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Donald Penning, MD

Professor, Anesthesiology

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Department Anesthesiology

Publications

  • Guerra-Londono CE, Dexter F, Mitchell JD, Forrest PB, Penning DH. Effect of a non-reactive absorbent with or without environmentally oriented electronic feedback on anesthesia provider's fresh gas flow rates: A greening initiative. J Clin Anesth. 2024 Aug;95:111441. PubMed PMID: 38452428
  • Bao X, Kumar SS, Shah NJ, Penning D, Weinstein M, Malhotra G, Rose S, Drover D, Pennington MW, Domino K, Meng L, Treggiari M, Clavijo C, Wagener G, Chitilian H, Maheshwari K. AcumenTM hypotension prediction index guidance for prevention and treatment of hypotension in noncardiac surgery: a prospective, single-arm, multicenter trial. Perioper Med (Lond). 2024 Mar 4;13(1):13. PubMed PMID: 38439069
  • Fayed M, Maroun W, Elnahla A, Yeldo N, Was JR, Penning DH. Prone Vs. Supine Position Ventilation in Intubated COVID-19 Patients: A Systematic Review and Meta-Analysis. Cureus. 2023 May;15(5):e39636. PubMed PMID: 37388580
  • Nizar R, Cazacu S, Xiang C, Krasner M, Barbiro-Michaely E, Gerber D, Schwartz J, Fried I, Yuval S, Brodie A, Kazimirsky G, Amos N, Unger R, Brown S, Rogers L, Penning DH, Brodie C. Propofol Inhibits Glioma Stem Cell Growth and Migration and Their Interaction with Microglia via BDNF-AS and Extracellular Vesicles. Cells. 2023 Jul 25;12(15). PubMed PMID: 37566001
  • Fayed M, Maroun W, Elnahla A, Yeldo N, Was JR, Penning DH. Prone Vs. Supine Position Ventilation in Intubated COVID-19 Patients: A Systematic Review and Meta-Analysis. Cureus. 2023 May 29;15(5):e39636. doi: 10.7759/cureus.39636. PMID: 37388580; PMCID: PMC10305786.
  • Nizar R, Cazacu S, Xiang C, Krasner M, Barbiro-Michaely E, Gerber D, Schwartz J, Fried I, Yuval S, Brodie A, Kazimirsky G, Amos N, Unger R, Brown S, Rogers L, Penning DH, Brodie C. Propofol Inhibits Glioma Stem Cell Growth and Migration and Their Interaction with Microglia via BDNF-AS and Extracellular Vesicles. Cells. 2023 Jul 25;12(15):1921. doi: 10.3390/cells12151921. PMID: 37566001; PMCID: PMC10417602.
  • Fayed M, Nowak K, Angappan S, Patel N, Abdulkarim F, Penning DH, Chhina AK. Emergent Surgical Airway Skills: Time to Re-evaluate the Competencies. Cureus. 2022 Mar 17;14(3):e23260. doi: 10.7759/cureus.23260. PMID: 35342673; PMCID: PMC8929234.
  • Penning DH, Jones B, Fayed M, Han X, Brodie C. Effect of Cocaine on Potassium-Evoked Release of Glutamate From Fetal Rat Brain Synaptosomes. Cureus. 2022 Oct 8;14(10):e30075. doi: 10.7759/cureus.30075. PMID: 36381732; PMCID: PMC9637459.
