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Tom Henthorn, MD

Professor, Anesthesiology

FacultyPhoto
Medical School
  • MD, Northwestern University The Feinberg School of Medicine (1978)
Undergraduate School
  • BA, Drake University (IA) (1978)
Internship
  • McGaw Medical Center of Northwestern University Program (1979)
Residency
  • McGaw Medical Center of Northwestern University Program, Anesthesiology (1983)
Fellowships
  • McGaw Medical Center of Northwestern University Program, Clinical Pharmacology (1982)
Languages English
Department Anesthesiology

Publications

  • Sunder RA, Henthorn TK, Anderson C, Gentry KR, Adams T, White KK, Polaner D. Revisiting infusion rate limitations for continuous lumbar plexus blocks in children and adolescents with 0.2% ropivacaine: a pharmacokinetic analysis. Anesthesiology. 2025 Sep 29. [Epub ahead of print] PubMed PMID: 41021756
  • Henthorn PK, Henthorn TK. Pharmacogenomic-Based Oral Morphine Dose Adjustment: Is It Hard to Swallow?. Anesth Analg. 2025 Sep 9. [Epub ahead of print] PubMed PMID: 40924622
  • Dooley G, Godbole S, Wrobel J, Henthorn T, Brooks-Russell A, Limbacher S, Kosnett M. Comparison of ?9-tetrahydrocannabinol in venous and capillary blood following ad libitum cannabis smoking by occasional and daily users. J Anal Toxicol. 2025 May 14. [Epub ahead of print] PubMed PMID: 40366742
  • Henthorn TK, Wang GS, Dooley G, Brooks-Russell A, Wrobel J, Limbacher S, Kosnett M. Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled ?9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users. Ther Drug Monit. 2024 Oct 1;46(5):672-680. PubMed PMID: 39235358
  • Henthorn TK, Wang GS, Dooley G, Brooks-Russell A, Wrobel J, Limbacher S, Kosnett M. Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled ?9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users. Ther Drug Monit. 2024 Oct 1;46(5):672-680. PubMed PMID: 39235358
  • Henthorn TK. Reversal for Respiratory Depression: Let's Take a Breath!. Anesthesiology. 2024 Jun 1;140(6):1059-1061. PubMed PMID: 38742998
  • Rzasa Lynn RS, Henthorn TK, Zuk J, Hammer GB, Drover DR, Levy RJ, Maxwell LG, Sadhasivam S, Suresh S, Galinkin JL. Multicenter Population Pharmacokinetics of Fentanyl in Neonatal Surgical Patients Using Dried Blood Spot Specimen Collection Demonstrates Maturation of Elimination Clearance. Anesth Analg. 2024 Feb 1;138(2):447-455. PubMed PMID: 38215717
  • Okada CR, Henthorn TK, Zuk J, Sempio C, Roosevelt G, Ruiz AG, Cohen MN, Chatterjee D, Galinkin JL. Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children. Anesth Analg. 2024 Jan 1;138(1):99-107. PubMed PMID: 37801572
  • Kosnett MJ, Ma M, Dooley G, Wang GS, Friedman K, Brown T, Henthorn TK, Brooks-Russell A. Blood cannabinoid molar metabolite ratios are superior to blood THC as an indicator of recent cannabis smoking. Clin Toxicol (Phila). 2023 May;61(5):355-362. PubMed PMID: 37293900
  • Rague JM, Ma M, Dooley G, Wang GS, Friedman K, Henthorn TK, Brooks-Russell A, Kosnett MJ. The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking. Clin Toxicol (Phila). 2023 May;61(5):363-369. PubMed PMID: 36939145
  • Kosnett MJ, Ma M, Dooley G, Wang GS, Friedman K, Brown T, Henthorn TK, Brooks-Russell A. Blood cannabinoid molar metabolite ratios are superior to blood THC as an indicator of recent cannabis smoking. Clin Toxicol (Phila). 2023 May;61(5):355-362. PubMed PMID: 37293900
  • Rague JM, Ma M, Dooley G, Wang GS, Friedman K, Henthorn TK, Brooks-Russell A, Kosnett MJ. The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking. Clin Toxicol (Phila). 2023 May;61(5):363-369. PubMed PMID: 36939145
  • Crouch CE, Wilkey BJ, Hendrickse A, Kaizer AM, Schniedewind B, Christians U, Henthorn TK, Fernandez-Bustamante A. Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology. 2023 Jan 1;138(1):71-81. PubMed PMID: 36512707
  • Dahan A, Olofsen E, Henthorn TK, van Velzen M, Niesters M. Ketamine Pharmacodynamics Entangled: Reply. Anesthesiology. 2022 Dec 1;137(6):748-749. PubMed PMID: 36095056
  • Dahan A, Henthorn TK. Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome. Front Pain Res (Lausanne). 2022;3:991569. PubMed PMID: 36081983
  • Dahan A, Olofsen E, Henthorn TK, van Velzen M, Niesters M. Ketamine Pharmacodynamics Entangled: Reply. Anesthesiology. 2022 Sep 9. [Epub ahead of print] PubMed PMID: 36095056
  • Dahan A, Henthorn TK. Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome. Front Pain Res (Lausanne). 2022;3:991569. PubMed PMID: 36081983
