Mingxia Huang, PhD

Publications

• Intracerebral age-independent reduction of endothelium-dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome Abigail N. Russell, Danielle A. Jeffrey, Gregory Seedorf, Hong Li, Kelly D. Sullivan, Huntington Potter, Mingxia Huang, Fabrice Dabertrand. J Physiology 2026 Jan 31. https://doi.org/10.1113/JP290174
• Li H, Zhang C, Bian L, Deng H, Blevins M, Han G, Fan B, Yang C, Zhao R, High W, Norris D, Fujita M, Wang XJ, Huang M. Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation. J Invest Dermatol. 2022 Feb;142(2):390-401. PubMed PMID: 34293351
• "C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment" International Journal of Biological Sciences, accepted for publication November 2019.
• "C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment" Int J Biol Sci 2020; 16(7):1107-1120. doi:10.7150/ijbs.42109
• Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. Mol Cell Biol. 2018 Mar 15;38(6). PubMed PMID: 29263158
• Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, Huang M. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017 Jul 7;292(27):11445-11451. PubMed PMID: 28515324
• Blevins MA, Huang M, Zhao R. The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target. Mol Cancer Ther. 2017 Jun;16(6):981-990. PubMed PMID: 28576945
• Liu L, Huang M. Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation. Protein Cell. 2015 Mar;6(3):194-210. PubMed PMID: 25645023
• Liu L, Huang M. Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation. Protein Cell. 2015 Mar;6(3):194-210. PubMed PMID: 25645023
• An X, Zhang C, Sclafani RA, Seligman P, Huang M. The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae. Microbiologyopen. 2015 Dec;4(6):941-51. PubMed PMID: 26450372
• Zhang, Y*., Li, H*., Zhang, C*., An, X., Liu, L., Stubbe, J.*, and Huang, M*. (2014) The conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc. Natl. Acad. Sci. (Epub week of 4/14/14)
• Zhang, C., Liu, G., and Huang, M. (2014) Ribonucleotide reductase metallocofactor: assembly, maintenance, and inhibition. Front. Biol. Vol 9(2) In press April 2014.
• Sanvisens N, Romero AM, An X, Zhang C, de Llanos R, Martínez-Pastor MT, Bañó MC, Huang M, Puig S. Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency. Mol Cell Biol. 2014 Sep;34(17):3259-71. PubMed PMID: 24958100
• Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, Huang M. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1695-704. PubMed PMID: 24733891
• Zhang C, Liu G, Huang M. Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition. Front Biol (Beijing). 2014 Jan 2;9(2):104-113. PubMed PMID: 24899886
• Huang M, Parker MJ, Stubbe J. Choosing the right metal: case studies of class I ribonucleotide reductases. J Biol Chem. 2014 Oct 10;289(41):28104-11. PubMed PMID: 25160629
• Zhang, Y., An, X., Stubbe, J., and Huang, M. (2013) Investigation of in vivo roles of the carboxyl terminal tails of the small subunit (ßß') of S. cerevisiae ribonucleotide reductase: contribution to cofactor formation and inter-subunit association within the active holoenzyme. J. Biol. Chem. Epub. 2013 Mar. 26. (This paper was selected as Paper of the Week)
• Zhang, Y., An, X., Stubbe, J., and Huang, M. (2013) Investigation of in vivo roles of the carboxyl terminal tails of the small subunit (ßß') of S. cerevisiae ribonucleotide reductase: contribution to cofactor formation and inter-subunit association within the active holoenzyme. J. Biol. Chem. 288, 13951-13959. (This paper was selected as Paper of the Week)
• Ahmad, M.F, Kaushal, P.S., Wan, Q., Wijerathna, S.R., An, X., Huang, M., and Dealwis, C. G. (2012) Role of arginine-293 and glutamine-288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. J. Mol. Biol. (epub Mar 29, 2012)
• Wu, X., Liu, L and Huang. M (2011) Checkpoint Studies Using the Budding Yeast Saccharomyces cerevisiae. Cell Cycle Checkpoints: Methods and Protocols by Humana Press.
• Zhang, Y., Liu, L., Wu, X., An, X., Stubbe, J. and Huang, M. (2011) Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2: requirement of Rnr4 and contribution of Grx3/4 and Dre2. J. Biol. Chem. 286, 41499-41509. (selected as paper of the week). PMID 21931161.
• Wu, X., Liu, L and Huang. M (2010) Checkpoint Studies Using the Budding Yeast Saccharomyces cerevisiae. Cell Cycle Checkpoints: Methods and Protocols by Humana Press.
• Sanvisens, N., Bañó. C., Huang, M. and Puig, S. (2011) Regulation of ribonucleotide reductase in response to iron deficiency. Mol. Cell, 44, 759-769. (This paper was accompanied with a Preview in the same issue)