  • Zador L, Nowak K, Sitarik A, MacLean L, Han X, Kalsi M, Yeldo N, Sibai N, Penning D, Lewis M. The Burnout Epidemic Within A Viral Pandemic: Impact of a Wellness Initiative. Perioper Care Oper Room Manag. 2022 Jun;27:100251. PubMed PMID: 35382030
  • Peleman JR, Tarwade P, Han X, Penning DH, Craig JR. Hemodynamic Changes with 1:1000 Epinephrine on Wrung-Out Pledgets Before and During Sinus Surgery. Ann Otol Rhinol Laryngol. 2021 May;130(5):490-496. PubMed PMID: 32945177
  • Penning DH, Cazacu S, Brodie A, Jevtovic-Todorovic V, Kalkanis SN, Lewis M, Brodie C. Neuron-Glia Crosstalk Plays a Major Role in the Neurotoxic Effects of Ketamine via Extracellular Vesicles. Front Cell Dev Biol. 2021 Sep 16;9:691648. doi: 10.3389/fcell.2021.691648. PMID: 34604212; PMCID: PMC8481868.
  • Dexter F, Epstein RH, Gostine AL, Penning DH, Loftus RW. Benefit of systematic selection of pairs of cases matched by surgical specialty for surveillance of bacterial transmission in operating rooms. Am J Infect Control. 2020 Jun;48(6):682-687. PubMed PMID: 31679749
  • Kuhar HN, Han X, Penning DH, Craig JR. Approximate Weight of 1:1000 Topical Epinephrine on Wrung-Out Epinephrine-Soaked Pledgets. Otolaryngol Head Neck Surg. 2020 Jan;162(1):60-63. PubMed PMID: 31739741
  • Dexter F, Epstein RH, Penning DH. Late first-case of the day starts do not cause greater minutes of over-utilized time at an endoscopy suite with 8-hour workdays and late running rooms. A historical cohort study. J Clin Anesth. 2020 Feb;59:18-25. PubMed PMID: 31195226
  • Guerra-Londono CE, Han X, Penning DH. Postoperative Pulmonary Complications in the Morbidly Obese: The Role of Tidal Volume and Type of Abdominal Surgery. Respir Care. 2020 Dec;65(12):1908-1915. PubMed PMID: 32694181
  • Walha S, Penning D. Spurious Hypoxemia During Craniotomy. J Neurosurg Anesthesiol. 2018 Jul;30(3):283-284. PubMed PMID: 28288035
  • Lee AJ, Palte HD, Chehade JM, Arheart KL, Ranasinghe JS, Penning DH. Ultrasound-guided bilateral transversus abdominis plane blocks in conjunction with intrathecal morphine for postcesarean analgesia. J Clin Anesth. 2013 Sep;25(6):475-82. PubMed PMID: 24012493
  • Wolfson A, Lee AJ, Wong RP, Arheart KL, Penning DH. Bilateral multi-injection iliohypogastric-ilioinguinal nerve block in conjunction with neuraxial morphine is superior to neuraxial morphine alone for postcesarean analgesia. J Clin Anesth. 2012 Jun;24(4):298-303. PubMed PMID: 22608584
  • Lee AJ, Ranasinghe JS, Chehade JM, Arheart K, Saltzman BS, Penning DH, Birnbach DJ. Ultrasound assessment of the vertebral level of the intercristal line in pregnancy. Anesth Analg. 2011 Sep;113(3):559-64. PubMed PMID: 21680856
  • Harris EA, Arheart KL, Penning DH. Endotracheal tube malposition within the pediatric population: a common event despite clinical evidence of correct placement. Can J Anaesth. 2008 Oct;55(10):685-90. PubMed PMID: 18835966
  • Cordone M, Wolfson A, Wolfson N, Penning D. Anesthetic management of labor in a patient with congenitally corrected transposition of the great arteries. Int J Obstet Anesth. 2008 Jan;17(1):57-60. PubMed PMID: 17693077
