cancer, Castle Connolly Medical Ltd. (2019)
• Lung Cancer Network Award for Distinguished Education and Research, University of Athens (2016)
• Giants in Cancer Care Award, OncLive (2016)
• Fellow, American Society of Clinical Oncology (2010)

Research Interests

Dr. Bunn is involved in clinical trials of novel molecular therapies and immunotherapies for lung cancer and other thoracic cancers.

Publications

• Schefter TE, Kavanagh BD, Raben D, Kane M, Chen C, Stuhr K, Kelly K, Mitchell JD, Bunn PA, Jr., Gaspar LE. A Phase I/II trial of stereotactic body radiation therapy (SBRT) for lung metastases: Initial report of dose escalation and early toxicity. Int J Radiation Oncology Biol Phys. 66(4):S120-S127, 2006.
• Dziadziuszko R, Hirsch FR, Bunn PA. Selecting Lung Cancer patients for Treatment with Epidermal Growth Factor Recptor-tyrosine Kinase Inhibitors by Immunohistochemistry and FISH – Why, When, and How? Clin Cancer Res 12(14): 4409s-4415s, 2006.
• Hanna N, Bunn PA, Jr., Langer C, Einhorn L, Guthrie T, Jr., Beck T, Ansari R, Ellis P, Byrne M, Morrison M, Hariharan S, Wang B, Sandler A. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol; 24(13):2038-43, 2006.
• Sunpaweravong P, Magree L, Rabinovitch R, Bunn P, Kelly K. A Phase I/II study of docetaxel, etoposide, and carboplatin before concurrent chemoradiotherapy with cisplatin and etoposide in limited-stage small cell lung cancer. Invest New Drugs. 2006; 24(3): 213-221.
• Hirsch FR, Bunn PA Jr. Progress in research on screening and genetics in lung cancer. Lancet Respir Med. 2014 Jan;2(1):19-21. PubMed PMID: 24461890
• Peled N, Zach L, Liran O, Ilouze M, Bunn PA Jr, Hirsch FR. Effective Crizotinib Schedule for Brain Metastases in ALK Rearrangement Metastatic Non-Small-Cell Lung Cancer. J Thorac Oncol. 2013 Dec;8(12):e112-3. PubMed PMID: 24389447
• Davies KD, Mahale S, Astling DP, Aisner DL, Le AT, Hinz TK, Vaishnavi A, Bunn PA Jr, Heasley LE, Tan AC, Camidge DR, Varella-Garcia M, Doebele RC. Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer. PLoS One. 2013;8(12):e82236. PubMed PMID: 24349229
• Miller YE, Vu KO, Kennedy TC, Hirsch FR, Petty TL, Bunn PA, Keith RL, Franklin WA, Wolf HJ, Prindiville S, Byers T. Lack of Association Between Sputum Atypia and Chronic Obstructive Pulmonary Disease Mortality. J Thoracic Oncol, 1(4):302-307, 2006.
• Bunn PA Jr, Franklin W, Doebele RC. The evolution of tumor classification: a role for genomics?. Cancer Cell. 2013 Dec 9;24(6):693-4. PubMed PMID: 24332038
• Shepherd FA, Bunn PA, Paz-Ares L. Lung cancer in 2013: state of the art therapy for metastatic disease. Am Soc Clin Oncol Educ Book. 2013;33:339-46. PubMed PMID: 23714542
• Weickhardt AJ, Doebele RC, Purcell WT, Bunn PA, Oton AB, Rothman MS, Wierman ME, Mok T, Popat S, Bauman J, Nieva J, Novello S, Ou SH, Camidge DR. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 1;119(13):2383-90. PubMed PMID: 23585220
• Ohashi K, Sequist LV, Arcila ME, Lovly CM, Chen X, Rudin CM, Moran T, Camidge DR, Vnencak-Jones CL, Berry L, Pan Y, Sasaki H, Engelman JA, Garon EB, Dubinett SM, Franklin WA, Riely GJ, Sos ML, Kris MG, Dias-Santagata D, Ladanyi M, Bunn PA Jr, Pao W. Characteristics of lung cancers harboring NRAS mutations. Clin Cancer Res. 2013 May 1;19(9):2584-91. PubMed PMID: 23515407
• Cappuzzo F, Toschi L, Tallini G, Ceresoli G, Domenichini I, Bartolini S, Finocchiaro G, Magrini E, Metro G, Cancellieri A, Trisolini R, Crino L, Bunn, Jr. PA, Santoro A, Franklin WA, Varella-Garcia M, Hirsch FR. Insulin-like growth factor receptor I (IGFR-I) is significantly associated with longer survival in non-small cell lung cancer (NSCLC) patients treated with Gefitinib. Annals Oncology; 17: 1120-1127, 2006.
• Peled N, Barash O, Tisch U, Ionescu R, Broza YY, Ilouze M, Mattei J, Bunn PA Jr, Hirsch FR, Haick H. Volatile fingerprints of cancer specific genetic mutations. Nanomedicine. 2013 Aug;9(6):758-66. PubMed PMID: 23428987
• Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Baron AE, Crino L, Franklin WA, Bunn Jr., PA. Varella-Garcia M, Danenberg LD and Hirsch F. Epidermal Growth Factor Receptor Messenger RNA Expression, gene dosage and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res 12: 3078-3084, 2006.
