Andrew Bubak, PhD

Publications

• Niemeyer CS, Merle L, Bubak AN, Baxter BD, Gentile Polese A, Colon-Reyes K, Vang S, Hassell JE Jr, Bruce KD, Nagel MA, Restrepo D. Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity. J Virol. 2024 Nov 19;98(11):e0096824. PubMed PMID: 39475273
• Niemeyer CS, Frietze S, Coughlan C, Lewis SWR, Bustos Lopez S, Saviola AJ, Hansen KC, Medina EM, Hassell JE Jr, Kogut S, Traina-Dorge V, Nagel MA, Bruce KD, Restrepo D, Mahalingam R, Bubak AN. Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. J Virol. 2024 Aug 20;98(8):e0084824. PubMed PMID: 39051773
• Niemeyer CS, Traina-Dorge V, Doyle-Meyers L, Das A, Looper J, Mescher T, Feia B, Medina E, Nagel MA, Mahalingam R, Bubak AN. Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aß40/42 alterations in serum and cerebrospinal fluid. J Neurovirol. 2024 Feb;30(1):86-99. PubMed PMID: 38453879
• Niemeyer CS, Harlander-Locke M, Bubak AN, Rzasa-Lynn R, Birlea M. Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment. Curr Pain Headache Rep. 2024 Apr;28(4):295-306. PubMed PMID: 38261232
• Arumugam I, Rajasekaran SS, Gopalakrishnan K, Gnanaskandan S, Jeganathan SN, Athi J, Shanmugaraj R, Ramesh R, Shankar V, Krishnasamy K, Ranganathan LN, Balakrishnan U, Mahalingam R, Bubak AN, Nagel MA, Srikanth P. Diagnostic value of anti-VZV IgG in neurological diseases among varicella unvaccinated individuals. J Neurovirol. 2024 Jun;30(3):327-335. PubMed PMID: 39085748
• Bubak AN, Merle L, Niemeyer CS, Baxter BD, Gentile Polese A, Ramakrishnan V, Gomez J, Madrigal L, Villegas-Lanau A, Lopera F, Macklin W, Frietze S, Nagel MA, Restrepo D. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiol Aging. 2023 Mar;123:75-82. PubMed PMID: 36638683
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2023 Jan;4(1):148. PubMed PMID: 36577897
• Bubak AN, Merle L, Niemeyer CS, Baxter BD, Gentile Polese A, Ramakrishnan V, Gomez J, Madrigal L, Villegas-Lanau A, Lopera F, Macklin W, Frietze S, Nagel MA, Restrepo D. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiol Aging. 2023 Mar;123:75-82. PubMed PMID: 36638683
• Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 Apr 18;227(8):993-1001. PubMed PMID: 36200236
• Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, Vollmer T, Alvarez E, Yu X. Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis. Cell Death Dis. 2023 Apr 8;14(4):254. PubMed PMID: 37031195
• Bubak AN, Como CN, Hassell JE Jr, Mescher T, Frietze SE, Niemeyer CS, Cohrs RJ, Nagel MA. Targeted RNA Sequencing of VZV-Infected Brain Vascular Adventitial Fibroblasts Indicates That Amyloid May Be Involved in VZV Vasculopathy. Neurol Neuroimmunol Neuroinflamm. 2022 Jan;9(1). PubMed PMID: 34759019
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2022 Nov;3(11):1300-1317. PubMed PMID: 36434392
• Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2022 Oct 6. [Epub ahead of print] PubMed PMID: 36200236
• Mahalingam R, Feia B, Coleman C, Anupindi K, Saravanan P, Luthens A, Bustillos A, Das A, de Haro E, Doyle-Meyers L, Looper J, Bubak AN, Niemeyer CS, Palmer B, Nagel MA, Traina-Dorge V. Simian Varicella Virus Pathogenesis in Skin during Varicella and Zoster. Viruses. 2022 May 27;14(6). PubMed PMID: 35746639
• Niemeyer CS, Mescher T, Bubak AN, Medina EM, Hassell JE Jr, Nagel MA. VZV Infection of Primary Human Adrenal Cortical Cells Produces a Proinflammatory Environment without Cell Death. Viruses. 2022 Mar 25;14(4). PubMed PMID: 35458404
• Sarkar L, Oko L, Gupta S, Bubak AN, Das B, Gupta P, Safiriyu AA, Singhal C, Neogi U, Bloom D, Banerjee A, Mahalingam R, Cohrs RJ, Koval M, Shindler KS, Pal D, Nagel M, Sarma JD. Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict ß-coronaviral infection and replication. Virology. 2022 Apr;569:13-28. PubMed PMID: 35219218
• Bubak AN, Como CN, Hassell JE Jr, Mescher T, Frietze SE, Niemeyer CS, Cohrs RJ, Nagel MA. Targeted RNA Sequencing of VZV-Infected Brain Vascular Adventitial Fibroblasts Indicates That Amyloid May Be Involved in VZV Vasculopathy. Neurol Neuroimmunol Neuroinflamm. 2022 Jan;9(1). PubMed PMID: 34759019
• Bubak, A., Swallow, J., Adeola, F. and Lailvaux, S.P., 2022. Maximum performance expression is affected by octopamine and antennae removal in Acheta domesticus. Behavioral Ecology.
• Stroke and Shingles: Mystery Solved?
