Zenggang Pan, MD, PhD

Professional Titles

• Professor

Publications

• Kong X, Xu-Monette ZY, Xu Z, Hsi E, Zhao X, Yan H, Nunns H, Au K, Visco C, Tzankov A, Dybkaer K, Yao S, Wu D, Wang C, Xu AM, Pan Z, Parsons BM, Chiu A, Tam W, Montes-Moreno S, Zhan F, Bernal-Mizrachi L, Zu Y, Zhang S, Møller MB, Chen W, Au Q, Merchant AA, Bhagat G, Li Y, Young KH. Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis. Blood Adv. 2025 Dec 4. [Epub ahead of print] PubMed PMID: 41346287
• Pollyea DA, Stevens BM, Abbott D, Amaya M, Gutman JA, Kent A, McMahon C, Schwartz M, Smith C, Dell-Martin J, Sohalski C, Ellis A, Haag M, Schowinsky J, Pan Z, Patel SB, Ransom M, Gillen A, Jordan CT, Pietras EM. Omacetaxine and azacitidine for untreated patients with myelodysplastic syndromes and excess blasts: a phase I/II clinical trial. EClinicalMedicine. 2025 Nov;89:103546. PubMed PMID: 41140451
• Fischer GM, Tsai HK, Huang J, Mochel MC, Sadigh S, Pan Z, Montesion M, Williams EA, Sabbagh M, Chetta P, Lip V, Ferry JA, Reimann JDR, Duncan L, Chen S, Kupper T, Liang MG, Vrooman LM, Pollard J, Pouli D, Fleming MD, Schmidt B, Harris MH, Bledsoe JR. Genomic Profiling of Pediatric Mycosis Fungoides, Lymphomatoid Papulosis, and Primary Cutaneous Anaplastic Large Cell Lymphoma Identifies Recurrent Tyrosine Kinase Gene Fusions. Mod Pathol. 2025 Oct 8;38(12):100908. [Epub ahead of print] PubMed PMID: 41072883
• Hidalgo Cedeno EF, Germans S, Pan Z, Mendez L, Weinberg OK, Xu ML. PAX5 as a diagnostic tool in unconventional acute leukemia: Establishing immunohistochemical evidence of B-cell lineage. Hum Pathol. 2025 Sep;163:105903. PubMed PMID: 40782987
• Shi W, Xu-Monette ZY, Jia Y, Tzankov A, Go H, Li L, Ponzoni M, Wang Y, Zhai Q, Perry AM, Wang S, Wang X, Chiu A, Xu ML, Visco C, Dybkaer K, Withers H, Long M, Yuan AF, Miao Y, Macias E, Wu D, Shuai W, Wang B, Li J, Bhagat G, Zu Y, Pan Z, Choi W, Montes-Moreno S, Chen W, Krieken JHV, Møller MB, Yu X, Parsons BM, Zhang S, Hsi ED, Sohani AR, Abramson JS, Ferreri AJM, Xu B, Li Y, Young KH. Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma. Blood Cancer J. 2025 Jul 17;15(1):123. PubMed PMID: 40675955
• Gisriel SD, Yuan J, Tang H, Xu J, Fang H, Li S, McCracken J, Li P, Braunberger RC, Xu-Monette ZY, Wu X, Wang E, Zhang QY, Soma LA, Katz SG, Zhang JJ, Matsumoto NP, Young KH, Xu ML, Pan Z. Concurrent or subsequent lymphomatous effusion in large B-cell lymphoma portends a dismal prognosis: A multi-institutional study. Am J Clin Pathol. 2025 Sep 9;164(3):390-401. PubMed PMID: 40581918
• Pandiri M, Stengel A, Zhang J, Wang P, Shao H, Velmurugan S, Jacob A, Symes E, Kaur A, Rojek A, Sojitra P, Wiredja D, Zhou Q, Chang H, Patil E, Patel JL, Patel AB, Menon M, Ghosh S, Wool GD, Arber DA, Pan Z, Findley A, Badar T, Tariq H, Sallman D, Bell RC, Perry A, Haferlach C, Fitzpatrick C, Venkataraman G. Karyotypic clonal fraction predicts adverse outcome in TP53-mutated myeloid neoplasms: an International TP53 investigators Network (iTiN) study. J Clin Pathol. 2025 Aug 18;78(9):629-635. PubMed PMID: 40571403
• Zhang L, Fink D, Pan Z. A Rare Case of Laryngeal ALK-Positive Histiocytosis With PRKAR1A::ALK Fusion. Ear Nose Throat J. 2025 May 20;:1455613251342897. [Epub ahead of print] PubMed PMID: 40395023
• Fitzpatrick MJ, Yuan J, Capa I, Bledsoe JR, Kibler CE, Tucker C, Shuai W, Matsumoto NP, Zhu GG, Ding Y, Wu X, Wang W, Hu Z, Jiang L, Jia Y, Zhao Y, Lin Y, Tian X, Galliani CA, Venkataraman G, Mehrotra S, Dal Cin P, Haag MM, Siegele B, Zhang W, Wang E, Castañeda-Sánchez I, Zhang QY, Perez-Atayde AR, Young KH, Sadigh S, Wang HY, Hasserjian RP, Medeiros LJ, Pan Z. Erythroblastic Sarcoma in Adults and Children: Different Pathways to the Same Destination. Mod Pathol. 2025 Aug;38(8):100716. PubMed PMID: 40126459