• Weiss G, Langer C, Rosell R, Hanna N, Shepherd F, Einhorn L, Nguyen B, Paul S, McAndrews P, Bunn Jr., P, Kelly K. Elderly patients (= 70 years old) benefit from second-line cytotoxic chemotherapy: A subset analysis of a randomized phase III trial of pemetrexed versus docetaxel in patients with advanced non-small cell lung cancer previously treated with chemotherapy. J Clin Onc; 24(27): 4405-4411, 2006.
• Bunn Jr., PA, Dziadziuszko R, Varella-Garcia M, Franklin WA, Witta SE, Kelly K, Hirsch FR. Biologic markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy. Clin Cancer Res. 12 (12):3652-3656, 2006.
• Coldren CD, Helfrich BA, Witta SE, Sugita M, Lapadat R, Zeng C, Baron A, Franklin WA, Hirsch FR, Geraci MW, Bunn PA, Jr. Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines. Mol Cancer Res. 4 (8):521-8, 2006.
• Dziadziuszko R, Holm B, Skov BG, Osterlind K, Sellers MV, Franklin WA, Bunn PA, Jr., Varella-Garcia M, Hirsch FR. Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small cell lung cancer patients treated with chemotherapy. Annals Oncology. E-published ahead of print, 2006.
• Mascaux C, Feser WJ, Lewis MT, Barón AE, Coldren CD, Merrick DT, Kennedy TC, Eckelberger JI, Rozeboom LM, Franklin WA, Minna JD, Bunn PA, Miller YE, Keith RL, Hirsch FR. Endobronchial miRNAs as biomarkers in lung cancer chemoprevention. Cancer Prev Res (Phila). 2013 Feb;6(2):100-8. PubMed PMID: 23268837
• Weiss, G. J., Rosell, R., Fosella, F., Perry, M., Stahel, R., Barata, F., Nguyen, B., Paul, S., McAndrews, P., Hanna, N., Kelly, K., Bunn, P. A., Jr. The impact of induction chemotherapy on the outcome of second-line therapy with Pemetrexed or Docetaxel in patients with advanced non-small-cell lung canger. Ann Oncol, in press. 2006.
• Hirsch FR, Varella-Garcia M, Bunn PA, Jr., Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D, Botwood N, Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol; 24(31), 5034-42, 2006.
• Helfrich, B. A., Raben, D., Varella-Garcia, M., Gustafson, D., Chan, D. C., Coldren, C., Baron, A., Zeng, C., Franklin, W. A., Hirsch, F. R., Gazdar, A., Minna, J., Bunn, P. A., Jr. Antitumor activity of the EGFR tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in NSCLC cell lines and xenografts correlates with gene copy number and EGFR mutations but not EGFR protein levels. Clin Can Research 12:(23), 7117-7125. 2006.
• Dziadziuszko, R., Siemiatkowska, A., Limon, J., Rzyman, W., Jassem, J., Bunn, P. A., Jr., Varella-Garcia, M, Hirsch, F. R. Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: A case report. JTO 2:(1), 91-92. 2007.
• Scarborough HA, Bunn PA Jr, DeGregori J. Personalized one-two punches for lung cancer. Cell Res. 2014 Dec 30. [Epub ahead of print] PubMed PMID: 25547118
• Iyengar P, Kavanagh BD, Wardak Z, Smith I, Ahn C, Gerber DE, Dowell J, Hughes R, Abdulrahman R, Camidge DR, Gaspar LE, Doebele RC, Bunn PA, Choy H, Timmerman R. Phase II Trial of Stereotactic Body Radiation Therapy Combined With Erlotinib for Patients With Limited but Progressive Metastatic Non-Small-Cell Lung Cancer. J Clin Oncol. 2014 Dec 1;32(34):3824-30. PubMed PMID: 25349291
• Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K, Nishio M, Brahmer J, Spreafico A, Ludovini V, Massion PP, Dziadziuszko R, Schiller J, Grigorieva J, Tsypin M, Hunsucker SW, Caprioli R, Duncan MW, Hirsch FR, Bunn PA, Jr., Carbone DP. Mass spectrometry to predict clinical outcome for NSCLC patients treated with EGFR TKIs: A multi-cohort cross institutional study. JNCI, in press, 2007.
• Villaruz LC, Socinski MA, Abberbock S, Berry LD, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Varella-Garcia M, Franklin WA, Camidge DR, Sequist LV, Haura EB, Ladanyi M, Kurland BF, Kugler K, Minna JD, Bunn PA, Kris MG. Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium. Cancer. 2014 Oct 1. [Epub ahead of print] PubMed PMID: 25273224
• Lynch TJ, Adjei AA, Bunn PA Jr., Eisen TG, Engelman J, Goss GD, Haber DA, Heymach JV, Janne PA, Johnson BE, Johnson DH, Lilenbaum RC, Meyerson M, Sandler AB, Sequist LV, Settleman J, Wong KK, Hart CS. Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents. Clin Cancer Res 12 (14): 4365s-4371s, 2006.