• Bubak AN, Mescher T, Mariani M, Frietze SE, Hassell JE Jr, Niemeyer CS, Como CN, Burnet AM, Subramanian PS, Cohrs RJ, Mahalingam R, Nagel MA. Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures. Neurol Neuroimmunol Neuroinflamm. 2021 Nov;8(6). PubMed PMID: 34493606
• Niemeyer CS, Mescher T, Griggs R, Orlicky DJ, Wilkerson GK, Bubak AN, Hassell JE Jr, Feia B, Mahalingam R, Traina-Dorge V, Nagel MA. Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection. Viruses. 2021 Jun 26;13(7). PubMed PMID: 34206909
• Baxter BD, Larson ED, Merle L, Feinstein P, Polese AG, Bubak AN, Niemeyer CS, Hassell J Jr, Shepherd D, Ramakrishnan VR, Nagel MA, Restrepo D. Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium. BMC Genomics. 2021 Mar 30;22(1):224. PubMed PMID: 33781205
• Mescher T, Boyer PJ, Bubak AN, Hassell JE Jr, Nagel MA. Detection of varicella zoster virus antigen and DNA in two cases of cerebral amyloid angiopathy. J Neurol Sci. 2021 Mar 15;422:117315. PubMed PMID: 33503519
• Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, Aß42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 Apr 8;223(7):1284-1294. PubMed PMID: 32809013
• Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2021 Apr 13;16(4):1009. PubMed PMID: 33852882
• Bubak AN, Traina-Dorge V, Como CN, Feia B, Pearce CM, Doyle-Meyers L, Das A, Looper J, Mahalingam R, Nagel MA. Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events. J Neurovirol. 2020 Dec;26(6):945-951. PubMed PMID: 32964407
• Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, Aß42, and Amyloid in VZV Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2020 Aug 18. [Epub ahead of print] PubMed PMID: 32809013
• Baxter BD, Larson ED, Feinstein P, Polese AG, Bubak AN, Niemeyer CS, Merle L, Shepherd D, Ramakrishnan VR, Nagel MA, Restrepo D. Transcriptional profiling reveals TRPM5-expressing cells involved in viral infection in the olfactory epithelium. bioRxiv. 2020 May 15. PubMed PMID: 32511400
• Bubak AN, Beseler C, Como CN, Tyring SK, Haley C, Mescher T, Hassell JE Jr, Cohrs RJ, Potter H, Nagel MA. Acute zoster plasma contains elevated amyloid, correlating with Aß42 and amylin levels, and is amyloidogenic. J Neurovirol. 2020 Jun;26(3):422-428. PubMed PMID: 32385803
• Nagel MA, Niemeyer CS, Bubak AN. Central nervous system infections produced by varicella zoster virus. Curr Opin Infect Dis. 2020 Jun;33(3):273-278. PubMed PMID: 32332223
• Bubak AN, Watt MJ, Yaeger JDW, Renner KJ, Swallow JG. The stalk-eyed fly as a model for aggression - is there a conserved role for 5-HT between vertebrates and invertebrates?. J Exp Biol. 2020 Jan 2;223(Pt 1). PubMed PMID: 31896721
• Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-ß, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 Mar 16;221(7):1088-1097. PubMed PMID: 31665341
• Bubak AN, Watt MJ, Yaeger JDW, Renner KJ, Swallow JG. The stalk-eyed fly as a model for aggression - is there a conserved role for 5-HT between vertebrates and invertebrates?. J Exp Biol. 2020 Jan 2;223(Pt 1). PubMed PMID: 31896721
• Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE Jr, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-beta, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2019 Oct 29. [Epub ahead of print] PubMed PMID: 31665341
• Nagel MA, Bubak AN. Herpes Zoster, a Rash of Cerebrovascular Events. Mayo Clin Proc. 2019 May;94(5):742-744. PubMed PMID: 31054599
• Jones D, Como CN, Jing L, Blackmon A, Neff CP, Krueger O, Bubak AN, Palmer BE, Koelle DM, Nagel MA. Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8 T cell effector function. PLoS Pathog. 2019 Mar;15(3):e1007650. PubMed PMID: 30870532
• Blackmon AM, Como CN, Bubak AN, Mescher T, Jones D, Nagel MA. Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells via Interleukin 6. J Infect Dis. 2019 Sep 26;220(9):1453-1461. PubMed PMID: 30835269
• Como CN, Bubak AN, Blackmon AM, Jones D, Mueller NH, Davidson R, Nagel MA. Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):704-711. PubMed PMID: 30786281
• Bubak AN, Watt MJ, Renner KJ, Luman AA, Costabile JD, Sanders EJ, Grace JL, Swallow JG. Sex differences in aggression: Differential roles of 5-HT2, neuropeptide F and tachykinin. PLoS One. 2019;14(1):e0203980. PubMed PMID: 30695038
• Bubak AN, et al., Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease. Neurobiology of Aging
• Plotkin's Vaccines 8th Edition: Varicella Vaccines (Ch. 63)

Practice Locations

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080