  • Sempio C, Huestis MA, Kaplan B, Klawitter J, Christians U, Henthorn TK. Urinary clearance of 11-nor-9-carboxy-?(9) -tetrahydrocannabinol: A detailed pharmacokinetic analysis. Drug Test Anal. 2022 Aug;14(8):1368-1376. PubMed PMID: 35332698
  • Olofsen E, Kamp J, Henthorn TK, van Velzen M, Niesters M, Sarton E, Dahan A. Ketamine Psychedelic and Antinociceptive Effects Are Connected. Anesthesiology. 2022 May 1;136(5):792-801. PubMed PMID: 35188952
  • Henthorn TK, Krejcie TC, Avram MJ. Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say. Anesthesiology. 2022 Feb 1;136(2):258-260. PubMed PMID: 34965290
  • Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome. Front Pain Res (Lausanne). 2022 Aug 23;3:991569. doi: 0.3389/fpain.2022.991569
  • Meissner K, Henthorn TK. How relevant is stereoselectivity to the side-effects of ketamine?. Br J Anaesth. 2021 Jul;127(1):1-2. PubMed PMID: 33965204
  • Sempio C, Bidwell LC, Hutchison K, Huestis MA, Klawitter J, Christians U, Henthorn TK. Using Population Pharmacokinetic Modeling to Estimate Exposure to ?9-Tetrahydrocannabinol in an Observational Study of Cannabis Smokers in Colorado. Ther Drug Monit. 2021 Aug 1;43(4):536-545. PubMed PMID: 33656464
  • Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2021 Aug 14;45(7):686-692. PubMed PMID: 33002141
  • Kamp J, Olofsen E, Henthorn TK, van Velzen M, Niesters M, Dahan A. Ketamine Pharmacokinetics. Anesthesiology. 2020 Dec 1;133(6):1192-1213. PubMed PMID: 32997732
  • Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E. In Memoriam: Professor Folke Sjöqvist. Ther Drug Monit. 2020 Jun;42(3):353. PubMed PMID: 32304489
  • Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
  • Brooks Peterson M, Cohen MN, O'Neill BR, Garg S, Child J, Henthorn TK, Galinkin JG. Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients. Anesth Analg. 2020 May;130(5):1435-1444. PubMed PMID: 31397701
  • Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
  • Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E. In Memoriam: Professor Folke Sjöqvist. Ther Drug Monit. 2020 Apr 15. [Epub ahead of print] PubMed PMID: 32304489
  • Kamp J, Olofsen E, Henthorn TK, van Velzen M, Niesters M, Dahan A. Ketamine Pharmacokinetics. Anesthesiology. 2020 Sep 30. [Epub ahead of print] PubMed PMID: 32997732
  • Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33002141
  • Doufas AG, Shafer SL, Henthorn TK. Opioid-induced Ventilatory Depression in Sleep Apnea: Reply. Anesthesiology. 2019 Oct;131(4):937-938. PubMed PMID: 31403499
  • Peterson MB, Cohen MN, O'Neill BR, Garg S, Child J, Henthorn TK, Galinkin JG. Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients. Anesth Analg. 2019 Aug 6. [Epub ahead of print] PubMed PMID: 31397701
  • Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
  • Henthorn TK, Olofsen E. Where's the Beef?: How Much Can We Skimp on Pharmacokinetic-Pharmacodynamic Data?. Anesthesiology. 2019 Feb;130(2):186-188. PubMed PMID: 30589650
  • Henthorn TK, Avram MJ, Dahan A, Gustafsson LL, Persson J, Krejcie TC, Olofsen E. Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S( ) and R(-) Ketamine Concentrations. Anesthesiology. 2018 Aug;129(2):260-270. PubMed PMID: 29771709
  • Henthorn TK, Mikulich-Gilbertson SK. µ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?. Anesthesiology. 2018 May;128(5):867-870. PubMed PMID: 29543630
  • Jonkman K, Duma A, Olofsen E, Henthorn T, van Velzen M, Mooren R, Siebers L, van den Beukel J, Aarts L, Niesters M, Dahan A. Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers. Anesthesiology. 2017 Oct;127(4):675-683. PubMed PMID: 28759464
  • Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062
  • Henthorn TK, Kharasch ED. Population pharmacokinetics of intravenous methadone enantiomers in adults: A comprehensive model. Clin Pharmacol Ther (accepted for publication on Nov. 7, 2025)
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Anesthesiology, Board Certification (1985)
  • Clinical Pharmacology, Board Certification (1991)

General Information

Medical Schools
  • MD, Northwestern University The Feinberg School of Medicine (1978)
Undergraduate Schools
  • BA, Drake University (IA) (1978)
Internships
  • McGaw Medical Center of Northwestern University Program (1979)
Residency Programs
  • McGaw Medical Center of Northwestern University Program, Anesthesiology(1983)
Fellowships
  • McGaw Medical Center of Northwestern University Program, Clinical Pharmacology (1982)
Languages English
Department Anesthesiology