Vera Fridman, MD

Professional Titles

• Associate Director, Medical Student Education

Publications

• Quartesan I, Facchini S, Manini A, Schnekenberg RP, Pisciotta C, Magri S, Negri S, Gaetano C, Rebelo A, Raposo JS, Mazanec R, Curro R, Dominik N, Efthymiou S, Laurà M, Grider T, Feely SM, Fridman V, Bertini A, Alves GM, Ferullo L, Ghia A, Caccia C, Balistreri F, Saveri P, Crivellari L, Moroni I, Danti FR, Mongini T, Taroni F, Auer-Grumbach M, Bugiardini E, Sleigh JN, Tucci A, Houlden H, Laššuthová P, Seeman P, Basile A, Giorgio E, Shy ME, Zuchner S, Reilly MM, Pareyson D, Cortese A. Gene-Pseudogene Inversions as a Hidden Source of Missing Heritability. medRxiv. 2025 Oct 7. PubMed PMID: 41282915
• Fridman V. A Case for Disease-Specific Biomarkers for Rare Genetic Disorders. Neurology. 2025 Dec 9;105(11):e214398. PubMed PMID: 41223344
• Ward KS, Ptak CP, Pashkova N, Grider T, Peterson TA, Pareyson D, Pisciotta C, Saveri P, Moroni I, Laura M, Burns J, Menezes MP, Cornett K, Finkel R, Mukherjee-Clavin B, Sumner CJ, Greene M, Abdul Hamid O, Herrmann D, Sadjadi R, Walk D, Züchner S, Reilly MM, Scherer SS, Piper RC, Shy ME. Charcot-Marie-Tooth disease type 1E: clinical natural history and molecular impact of PMP22 variants. Brain. 2025 Jun 9. [Epub ahead of print] PubMed PMID: 40488457
• Adams D, Wixner J, Polydefkis M, Berk JL, Conceição IM, Dispenzieri A, Peltier A, Ueda M, Bender S, Capocelli K, Jay PY, Yureneva E, Obici L. Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension. JAMA Neurol. 2025 Mar 1;82(3):228-236. PubMed PMID: 39804640
• Xu IRL, Danzi MC, Ruiz A, Raposo J, De Jesus YA, Reilly MM, Cortese A, Shy ME, Scherer SS, Herrmann DN, Fridman V, Baets J, Saporta M, Seyedsadjadi R, Stojkovic T, Claeys KG, Patel P, Feely S, Rebelo AP, Dohrn MF, Züchner S. A study concept of expeditious clinical enrollment for genetic modifier studies in Charcot-Marie-Tooth neuropathy 1A. J Peripher Nerv Syst. 2024 Jun;29(2):202-212. PubMed PMID: 38581130
• McCray BA, Fridman V. Clinical Outcome Assessments and Biomarkers in Charcot-Marie-Tooth Disease. Neurology. 2024 Dec 24;103(12):e210120. PubMed PMID: 39586049
• Fridman V, Sillau S, Bockhorst J, Smith K, Moroni I, Pagliano E, Pisciotta C, Piscosquito G, Laurá M, Muntoni F, Bacon C, Feely S, Grider T, Gutmann L, Shy R, Wilcox J, Herrmann DN, Li J, Ramchandren S, Sumner CJ, Lloyd TE, Day J, Siskind CE, Yum SW, Sadjadi R, Finkel RS, Scherer SS, Pareyson D, Reilly MM, Shy ME. Disease Progression in Charcot-Marie-Tooth Disease Related to MPZ Mutations: A Longitudinal Study. Ann Neurol. 2023 Mar;93(3):563-576. PubMed PMID: 36203352
• Fridman V, Sillau S, Ritchie A, Bockhorst J, Coughlan C, Araya P, Espinosa JM, Smith K, Lange EM, Lange LA, Ghormli LE, Drews KL, Zeitler P, Reusch JEB. Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy. J Peripher Nerv Syst. 2023 Sep;28(3):460-470. PubMed PMID: 37341347
• Record CJ, Skorupinska M, Laura M, Rossor AM, Pareyson D, Pisciotta C, Feely SME, Lloyd TE, Horvath R, Sadjadi R, Herrmann DN, Li J, Walk D, Yum SW, Lewis RA, Day J, Burns J, Finkel RS, Saporta MA, Ramchandren S, Weiss MD, Acsadi G, Fridman V, Muntoni F, Poh R, Polke JM, Zuchner S, Shy ME, Scherer SS, Reilly MM. Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants. Brain. 2023 Oct 3;146(10):4336-4349. PubMed PMID: 37284795
• Xia C, Suriyanarayanan S, Gong Y, Fridman V, Selig M, Li J, Rutkove S, Hornemann T, Eichler F. Long-term effects of l-serine supplementation upon a mouse model of diabetic neuropathy. J Diabetes Complications. 2023 Feb;37(2):108383. PubMed PMID: 36610321
