Gregory Owens, PhD

Publications

• Given KS, Acker EG, Macklin WB, Carlin D, Owens GP, Bennett JL. Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica. Acta Neuropathol Commun. 2025 Jun 12;13(1):129. PubMed PMID: 40506785
• Borko TL, Winters P, Money KM, Sillau S, Eggmann S, Selva S, Ritchie A, Kammeyer R, Owens GP, Bennett JL, Piquet AL. Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury. Front Neurol. 2025;16:1583892. PubMed PMID: 40470500
• Owens GP, Fellin T, Matschulat A, Salas V, Schaller K, Given KS, Ritchie AM Navarro A, Blauth K, Hughes E, Macklin WB, and Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1–anchored membrane domains. Journal of Clinical Investigation 2023; 133(19):e162731 https://doi.org/10.1172/JCI162731.
• Kammeyer R, Mizenko C, Sillau S, Richie A, Owens G, Nair KV, Alvarez E, Vollmer TL, Bennett JL, Piquet AL. Evaluation of Plasma Neurofilament Light Chain Levels as a Biomarker of Neuronal Injury in the Active and Chronic Phases of Autoimmune Neurologic Disorders. Front Neurol. 2022;13:689975. PubMed PMID: 35309573
• Mizenko C, Bennett JL, Owens G, Vollmer TL, Piquet AL. A Longitudinal, Observational Analysis of Neuronal Injury Biomarkers in a Case Report of a Patient With Paraneoplastic Anti-CRMP5 Antibody-Associated Transverse Myelitis. Front Neurol. 2021;12:691509. PubMed PMID: 34349723
• Ruschil C, Gabernet G, Lepennetier G, Heumos S, Kaminski M, Hracsko Z, Irmler M, Beckers J, Ziemann U, Nahnsen S, Owens GP, Bennett JL, Hemmer B, Kowarik MC. Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses. Front Immunol. 2020;11:606338. PubMed PMID: 33391273
• Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. PubMed PMID: 31029597
• Soltys J, Liu Y, Ritchie A, Wemlinger S, Schaller K, Schumann H, Owens GP, Bennett JL. Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica. J Clin Invest. 2019 Apr 8;129(5):2000-2013. PubMed PMID: 30958797
• Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL. Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica. Glia. 2018 Dec;66(12):2575-2588. PubMed PMID: 30240044
• Owens GP, Nagel MA, Mahalingam R, Cohrs RJ. Donald H. Gilden, M.D. J Neuroimmunol. 2017 Jan 6. [Epub ahead of print] PubMed PMID: 28087078
• Owens GP. A Neuroprimer: Principles of Central Nervous System Immunity. Semin Pediatr Neurol. 2017 Aug;24(3):145-151. PubMed PMID: 29103421
• Shimizu F, Schaller KL, Owens GP, Cotleur AC, Kellner D, Takeshita Y, Obermeier B, Kryzer TJ, Sano Y, Kanda T, Lennon VA, Ransohoff RM, Bennett JL. Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica. Sci Transl Med. 2017 Jul 5;9(397). PubMed PMID: 28679661
• Kowarik MC, Astling D, Gasperi C, Wemlinger S, Schumann H, Dzieciatkowska M, Ritchie AM, Hemmer B, Owens GP, Bennett JL. CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder. Ann Clin Transl Neurol. 2017 Jun;4(6):369-380. PubMed PMID: 28589164
• Bennett JL, Owens GP. Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy. J Neuroophthalmol. 2017 Sep;37(3):291-299. PubMed PMID: 28410278
• Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 Mar 24;5(1):25. PubMed PMID: 28340598
• Owens GP, Nagel MA, Mahalingam R, Cohrs RJ. Donald H. Gilden, M.D. J Neuroimmunol. 2017 Jul 15;308:2-5. PubMed PMID: 28087078
• Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 Dec 1;13(1):301. PubMed PMID: 27905992
• Blauth K, Owens GP, Bennett JL. The Ins and Outs of B Cells in Multiple Sclerosis. Front Immunol. 2015;6:565. PubMed PMID: 26594215
• Blauth K, Soltys J, Matschulat A, Reiter CR, Ritchie A, Baird NL, Bennett JL, Owens GP. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants. Acta Neuropathol. 2015 Dec;130(6):765-81. PubMed PMID: 26511623
• Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 8;290(19):12123-34. PubMed PMID: 25792738
• Kowarik MC, Dzieciatkowska M, Wemlinger S, Ritchie AM, Hemmer B, Owens GP, Bennett JL. The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. J Neuroinflammation. 2015 Jan 28;12:19. PubMed PMID: 25626447
• Saadoun S, Waters P, Owens GP, Bennett JL, Vincent A, Papadopoulos MC. Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain. Acta Neuropathologica Communications 235: in press.
• Saadoun S, Waters P, Owens GP, Bennett JL, Vincent A, Papadopoulos MC. Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain. Acta Neuropathologica Communications 2;35, 2014.
• Birlea, M, Owens GP, Eschelmann EM, Ritchie A, Traktinskiy I, Bos N, Seitz S, Azarkh Y, Mahalingham R, Gilden DH, Cohrs RJ. Human anti-Varicella-Zoster Virus (VZV) recombinant monoclonal antibody produced after Zostavax immunization recognizes the gH/gL complex and neutralizes VZV infection. J. Virol. 87: 415-421, 2013.
• Marius Birlea, Gregory P. Owens, Emily M. Eshleman, Alanna Ritchie, Igor Traktinskiy, Nathan Bos, Scott Seitz,Yevgeniy Azarkh, Ravi Mahalingam, Don Gilden and Randall Cohrs. Human Anti-Varicella-Zoster Virus (VZV)Recombinant Monoclonal Antibody Produced after Zostavax Immunization Recognizes the gH/gL Complex and Neutralizes VZV Infection. Journal of Virology 2013, 87(1):415.
• Owens GP, Bennett JL. Trigger, Pathogen, or Bystander: the complex nexus linking Epstein-Barr Virus and Multiple Sclerosis. Multiple Sclerosis Journal 18;1204-1208, 2012.
• Bennett JL,Owens GP. CSF Proteomics: a new window for understanding human demyelinating disorders? Annals Neurology,in press
• Lassmann H and the NeuroPromise EBV Working Group. Epstein-Barr virus in the multiple sclerosis brain: a controversial issue- report on a foucsed workshop held in the Centre for Brain Research of the Medical University of Vienna. Brain 134:2772-2786
• Kathryn M. Brennana, b, Francesc Galban-Horcajoa, Simon Rinaldia, b, Colin P. O'Learyb, Carl S. Goodyeara, Gabriela Kalnac, Ariel Arthura, Christina Elliota, Sue Barnetta, Christopher Liningtona, Jeffrey L. Bennettd, e, Gregory P. Owensd, Hugh J. Willisona, b,Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. J Neuroimmunology 238:87-95, 2011.
• Yu X., Gilden D., Schambers L., Barmina O., Burgoon M., Bennett J., Owens G.: Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF. J Neuroimmunol. 233: 192-201, 2011.
• Kowarik MS, Astling D, Lepenntier G, Ritchie A, Hemmer B, Owens GP, and Bennett JL. Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients. Neurotherapeutics, in press
• Markus C. Kowarik, Monika Dzieciatkowska, Scott Wemlinger, Bernhard Hemmer, Gregory P. Owens, Jeffrey L. Bennett. The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. Journal of Neuroinflammation, in press