Research Interests
My research focuses on epidemiological and clinical trials in the acute care setting, with a particularly focus on early care of critically ill and injured patients. Specifically, I have extensive experience with designing, overseeing, and implementing clinical trials in a variety of clinical environments including emergency department, inpatient (including intensive care unit), perioperative, and outpatient settings, particularly in the areas of acute respiratory failure and sepsis/infection (including COVID-19). I have been the lead investigator for 12 large multicenter clinical trials and participated in the design (as protocol committee member and co-investigator) and implementation (as site PI) of over 20 other clinical trials. National leadership in clinical trials networks include the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) network executive and steering committees and steering committees for the NHLBI Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (CONNECTS), the trans-NIH Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)-3, the CDC-funded Influenza and Other Viruses in the Acutely Ill (IVY), the DoD-funded Pragmatic Critical Care Research Group (PCCRG), DoD-funded SAVE-O2 network, and the NIAID Strategies and Treatments for Respiratory & Viral Diseases (STRIVE). Funding for my research includes NIH (including NHLBI, NCATS, NIAID, NINDS, NIA), DoD, CDC, PCORI, foundation, and industry sponsors, and I have published over 380 original research articles in leading medical journals.