• Ohlstrom D, Walker ZJ, Pandey A, Davis LN, Engel KL, Pan Z, Forsberg PA, Mark TM, Gillen AE, Sherbenou DW. Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression. Cancer Res Commun. 2025 Jan 1;5(1):106-118. PubMed PMID: 39699274
• Song JY, Pan Z. Aberrant expression in lymphoma, a diagnostic pitfall. Hum Pathol. 2025 Feb;156:105706. PubMed PMID: 39674282
• Ohlstrom D, Walker ZJ, Pandey A, Davis LN, Engel KL, Pan Z, Forsberg PA, Mark TM, Gillen AE, Sherbenou DW. Single Cell RNA Sequencing Before and After Light Chain Escape Reveals Intra-patient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression. Cancer Res Commun. 2024 Dec 19. [Epub ahead of print] PubMed PMID: 39699274
• Song JY, Pan Z. Aberrant expression in lymphoma, a diagnostic pitfall. Hum Pathol. 2024 Dec 16;:105706. [Epub ahead of print] PubMed PMID: 39674282
• Collins N, Willard N, Pan Z. Mast cell sarcoma with KIT p.D816V mutation and concurrent systemic mastocytosis. J Hematop. 2024 Dec;17(4):281-287. PubMed PMID: 39621254
• Johnson M, Willard N, Pan Z. Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement. J Hematop. 2024 Dec;17(4):265-270. PubMed PMID: 39207720
• Fang J, Bosma G, Aisner D, McMahon C, Amaya M, Schwartz M, Kaiser J, Abbott D, Pan Z, Schowinsky J, Pang C, Gutman JA, Pollyea DA. White blood cell count nadir to zero following intensive chemotherapy as a predictive factor for patients with acute myeloid leukemia. Leuk Lymphoma. 2024 Jun;65(6):800-807. PubMed PMID: 38814858
• Zheng G, Li P, Zhang X, Pan Z. The fifth edition of the World Health Organization Classification and the International Consensus Classification of myeloid neoplasms: evolving guidelines in the molecular era with practical implications. Curr Opin Hematol. 2023 Mar 1;30(2):53-63. PubMed PMID: 36728868
• Li Y, Xu-Monette ZY, Abramson J, Sohani AR, Bhagat G, Tzankov A, Visco C, Zhang S, Dybkaer K, Pan Z, Xu M, Tam W, Zu Y, Hsi ED, Hagemeister FB, Go H, van Krieken JH, Winter JN, Ponzoni M, Ferreri AJM, Møller MB, Piris MA, Wang Y, Zhang M, Young KH. EBV-positive DLBCL frequently harbors somatic mutations associated with clonal hematopoiesis of indeterminate potential. Blood Adv. 2023 Apr 11;7(7):1308-1311. PubMed PMID: 36399513
• Choudhuri J, Pan Z, Yuan J, Chen M, Wu X, Zheng G, Zhao C, Yuan Y, Agarwal B, Liu J, Ma MY, Wang Y, Shi Y. CD138- Plasmablastic Lymphoma: A Multi-institutional Study and Review of the Literature. Arch Pathol Lab Med. 2023 Jun 1;147(6):643-654. PubMed PMID: 36161544
• Young KHH, Li Y, Xu-Monette ZY, Abramson JS, Sohani A, Bhagat G, Tzankov A, Visco C, Zhang S, Dybkaer K, Pan Z, Xu ML, Tam W, Zu Y, Hsi ED, Hagemeister FB, Go H, van Krieken J, Winter JN, Ponzoni M, Ferreri AJM, Møller MB, Piris MA, Wang Y, Zhang M. EBV-positive DLBCL frequently harbors somatic mutations associated with clonal hematopoiesis of indeterminate potential. Blood Adv. 2022 Nov 18. [Epub ahead of print] PubMed PMID: 36399513
• Gisriel SD, Yuan J, Braunberger RC, Maracaja DLV, Chen X, Wu X, McCracken J, Chen M, Xie Y, Brown LE, Li P, Zhou Y, Sethi T, McHenry A, Hauser RG, Paulson N, Tang H, Hsi ED, Wang E, Zhang QY, Young KH, Xu ML, Pan Z. Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics. Mod Pathol. 2022 Oct;35(10):1411-1422. PubMed PMID: 35562413