• Weiss GJ, Bunn PA, Jr., Camidge DR. From radiotherapy to targeted therapy: 20 years in the management of non-small-cell lung cancer. Oncol 20 (12): 1515-1524, 2006.
• Johnson DH, Schiller JH, Bunn PA. Reply to A. Braillon. J Clin Oncol. 2014 Nov 1;32(31):3575. PubMed PMID: 25225428
• Taguchi F, Solomon B Gregorc V, Kasahara K, Nishio M, Grigorieva J, Hunsucker SW, Duncan M, Hirsch FR, Bunn Jr., PA, Caprioli RM, Roder H, Carbone DP. Serum proteomic profiles for predicting response to gefitinib, a cross-laboratory technical validation study. Proc. AACR. 47: #2852, 2006.
• Solomon B, Gregorc V, Taguchi F, Kasahara K, Nishio M, Roder H, Hirsch FR, Duncan MW, Bunn, Jr. PA, Carbone DP. Prediction of clinical outcome in non-small cell lung cancer (NSCLC) patients treated with gefitinib using Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) of serum. Proc. ASCO. J Clin Oncol 24: #7004, 2006.
• Hirsch FR, Franklin WA, McCoy J, Cappuzzo F, Varella-Garcia M, Witta SE, Gumerlock P, West H, Gandara DR, Bunn Jr., PA. Predicting clinical benefit from EGFR TKIs: Not all EGFR mutations are equal. Proc. ASCO. J clin Oncol 24: #7072, 2006.
• Varella-Garcia M, Mitsudomi T, Yatabe Y, Kasaka T, Nakajima E, Franklin W, Bunn Jr., PA, Hirsch FR. EGFR genomic gain in Japanese non-small cell lung cancer patients treated with gefitinib. Proc. ASCO. J Clin Oncol 24: # 7164, 2006.
• Dziadziuszko R, Holm B, Skov BG, Osterlind K, Franklin WA, Varella-Garcia M, Bunn, Jr. PA, Hirsch FR. Prognostic significance of EGFR FISH and IHC in non small-cell lung cancer patients treated with chemotherapy alone. Proc. ASCO. J Clin Oncol 24: #7193, 2006.
• Hirsch FR, Bunn PA Jr, Herbst RS. "Companion diagnostics": has their time come and gone?. Clin Cancer Res. 2014 Sep 1;20(17):4422-4. PubMed PMID: 25059519
• Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014 May 21;311(19):1998-2006. PubMed PMID: 24846037
• Nakajima E, Helfrich B, Chan D, Zhang Z, Hirsch FR, Chen V, Ma D, Bunn Jr. PA: Enzastaurin, a protein kinase Cbeta-selective inhibitor, inhibits the growth of SCLC and NSCLC cell lines. Proc. ASCO. J Clin Oncol 24: #13138, 2006.
• Wynes MW, Hinz TK, Gao D, Martini M, Marek LA, Ware KE, Edwards MG, Böhm D, Perner S, Helfrich BA, Dziadziuszko R, Jassem J, Wojtylak S, Sejda A, Gozgit JM, Bunn PA Jr, Camidge DR, Tan AC, Hirsch FR, Heasley LE. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin Cancer Res. 2014 Jun 15;20(12):3299-309. PubMed PMID: 24771645
• Chan DC, Chen VJ, Zhang Z, Helfrich B, Hirsch FR, Ma D, Bunn Jr. PA: Studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancer models. Proc. ASCO. J Clin Oncol 24(18S):#17114, 2006.
• Bunn PA Jr, Hirsch FR, Aisner DL. Is there clinical value to prognostic signatures in early-stage NSCLC?. Clin Cancer Res. 2014 Apr 1;20(7):1727-9. PubMed PMID: 24583801
• Johnson DH, Schiller JH, Bunn PA Jr. Recent clinical advances in lung cancer management. J Clin Oncol. 2014 Apr 1;32(10):973-82. PubMed PMID: 24567433
• Hirsch FR, Bunn PA Jr. Progress in research on screening and genetics in lung cancer. Lancet Respir Med. 2014 Jan;2(1):19-21. PubMed PMID: 24461890
• Hirsch, F.R., Bunn, P.A., Jr., Kato, H., Mulshine, J.L. (eds.). Textbook of Prevention and Detection of Early Lung Cancer. Taylor & Francis, 2006
• Hirsch FR, Varella-Garcia M, Franklin WA, Bunn Jr. PA; Reply to Unraveling the mystery of prognostic and predictive factors in epidermal growth factor receptor therapy. J Clin Oncol 24(7): 1220-1, 2006.
• Paz-Ares LG, Zimmermann A, Ciuleanu T, Bunn PA, Antonio BS, Denne J, Iturria N, John W, Scagliotti GV. Meta-analysis examining impact of age on overall survival with pemetrexed for the treatment of advanced non-squamous non-small cell lung cancer. Lung Cancer. 2017 Feb;104:45-51. PubMed PMID: 28212999
• Bunn PA Jr. Karnofsky Award 2016: A Lung Cancer Journey, 1973 to 2016. J Clin Oncol. 2017 Jan 10;35(2):243-252. PubMed PMID: 28056194
• He Y, Bunn PA, Zhou C, Chan D. KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer. Oncotarget. 2016 Dec 13;7(50):82104-82111. PubMed PMID: 27893413
• Hirsch FR, Varella-Garcia M, Cappuzzo F, McCoy J, Bemis L, Xavier AC, Dziadziuszko R, Gumerlock P, Chansky K, West H, Gazdar AF, Crino L, Gandara DR, Franklin WA, Bunn PA, Jr. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann Oncol, in press, 2007.