  • Sexton JB, Holzmueller CG, Pronovost PJ, Thomas EJ, McFerran S, Nunes J, Thompson DA, Knight AP, Penning DH, Fox HE. Variation in caregiver perceptions of teamwork climate in labor and delivery units. J Perinatol. 2006 Aug;26(8):463-70. PubMed PMID: 16775621
  • Holcroft CJ, Graham EM, Penning DH. Cord gas analysis, decision-to-delivery interval and the 30-minute rule for emergency cesareans. J Perinatol. 2005 Sep;25(9):616. PubMed PMID: 16123793
  • Holcroft CJ, Graham EM, Aina-Mumuney A, Rai KK, Henderson JL, Penning DH. Cord gas analysis, decision-to-delivery interval, and the 30-minute rule for emergency cesareans. J Perinatol. 2005 Apr;25(4):229-35. PubMed PMID: 15616612
  • Loeliger M, Watson CS, Reynolds JD, Penning DH, Harding R, Bocking AD, Rees SM. Extracellular glutamate levels and neuropathology in cerebral white matter following repeated umbilical cord occlusion in the near term fetal sheep. Neuroscience. 2003;116(3):705-14. PubMed PMID: 12573713
  • Dexter F, Blake JT, Penning DH, Sloan B, Chung P, Lubarsky DA. Use of linear programming to estimate impact of changes in a hospital's operating room time allocation on perioperative variable costs. Anesthesiology. 2002 Mar;96(3):718-24. PubMed PMID: 11873050
  • Dexter F, Macario A, Penning DH, Chung P. Development of an appropriate list of surgical procedures of a specified maximum anesthetic complexity to be performed at a new ambulatory surgery facility. Anesth Analg. 2002 Jul;95(1):78-82, table of contents. PubMed PMID: 12088947
  • Dexter F, Blake JT, Penning DH, Lubarsky DA. Calculating a potential increase in hospital margin for elective surgery by changing operating room time allocations or increasing nursing staffing to permit completion of more cases: a case study. Anesth Analg. 2002 Jan;94(1):138-42, table of contents. PubMed PMID: 11772816
  • Bell EA, Jones BP, Olufolabi AJ, Dexter F, Phillips-Bute B, Greengrass RA, Penning DH, Reynolds JD. Iliohypogastric-ilioinguinal peripheral nerve block for post-Cesarean delivery analgesia decreases morphine use but not opioid-related side effects. Can J Anaesth. 2002 Aug-Sep;49(7):694-700. PubMed PMID: 12193488
  • Lockhart EM, Warner DS, Pearlstein RD, Penning DH, Mehrabani S, Boustany RM. Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. Neurosci Lett. 2002 Aug 2;328(1):33-6. PubMed PMID: 12123853
  • Penning D. Trauma in pregnancy. Can J Anaesth. 2001 Jun;48(Suppl 1):R34-R40. PubMed PMID: 27688134
  • Dexter F, Penning DH, Traub RD. Statistical analysis by Monte-Carlo simulation of the impact of administrative and medical delays in discharge from the postanesthesia care unit on total patient care hours. Anesth Analg. 2001 May;92(5):1222-5. PubMed PMID: 11323350
  • Dexter F, Epstein RH, Penning DH. Statistical analysis of postanesthesia care unit staffing at a surgical suite with frequent delays in admission from the operating room--a case study. Anesth Analg. 2001 Apr;92(4):947-9. PubMed PMID: 11273932
  • Penning D. Trauma in pregnancy. Can J Anaesth. 2001 Jun;48(Suppl 1):R34-R40. doi: 10.1007/BF03028176. PMID: 27688134.