• Choudhuri J, Pan Z, Yuan J, Chen M, Wu X, Zheng G, Zhao C, Yuan Y, Agarwal B, Liu J, Ma MY, Wang Y, Shi Y. CD138- Plasmablastic Lymphoma. Arch Pathol Lab Med. 2022 Sep 26. [Epub ahead of print] PubMed PMID: 36161544
• Matsumoto NP, Yuan J, Wang J, Shen Q, Chen X, Kim Y, Zuppan CW, Chang CC, Cui W, Chen D, Shi M, Gisriel SD, Chen M, Xu ML, Pan Z. Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature. Mod Pathol. 2022 Jul;35(7):865-874. PubMed PMID: 35105959
• Zeng G, Li P, Zhang XH, Pan ZG. The 5th edition of the World Health Organization Classification and the International Consensus Classification of myeloid neoplasms: evolving guidelines in the molecular era with practical implications. Current Opinion in Hematology. December 2022.
• Pan Z, Hu S, Li M, Zhou Y, Kim YS, Reddy V, Sanmann JN, Smith LM, Chen M, Gao Z, Wang HY, Yuan J. ALK-positive Large B-cell Lymphoma: A Clinicopathologic Study of 26 Cases With Review of Additional 108 Cases in the Literature. Am J Surg Pathol. 2017 Jan;41(1):25-38. PubMed PMID: 27740969
• Pan Z, Kleinschmidt-DeMasters BK. CNS Erdheim-Chester Disease: A Challenge to Diagnose. J Neuropathol Exp Neurol. 2017 Dec 1;76(12):986-996. PubMed PMID: 29096034
• Morabito J, Bell MT, Montenij LJ, Mayes LM, Pan Z, Dieleman JM, Meguid RA, Bartels K. Perioperative Considerations for Chylothorax. J Cardiothorac Vasc Anesth. 2017 Dec;31(6):2277-2281. PubMed PMID: 28939323
• Melani C, Major A, Schowinsky J, Roschewski M, Pittaluga S, Jaffe ES, Pack SD, Abdullaev Z, Ahlman MA, Kwak JJ, Morgan R, Rabinovitch R, Pan Z, Haverkos BM, Gutman JA, Pollyea DA, Smith CA, Wilson WH, Kamdar M. PD-1 Blockade in Mediastinal Gray-Zone Lymphoma. N Engl J Med. 2017 Jul 6;377(1):89-91. PubMed PMID: 28679093
• Haverkos BM, Coleman C, Gru AA, Pan Z, Brammer J, Rochford R, Mishra A, Oakes CC, Baiocchi RA, Freud AG, Porcu P. Emerging insights on the pathogenesis and treatment of extranodal NK/T cell lymphomas (ENKTL). Discov Med. 2017 Mar;23(126):189-199. PubMed PMID: 28472613
• Major A, Pan Z, Kamdar M. Secondary CNS involvement of ALK-negative anaplastic large cell lymphoma. Am J Hematol. 2017 Nov;92(11):1267-1268. PubMed PMID: 28370436
• Haverkos BM, Pan Z, Gru AA, Freud AG, Rabinovitch R, Xu-Welliver M, Otto B, Barrionuevo C, Baiocchi RA, Rochford R, Porcu P. Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases. Curr Hematol Malig Rep. 2016 Dec;11(6):514-527. PubMed PMID: 27778143
• Haverkos BM, Pan Z, Gru AA, Freud AG, Rabinovitch R, Xu-Welliver M, Otto B, Barrionuevo C, Baiocchi RA, Rochford R, Porcu P. Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases. Curr Hematol Malig Rep. 2016 Dec;11(6):514-527. PubMed PMID: 27778143
• Pan Z, Hu S, Li M, Zhou Y, Kim YS, Reddy V, Sanmann JN, Smith LM, Chen M, Gao Z, Wang HY, Yuan J. ALK-positive Large B-cell Lymphoma: A Clinicopathologic Study of 26 Cases With Review of Additional 108 Cases in the Literature. Am J Surg Pathol. 2017 Jan;41(1):25-38. PubMed PMID: 27740969
• Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z. Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers. Histopathology. 2016 Nov;69(5):775-783. PubMed PMID: 27319306
• Zenggang Pan, Jiehao Zhou. IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. International Journal of Clinical and Experimental Pathology (Review Article. Accepted, 06/20/16) (Corresponding Author)
• Sanjana Mehrotra, Zenggang Pan. Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: A case of transdifferentiation from low-grade follicular lymphoma. Diagnostic Cytopathology 2015 Aug;43(8):659-663