• Scarborough HA, Helfrich BA, Casás-Selves M, Schuller AG, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res. 2016 Sep 23. [Epub ahead of print] PubMed PMID: 27663586
• Miller, Y. E., Blatchford, P., Hyun, D. S., Keith, R. L., Kennedy, T. C., Wolf, H., Byers, T., Bunn, P. A. Jr., Lewis, M. T., Franklin, W. A., Hirsch, F. R., Kittelson, J. Bronchial epithelial Ki-67 index is related to histology, smoking and gender but not lung cancer or chronic obstructive pulmonary disease. Cancer Epidemiol Biomarkers Prev, 16(11):2425-2431, 2007.
• Frederick B., Helfrich B., Coldren C.,. Zheng D., Chan D, Bunn P.A., Jr, Raben D. Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small-cell lung cancer. Mol Cancer Ther 6:(6), 2007.
• Suda K, Bunn PA Jr, Rivard CJ, Mitsudomi T, Hirsch FR. Primary Double-Strike Therapy for Cancers to Overcome EGFR Kinase Inhibitor Resistance: Proposal from the Bench. J Thorac Oncol. 2017 Jan;12(1):27-35. PubMed PMID: 27642065
• Hirsch FR, Suda K, Wiens J, Bunn PA Jr. New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet. 2016 Sep 3;388(10048):1012-24. PubMed PMID: 27598681
• Helfrich BA, Kim J, Gao D, Chan DC, Zhang Z, Tan AC, Bunn PA Jr. Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo. Mol Cancer Ther. 2016 Oct;15(10):2314-2322. PubMed PMID: 27496133
• Varella-Garcia M., Miller Y.E., Hirsch F.R., Mitchell J.D., Keith R.L. Baron A.E. Bunn P.A., Jr., Franklin W.A. Spectral karyotyping detects chromosome damage in bronchial cells of smokers and cancer patients. Am J Respir Crit Care Med,176:(5), 505-12, 2007.
• Tan DS, Yom SS, Tsao MS, Pass HI, Kelly K, Peled N, Yung RC, Wistuba II, Yatabe Y, Unger M, Mack PC, Wynes MW, Mitsudomi T, Weder W, Yankelevitz D, Herbst RS, Gandara DR, Carbone DP, Bunn PA Jr, Mok TS, Hirsch FR. The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation-Positive Non-Small Cell Lung Cancer: Status in 2016. J Thorac Oncol. 2016 Jul;11(7):946-63. PubMed PMID: 27229180
• Patil T, Aisner DL, Noonan SA, Bunn PA, Purcell WT, Carr LL, Camidge DR, Doebele RC. Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status. Lung Cancer. 2016 Jun;96:27-32. PubMed PMID: 27133746
• Tsao AS, Scagliotti GV, Bunn PA Jr, Carbone DP, Warren GW, Bai C, de Koning HJ, Yousaf-Khan AU, McWilliams A, Tsao MS, Adusumilli PS, Rami-Porta R, Asamura H, Van Schil PE, Darling GE, Ramalingam SS, Gomez DR, Rosenzweig KE, Zimmermann S, Peters S, Ignatius Ou SH, Reungwetwattana T, Jänne PA, Mok TS, Wakelee HA, Pirker R, Mazières J, Brahmer JR, Zhou Y, Herbst RS, Papadimitrakopoulou VA, Redman MW, Wynes MW, Gandara DR, Kelly RJ, Hirsch FR, Pass HI. Scientific Advances in Lung Cancer 2015. J Thorac Oncol. 2016 May;11(5):613-38. PubMed PMID: 27013409
• Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?. J Thorac Oncol. 2016 Apr;11(4):453-74. PubMed PMID: 26829312
• Bunn PA Jr, Gaspar LE, Weyant MJ, Mitchell JD. Neoadjuvant combination chemotherapy for unresectable stage III non-small cell lung cancer. Cancer. 2016 Mar 1;122(5):674-5. PubMed PMID: 26700372
• Steuer CE, Behera M, Berry L, Kim S, Rossi M, Sica G, Owonikoko TK, Johnson BE, Kris MG, Bunn PA, Khuri FR, Garon EB, Ramalingam SS. Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium. Cancer. 2016 Mar 1;122(5):766-72. PubMed PMID: 26695526
• Weiss G., Vokes E., Bunn P.A.,Jr., Magree, L., Rusk, J., Albert, D., Kelly, K. Docetaxel and Exisulind in previously treated non-cmall cell lung cancer (NSCLC) patients: A multicenter, phase II clinical trial. J Thor Oncol 2(10), 933-38, 2007.