  • Olufolabi AJ, Booth JV, Wakeling HG, Glass PS, Penning DH, Reynolds JD. A preliminary investigation of remifentanil as a labor analgesic. Anesth Analg. 2000 Sep;91(3):606-8. PubMed PMID: 10960385
  • Jones BP, Milliken BC, Penning DH. Anesthesia for Cesarean section in a patient with paraplegia resulting from tumour metastases to spinal cord. Can J Anaesth. 2000 Nov;47(11):1122-8. PubMed PMID: 11097545
  • Bell ED, Penning DH, Cousineau EF, White WD, Hartle AJ, Gilbert WC, Lubarsky DA. How much labor is in a labor epidural? Manpower cost and reimbursement for an obstetric analgesia service in a teaching institution. Anesthesiology. 2000 Mar;92(3):851-8. PubMed PMID: 10719964
  • Smith GN, Kingdom JC, Penning DH, Matthews SG. Antenatal corticosteroids: is more better?. Lancet. 2000 Jan 22;355(9200):251-2. PubMed PMID: 10675070
  • Booth JV, Lindsay DR, Olufolabi AJ, El-Moalem HE, Penning DH, Reynolds JD. Subarachnoid meperidine (Pethidine) causes significant nausea and vomiting during labor. The Duke Women's Anesthesia Research Group. Anesthesiology. 2000 Aug;93(2):418-21. PubMed PMID: 10910491
  • Reynolds JD, Grubbs EG, Dexter F, Punnahitananda S, Dense TA, Penning DH. Acute cord occlusion increases blood ionized magnesium concentration in preterm fetal sheep during maternal magnesium sulfate exposure. Can J Physiol Pharmacol. 2000 Apr;78(4):301-6. PubMed PMID: 10772057
  • Penning DH, Dexter F, Henderson JL, Chestnut DH, Reynolds JD. Bolus maternal cocaine administration does not produce a large increase in fetal sheep cerebral cortical glutamate concentration. Neurotoxicol Teratol. 1999 Mar-Apr;21(2):177-80. PubMed PMID: 10192278
  • Lockhart EM, Penning DH, Olufolabi AJ, Bell EA, Booth JV, Kern FH. SvO2 monitoring during spinal anesthesia and cesarean section in a parturient with severe cyanotic congenital heart disease. Anesthesiology. 1999 Apr;90(4):1213-5. PubMed PMID: 10201698
  • Hilton AB, Lockhart EM, Penning DH. Epidural analgesia in parturients with previous spinal irradiation. Can J Anaesth. 1998 Sep;45(9):884-7. PubMed PMID: 9818113
  • Goldsmith RJ, Henderson JL, Reynolds JD, Penning DH. Management of a parturient with an uncorrected atrioventricular canal defect. Int J Obstet Anesth. 1998 Jul;7(3):181-4. PubMed PMID: 15321214
  • Henderson JL, Reynolds JD, Dexter F, Atkins B, Hrdy J, Poduska D, Penning DH. Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep. Brain Res Dev Brain Res. 1998 Feb 10;105(2):287-93. PubMed PMID: 9541746
  • Dexter F, Penning DH, Lubarsky DA, DeLong E, Sanderson I, Gilbert BC, Bell E, Reves JG. Use of an automated anesthesia information system to determine reference limits for vital signs during cesarean section. J Clin Monit Comput. 1998 Dec;14(7-8):491-8. PubMed PMID: 10385858
  • Reynolds JD, Zeballos GA, Penning DH, Kimura KA, Atkins B, Brien JF. Nitrate and nitrite anion concentration in the intact cerebral cortex of preterm and nearterm fetal sheep: indirect index of in vivo nitric oxide formation. J Pharmacol Toxicol Methods. 1998 Apr;39(3):125-8. PubMed PMID: 9741385
  • Reynolds JD, Penning DH, Kimura KA, Dexter F, Henderson JL, Atkins B, Poduska D, Brien JF. Ethanol-induced changes in prostaglandin E concentration in the intact cerebral cortex of preterm and near-term fetal sheep. Alcohol Clin Exp Res. 1997 Sep;21(6):997-1004. PubMed PMID: 9309308
  • Reynolds JD, Chestnut DH, Dexter F, McGrath J, Penning DH. Magnesium sulfate adversely affects fetal lamb survival and blocks fetal cerebral blood flow response during maternal hemorrhage. Anesth Analg. 1996 Sep;83(3):493-9. PubMed PMID: 8780269