• Poomy Pandey, Satyanarayana Rachagani, Srustidhar Das, Parthasarathy Seshacharyulu, Yuri Sheinin, Naava Naslavsky, Zenggang Pan, Brittney L. Smith, Haley L. Peters, Prakash Radhakrishnan, Nicole R. McKenna, Sai Srinivas Panapakkam Giridharan, Dhanya Haridas, Sukhwinder Kaur, Michael A. Hollingsworth, Richard G. MacDonald, Jane L. Meza, Steve Caplan, Surinder K. Batra, and Joyce C. Solheim. Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Oncotarget. 2015 Feb 10;6(4):2064-2075.
• Merkel cell carcinoma of lymph node with unknown primary has a significantly lower association with Merkel cell polyomavirus than its cutaneous counterpart. Pan Z, Chen YY, Wu X, Trisal V, Wilczynski SP, Weiss LM, Chu PG, Wu H. Mod Pathol. 2014 Sep;27(9):1182-92.
• Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Pandey P, Rachagani S, Das S, Seshacharyulu P, Sheinin Y, Naslavsky N, Pan Z, Smith BL, Peters HL, Radhakrishnan P, McKenna NR, Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, MacDonald RG, Meza JL, Caplan S, Batra SK, Solheim JC. Oncotarget. 2014 Dec 11.
• Matney KD, Meltesen L, Swisshelm K, Pan Z (2014) Novel Report of a Clonal Myeloproliferative Disorder with Prominent Histiocytic Differentiation. Ann Clin Pathol 2(5): 1034.
• Zenggang Pan, Yuanyuan Chen, Xiaojun Wu, Vijay Trisal, Sharon Wilczynski, Peiguo Chu, Huiqing Wu. Merkel Cell Carcinoma of Lymph Node with Unknown Primary Has a Significant Lower Association with Merkel Cell Polyomavirus Than Its Cutaneous Counterpart. Modern Pathology. 2014 January (10)
• Zenggang Pan, Qingmei Xie, Susan Repertinger, Bill G. Richendollar, Wing C. Chan, and Qin Huang. Plasmablastic Lymphomas Directly Transformed from Chronic Lymphocytic Leukemia with Newly Acquired C-Myc Gene Rearrangement. Human Pathology. 2013 October;44(10):2139-2148.
• Zenggang Pan, William Grizzle, and Omar Hameed. Immunohistochemical Expression of Renal Markers in Matched Primary and Metastatic Renal Cell Carcinomas. American Journal of Clinical Pathology. 2013 September;140(3):410-418.
• Zenggang Pan, William Grizzle, and Omar Hameed. Immunohistochemical Expression of Renal Markers in Matched Primary and Metastatic Renal Cell Carcinomas. American Journal of Clinical Pathology. (Accepted)
• • Zenggang Pan, Qianyun Zhang, Zhengbin Lu, Tobi Quinto, Igor B. Rozenvald, Lanting Liu, David Wilson, Vishnu Reddy, Huanyou Wang, Yongsheng Ren. Extracavitary KSHV-Associated Large B-Cell Lymphoma: A Distinct Entity or a Subtype of Primary Effusion Lymphoma? Study of 9 Cases and Review of Additional 43 Cases. American Journal of Surgical Pathology. 2012 August;36(8):1129-40.
• CD3-Positive Plasmablastic Lymphoma and Plasmablastic Plasma Cell Neoplasm: A Diagnostic Pitfall. Modern Pathology

Professional Memberships

• • American Medical Association (AMA), Member
• • American Society for Clinical Pathology , Member
• • College of American Pathologists (CAP), Member
• • United States and Canadian Academy of Pathology (USCAP), Member
• Colorado Society of Clinical Pathologists, Member

Practice Locations

• University of Colorado Hospital

Specialty Information

• Anatomic and Clinical, Board Certification (2010)
• Hematopathology, Certificate (2012)
• Surgical pathology, Certificate (2011)

• Blood / Lymphatic System - Blood Disorders
• Blood / Lymphatic System - Bleeding Disorders
• Cancers - Myeloma
• Cancers - Lymphoma
• Cancers - Leukemia (Childhood)
• Cancers - Leukemia (Adult Chronic)
• Cancers - Leukemia (Adult Acute)
• Cancers - Cancer Pathology
• Blood / Lymphatic System
• Cancers