• Byers, T., Wolf, H. J., Franklin, W. A., Braudrick, S., Merrick, D. T., Shroyer, K. R., Hirsch, F. R., Zeng, C., Baron, A. E., Bunn, P. A., Miller, Y. E., Kennedy, T. C. Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity. Cancer Epidemiol Biomarkers Prev 17:(1), 158-162. 2008.
• Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA Jr, Franklin WA. Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2016 Jan;9(1):96-104. PubMed PMID: 26542061
• Hirsch FR, Dziadziuszko R, Varella-Garcia M, Thatcher N, Mann H, Watkins C, Parums D, Speake G, botwood N, Holloway B, Bunn PA, Jr., Franklin WA. Epidermal growth factor receptor immunohistochemistry: Comparison of antibodies and cut-off points to predict benefit from gefitinib in a phase III placebo-controlled study in advanced non-small cell lung cancer. Clin Cancer, in press, 2008
• 266. Weiss, G. J., Bemis, L. T., Nakajima, E., Sugita, M., Birks, D. K., Robinson, W. A., Varella-Garcia, M., Bunn, P. A., Jr., Haney, J., Helfrich, B. A., Kato, H., Hirsch, F. R., Franklin, W. A. EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Annals of Oncology, mdn006. 2008.
• Weiss,G.J.; Zeng,C.; Kelly,K.; Tran,Z.V.; Bunn,P.A.,Jr. Single-Institution Experience with Pemetrexed and Bevacizumab as Salvage Therapy in Advanced Non-Small-Cell Lung Cancer. Clinical Lung Cancer 8(5):335-338, 2007.
• Solomon, B.,Bunn, P. A., Jr. Adjuvant chemotherapy for non-small cell lung cancer. Cancer Invest 25:(4), 217-225. 2007.
• Aisner DL, Sholl LM, Berry L, Rossi M, Chen H, Fujimoto J, Moreira AL, Ramalingam S, Villaruz LC, Otterson GA, Haura EB, Politi K, Glisson BS, Cetnar J, Garon E, Schiller J, Waqar S, Sequist LV, Brahmer JR, Shyr Y, Kugler K, Wistuba II, Johnson BE, Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ. The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations - the Lung Cancer Mutation Consortium (LCMC2). Clin Cancer Res. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29217530
• Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer. 2017 Nov 10;17(12):765. [Epub ahead of print] PubMed PMID: 29123245
• Pacheco JM, Dimou A, Bunn PA. Advances in lung cancer. Oncotarget. 2017 Oct 3;8(45):78247-78248. PubMed PMID: 29108218
• Bunn, P. A., Jr. Can acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors be overcome by different small-molecule tyrosine kinase inhibitors? J Clin Oncol 25:(18), 2504-2505. 2007.
• Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer. 2017 Dec;17(12):725-737. PubMed PMID: 29077690
• Varella-Garcia M, Acheson K. Marshall GB, McCormarck RM, Rya A, Hirsch FR, Bunn Jr. PA, Hickinson DM, Speake G. Role of EGFR but not HER2 or HER3 gene copy number in predicting sensitivity of head and neck squamous cell carcinoma (SCCHN) cell lines to EGFR tyrosine kinase inhibitors. Proc. ASCO, J Clin Oncol 25, #6063, 2007.
• Solomon BJ, Roder H, Robert R, Taguchi F, Brahmer J, Joan SH, Duncan MW, Hirsch FR, Bunn Jr. PA, Carbone DP. Validation of preteomic classifier for clinical benefit from erlotinib as first line treatment for advanced non-small cell lung cancer (ECOG 3503). Proc. ASCO. J Clin Oncol 25: #7508, 2007.
• Merrick DT, Dziadziuszko R, Szostakiewicz B, Szymanowska A, Rzyman W, Jassem E, Jassem J, Franklin WA, Bunn Jr. PA, Hirsch FR. High insulin-like growth factor 1 receptor (IGF 1R) expression is associated with poor survival in surgically treated non-small cell lung cancer (NSCLC) patients (pts). Proc. ASCO. J Clin Oncol 25: # 7550, 2007.
• Hirsch FR, Varella-Garcia M, Bunn Jr. PA, Dziadziuszko R, Xiao Y, Gajapathy S, Skokan M, Lin M, Waring P, O’Neill V. Fluorescence in situ hybridization (FISH) subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in NSCLC. Proc. ASCO. J Clin Oncol 25: # 7570, 2007.
• Leonard SC, Lee H, Gaddy DF, Klinz SG, Paz N, Kalra AV, Drummond DC, Chan DC, Bunn PA, Fitzgerald JB, Hendriks BS. Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer. Anticancer Drugs. 2017 Nov;28(10):1086-1096. PubMed PMID: 28857767
• Noonan SA, Patil T, Gao D, King GG, Thibault JR, Lu X, Bunn PA, Doebele RC, Purcell WT, Barón AE, Camidge DR. Baseline and On-Treatment Characteristics of Serum Tumor Markers in Stage IV Oncogene-Addicted Adenocarcinoma of the Lung. J Thorac Oncol. 2018 Jan;13(1):134-138. PubMed PMID: 28843358
• Bunn PA Jr. Robert Comis, MD, The Passing of a "Lung Man". J Thorac Oncol. 2017 Aug;12(8):1323-1324. PubMed PMID: 28748814
• Dziadziuszko R, Hirsch FR, Varella-Garcia M, Thatcher N, Mann H, Watkins C, Speake G, Holloway B, Bunn Jr. PA, Franklin WA. Epidermal growth factor receptor (EGFR) immunohistochemistry. Comparison of antibodies (Abs) and cut points to predict benefit from gefitinib in a phase III placebo-controlled study in advanced non-small cell lung cancer (NSCLC). Proc. ASCO. J Clin Oncol 25: # 7576, 2007.
