Professional Titles
- Associate Research Professor
Publications
- Sakthi Asokan, WENBO ZHOU, …Xiaoli Yu. The CNS compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity Frontiers in Immunology, section Multiple Sclerosis and Neuroimmunology. 2026. Accepted.
- S. Asokan, M. Fultz, X. Yu. Complement Activation in Multiple Sclerosis. ACTRIMS, West Palm Beach, Feb 27 to March 1, 2025.
- Apeltsin, L.; Yu, X. IgG Biomarkers in Multiple Sclerosis: Deciphering Their Puzzling Protein A Connection. Biomolecules 2025, 15, 369.
- Kennedy, P.G.E.; Fultz, M.; Phares, J.; Yu, X. Immunoglobulin G and Complement as Major Players in the Neurodegeneration of Multiple Sclerosis. Biomolecules 2024, 14, 1210. https://doi.org/10.3390/biom14101210
- Kennedy PGE, George W., YU X. The elusive nature of the oligoclonal bands in multiple sclerosis. Journal of Neurology. 2024 Jan;271(1):116-124. doi: 10.1007/s00415-023-12081-7.
- Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Grimaldo-Garcia S, Metzger B, Bolus V, Kopper TJ, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW. Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells. Neurol Int. 2024 Nov 6;16(6):1355-1384. doi: 10.3390/neurolint16060103. PMID: 39585062; PMCID: PMC11587087.
- Kennedy PGE, George W, Yu X. The elusive nature of the oligoclonal bands in multiple sclerosis. J Neurol. 2024 Jan;271(1):116-124. PubMed PMID: 37945762
- Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 Feb 2. [Epub ahead of print] PubMed PMID: 36727508
- Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, Vollmer T, Alvarez E, Yu X. Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis. Cell Death Dis. 2023 Apr 8;14(4):254. PubMed PMID: 37031195
- Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, Vollmer T, Alvarez E, Yu X. Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis. Cell Death Dis. 2023 Apr 8;14(4):254. PubMed PMID: 37031195
- Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 Nov;256:109801. PubMed PMID: 37816415
- Kopper TJ, Yu X, Graner MW. Immunopathology of Extracellular Vesicles in Macrophage and Glioma Cross-Talk. J Clin Med. 2023 May 12;12(10). PubMed PMID: 37240536
- Kennedy PGE, Graner MW, Fringuello A, Zhou W, Pointon T, Alquatli K, Bisel S, Langford D, Yu X. Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders. J Neuroimmune Pharmacol. 2022 Dec;17(3-4):526-537. PubMed PMID: 34989971
- Zhou W, Craft J, Ojemann A, Bergen L, Graner A, Gonzales A, He Q, Kopper T, Smith M, Graner MW, Yu X. Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity. Int J Mol Sci. 2022 Jun 28;23(13). PubMed PMID: 35806205
- Kennedy PGE, George W, Yu X. The Possible Role of Neural Cell Apoptosis in Multiple Sclerosis. Int J Mol Sci. 2022 Jul 8;23(14). PubMed PMID: 35886931
- Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, Kennedy PGE, Graner AN, Lillehei KO, Ormond DR, Youssef AS, Graner MW, Yu X. Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles. Biomedicines. 2022 Oct 27;10(11). PubMed PMID: 36359238
- Kennedy, PGE, Graner, M., Li, X., Pointon, T., Dennison, K., Im, G., Curley, T., Tanimoto, K., Frank, L., Vollmer, T., Yu, X. Aberrant Immunoglobulin G glycosylation in Multiple Sclerosis. Journal of Neuroimmune Pharmacology. 2021.
- Anthony Fringuello, Philip Tatman, Tadeusz H Wroblewski, John A Thompson, Xiaoli Yu, Kevin O Lillehei, Robert G Kowalski, Michael William Graner. Cytokine Laden Extracellular Vesicles Predict Patient Prognosis After Cerebrovascular Accident. International Journal of Molecular Sciences. 2021.
- Yu, X., Zizzo, Z., Kennedy, PGE. An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis. Multiple Sclerosis and Related Disorders. 2021.
- Nicholas L. Baird, Jacqueline L. Bowlin, Xiaoli Yu, Stipan Jonjic,, Jürgen Haasd, Randall J. Cohrs and Don Gilden. Varicella Zoster Virus DNA Does Not Accumulate in Infected Human Neurons. Virology. Accepted for publication. 2014.