• Fridman V, Sillau S, Bockhorst J, Smith K, Moroni I, Pagliano E, Pisciotta C, Piscosquito G, Laurá M, Muntoni F, Bacon C, Feely S, Grider T, Gutmann L, Shy R, Wilcox J, Herrmann DN, Li J, Ramchandren S, Sumner CJ, Lloyd TE, Day J, Siskind CE, Yum SW, Sadjadi R, Finkel RS, Scherer SS, Pareyson D, Reilly MM, Shy ME. Disease Progression in Charcot-Marie-Tooth Disease Related to MPZ Mutations: A Longitudinal Study. Ann Neurol. 2022 Oct 6. [Epub ahead of print] PubMed PMID: 36203352
• Forbes E, Smith K, Petluru M, Nystrom J, Fridman V. Adult-onset Krabbe disease presenting as isolated sensorimotor demyelinating polyneuropathy: A case report. J Peripher Nerv Syst. 2022 Dec;27(4):320-324. PubMed PMID: 36057781
• Plasma Neurofilament Light Chain Concentrations are Elevated in Youth-onset T2D and Associate with Neuropathy, International Diabetes Neuropathy Consortium (IDNC), Peripheral Nerve Society Annual Meeting, Miami, FL. Oral poster presentation. May 2022.
• Fridman V, Saporta MA. Mechanisms and Treatments in Demyelinating CMT. Neurotherapeutics. 2021 Nov 8. [Epub ahead of print] PubMed PMID: 34750751
• Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021 Apr;35(4):107852. PubMed PMID: 33485750
• Bartholomew RA, Zamani AA, Kim GS, Alyono JC, Steinert H, Fridman V, Sadjadi R, Jackler RK, Corrales CE (2020). Prevalence and significance of cranial nerve imaging abnormalities in patients with hereditary neuropathies: Clinical implications at the skull base. Laryngoscope Investigative Otolaryngology.
• Fridman V, Sillau S, Acsadi G, Bacon C, Dooley K, Burns J, Day J, Feely S, Finkel RS, Grider T, Gutmann L, Herrmann DN, Kirk CA, Knause SA, Laurá M, Lewis RA, Li J, Lloyd TE, Moroni I, Muntoni F, Pagliano E, Pisciotta C, Piscosquito G, Ramchandren S, Saporta M, Sadjadi R, Shy RR, Siskind CE, Sumner CJ, Walk D, Wilcox J, Yum SW, Züchner S, Scherer SS, Pareyson D, Reilly MM, Shy ME. A longitudinal study of CMT1A using Rasch analysis based CMT neuropathy and examination scores. Neurology. 2020 Mar 3;94(9):e884-e896. PubMed PMID: 32047073
• Bartholomew RA, Zamani AA, Kim GS, Alyono JC, Steinert H, Fridman V, Sadjadi R, Jackler RK, Corrales CE. Prevalence and significance of cranial nerve imaging abnormalities in patients with hereditary neuropathies: Clinical implications at the skull base. Laryngoscope Investig Otolaryngol. 2020 Feb;5(1):11-18. PubMed PMID: 32128425
• Callaghan BC, Gallagher G, Fridman V, Feldman EL. Diabetic neuropathy: what does the future hold?. Diabetologia. 2020 May;63(5):891-897. PubMed PMID: 31974731
• Fridman V, Suriyanarayanan S, Novak P, David W, Macklin EA, McKenna-Yasek D, Walsh K, Aziz-Bose R, Oaklander AL, Brown R, Hornemann T, Eichler F. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019 Jan 22;92(4):e359-e370. PubMed PMID: 30626650
• Fridman V, Oaklander AL, David WS, Johnson EA, Pan J, Novak P, Brown RH Jr, Eichler FS. Natural history and biomarkers in hereditary sensory neuropathy type 1. Muscle Nerve. 2015 Apr;51(4):489-95. PubMed PMID: 25042817
• Fridman V, Bundy B, Reilly MM, Pareyson D, Bacon C, Burns J, Day J, Feely S, Finkel RS, Grider T, Kirk CA, Herrmann DN, Laurá M, Li J, Lloyd T, Sumner CJ, Muntoni F, Piscosquito G, Ramchandren S, Shy R, Siskind CE, Yum SW, Moroni I, Pagliano E, Zuchner S, Scherer SS, Shy ME. CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis. J Neurol Neurosurg Psychiatry. 2015 Aug;86(8):873-8. PubMed PMID: 25430934