• Pillai RN, Behera M, Berry LD, Rossi MR, Kris MG, Johnson BE, Bunn PA, Ramalingam SS, Khuri FR. HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. Cancer. 2017 Nov 1;123(21):4099-4105. PubMed PMID: 28743157
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• Chansky K. Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw P, Bunn PA, Jr. International Staging Committee and Participating Institutions. The International Association for the Study of Lung Cancer Staging Project prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer. J Thorac Oncol 4: 792-801, 2009.
• Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Jackson MK, Hirsch FR, Bunn PA, Miller YE. A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. Cancer Prev Res 2: 440-449. 2009.
• Gera L, Chan DC, Simkeviciene V, Bunn PA, Jr., Stewart JM. N-(Fluorenyl-9-methoxycarbonyl)amino acid amide derivatives as a new class of anti-cancer agents. Adv Exo Med Biol 611: 465-466, 2009.
• Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P, Bunn, PA, Jr. The IASLC lung cancer staging project: a proposal for a new international lymph node amp in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 4: 568-77, 2009.
• Vallieres E, Crowley JJ, Franklin W, Bunn P, Ginsberg RJ, Putnam JB, Chansky K, Gandara DR. Surgery with or without preoperative paclitaxel and carboplatin in early-stage non-small cell lung cancer: Southwest Oncology ///group Trial S9900, an intergroup, randomized, phase III trial. In Press, J Clin Oncol 2010.
• Bunn, PA, Jr. Novel therapies for non-small-cell lung cancer: a 2008 update. Clin Lung Cancer, suppl. 1: S6, 2009.
• Hirsch FR, Bunn PA, Jr. EGFR testing in lung cancer is ready for prime time. Lancet Oncol 10: 432-433, 2009.
• Camidge R, Gaspar L, Goss G, Kelly K, Ramalingam S, Reckamp K, Simon G, Tsao M, West HJ, Herbst R, Johnson D, Bunn P, Govindan R. Summary of selected presentations from the 8th annual targeted therapy in lung cancer symposium. J Thorac Oncol 4: 930-935, 2009.
• Dziadziusko R, Merrick DT, Witta SE, Mendoza AD, Szostakiewicz B, Rzyman W, Jassem J, Bunn PA, Varella-Garcia M, Hirsch FR. Insulin-like growth factor receptor 1 (IGF1R) protein expression, mRNA expression and gene copy number in operable non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol, J Clin Oncol 27: 388, 2009.
• Hirsch FR, Dziadziuszko R, Kabbinavar F, Camidge DR, Richardson K, Rusk J, Wacker B, Franklin WA, Varella-Garcia M, Bunn PA Jr. Randomized phase II study of erlotinib (E) or intercalated E with carboplatin/paclitaxel (C/P) in chemo-naive advanced NSCLC: Biomarker status correlates with clinical benefit. Proc Am Soc Clin Oncol, J Clin Oncol 27: 413, 2009.
• Witta SE; Franekova V; Igolnikov I; Yoshida K; Coldren C; Frederick B; Varella-Garcia M; Bunn PA,Jr.; Hirsch FR. Synergistic effect of SNDX-275 with lapatinib or erlotinib in breast, lung or head and neck cancer cell lines expressing Her2. Proc Am Soc Clin Oncol, submitted, 2009.
• Franekova V; Witta SE; Bunn PA,Jr.; Hirsch FR. The HDAC inhibitor SNDX-275 synergizes with erlotinib and induces mesenchymal to epithelial transition in pancreatic carcinoma. Proc Am Assoc Cancer Res, 2009.
• Conner A; Helfrich B; Chan DF; Bunn PA,Jr. EGFR expression confers resistance to IGF1R inhibition in ovarian cancer cell lines. Proc Am Assoc Cancer, submitted, 2009.
• Bunn PA, Jr. Signal transduction overview. Proceeding. J Thorac Oncol 4: S149, 2009
• Pisters KM, Vallieres E, Bunn P, Crowley J, Chansky K, Gandara R. S9900 trial update, mature analysis. Procceding. J Thorac Oncol 4, S201, 2009.
• Peled N, Adams O, Koichi Y, Bunn P, Haick H, Hirsch FR. The unique “smell print” of NSCLC cell lines. Proceeding. J Thorac Oncol 4, S329, 2009
• Keith RL, Kittelson JK, Blatchford P, Jackson M, Franklin WA, Hirsch FR, Minna J, Bunn PA, Miller YE. Oral Iloprost improves endobronchial dysplasia in former smokers. Proceeding, J Thorac Oncol 4: S380, 2009.