  • Reynolds JD, Penning DH, Dexter F, Atkins B, Hrdy J, Poduska D, Brien JF. Ethanol increases uterine blood flow and fetal arterial blood oxygen tension in the near-term pregnant ewe. Alcohol. 1996 May-Jun;13(3):251-6. PubMed PMID: 8734839
  • McArdle P, Penning DH, Dexter F, Reynolds JD. Flumazenil does not affect the increase in rat hippocampal extracellular glutamate concentration produced during thioacetamide-induced hepatic encephalopathy. Metab Brain Dis. 1996 Dec;11(4):329-342. PubMed PMID: 8979252
  • Penning DH, Chestnut DH, Dexter F, Hrdy J, Poduska D, Atkins B. Glutamate release from the ovine fetal brain during maternal hemorrhage. A study using chronic in utero cerebral microdialysis. Anesthesiology. 1995 Feb;82(2):521-30. PubMed PMID: 7856910
  • Vincent RD Jr, Syrop CH, Van Voorhis BJ, Chestnut DH, Sparks AE, McGrath JM, Choi WW, Bates JN, Penning DH. An evaluation of the effect of anesthetic technique on reproductive success after laparoscopic pronuclear stage transfer. Propofol/nitrous oxide versus isoflurane/nitrous oxide. Anesthesiology. 1995 Feb;82(2):352-8. PubMed PMID: 7856893
  • Reynolds JD, Penning DH, Dexter F, Atkins B, Hrdy J, Poduska D, Chestnut DH, Brien JF. Dose-dependent effects of acute in vivo ethanol exposure on extracellular glutamate concentration in the cerebral cortex of the near-term fetal sheep. Alcohol Clin Exp Res. 1995 Dec;19(6):1447-53. PubMed PMID: 8749809
  • Catlin MC, Penning DH, Brien JF. Effect of exposure in vitro to ethanol and hypoxia on gamma-aminobutyric acid efflux in the hippocampus of the fetal and adult guinea-pig. Reprod Fertil Dev. 1995;7(5):1339-44. PubMed PMID: 8848609
  • Penning DH, Grafe MR, Hammond R, Matsuda Y, Patrick J, Richardson B. Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia. Am J Obstet Gynecol. 1994 May;170(5 Pt 1):1425-32. PubMed PMID: 8178885
  • Chestnut DH, McGrath JM, Vincent RD Jr, Penning DH, Choi WW, Bates JN, McFarlane C. Does early administration of epidural analgesia affect obstetric outcome in nulliparous women who are in spontaneous labor?. Anesthesiology. 1994 Jun;80(6):1201-8. PubMed PMID: 8010466
  • Penning DH, Goh JW, el-Beheiry H, Brien JF. Effect of hypoxia on glutamate efflux and synaptic transmission in the guinea pig hippocampus. Brain Res. 1993 Aug 27;620(2):301-4. PubMed PMID: 8103702
  • Pattee CL, Penning DH. Obstetrical analgesia in a parturient with antithrombin III deficiency. Can J Anaesth. 1993 Jun;40(6):507-10. PubMed PMID: 8403113
  • Penning DH, Jhamandas K. Yohimbine-precipitated clonidine withdrawal: an experimental model of the antihypertensive drug withdrawal syndrome. Can J Physiol Pharmacol. 1992 Jun;70(6):853-8. PubMed PMID: 1358421
  • Penning DH, Patrick J, Jimmo S, Brien JF. Release of glutamate and gamma-aminobutyric acid in the ovine fetal hippocampus: ontogeny and effect of hypoxia. J Dev Physiol. 1991 Nov;16(5):301-7. PubMed PMID: 1688088
  • Yee DA, Penning DH. Ambulatory surgery questionnaire. Can J Anaesth. 1990 May;37(4 Pt 2):S8. PubMed PMID: 2361318
  • Penning DH, Patrick J, Brien J. Effects of hypoxia on release of amino acid neurotransmitters from fetal lamb brain in vitro. Can J Anaesth. 1990 May;37(4 Pt 2):S2. PubMed PMID: 1972913
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Specialty Information

Specialties
  • Anesthesiology

General Information

Department Anesthesiology