- Yu X,, Dennis K, Pointon T, Vollmer T. (P4.135) Reduced level of Sialylated IgG Antibody in the CSF of Patients with Multiple Sclerosis. Poster and abstracted accepted for presentation at the annual meeting of the American Academy of Neurology, Philadelphia, PA April, 2014.
- Jacqueline Bowlin, Charles Grose, Randall Cohrs, Nicholas Baird, Xiaoli Yu, and Don Gilden. Varicella Zoster Virus – Human Neuron Interaction. 2nd Annual CDI User Group Meeting, Madison, WI. August, 2013.
- Charles Grose, Jacqueline Bowlin, Tiffany Pointon, Dicle Gunaydin, Randall Cohrs, Don Gilden, and Xiaoli Yu. Ultrastructural and gC expression analysis of VZV-infected human neurons. Rocky Mountain Branch of the American Society for Microbiology Spring meeting, Colorado State University, Ft. Collins, CO. June, 2013.
- Charles Grose, Jacqueline Bowlin, Tiffany Pointon, Dicle Gunaydin, Randall Cohrs, Don Gilden, and Xiaoli Yu. Ultrastructural and gC expression analysis of VZV-infected human neurons. Rocky Mountain Regional Neuroscience Group Annual Meeting. Anschutz Medical Campus, Aurora, CO. May, 2013.
- Nicholas L. Baird, Jacqueline L. Bowlin, Kenneth L. Jones, Xiaoli Yu, Randall J. Cohrs and Don Gilden. Neurons are not killed by varicella zoster virus. 12th International Symposium on Neurovirology. Washington DC. November, 2013.
- Yu, X., Seitz, S., Pointon, T., Bowlin, J., Cohrs, R., Jonjic, S., Haas, J., Wellish, M. and Gilden, D. Varicella zoster virus infection of highly pure terminally differentiated human neurons. J. Neurovirol. 2013.
- Grose, C, Yu, X., Cohrs, R., Carpenter, J., Johnson, J., and Gilden, D. Aberrant Virion Assembly and Limited gC Production in Varicella Zoster Virus Infected Neurons. Journal of Virology. doi:10.1128/JVI.01506-13, 2013.
- Baird, N, Yu, X., Cohrs, R, and Gilden, D. VZV-Human Neuron Interaction. Viruses, 5, 2106-2115. 2013.
- Varicella zoster virus infection of highly pure terminally differentiated human neurons Xiaoli Yu & Scott Seitz & Tiffany Pointon & Jacqueline L. Bowlin & Randall J. Cohrs & Stipan Jonjic & Jürgen Haas & Mary Wellish & Don Gilden J. Neurovirol.2012
- Yu, X., Gilden, D., Schambers, L., Barmina, O., Burgoon, M., Bennett, JL, and Owens, GP. Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF. J. Neuroimmunol. 233: 192-203, 2011. PMID: 21176973
- Yu. X., Green M., Gilden, D., Lam C., Bautista A., Bennett, L. Identification of peptide targets in neuromyelitis optica. J. Neuroimmunol (2011), doi: 10.1016/j.jneuroim.2011.04.007.
- Owens, G.P., Gilden, D.H., Burgoon, M.P., Yu, X., Bennett, J.L. Viruses and Multiple Sclerosis. The Neuroscientist. 2011, in press.
- Yu, X., Gilden, D., Schambers, L., Barmina, O., Burgoon, M., Bennett, JL, and Owens, GP. Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF. J. Neuroimmunol. 233: 192-203, 2011.
- Yu. X., Green M., Gilden, D., Lam C., Bautista A., Bennett, L. Identification of peptide targets in neuromyelitis optica. J. Neuroimmunol. 236 (1-2): 65-71, 2011.
- Yu. X., Burgoon, M., Green M., Barmina O., Dennison K., Pointon T., Davis M and Gilden D. Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time. J. Neuroimmunol. (2011), doi:10.1016/j.jneuroim.2011.10.009.
- Owens, G.P., Gilden, D.H., Burgoon, M.P., Yu, X., Bennett, J.L. Viruses and Multiple Sclerosis. The Neuroscientist. 2011, in press. PMID: 21531984
- Wu, F.F., Chen, L., Liu, X., Su, P. Li, M, Yu, X., Li, Q. A novel CD29-like protein expressed in Japanese lamprey (Lethenteron japonicum) and involved in immune response. Fish & Shellfish Immunology. 29: 407-413 (2010). PMID: 20488245