• Kavanagh BD, Adulrahman R, Camidge DR, Gerber DE, Bunn PA, Schiller J, Choy H, Gasper LE, Wu, J, King T, Timmerman RD. A pilot trial of erlotinib in combination with stereotactic body irradiation therapy (SBRT) for patients with recurrent non-small cell lung cancer (NSCLC). Proceeding, J Thorac Oncol 4: S590, 2009.
• Witta SE, Girard L, Zheng D, Zhang Z, Minna J, Bunn PA, Jr., Chan D, Hirsch FR. Cetuximab activity in non-small cell lung cancer is enhanced in vivo by the HDAC inhibitor entinostat. Proceeding, J Thorac Oncol 4: S 597, 2009
• Chan DC, Gupta M, Zhang Z, Zheng D, Sui X. Peters W. Bunn PA, Jr. Anti-tumor activity of ADH-1 in vitro and in vivo in combination with erlotinib (Tarceva) in lung cancer cell lines. Proceeding, J Thorax Oncol 4: S795, 2009.
• Chan DC, Zheng D, Zhang Z, Sui X, Tiffany T, Sugita M, Bunn Jr. PA. Roles of natural killer-cell immunoglobulin-like receptors (KIR) in immune escape and cancer metastasis. Proceeding, J Thorax Oncol 4: S900, 2009.
• Chan DC, Witta SE, Zheng D, Franekova V, Sui Z, Ordentlich P, Bunn PA, Jr., Hirsch FR. Characterization of the class 1 histone deacetylase inhibitor entinostat in EGFRi acquired resistance models and in combination with cetuximab in NSCLC. Proceeding AACR, April 2010.
• Jonsson S, Moller YE, Kennedy TC, Varella-Garcia M, Skokan M, Wolf H, Feser W, Byers T, Haney J, Merrick D, Bunn PA, Jr., Keith RL, Hirsch FR, Franklin WA. Histological and molecular characteristics of twenty-nice cases of carcinoma in situ from a prospective bronchoscope cohort. Proceeding AACR, April 2010.
• 282. Pisters KM, Vallieres E, Crowley JJ, Franklin W, Bunn P, Ginsberg RJ, Putnam JB, Chansky K, Gandara DR. Surgery with or without preoperative paclitaxel and carboplatin in early-stage non-small cell lung cancer: Southwest Oncology ///group Trial S9900, an intergroup, randomized, phase III trial. J Clin Oncol 28: 1843-1849, 2010.
• Gemmill RM, Roche J, Potiron VA, Nasarre P, Mitas M, Coldren CD, Helfrich BA, Garrett-Mayer E, Bunn PA, Drabkin HA. ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett, October 25, 2010
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• Doebele RC, Oton AB, Peled N, Camidge DR, Bunn PA, Jr. New strategies to overcome limitations of reversible EGFR tyrosine kinase inhibitors therapy in non-small cell lung cancer. Lung Cancer January 2010
• Bunn PA, Jr. Optimal therapy for elderly patients with early stage non-small cell lung cancere. Am J Respir Crit Care Med 181: 201-202, 2010
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• Chan DC, Witta SE, Zheng D, Franekova V, Sui Z, Ordentlich P, Bunn PA, Jr., Hirsch FR. Characterization of the class 1 histone deacetylase inhibitor entinostat in EGFRi acquired resistance models and in combination with cetuximab in NSCLC. Proceeding AACR, April 2010.
• Jonsson S, Moller YE, Kennedy TC, Varella-Garcia M, Skokan M, Wolf H, Feser W, Byers T, Haney J, Merrick D, Bunn PA, Jr., Keith RL, Hirsch FR, Franklin WA. Histological and molecular characteristics of twenty-nice cases of carcinoma in situ from a prospective bronchoscope cohort. Proceeding AACR, April 2010.
• Peled N, Hakim M, Haick H, Bunn PA, Miller YE, Kennedy TC, Mitchell JD, Weyant MJ, Hirsch FR. Use of a nanoparticle-based artificial olfactory system, NaNose to distinguish malignant from benign pulmonary nodules. Proceeding, ASCO # 10521, 2010.
• Varella-Garcia M, Cho Y, Lu X, Baron AE, Terracciano L, Camidge DR, Bunn PA, Franklin WA, Cappuzzo F, Doebele RC. ALK gene rearrangements in unselected caucasians with non-small cell lung carcinoma (NSCLC). Proceeding, ASCO # 10533, 2010.
• Hirsch FR, Wynes MW, Gandara DR, Bunn PA, Jr. The tissue is the issue: personalized medicine for non-small cell lung cancer. Clin Cancer Res 16: 49-9-4911, 2010
• Bunn PA Jr., Hirsch FR, Doebele RC, Camidge DR, Varella-Garcia M, Franklin W. Biomarkers are here to stay for clinical research and standard care. J Thorac Oncol 5: 1113 – 1115, 2010.
• Hirsch FR, Mok TS, Borges V, Bunn PA Jr. Molecularly targeted therapy: when to stop and when to continue? Lancet Oncol 11: 709-711, 2010.