• Fridman V, Reilly MM. Inherited Neuropathies. Semin Neurol. 2015 Aug;35(4):407-23. PubMed PMID: 26502764
• Fridman V, Bundy B, Reilly MM, Pareyson D, Bacon C, Burns J, Day J, Feely S, Finkel RS, Grider T, Kirk CA, Herrmann DN, Laurá M, Li J, Lloyd T, Sumner CJ, Muntoni F, Piscosquito G, Ramchandren S, Shy R, Siskind CE, Yum SW, Moroni I, Pagliano E, Zuchner S, Scherer SS, Shy ME, on behalf of the Inherited Neuropathies Consortium. CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis. J Neurol Neurosurg Psychiatry. 2014 Nov 27. [Epub ahead of print] PubMed PMID: 25430934
• Fridman V, Oaklander AL, David WS, Johnson EA, Pan J, Novak P, Brown RH Jr, Eichler FS. Natural history and biomarkers in hereditary sensory neuropathy type 1. Muscle Nerve. 2014 Jul 10. [Epub ahead of print] PubMed PMID: 25042817
• Fridman V, Murphy SM. The spectrum of axonopathies: from CMT2 to HSP. Neurology. 2014 Aug 12;83(7):580-1. PubMed PMID: 25008393
• Fridman V, Sillau S, Bockhorst J, Smith K, Moroni I, Pagliano E, Pisciotta C, Piscosquito G, Laura, M, Muntoni F, Bacon C, Feely S, Grider T, Gutmann L, Shy R, Wilcox J, Scherer S, Herrmann D, Li J, Ramchandren S, Sumner C, Lloyd T, Day J, Siskind C, Yum S, Sadjadi R, Finkel R, Reilly M, Pareyson D, Shy ME, and the Inherited Neuropathies Consortium-Rare Diseases Clinical Research Network (INC-RDCRN). Disease Progression in CMT related to MPZ Mutations: A Longitudinal Study Using Rasch Weighted CMT Examination Scores. In press.
• Fridman V, Sillau S, Ritchie A, Bockhorst J, Coughlan C, Araya P, Espinsoa JM, Smith K, Lange EM, Lange LA, El ghormli L, Drews KL, Zeitler P, Reusch JEB. Plasma Neurofilament Light Chain Concentrations are Elevated in Youth-onset Type 2 Diabetes and Associate with Neuropathy. In press – Neurology. Dec 2022.
• Eichler F., Fridman V, Chuying X. Long-term effects of L-serine supplementation upon a mouse model of diabetic neuropathy. Journal of Diabetes and its Complcations.
• Fridman V. Diabetic Neuropathy. Continuum. 2025 Oct. In press
• Fridman V, Elafros M, Eid S, Reynolds EL, McCray B, Callaghan BC. Advances in Diabetic Peripheral Neuropathy. BMJ. 2025 Oct. In press
• Fridman, V., Sillau S., Acsadi G., Bacon C., Bray K., Burns J., Day J.W., Feely, S., Finkel R., Grider T., Gutmann L., Herrmann D.N., Kirk C.A., Knause S., Laura M., Lewis R.A., Li J., Lloyd T.E., Moroni I., Muntoni F., Pagliano E., Pareyson, D., Pisciotta C., Piscosquito G., Ranchandren S., Saporta M.A., Sadjadi R., Shy R.R., Siskind C.E., Sumner C.J., Walk D., Wilcox J.E., Yum S.W., Züchner S., Scherer S.S., Reilly M.M., Shy M.E., and the Inherited Neuropathies Consortium – Rare Diseases Clinical Research Network (INC-RDCRN). (2019). A Longitudinal Study of CMT1A Using Rasch Analysis Based CMT Neuropathy and Examination Scores. Neurology. Accepted for publication, in press”.
• Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC (2020). Altered Plasma Serine and 1-Deoxydihydroceramide Profiles are Associated with Neuropathy in Type 2 Diabetes and Obesity. Journal of Diabetes and its Complications. Manuscript under review.

Professional Memberships

• American Academy of Neurology, Active Member
• Peripheral Nerve Society, Member
• American Neurology Association, Active Member
• American Diabetes Association, Active Member

Practice Locations

• University of Colorado Hospital

Specialty Information

• Neurology, Board Certification
• Neuromuscular Medicine

• Brain and Nervous System
• Brain and Nervous System - Peripheral Nerve Repair
• Brain and Nervous System - Neuromuscular Diseases