• Bunn PA Jr. Optimal therapy for elderly patients with early stage non-small cell lung cancer. Am J Respir Crit Care Med 181: 201-202, 2010
• Rafnar T, Sulem P, Besenbacher S, Gudbjartsson DF, Zanon C, Gudmundsson J, Stacey SN, Kostic JP, Thorgeirsson TE, Thorleifsson G, Bjarnason H, Skuladottir H, Gudbjartsson T, Isaksson HJ, Isla D, Murillo L, Garcia-Prats MD, Panadero A, Aben KK, Vermeulen SH, van der Heijden HF, Feser WJ, Miller YE, Bunn PA, Kong A, Wolf HJ, Franklin WA, Mayordomo Jl, Kiemeney LA, Jonsson S, Thorsteinsdottir U, Stefansson L. Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. Cancer Res. 71: 1356-1361, 2011.
• Gemmill RM, Roche J, Potiron VA, Nasarre P, Mitas M, Coldren CD, Helfrich BA, Garret-Mayer E, Bunn PA, Drabkin HA. ZEB1-responsive genes in non-small cell lung cancer. Cancer Lett 300: 66-78, 2011.
• Keith RL, Blatchford PJ, Kittelson J, Minna JD, Kelly K, Massion PP, Franklin WA, Mao J, Wilson DO, Merrick DT, Hirsch FR, Kennedy TC, Bunn PA Jr., Geraci MW, Miller YE. Oral iloprost improves endobronchial dysplasia in former smokers. Cancer Prev Res 365: 793-902, 2011.
• Hirsch FR, Kabbinavar F, Eisen T, Martins R, Schnell FM, Dziadziuszko R, Richardson K, Richardson F, Wacker B, Sternberg DW, Rusk J, Franklin WA, Varella-Garcia M, Bunn PA Jr., Camidge DR. A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer. J Clin Oncol 29: 3567-3573, 2011.
• Barash O, Peled N, Tisch U, Bunn PA Jr, Hirsch FR, Haick H. Classification of lung cancer histology by gold nanoparticle sensors. Nanomedicine, October 25, 2011.
• Bunn PA Jr, Doebele RC. Genetic testing for lung cancer: reflex verusus clinical selection. J Clin Oncol 29: 1943-1945, 2011.
• Doebele RC, Sumey C, Maxson DA, Lu X, Baron AB, Bunn PA, Varella-Garcia M, Aisner DL, Franklin WA, Camidge DR. Oncogene Status in Lung Adenocarcinomas Predicts patterns of metastatic spread. Proceeding IASLC WCLC 2011.
• Barash O, Peled N, Tisch U, Bunn PA Jr, Hirsch FR, Haick H. Classification of lung cancer histology by gold nanoparticle sensors. Nanomedicine, 8: 580-589, 2012.
• Witta SE, Jotte RM, Konduri K, Neubauer MA, Spisa AI, Ruxer RL, Varella-Garcia M, Bunn Jr. PA, Hirsch FR. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small cell lung cancer who progressed on prior chemotherapy. JCO 30: 2248-2255, 2012.
• Doebele RC, Lu X, Sumey C, Maxson DA, Weickhardt AJ, Oton AB, Bunn PA Jr, Baron AE, Franklin WA, Aisner DL, Varella-Garcia M, Camidge DR. Oncogene status predicts patterns of metastatic spread in treatment-naïve nonsmall cell lung cancer. Cancer , 118: 4502-4510, 2012.
• Casas-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA, Jr., Chan DC, Tan AC, DeGregori J. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res 72: 4154-4164, 2012.
• Peled N, Hakim M, Bunn PA, Jr., Miller YE, Kennedy TC, Mattel J, Mitchell JD, Hirsch FR, Haick H. Non-invasive breath analysis of pulmonary nodules. J Thorac Oncol 7: 1528-1533, 2012
• Weickhardt AJ, Scheier B, Burke JM, Gan G, Lu X, Bunn PA, Jr., Aisner DL, Gaspar LE, Kavanagh BD, Doebele RC, Camidge DR. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thoracic Oncol 7: 1807 – 1814, 2012
• Hirsch FR, Bunn PA, Jr. A new generation of EGFR tyrosine-kinase inhibitors in NSCLC. Lancet Oncol 13: 442-443, 2012

Professional Memberships

• American Association for Cancer Research, Member
• American Society of Clinical Oncology, Fellow
• International Association for Study of Lung Cancer, Member
• American Association for Advancement of Science, Member
• Westerm Association of Physicians, Member
• Southwest Oncology Group, Member
• American College of Physicians (ACP), Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Valley View Hospital Cancer Center
1906 Blake Ave.
Glenwood Springs, CO 81601
970-384-7570

UCHealth Lung Cancer Clinic - Anschutz Medical Campus
1665 Aurora Ct
Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-0300

University of Colorado Cancer Center - Anschutz Medical Campus
1665 Aurora Ct
Aurora, CO 80045
720-848-0300

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center

Specialty Information

Specialties

• Internal Medicine, Board Certification (1974)
• Medical Oncology, Board Certification (1975)
• American Board of Internal Medicine and Medical Oncology, Board Certification (1976)

Conditions & Treatments

• Cancers - Lung Cancer
• Cancers
• Cancers - Thoracic (Tracheal, Esophageal)